LOCUS       NM_015758               1625 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus forkhead box E3 (Foxe3), mRNA.
ACCESSION   NM_015758
VERSION     NM_015758.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1625)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1625)
  AUTHORS   Sun,Q., Li,J., Ma,J., Zheng,Y., Ju,R., Li,X., Ren,X., Huang,L.,
            Chen,R., Tan,X. and Luo,L.
  TITLE     JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens
            Fiber Maturation in Murine Lens Development
  JOURNAL   Invest Ophthalmol Vis Sci 64 (15), 15 (2023)
   PUBMED   38095908
REFERENCE   3  (bases 1 to 1625)
  AUTHORS   Xiang,J., Pompetti,A.J., Faranda,A.P., Wang,Y., Novo,S.G., Li,D.W.
            and Duncan,M.K.
  TITLE     ATF4 May Be Essential for Adaption of the Ocular Lens to Its
            Avascular Environment
  JOURNAL   Cells 12 (22), 2636 (2023)
   PUBMED   37998373
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1625)
  AUTHORS   Faranda,A.P., Shihan,M.H., Wang,Y. and Duncan,M.K.
  TITLE     The aging mouse lens transcriptome
  JOURNAL   Exp Eye Res 209, 108663 (2021)
   PUBMED   34119483
  REMARK    GeneRIF: The aging mouse lens transcriptome.
REFERENCE   5  (bases 1 to 1625)
  AUTHORS   Vetrivel,S., Tiso,N., Kugler,A., Irmler,M., Horsch,M., Beckers,J.,
            Hladik,D., Giesert,F., Gailus-Durner,V., Fuchs,H., Sabrautzki,S.,
            Hrabe de Angelis,M. and Graw,J.
  TITLE     Mutation in the mouse histone gene Hist2h3c1 leads to degeneration
            of the lens vesicle and severe microphthalmia
  JOURNAL   Exp Eye Res 188, 107632 (2019)
   PUBMED   30991053
REFERENCE   6  (bases 1 to 1625)
  AUTHORS   Blixt,A., Mahlapuu,M., Aitola,M., Pelto-Huikko,M., Enerback,S. and
            Carlsson,P.
  TITLE     A forkhead gene, FoxE3, is essential for lens epithelial
            proliferation and closure of the lens vesicle
  JOURNAL   Genes Dev 14 (2), 245-254 (2000)
   PUBMED   10652278
REFERENCE   7  (bases 1 to 1625)
  AUTHORS   Janne,P.A., Rochelle,J.M., Martin-DeLeon,P.A., Stambolian,D.,
            Seldin,M.F. and Nussbaum,R.L.
  TITLE     Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b)
            to distal mouse chromosome 4 and its exclusion as a candidate gene
            for dysgenetic lens
  JOURNAL   Genomics 28 (2), 280-285 (1995)
   PUBMED   8530037
REFERENCE   8  (bases 1 to 1625)
  AUTHORS   Sanyal,S., Van Nie,R., De Moes,J. and Hawkins,R.K.
  TITLE     Map position of dysgenetic lens (dyl) locus on chromosome 4 in the
            mouse
  JOURNAL   Genet Res 48 (3), 199-200 (1986)
   PUBMED   3569904
REFERENCE   9  (bases 1 to 1625)
  AUTHORS   Brahma,S.K. and Sanyal,S.
  TITLE     Immunohistochemical studies of lens crystallins in the dysgenetic
            lens (dyl) mutant mice
  JOURNAL   Exp Eye Res 38 (3), 305-311 (1984)
   PUBMED   6373332
REFERENCE   10 (bases 1 to 1625)
  AUTHORS   Sanyal,S. and Hawkins,R.K.
  TITLE     Dysgenetic lens (dyl)--a new gene in the mouse
  JOURNAL   Invest Ophthalmol Vis Sci 18 (6), 642-645 (1979)
   PUBMED   109409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670035.15.
            
            On Jun 20, 2019 this sequence version replaced NM_015758.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC141057.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1625              AL670035.15        33464-35088         c
FEATURES             Location/Qualifiers
     source          1..1625
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 52.73 cM"
     gene            1..1625
                     /gene="Foxe3"
                     /gene_synonym="dyl; FREAC8; rct"
                     /note="forkhead box E3"
                     /db_xref="GeneID:30923"
                     /db_xref="MGI:MGI:1353569"
     exon            1..1625
                     /gene="Foxe3"
                     /gene_synonym="dyl; FREAC8; rct"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..921
                     /gene="Foxe3"
                     /gene_synonym="dyl; FREAC8; rct"
                     /note="dysgenetic lens; Rinshoken cataract"
                     /codon_start=1
                     /product="forkhead box protein E3"
                     /protein_id="NP_056573.1"
                     /db_xref="CCDS:CCDS18483.1"
                     /db_xref="GeneID:30923"
                     /db_xref="MGI:MGI:1353569"
                     /translation="MDAQVAFSGFPALPSLTPSGPQLPTLAGAEPGREPEEVVGGGDA
                     EPTAVPGPGKRRRRPLQRGKPPYSYIALIAMALAHAPGRRLTLAAIYRFITERFAFYR
                     DSPRKWQNSIRHNLTLNDCFVKVPREPGNPGKGNYWTLDPAAADMFDNGSFLRRRKRF
                     KRAELPAPPPPPPPFPYAPFPPPPAPASAPPARLFRLDSLLGLQPEPPGPVAPEPPCC
                     AAPDAAFPPCAAAASPPLYSPASERLGLPAPLPAQPLLALAGSAGALGPLGAGEAYLR
                     QPGFAPGLERYL"
     regulatory      1605..1610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxe3"
                     /gene_synonym="dyl; FREAC8; rct"
                     /note="hexamer: ATTAAA"
     polyA_site      1625
                     /gene="Foxe3"
                     /gene_synonym="dyl; FREAC8; rct"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgcgag cagggactcc gcatccctag gacccccacc cccacccccc gcacatggat
       61 gcgcaagtcg ctttctcggg cttcccggcc ttgccctcgc tcacgccgtc cgggccgcag
      121 ctgccgacgc tggcgggagc cgaaccgggg cgcgaaccgg aggaagtggt gggcggtggg
      181 gacgccgagc ccacggccgt gcctggcccg gggaagcgac ggcggcggcc actacagcgt
      241 gggaagccgc cctactcata catcgcgctc attgccatgg ccctggcgca cgctcccggc
      301 cgccgtctaa cgctggcagc catctaccgc ttcatcaccg agcgcttcgc cttctaccgc
      361 gacagcccgc gcaagtggca gaacagcatc cgccacaacc tcaccctcaa cgactgtttc
      421 gtcaaggtgc cgcgcgagcc gggcaatccg ggcaagggca actactggac gctcgatccc
      481 gcggccgctg acatgttcga caacggtagc ttcctgcggc gccgcaagcg cttcaagcgc
      541 gctgagctgc ccgcaccgcc gccgccgccg ccgcccttcc cctatgcgcc cttcccgccc
      601 ccgccagcac ccgcgtccgc tccgcccgcg cgcctcttcc gcctggacag cctgttgggc
      661 ttgcagcctg agccgccggg acccgtggcg cccgagccgc cttgctgcgc cgcgcccgac
      721 gccgccttcc cgccctgtgc cgccgcagcc tcgccgccgc tctactcgcc agcgtccgag
      781 cgcctggggt tacccgcgcc gctgcccgcc cagcctctcc tggccttggc gggatcggcc
      841 ggcgcgctcg ggccgctcgg agccggggaa gcctacctga gacagccggg cttcgcgccg
      901 gggctggagc gctacctgtg agtcgctttc cgctgcggga gcgcctggtg gagccttctg
      961 ccccggcctg cgctggagca gtgcgagctt gtccgtggta cccgtacccg cccgcccgca
     1021 gcgtggcgca attcgctggg tccccgagcc ttgcttgggg ctaagccttc cctgccctcc
     1081 tccatccctg gggagaccct ggctgtctca ccaccagact gaagcgccct ctccaatttg
     1141 aggtctttcc tccctttact tgtgctcccc acataagcac ccttgcactg ccaaatccgg
     1201 tgctttggaa ctccagcccc agccccaaat gtccctgtga gttccagtct gtggaaactt
     1261 ttcgttccaa ggcacctcct ccatctctga tgttttgcca acacatcaga ggtcagactc
     1321 ctgggttcat tacttctacc ccatcttcct ccatttaccg ataagtttgg caaatttgtt
     1381 ccctgcccta ggtttacagt ctgtgcttgt tttcttaccg agcctgtctc cgacaaagac
     1441 tcacctgagg gctctgctct gaacagttct tcagattttc taggttactc ggcaccagga
     1501 tctcctgact gaatggggaa ttaatgggag tctgtggctg ctccacccca tggaaagcac
     1561 agaacttatc tgtttatggt tatttttcaa tcaaagctgg tttaattaaa acaaaaacaa
     1621 agaaa
//
