LOCUS       NP_899121                371 aa            linear   ROD 18-FEB-2025
DEFINITION  forkhead box protein E1 [Mus musculus].
ACCESSION   NP_899121 XP_980836
VERSION     NP_899121.1
DBSOURCE    REFSEQ: accession NM_183298.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 371)
  AUTHORS   Trinh,L.T., Finnel,R.R., Osipovich,A.B., Musselman,J.R.,
            Sampson,L.L., Wright,C.V.E. and Magnuson,M.A.
  TITLE     Positive autoregulation of Sox17 is necessary for gallbladder and
            extrahepatic bile duct formation
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39745200
REFERENCE   2  (residues 1 to 371)
  AUTHORS   Zhang,C., Zheng,Y., Qu,Y., Huang,R., Huang,H., Li,J., Qiu,M. and
            Li,F.
  TITLE     Transcriptional factor ISL1 regulates palate development by tuning
            the SHH cascade
  JOURNAL   FEBS J (2024) In press
   PUBMED   39704783
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 371)
  AUTHORS   Zhang,Z., Wu,Y., Fu,J., Yu,X., Su,Y., Jia,S., Cheng,H., Shen,Y.,
            He,X., Ren,K., Zheng,X., Guan,H., Rao,F. and Zhao,L.
  TITLE     Proteostatic reactivation of the developmental transcription factor
            TBX3 drives BRAF/MAPK-mediated tumorigenesis
  JOURNAL   Nat Commun 15 (1), 4108 (2024)
   PUBMED   38750011
  REMARK    Erratum:[Nat Commun. 2024 Jun 10;15(1):4936. doi:
            10.1038/s41467-024-49330-w.. PMID: 38858379]
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 371)
  AUTHORS   Kang,H.S., Grimm,S.A., Liao,X.H. and Jetten,A.M.
  TITLE     GLIS3 expression in the thyroid gland in relation to TSH signaling
            and regulation of gene expression
  JOURNAL   Cell Mol Life Sci 81 (1), 65 (2024)
   PUBMED   38281222
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 371)
  AUTHORS   Didier-Mathon,H., Stoupa,A., Kariyawasam,D., Yde,S.,
            Cochant-Priollet,B., Groussin,L., Sebag,F., Cagnard,N.,
            Nitschke,P., Luton,D., Polak,M. and Carre,A.
  TITLE     Borealin/CDCA8 deficiency alters thyroid development and results in
            papillary tumor-like structures
  JOURNAL   Front Endocrinol (Lausanne) 14, 1286747 (2023)
   PUBMED   37964961
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 371)
  AUTHORS   Meng,T., Shi,J.Y., Wu,M., Wang,Y., Li,L., Liu,Y., Zheng,Q.,
            Huang,L. and Shi,B.
  TITLE     Overexpression of mouse TTF-2 gene causes cleft palate
  JOURNAL   J Cell Mol Med 16 (10), 2362-2368 (2012)
   PUBMED   22304410
  REMARK    GeneRIF: Overexpression of TTF-2 during the palatogenesis may
            contribute to cleft palate.
REFERENCE   7  (residues 1 to 371)
  AUTHORS   Dathan,N., Parlato,R., Rosica,A., De Felice,M. and Di Lauro,R.
  TITLE     Distribution of the titf2/foxe1 gene product is consistent with an
            important role in the development of foregut endoderm, palate, and
            hair
  JOURNAL   Dev Dyn 224 (4), 450-456 (2002)
   PUBMED   12203737
  REMARK    GeneRIF: Data report a detailed expression pattern of thyroid
            transcription factor-2 protein during mouse embryogenesis.
REFERENCE   8  (residues 1 to 371)
  AUTHORS   Martinez Barbera,J.P., Clements,M., Thomas,P., Rodriguez,T.,
            Meloy,D., Kioussis,D. and Beddington,R.S.
  TITLE     The homeobox gene Hex is required in definitive endodermal tissues
            for normal forebrain, liver and thyroid formation
  JOURNAL   Development 127 (11), 2433-2445 (2000)
   PUBMED   10804184
REFERENCE   9  (residues 1 to 371)
  AUTHORS   De Felice,M., Ovitt,C., Biffali,E., Rodriguez-Mallon,A., Arra,C.,
            Anastassiadis,K., Macchia,P.E., Mattei,M.G., Mariano,A.,
            Scholer,H., Macchia,V. and Di Lauro,R.
  TITLE     A mouse model for hereditary thyroid dysgenesis and cleft palate
  JOURNAL   Nat Genet 19 (4), 395-398 (1998)
   PUBMED   9697704
REFERENCE   10 (residues 1 to 371)
  AUTHORS   Zannini,M., Avantaggiato,V., Biffali,E., Arnone,M.I., Sato,K.,
            Pischetola,M., Taylor,B.A., Phillips,S.J., Simeone,A. and Di
            Lauro,R.
  TITLE     TTF-2, a new forkhead protein, shows a temporal expression in the
            developing thyroid which is consistent with a role in controlling
            the onset of differentiation
  JOURNAL   EMBO J 16 (11), 3185-3197 (1997)
   PUBMED   9214635
  REMARK    Erratum:[EMBO J 2001 Apr 17;20(8):2108]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL806523.14.
            
            On May 4, 2006 this sequence version replaced XP_980836.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 24.68 cM"
     Protein         1..371
                     /product="forkhead box protein E1"
                     /note="thyroid transcription factor 2"
                     /calculated_mol_wt=37637
     Region          21..53
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2I0.2)"
     Region          55..143
                     /region_name="FH_FOXE"
                     /note="Forkhead (FH) domain found in the Forkhead box
                     protein E (FOXE) subfamily; cd20019"
                     /db_xref="CDD:410793"
     Site            order(60,78..79,82,101..102,104..105,108,115,125..127,129)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410793"
     CDS             1..371
                     /gene="Foxe1"
                     /gene_synonym="Titf2; TTF-2"
                     /coded_by="NM_183298.2:551..1666"
                     /db_xref="CCDS:CCDS18147.1"
                     /db_xref="GeneID:110805"
                     /db_xref="MGI:MGI:1353500"
ORIGIN      
        1 mtaesapppp pqpetlaavk eergeaaaag agvpaeaagr gaggrrrkrp lqrgkppysy
       61 ialiamaiah aperrltlgg iykfiterfp fyrdnpkkwq nsirhnltln dcflkiprea
      121 grpgkgnywa ldpnaedmfe sgsflrrrkr fkrsdlstyp aymhdaaaaa aaaaaaifpg
      181 avpaarpayp gavyagyapp laapppvyyp aaspgpcrvf glvperplsp dlgpapsaag
      241 gscafaaaag aagtgsfqpa vctgarpvnp aayaaayagp dgaypqgass alfaaaagrl
      301 agpasppagg gsggveatvd fygrtspgqf gaalgpcynp ggqlgagggg ayhsrhatay
      361 pgavdrfvsa m
//
