LOCUS       NM_008022               2074 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus forkhead box D4 (Foxd4), mRNA.
ACCESSION   NM_008022
VERSION     NM_008022.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2074)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2074)
  AUTHORS   Dykes,I.M., Szumska,D., Kuncheria,L., Puliyadi,R., Chen,C.M.,
            Papanayotou,C., Lockstone,H., Dubourg,C., David,V., Schneider,J.E.,
            Keane,T.M., Adams,D.J., Brown,S.D.M., Mercier,S., Odent,S.,
            Collignon,J. and Bhattacharya,S.
  TITLE     A Requirement for Zic2 in the Regulation of Nodal Expression
            Underlies the Establishment of Left-Sided Identity
  JOURNAL   Sci Rep 8 (1), 10439 (2018)
   PUBMED   29992973
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2074)
  AUTHORS   Gaur,S., Mandelbaum,M., Herold,M., Majumdar,H.D., Neilson,K.M.,
            Maynard,T.M., Mood,K., Daar,I.O. and Moody,S.A.
  TITLE     Neural transcription factors bias cleavage stage blastomeres to
            give rise to neural ectoderm
  JOURNAL   Genesis 54 (6), 334-349 (2016)
   PUBMED   27092474
  REMARK    GeneRIF: We demonstrate that mouse and human homologs of Foxd4l1
            have similar functional domains compared to the frog protein, as
            well as conserved transcriptional activities when expressed in
            Xenopus embryos and blastomere explants.
REFERENCE   4  (bases 1 to 2074)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 2074)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2074)
  AUTHORS   Rhinn,M., Dierich,A., Shawlot,W., Behringer,R.R., Le Meur,M. and
            Ang,S.L.
  TITLE     Sequential roles for Otx2 in visceral endoderm and neuroectoderm
            for forebrain and midbrain induction and specification
  JOURNAL   Development 125 (5), 845-856 (1998)
   PUBMED   9449667
REFERENCE   7  (bases 1 to 2074)
  AUTHORS   Kaestner,K.H., Schutz,G. and Monaghan,A.P.
  TITLE     Expression of the winged helix genes fkh-4 and fkh-5 defines
            domains in the central nervous system
  JOURNAL   Mech Dev 55 (2), 221-230 (1996)
   PUBMED   8861101
REFERENCE   8  (bases 1 to 2074)
  AUTHORS   Kaestner,K.H., Monaghan,A.P., Kern,H., Ang,S.L., Weitz,S.,
            Lichter,P. and Schutz,G.
  TITLE     The mouse fkh-2 gene. Implications for notochord, foregut, and
            midbrain regionalization
  JOURNAL   J Biol Chem 270 (50), 30029-30035 (1995)
   PUBMED   8530406
REFERENCE   9  (bases 1 to 2074)
  AUTHORS   Pierrou,S., Hellqvist,M., Samuelsson,L., Enerback,S. and
            Carlsson,P.
  TITLE     Cloning and characterization of seven human forkhead proteins:
            binding site specificity and DNA bending
  JOURNAL   EMBO J 13 (20), 5002-5012 (1994)
   PUBMED   7957066
REFERENCE   10 (bases 1 to 2074)
  AUTHORS   Kaestner,K.H., Lee,K.H., Schlondorff,J., Hiemisch,H., Monaghan,A.P.
            and Schutz,G.
  TITLE     Six members of the mouse forkhead gene family are developmentally
            regulated
  JOURNAL   Proc Natl Acad Sci U S A 90 (16), 7628-7631 (1993)
   PUBMED   7689224
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123930.4.
            
            On Feb 7, 2020 this sequence version replaced NM_008022.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC138432.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2074              AC123930.4         55503-57576
FEATURES             Location/Qualifiers
     source          1..2074
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 19.86 cM"
     gene            1..2074
                     /gene="Foxd4"
                     /gene_synonym="Fkh2; FREAC5"
                     /note="forkhead box D4"
                     /db_xref="GeneID:14237"
                     /db_xref="MGI:MGI:1347467"
     exon            1..2074
                     /gene="Foxd4"
                     /gene_synonym="Fkh2; FREAC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1517
                     /gene="Foxd4"
                     /gene_synonym="Fkh2; FREAC5"
                     /note="FREAC-5; transcription factor FKH-2;
                     forkhead-related protein FKHL9; forkhead-related
                     transcription factor 5; forkhead homolog 2"
                     /codon_start=1
                     /product="forkhead box protein D4"
                     /protein_id="NP_032048.1"
                     /db_xref="CCDS:CCDS29715.1"
                     /db_xref="GeneID:14237"
                     /db_xref="MGI:MGI:1347467"
                     /translation="MNSARAGHLRSTPPPSPLSSDQDEVEIDVLAEEEDGDQTEEEDD
                     EEESHKCLERSLQRPGARTLAGRSAGDCGDLSNSSGFLRKFRAPRTPATTTADGPQPA
                     KPPYSYIALITMAILQSPHKRLTLSGICAFISGRFPYYRRKFPAWQNSIRHNLSLNDC
                     FVKIPREPGHPGKGNYWSLDPASQDMFDNGSFLRRRKRFKRHHPPSGGHPHCPFPPPA
                     VPATLHVSQPSLLLRYSAPPQPNLAAHPAAPPRSHPCAPLHPHPMRYLLLAAPAYGDN
                     PRKAEGADPATPLAIPALQPVLGSQPWERDQSSGTRSGRGCASFTIESIMQGVTGGGT
                     GSAQSPSFAPWSYCHLLQHPPCLLHPQAASPLFHMSAGSRTILPQQPQPPLPLQQEQH
                     HCAISCAPGKGVRLGQHLSAVAALLRQQPAADDGRLTTLAALSGREGTLPEF"
     regulatory      2050..2055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxd4"
                     /gene_synonym="Fkh2; FREAC5"
                     /note="hexamer: AATAAA"
     polyA_site      2074
                     /gene="Foxd4"
                     /gene_synonym="Fkh2; FREAC5"
                     /note="major polyA site"
ORIGIN      
        1 ttaaaacacc aagtgctcct tgccaaaggg tgttagaaag aaaaagcaga aaagaacaag
       61 gaagcctaac ctaggagcgc tccagtttcc cagcagactc atccttgcta actcacccat
      121 cccaaaccag gtgagctgcc cccacgtccg tcccctcctc tccctcttcc ctcctatcct
      181 ccatgaactc agcaagagct gggcaccttc gttccactcc accgcccagt cctctaagtt
      241 ccgaccagga tgaggtggag atcgacgtgc tggcagagga ggaagatgga gatcagacgg
      301 aagaagagga tgacgaggag gagagccata agtgcctgga gcgatccctg cagaggcccg
      361 gagcccgcac tcttgcaggg aggagcgcgg gggactgcgg cgatctgagt aactcctccg
      421 ggttcctccg caagttccga gcaccacgga ccccggcgac caccacagcc gacggcccgc
      481 agcccgccaa acccccgtac tcctacatcg cgctcatcac catggccatc ctgcagagcc
      541 cgcacaagcg cctgacgctc agcggtatct gcgccttcat cagcggccgc ttcccctatt
      601 accgccgtaa gttccccgcc tggcagaaca gcatccgcca caacctgtcg ctcaacgact
      661 gcttcgtcaa gatccctcgc gagccgggcc acccgggcaa gggcaactat tggagcctgg
      721 accccgcctc ccaggacatg ttcgacaacg gcagcttcct ccggcgcagg aagcgcttca
      781 agcgccacca cccgccctcg ggaggccacc cgcactgccc tttccctcca cccgctgtgc
      841 ccgccaccct gcacgtctcc cagcccagcc tcctgctccg ctactctgcc ccaccacagc
      901 ctaacctcgc agctcatccc gctgccccgc ctcggagtca cccgtgcgcc ccgctgcatc
      961 cgcatcccat gcgctacctg ctgctcgcgg ccccggccta tggcgacaac cctagaaaag
     1021 cggaaggcgc ggaccccgcc acccccttag ccattcccgc gctgcagccc gtactgggtt
     1081 cccagccttg ggagagagac cagagctctg gaactcggtc cggacgcggg tgcgcttcgt
     1141 tcaccatcga gagcatcatg cagggggtta caggaggagg aactgggtct gcgcagagtc
     1201 cgtcctttgc tccgtggagc tactgccacc tgctgcaaca tccaccgtgc ctgctgcacc
     1261 cccaggccgc ttcccctttg tttcacatgt ccgcaggttc ccggacaata ttgcctcagc
     1321 agccgcaacc gccgctgccg ctgcagcaag aacagcatca ctgtgccatt agctgcgctc
     1381 ccggtaaagg cgtgcggtta ggccagcacc tgtccgccgt tgcggcgctg ctgaggcaac
     1441 agcctgcagc tgacgacggt aggctgacaa ccctggccgc tctttcgggc cgagagggga
     1501 ccttgcccga attttaagca gcacccaggc ccagcctcca ggctgggtcg ccttggcaca
     1561 cctggagcca agtggcaaaa tggaaccact ttctaggttt gcaccacccg cctgctaggc
     1621 ttgtgcgtag aaagccagca gcggagtgcg cactaagtcc ttccaaattg ttacaaatgt
     1681 gttctgctcg cttgacaaca caaaagtggg aaaatcctgg atctacaagt cttgcttggt
     1741 cttgtccgct tcggttgtgg cttccacggt tttcccgact tacatacttc ccgaggacct
     1801 atgactatga aagtgagtga ggtgttttgc tgttaataaa aacaaaacag tctgcaatac
     1861 aaaacatcac catccacatt gcttaggaac tgccagtgtt cccagtggcg actgcgactg
     1921 cgaatgcgta catgctccga aacccgtagg taatacaaat agggtaattt cataacattt
     1981 atctcttgta tatacgacgt gtcctactcc aacggggagt gttaaaacta agcctagtta
     2041 tagagattga ataaaatacg aaactacaat gcta
//
