LOCUS       NM_008593               2619 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus forkhead box D2 (Foxd2), mRNA.
ACCESSION   NM_008593
VERSION     NM_008593.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2619)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 2619)
  AUTHORS   Zhang,C., Zheng,Y., Qu,Y., Huang,R., Huang,H., Li,J., Qiu,M. and
            Li,F.
  TITLE     Transcriptional factor ISL1 regulates palate development by tuning
            the SHH cascade
  JOURNAL   FEBS J 292 (4), 851-863 (2025)
   PUBMED   39704783
REFERENCE   3  (bases 1 to 2619)
  AUTHORS   Riedhammer,K.M., Nguyen,T.T., Kosukcu,C., Calzada-Wack,J., Li,Y.,
            Assia Batzir,N., Saygili,S., Wimmers,V., Kim,G.J., Chrysanthou,M.,
            Bakey,Z., Sofrin-Drucker,E., Kraiger,M., Sanz-Moreno,A.,
            Amarie,O.V., Rathkolb,B., Klein-Rodewald,T., Garrett,L.,
            Holter,S.M., Seisenberger,C., Haug,S., Schlosser,P., Marschall,S.,
            Wurst,W., Fuchs,H., Gailus-Durner,V., Wuttke,M., Hrabe de
            Angelis,M., Comic,J., Akgun Dogan,O., Ozluk,Y., Tasdemir,M.,
            Agbas,A., Canpolat,N., Orenstein,N., Caliskan,S., Weber,R.G.,
            Bergmann,C., Jeanpierre,C., Saunier,S., Lim,T.Y., Hildebrandt,F.,
            Alhaddad,B., Basel-Salmon,L., Borovitz,Y., Wu,K., Antony,D.,
            Matschkal,J., Schaaf,C.W., Renders,L., Schmaderer,C., Rogg,M.,
            Schell,C., Meitinger,T., Heemann,U., Kottgen,A., Arnold,S.J.,
            Ozaltin,F., Schmidts,M. and Hoefele,J.
  TITLE     Implication of transcription factor FOXD2 dysfunction in syndromic
            congenital anomalies of the kidney and urinary tract (CAKUT)
  JOURNAL   Kidney Int 105 (4), 844-864 (2024)
   PUBMED   38154558
  REMARK    GeneRIF: Implication of transcription factor FOXD2 dysfunction in
            syndromic congenital anomalies of the kidney and urinary tract
            (CAKUT).
REFERENCE   4  (bases 1 to 2619)
  AUTHORS   Zhang,W., Yu,J., Fu,G., Li,J., Huang,H., Liu,J., Yu,D., Qiu,M. and
            Li,F.
  TITLE     ISL1/SHH/CXCL12 signaling regulates myogenic cell migration during
            mouse tongue development
  JOURNAL   Development 149 (21) (2022)
   PUBMED   36196625
REFERENCE   5  (bases 1 to 2619)
  AUTHORS   Millington,G., Elliott,K.H., Chang,Y.T., Chang,C.F., Dlugosz,A. and
            Brugmann,S.A.
  TITLE     Cilia-dependent GLI processing in neural crest cells is required
            for tongue development
  JOURNAL   Dev Biol 424 (2), 124-137 (2017)
   PUBMED   28286175
REFERENCE   6  (bases 1 to 2619)
  AUTHORS   Zhao,G.Q. and Hogan,B.L.
  TITLE     Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that
            play a role in spermatogenesis and placental development
  JOURNAL   Mech Dev 57 (2), 159-168 (1996)
   PUBMED   8843393
REFERENCE   7  (bases 1 to 2619)
  AUTHORS   Labosky,P.A., Winnier,G.E., Sasaki,H., Blessing,M. and Hogan,B.L.
  TITLE     The chromosomal mapping of four genes encoding winged helix
            proteins expressed early in mouse development
  JOURNAL   Genomics 34 (2), 241-245 (1996)
   PUBMED   8661058
REFERENCE   8  (bases 1 to 2619)
  AUTHORS   Miura,N., Wanaka,A., Tohyama,M. and Tanaka,K.
  TITLE     MFH-1, a new member of the fork head domain family, is expressed in
            developing mesenchyme
  JOURNAL   FEBS Lett 326 (1-3), 171-176 (1993)
   PUBMED   8325367
REFERENCE   9  (bases 1 to 2619)
  AUTHORS   Clevidence,D.E., Overdier,D.G., Tao,W., Qian,X., Pani,L., Lai,E.
            and Costa,R.H.
  TITLE     Identification of nine tissue-specific transcription factors of the
            hepatocyte nuclear factor 3/forkhead DNA-binding-domain family
  JOURNAL   Proc Natl Acad Sci U S A 90 (9), 3948-3952 (1993)
   PUBMED   7683413
REFERENCE   10 (bases 1 to 2619)
  AUTHORS   Sasaki,H. and Hogan,B.L.
  TITLE     Differential expression of multiple fork head related genes during
            gastrulation and axial pattern formation in the mouse embryo
  JOURNAL   Development 118 (1), 47-59 (1993)
   PUBMED   8375339
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670035.15.
            
            On Dec 11, 2007 this sequence version replaced NM_008593.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2619              AL670035.15        15301-17919         c
FEATURES             Location/Qualifiers
     source          1..2619
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 52.73 cM"
     gene            1..2619
                     /gene="Foxd2"
                     /gene_synonym="Mf2"
                     /note="forkhead box D2"
                     /db_xref="GeneID:17301"
                     /db_xref="MGI:MGI:1347471"
     exon            1..2619
                     /gene="Foxd2"
                     /gene_synonym="Mf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1556
                     /gene="Foxd2"
                     /gene_synonym="Mf2"
                     /note="MF-2; mesoderm/mesenchyme forkhead 2"
                     /codon_start=1
                     /product="forkhead box protein D2"
                     /protein_id="NP_032619.1"
                     /db_xref="CCDS:CCDS18482.1"
                     /db_xref="GeneID:17301"
                     /db_xref="MGI:MGI:1347471"
                     /translation="MTLGSCCCEIMSSESSPAALSEPDADIDVVGGGSGGGELTARSG
                     PRAPRDVLPHGHEPPPEEAEADVAEDEEESGGCSDCEPRALAPRGAAAAAGSPGPGVQ
                     AARGATGPGPGPGPPSGGAATRSPLVKPPYSYIALITMAILQSPKKRLTLSEICEFIS
                     GRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSF
                     LRRRKRFKRQPLPPPHPHPHPHPELLLRGGAAAAGDPGAFLSSFAAYGAYGYGYGLAL
                     PAYGAPPPGPAPHPHPHPHAFAFAATAPCQLSVPPGRAAAPPPGPPTASVFASAASAP
                     APAPAPGSGPSPAGLPAFLGAELGCAKAFYPASLSPPAAGTAASLSTALLRQGLKTDA
                     GGGAGGGGAGTGQRPSFSIDHIMGHGGGGAAPPGSGDGSPGSPFAAAAGPGGQAQVLA
                     MLTAPALTPVAGHIRLSHPGDSLLSSGPSFASKVAGLSGCHF"
     regulatory      2598..2603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxd2"
                     /gene_synonym="Mf2"
                     /note="hexamer: AATAAA"
     polyA_site      2617
                     /gene="Foxd2"
                     /gene_synonym="Mf2"
                     /note="major polyA site"
ORIGIN      
        1 gagccgcggg ccgagcggag ccggagagcg gcggcggagg aggcggcgga ggaggcggcg
       61 gcggcggcgg cggcaccatg accctgggca gctgctgctg cgagatcatg tcctccgaga
      121 gctccccggc cgcgctgtct gagcccgacg cagacataga cgtggtgggc ggcggcagcg
      181 gtggggggga gctcacagcc cgctccgggc cccgcgcccc tcgggacgtg ctccctcacg
      241 gccacgagcc tcccccggag gaagccgagg cggacgtggc tgaggacgag gaagagtcgg
      301 gaggttgctc tgactgcgag ccccgcgctc tagcgccccg gggggcggcg gccgcagcgg
      361 gaagcccggg gcccggcgtg caggcagccc gaggcgcaac ggggccgggg ccgggacccg
      421 ggccgccgtc ggggggcgcg gcgacacgga gccctctggt gaaaccacct tattcgtaca
      481 tcgccctcat caccatggcc atcctgcaga gccccaagaa gcgcctgacg ctgagcgaga
      541 tctgcgagtt catcagcggc cgcttcccct actaccggga gaagttccct gcctggcaga
      601 atagcatccg ccacaacctc tccctcaacg actgcttcgt taagatcccc cgcgagccgg
      661 gcaacccggg caagggcaac tactggacgc tcgacccgga gtcggccgac atgttcgaca
      721 acggcagttt cctgcggcgc cgcaagcgct tcaagcggca gcctctgccg ccaccgcatc
      781 cacacccgca tcctcacccg gagctgctgt tgcgtggcgg ggctgccgcg gccggggacc
      841 ctggcgcctt cctctcgagc ttcgccgctt acggcgctta cggctacggc tacgggctgg
      901 cgctcccggc ctacggtgca cctccaccgg gcccggcccc acacccgcat ccgcacccgc
      961 acgccttcgc cttcgccgcc accgcgcctt gccagctgtc agttcccccg ggccgcgccg
     1021 cggcgcctcc tcccggacct ccgacggcct cggtcttcgc aagcgcggcc tcggcgccgg
     1081 cccctgcgcc tgccccggga tctggcccga gccccgcagg gctgcctgcc ttcctaggcg
     1141 cagagctggg ttgcgccaag gctttctacc ccgcgtcctt gagtcccccc gcagctggca
     1201 cagcggctag cctgtccact gcactcctgc gtcagggcct caagacggac gccggcggtg
     1261 gtgcgggtgg cgggggcgcg gggacaggcc agaggccttc cttttctata gaccacatca
     1321 tgggccacgg tggtggcggg gccgcacccc cgggcagcgg cgacggttct ccgggatcgc
     1381 cattcgccgc agccgcaggt cctgggggtc aagcccaagt cttggccatg ctgactgccc
     1441 cggccctgac tccggtggct ggccacatcc gcctctcgca cccaggggac tcactcctgt
     1501 cttcagggcc ctcgtttgcc agcaaagtcg cgggcctcag tggctgccac ttttgaccgc
     1561 accgggctcg ggccagttag gccctcactc cttaacctct ctggggagct cggccggtcc
     1621 cagcggaatt cagggagtct atttatgaag agtctccaga cctaggccgt cgcgcgttat
     1681 cgggcacttc aagctgcaag ctcagaatgt caccggcagt tgggacgaag cgggctccct
     1741 ggcctccctg atctacgcaa taggtttaaa gcggagaccg cttttctgtt tgagcatcaa
     1801 aaaggagagc aggaaccttc tctgtgtctt gcctttgcgc ctttcacagt cagagaatgc
     1861 tttggcagag atacgcctgt cggttgttgg atcgcgccag aatcacccat ggcttgaaaa
     1921 aacccactgc cccattcctt cctcaacttt gagacccgct catccaatat tataatttaa
     1981 agacatctgt tatctgcttt gtgcttaaga gaaattttca aaaaaaattt ttttggttcc
     2041 ttttgctgtt cttcaaggaa gctggttccc tccaagccta aggcaggctc ttcacagtcg
     2101 ggaagctaag agaagtgaaa cggggtctcc acaatccttg aagaaaccgc agagcccatt
     2161 tccccgagga aaatgttttc tctctggtgt ttggctgttt tttattttat tttttatttt
     2221 aaaaaaagcc ctctttggct tttcccgtgg tccataggcc cagccatcca gggctagcgg
     2281 tcctcttggc cttctcctct gccccaggcc ctgtgatatt tattgtagtt aaaggcaatg
     2341 agagtgggtg ggagaagagg gtctggagag gtgggaattg ggtgggcaag ggcacagagc
     2401 tgtggcgggg ggggggctcc tatagttata tgtaaatatc tgtacagcgg gctgcccccc
     2461 tccccaacgc attctctgtc cactggtgtg cattgattta gacttctcca cttagcggag
     2521 actctgtgaa atcgtctgat ggtctgtatg gaagaaaaaa aaattgtctc cctctccctc
     2581 ttcattggtg tcaattgaat aaatgtatgt gaacttagc
//
