LOCUS       NM_183298               2131 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus forkhead box E1 (Foxe1), mRNA.
ACCESSION   NM_183298 XM_975742
VERSION     NM_183298.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2131)
  AUTHORS   Trinh,L.T., Finnel,R.R., Osipovich,A.B., Musselman,J.R.,
            Sampson,L.L., Wright,C.V.E. and Magnuson,M.A.
  TITLE     Positive autoregulation of Sox17 is necessary for gallbladder and
            extrahepatic bile duct formation
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39745200
REFERENCE   2  (bases 1 to 2131)
  AUTHORS   Zhang,C., Zheng,Y., Qu,Y., Huang,R., Huang,H., Li,J., Qiu,M. and
            Li,F.
  TITLE     Transcriptional factor ISL1 regulates palate development by tuning
            the SHH cascade
  JOURNAL   FEBS J (2024) In press
   PUBMED   39704783
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 2131)
  AUTHORS   Zhang,Z., Wu,Y., Fu,J., Yu,X., Su,Y., Jia,S., Cheng,H., Shen,Y.,
            He,X., Ren,K., Zheng,X., Guan,H., Rao,F. and Zhao,L.
  TITLE     Proteostatic reactivation of the developmental transcription factor
            TBX3 drives BRAF/MAPK-mediated tumorigenesis
  JOURNAL   Nat Commun 15 (1), 4108 (2024)
   PUBMED   38750011
  REMARK    Erratum:[Nat Commun. 2024 Jun 10;15(1):4936. doi:
            10.1038/s41467-024-49330-w.. PMID: 38858379]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2131)
  AUTHORS   Kang,H.S., Grimm,S.A., Liao,X.H. and Jetten,A.M.
  TITLE     GLIS3 expression in the thyroid gland in relation to TSH signaling
            and regulation of gene expression
  JOURNAL   Cell Mol Life Sci 81 (1), 65 (2024)
   PUBMED   38281222
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2131)
  AUTHORS   Didier-Mathon,H., Stoupa,A., Kariyawasam,D., Yde,S.,
            Cochant-Priollet,B., Groussin,L., Sebag,F., Cagnard,N.,
            Nitschke,P., Luton,D., Polak,M. and Carre,A.
  TITLE     Borealin/CDCA8 deficiency alters thyroid development and results in
            papillary tumor-like structures
  JOURNAL   Front Endocrinol (Lausanne) 14, 1286747 (2023)
   PUBMED   37964961
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2131)
  AUTHORS   Meng,T., Shi,J.Y., Wu,M., Wang,Y., Li,L., Liu,Y., Zheng,Q.,
            Huang,L. and Shi,B.
  TITLE     Overexpression of mouse TTF-2 gene causes cleft palate
  JOURNAL   J Cell Mol Med 16 (10), 2362-2368 (2012)
   PUBMED   22304410
  REMARK    GeneRIF: Overexpression of TTF-2 during the palatogenesis may
            contribute to cleft palate.
REFERENCE   7  (bases 1 to 2131)
  AUTHORS   Dathan,N., Parlato,R., Rosica,A., De Felice,M. and Di Lauro,R.
  TITLE     Distribution of the titf2/foxe1 gene product is consistent with an
            important role in the development of foregut endoderm, palate, and
            hair
  JOURNAL   Dev Dyn 224 (4), 450-456 (2002)
   PUBMED   12203737
  REMARK    GeneRIF: Data report a detailed expression pattern of thyroid
            transcription factor-2 protein during mouse embryogenesis.
REFERENCE   8  (bases 1 to 2131)
  AUTHORS   Martinez Barbera,J.P., Clements,M., Thomas,P., Rodriguez,T.,
            Meloy,D., Kioussis,D. and Beddington,R.S.
  TITLE     The homeobox gene Hex is required in definitive endodermal tissues
            for normal forebrain, liver and thyroid formation
  JOURNAL   Development 127 (11), 2433-2445 (2000)
   PUBMED   10804184
REFERENCE   9  (bases 1 to 2131)
  AUTHORS   De Felice,M., Ovitt,C., Biffali,E., Rodriguez-Mallon,A., Arra,C.,
            Anastassiadis,K., Macchia,P.E., Mattei,M.G., Mariano,A.,
            Scholer,H., Macchia,V. and Di Lauro,R.
  TITLE     A mouse model for hereditary thyroid dysgenesis and cleft palate
  JOURNAL   Nat Genet 19 (4), 395-398 (1998)
   PUBMED   9697704
REFERENCE   10 (bases 1 to 2131)
  AUTHORS   Zannini,M., Avantaggiato,V., Biffali,E., Arnone,M.I., Sato,K.,
            Pischetola,M., Taylor,B.A., Phillips,S.J., Simeone,A. and Di
            Lauro,R.
  TITLE     TTF-2, a new forkhead protein, shows a temporal expression in the
            developing thyroid which is consistent with a role in controlling
            the onset of differentiation
  JOURNAL   EMBO J 16 (11), 3185-3197 (1997)
   PUBMED   9214635
  REMARK    Erratum:[EMBO J 2001 Apr 17;20(8):2108]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL806523.14.
            
            On May 5, 2018 this sequence version replaced NM_183298.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2131              AL806523.14        170600-172730
FEATURES             Location/Qualifiers
     source          1..2131
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 24.68 cM"
     gene            1..2131
                     /gene="Foxe1"
                     /gene_synonym="Titf2; TTF-2"
                     /note="forkhead box E1"
                     /db_xref="GeneID:110805"
                     /db_xref="MGI:MGI:1353500"
     exon            1..2131
                     /gene="Foxe1"
                     /gene_synonym="Titf2; TTF-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             551..1666
                     /gene="Foxe1"
                     /gene_synonym="Titf2; TTF-2"
                     /note="thyroid transcription factor 2"
                     /codon_start=1
                     /product="forkhead box protein E1"
                     /protein_id="NP_899121.1"
                     /db_xref="CCDS:CCDS18147.1"
                     /db_xref="GeneID:110805"
                     /db_xref="MGI:MGI:1353500"
                     /translation="MTAESAPPPPPQPETLAAVKEERGEAAAAGAGVPAEAAGRGAGG
                     RRRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNS
                     IRHNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYP
                     AYMHDAAAAAAAAAAAIFPGAVPAARPAYPGAVYAGYAPPLAAPPPVYYPAASPGPCR
                     VFGLVPERPLSPDLGPAPSAAGGSCAFAAAAGAAGTGSFQPAVCTGARPVNPAAYAAA
                     YAGPDGAYPQGASSALFAAAAGRLAGPASPPAGGGSGGVEATVDFYGRTSPGQFGAAL
                     GPCYNPGGQLGAGGGGAYHSRHATAYPGAVDRFVSAM"
ORIGIN      
        1 ggagctggcc caggtgtgtg caggagagcg cctcgccggc cggactccgt gctggagttc
       61 agagccgcag aacggagcac ttgctcgcca cctggcccgg cccgctcgcc cgtctcgcct
      121 ctctgccctc cgcttgggtt gtaccttcca ccgtaggggt gcggcatggg cggcccctgc
      181 aggggtgtac ggtgccccca ctgaaggccc tggcacgaga ccccagcctg cagcctcctc
      241 tacgcgcacc gcctcgacgg tcatcctcag acccgcaggg actcccaaac agctgccgcc
      301 accccggcct tcgagccacg tccggacccc ttgatcgcct ggcaccagag cgccaaggat
      361 cctctggccg gtgccccaca ggagccgtcg gtggactcag cgctccagac cccgaagttc
      421 cctgccctca gcgctctcgg tgcccgctgc aaagccccgg cgtcggctcc cgtgggatcg
      481 ggattgcggc cagagcggtc gtctacagct gaagacgacg gggggtacgg gggggaggga
      541 ccgcggcgcc atgacggccg agagcgcgcc gcctcccccg ccgcagcccg agacgctggc
      601 ggccgtgaag gaagagcgcg gtgaggcggc ggcggcgggc gcgggggtcc cggcggaggc
      661 tgcgggtcgc ggcgcgggag gacggcgacg caagcgcccc ctgcagcggg ggaagccgcc
      721 ctacagctac atcgcgctca tcgctatggc catcgcgcac gcgcccgagc gccgcctgac
      781 tctgggcggc atctacaagt tcatcaccga gcgcttcccg ttctaccgcg acaaccccaa
      841 gaagtggcag aacagcatcc gccacaacct caccctcaac gactgcttcc tcaagatccc
      901 gcgcgaggcg ggccgcccgg gcaagggcaa ttactgggcg ctcgacccca acgccgagga
      961 catgttcgaa agcggcagct tcctgcgccg ccgcaagcgc ttcaagcgct cggacctgtc
     1021 cacctacccg gcctacatgc acgatgcagc cgctgccgcc gccgctgccg ctgccgccat
     1081 cttcccgggc gccgtgcctg ccgcaaggcc ggcttacccg ggcgccgtct atgcgggcta
     1141 cgcgccgcca ctcgccgcgc ctccgccggt ctactacccc gccgcgtcgc cggggccctg
     1201 ccgggtcttc ggcttggttc ccgagcggcc gctcagcccc gatctgggcc ccgcgccgtc
     1261 agcggccggc ggctcgtgcg ccttcgcggc tgcggcgggc gcggcgggca ccgggagctt
     1321 ccagccggcg gtgtgcaccg gagcgcggcc ggtcaacccc gccgcctatg ccgccgccta
     1381 cgcgggcccc gacggcgcgt acccgcaagg agcgagcagt gcgctcttcg ccgctgctgc
     1441 gggccgcctg gccggaccgg cctcgccccc cgcgggaggc ggcagcggcg gcgtggaggc
     1501 cacggtggac ttctacgggc gcacgtcgcc gggccagttc ggagcggcgc tgggaccctg
     1561 ctacaatccc ggtgggcaac tcggagccgg tggtggcggt gcctaccact cccgccacgc
     1621 caccgcctac cccggcgcgg tggatcggtt cgtgtctgcc atgtgagccc gggtaggcac
     1681 gaaacctcac taactccagg acgttctgaa agatgtaaat cccccgagac cggcggacag
     1741 gactaaaacg tgtattgtac tgagactcac gtgcgaggcc ccctgagggc cgtggaggct
     1801 cggtgtcttg cactgttcac agccccgatt tggacgtggg cggacgtagg gaggccacgg
     1861 ccgcgtttgg cctgacacaa aggaccctcg atgacgcgaa actccaaaga gcatgacttt
     1921 ctgcagttct actagggagg gccctaggct gtaaagggtg gagagttgca gagctatgta
     1981 cgccagaatc taggatcccg aactgtggtg gagtcgtaag gcttcaccgt gtgctatgcc
     2041 acgccaaact cgggcttttt acatgctcgc gtcttgtact tttgactatc gtacccaata
     2101 aaaggctcgg acagtgtctt tataattcaa a
//
