LOCUS       NP_032048                444 aa            linear   ROD 30-APR-2025
DEFINITION  forkhead box protein D4 [Mus musculus].
ACCESSION   NP_032048
VERSION     NP_032048.1
DBSOURCE    REFSEQ: accession NM_008022.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 444)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 444)
  AUTHORS   Dykes,I.M., Szumska,D., Kuncheria,L., Puliyadi,R., Chen,C.M.,
            Papanayotou,C., Lockstone,H., Dubourg,C., David,V., Schneider,J.E.,
            Keane,T.M., Adams,D.J., Brown,S.D.M., Mercier,S., Odent,S.,
            Collignon,J. and Bhattacharya,S.
  TITLE     A Requirement for Zic2 in the Regulation of Nodal Expression
            Underlies the Establishment of Left-Sided Identity
  JOURNAL   Sci Rep 8 (1), 10439 (2018)
   PUBMED   29992973
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 444)
  AUTHORS   Gaur,S., Mandelbaum,M., Herold,M., Majumdar,H.D., Neilson,K.M.,
            Maynard,T.M., Mood,K., Daar,I.O. and Moody,S.A.
  TITLE     Neural transcription factors bias cleavage stage blastomeres to
            give rise to neural ectoderm
  JOURNAL   Genesis 54 (6), 334-349 (2016)
   PUBMED   27092474
  REMARK    GeneRIF: We demonstrate that mouse and human homologs of Foxd4l1
            have similar functional domains compared to the frog protein, as
            well as conserved transcriptional activities when expressed in
            Xenopus embryos and blastomere explants.
REFERENCE   4  (residues 1 to 444)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (residues 1 to 444)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 444)
  AUTHORS   Rhinn,M., Dierich,A., Shawlot,W., Behringer,R.R., Le Meur,M. and
            Ang,S.L.
  TITLE     Sequential roles for Otx2 in visceral endoderm and neuroectoderm
            for forebrain and midbrain induction and specification
  JOURNAL   Development 125 (5), 845-856 (1998)
   PUBMED   9449667
REFERENCE   7  (residues 1 to 444)
  AUTHORS   Kaestner,K.H., Schutz,G. and Monaghan,A.P.
  TITLE     Expression of the winged helix genes fkh-4 and fkh-5 defines
            domains in the central nervous system
  JOURNAL   Mech Dev 55 (2), 221-230 (1996)
   PUBMED   8861101
REFERENCE   8  (residues 1 to 444)
  AUTHORS   Kaestner,K.H., Monaghan,A.P., Kern,H., Ang,S.L., Weitz,S.,
            Lichter,P. and Schutz,G.
  TITLE     The mouse fkh-2 gene. Implications for notochord, foregut, and
            midbrain regionalization
  JOURNAL   J Biol Chem 270 (50), 30029-30035 (1995)
   PUBMED   8530406
REFERENCE   9  (residues 1 to 444)
  AUTHORS   Pierrou,S., Hellqvist,M., Samuelsson,L., Enerback,S. and
            Carlsson,P.
  TITLE     Cloning and characterization of seven human forkhead proteins:
            binding site specificity and DNA bending
  JOURNAL   EMBO J 13 (20), 5002-5012 (1994)
   PUBMED   7957066
REFERENCE   10 (residues 1 to 444)
  AUTHORS   Kaestner,K.H., Lee,K.H., Schlondorff,J., Hiemisch,H., Monaghan,A.P.
            and Schutz,G.
  TITLE     Six members of the mouse forkhead gene family are developmentally
            regulated
  JOURNAL   Proc Natl Acad Sci U S A 90 (16), 7628-7631 (1993)
   PUBMED   7689224
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123930.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC138432.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 19.86 cM"
     Protein         1..444
                     /product="forkhead box protein D4"
                     /note="FREAC-5; transcription factor FKH-2;
                     forkhead-related protein FKHL9; forkhead-related
                     transcription factor 5; forkhead homolog 2"
                     /calculated_mol_wt=47916
     Region          1..70
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60688.1)"
     Region          103..198
                     /region_name="FH_FOXD4-like"
                     /note="Forkhead (FH) domain found in Forkhead box protein
                     D4 (FOXD4) and similar proteins; cd20048"
                     /db_xref="CDD:410822"
     Site            order(104..109,126..127,145..146,148..150,152..154,157,
                     163..168,170,172..177,194..198)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410822"
     Region          234..256
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60688.1)"
     CDS             1..444
                     /gene="Foxd4"
                     /gene_synonym="Fkh2; FREAC5"
                     /coded_by="NM_008022.3:183..1517"
                     /db_xref="CCDS:CCDS29715.1"
                     /db_xref="GeneID:14237"
                     /db_xref="MGI:MGI:1347467"
ORIGIN      
        1 mnsaraghlr stpppsplss dqdeveidvl aeeedgdqte eeddeeeshk clerslqrpg
       61 artlagrsag dcgdlsnssg flrkfraprt patttadgpq pakppysyia litmailqsp
      121 hkrltlsgic afisgrfpyy rrkfpawqns irhnlslndc fvkiprepgh pgkgnywsld
      181 pasqdmfdng sflrrrkrfk rhhppsgghp hcpfpppavp atlhvsqpsl llrysappqp
      241 nlaahpaapp rshpcaplhp hpmrylllaa paygdnprka egadpatpla ipalqpvlgs
      301 qpwerdqssg trsgrgcasf tiesimqgvt gggtgsaqsp sfapwsychl lqhppcllhp
      361 qaasplfhms agsrtilpqq pqpplplqqe qhhcaiscap gkgvrlgqhl savaallrqq
      421 paaddgrltt laalsgregt lpef
//
