LOCUS       NM_013519               2739 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus forkhead box C2 (Foxc2), mRNA.
ACCESSION   NM_013519
VERSION     NM_013519.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2739)
  AUTHORS   Argiro,L., Chevalier,C., Choquet,C., Nandkishore,N., Ghata,A.,
            Baudot,A., Zaffran,S. and Lescroart,F.
  TITLE     Gastruloids are competent to specify both cardiac and skeletal
            muscle lineages
  JOURNAL   Nat Commun 15 (1), 10172 (2024)
   PUBMED   39580459
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2739)
  AUTHORS   Almubarak,A., Zhang,Q., Zhang,C.H., Abdelwahab,N., Kume,T.,
            Lassar,A.B. and Berry,F.B.
  TITLE     FOXC1 and FOXC2 regulate growth plate chondrocyte maturation
            towards hypertrophy in the embryonic mouse limb skeleton
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39012257
  REMARK    GeneRIF: FOXC1 and FOXC2 regulate growth plate chondrocyte
            maturation towards hypertrophy in the embryonic mouse limb
            skeleton.
REFERENCE   3  (bases 1 to 2739)
  AUTHORS   Zhang,L., Liu,X., Li,W., Liu,K., Zhang,J., Liu,X. and Wang,J.
  TITLE     Integrative transcriptomic profiling of ncRNAs and mRNAs in
            developing mouse lens
  JOURNAL   Front Genet 15, 1405715 (2024)
   PUBMED   38933921
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2739)
  AUTHORS   Wei,W., Li,B., Li,F., Sun,K., Jiang,X. and Xu,R.
  TITLE     Variants in FOXC1 and FOXC2 identified in patients with conotruncal
            heart defects
  JOURNAL   Genomics 116 (3), 110840 (2024)
   PUBMED   38580085
REFERENCE   5  (bases 1 to 2739)
  AUTHORS   Seo,S., Sonn,S.K., Kweon,H.Y., Jin,J., Kume,T., Ko,J.Y., Park,J.H.
            and Oh,G.T.
  TITLE     Primary Cilium in Neural Crest Cells Crucial for Anterior Segment
            Development and Corneal Avascularity
  JOURNAL   Invest Ophthalmol Vis Sci 65 (3), 30 (2024)
   PUBMED   38517430
REFERENCE   6  (bases 1 to 2739)
  AUTHORS   Labosky,P.A., Winnier,G.E., Sasaki,H., Blessing,M. and Hogan,B.L.
  TITLE     The chromosomal mapping of four genes encoding winged helix
            proteins expressed early in mouse development
  JOURNAL   Genomics 34 (2), 241-245 (1996)
   PUBMED   8661058
REFERENCE   7  (bases 1 to 2739)
  AUTHORS   Kaestner,K.H., Lee,K.H., Schlondorff,J., Hiemisch,H., Monaghan,A.P.
            and Schutz,G.
  TITLE     Six members of the mouse forkhead gene family are developmentally
            regulated
  JOURNAL   Proc Natl Acad Sci U S A 90 (16), 7628-7631 (1993)
   PUBMED   7689224
REFERENCE   8  (bases 1 to 2739)
  AUTHORS   Miura,N., Wanaka,A., Tohyama,M. and Tanaka,K.
  TITLE     MFH-1, a new member of the fork head domain family, is expressed in
            developing mesenchyme
  JOURNAL   FEBS Lett 326 (1-3), 171-176 (1993)
   PUBMED   8325367
REFERENCE   9  (bases 1 to 2739)
  AUTHORS   Clevidence,D.E., Overdier,D.G., Tao,W., Qian,X., Pani,L., Lai,E.
            and Costa,R.H.
  TITLE     Identification of nine tissue-specific transcription factors of the
            hepatocyte nuclear factor 3/forkhead DNA-binding-domain family
  JOURNAL   Proc Natl Acad Sci U S A 90 (9), 3948-3952 (1993)
   PUBMED   7683413
REFERENCE   10 (bases 1 to 2739)
  AUTHORS   Sasaki,H. and Hogan,B.L.
  TITLE     Differential expression of multiple fork head related genes during
            gastrulation and axial pattern formation in the mouse embryo
  JOURNAL   Development 118 (1), 47-59 (1993)
   PUBMED   8375339
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146887.1, X92499.1, AK076319.1 and AI852431.1.
            
            On Nov 2, 2007 this sequence version replaced NM_013519.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK146887.1, AK076319.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-987               AK146887.1         2-988
            988-2192            X92499.1           572-1776
            2193-2720           AK076319.1         2194-2721
            2721-2739           AI852431.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2739
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 70.33 cM"
     gene            1..2739
                     /gene="Foxc2"
                     /gene_synonym="Fkh14; Hfhbf3; MFH-1; Mfh1"
                     /note="forkhead box C2"
                     /db_xref="GeneID:14234"
                     /db_xref="MGI:MGI:1347481"
     exon            1..2725
                     /gene="Foxc2"
                     /gene_synonym="Fkh14; Hfhbf3; MFH-1; Mfh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             445..1929
                     /gene="Foxc2"
                     /gene_synonym="Fkh14; Hfhbf3; MFH-1; Mfh1"
                     /note="BF-3; brain factor 3; transcription factor FKH-14;
                     mesenchyme fork head protein 1; forkhead-related protein
                     FKHL14; forkhead homolog 14"
                     /codon_start=1
                     /product="forkhead box protein C2"
                     /protein_id="NP_038547.2"
                     /db_xref="CCDS:CCDS40499.1"
                     /db_xref="GeneID:14234"
                     /db_xref="MGI:MGI:1347481"
                     /translation="MQARYSVSDPNALGVVPYLSEQNYYRAAGSYGGMASPMGVYSGH
                     PEQYGAGMGRSYAPYHHQPAAPKDLVKPPYSYIALITMAIQNAPEKKITLNGIYQFIM
                     DRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSF
                     LRRRRRFKKKDVPKDKEERAHLKEPPSTTAKGAPTGTPVADGPKEAEKKVVVKSEAAS
                     PALPVITKVETLSPEGALQASPRSASSTPAGSPDGSLPEHHAAAPNGLPGFSVETIMT
                     LRTSPPGGDLSPAAARAGLVVPPLALPYAAAPPAAYTQPCAQGLEAAGSAGYQCSMRA
                     MSLYTGAERPAHVCVPPALDEALSDHPSGPGSPLGALNLAAGQEGALGASGHHHQHHG
                     HLHPQAPPPAPQPPPAPQPATQATSWYLNHGGDLSHLPGHTFATQQQTFPNVREMFNS
                     HRLGLDNSSLGESQVSNASCQLPYRATPSLYRHAAPYSYDCTKY"
     regulatory      2697..2702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxc2"
                     /gene_synonym="Fkh14; Hfhbf3; MFH-1; Mfh1"
                     /note="hexamer: AATAAA"
     polyA_site      2725
                     /gene="Foxc2"
                     /gene_synonym="Fkh14; Hfhbf3; MFH-1; Mfh1"
                     /note="major polyA site"
ORIGIN      
        1 gaaacttttc ccaatcccta aaagggactt tgcttctttt tccgggctcg gccgcgcagc
       61 ctctccggac cctagctcgc tgacgctgcg ggctgcagtt ctcctggcgg ggccccgaga
      121 gccgctgtct ccttttctag cactcggaag ggctggtgtc gctccacggt cgcgcgtggc
      181 gtctgtgccg ccagctcagg gctgccaccc gccaagccga gagtgcgcgg ccagcggggc
      241 cgcctgccgt gcacccttca ggatgccgat ccgcccggtc ggctgaaccc gagcgccggc
      301 gtcttccgcg cgtggaccgc gaggctgccc cgagtcgggg ctgcctgcat cgctccgtcc
      361 cttcctgctc tcctgctccg ggcctcgctc gccgcgggcc gcagtcggtg cgcgcaggcg
      421 gcgaccgggc gtctgggacg cagcatgcag gcgcgttact cggtatcgga ccccaacgcc
      481 ctgggagtgg taccctattt gagtgagcaa aactactacc gggcggccgg cagctacggc
      541 ggcatggcca gccccatggg cgtctactcc ggccacccgg agcagtacgg cgccggcatg
      601 ggccgctcct acgcgcccta ccaccaccag cccgcggcgc ccaaggacct ggtgaagccg
      661 ccctacagct atatagcgct catcaccatg gcgatccaga acgcgccaga gaagaagatc
      721 actctgaacg gcatctacca gttcatcatg gaccgtttcc ccttctaccg cgagaacaag
      781 cagggctggc agaacagcat ccgccacaac ctgtcactca atgagtgctt cgtgaaagtg
      841 ccgcgcgacg acaagaagcc gggcaagggc agctactgga cgctcgaccc ggactcctac
      901 aacatgttcg agaatggcag cttcctgcgg cggcggcggc gcttcaagaa gaaggatgtg
      961 cccaaggaca aggaggagcg ggcccacctc aaggagccgc cctcgaccac ggccaagggc
     1021 gctccgacag ggaccccggt agctgacggg cccaaggagg ccgagaagaa agtcgtggtt
     1081 aagagcgagg cggcgtcccc cgcgctgccg gtcatcacca aggtggagac gctgagcccc
     1141 gagggagcgc tgcaggccag tccgcgcagc gcatcctcca cgcccgcagg ttccccagac
     1201 ggctcgctgc cggagcacca cgccgcggcg cctaacgggc tgcccggctt cagcgtggag
     1261 accatcatga cgctgcgcac gtcgcctccg ggcggcgatc tgagcccagc ggccgcgcgc
     1321 gccggcctgg tggtgccacc gctggcactg ccatacgccg cagcgccacc cgccgcttac
     1381 acgcagccgt gcgcgcaggg cctggaggct gcgggctccg cgggctacca gtgcagtatg
     1441 cgggctatga gtctgtacac cggggccgag cggcccgcgc acgtgtgcgt tccgcccgcg
     1501 ctggacgagg ctctgtcgga ccacccgagc ggccccggct ccccgctcgg cgccctcaac
     1561 ctcgcagcgg gtcaggaggg cgcgttgggg gcctcgggtc accaccacca gcatcacggc
     1621 cacctccacc cgcaggcgcc accgcccgcc ccgcagcccc ctcccgcgcc gcagcccgcc
     1681 acccaggcca cctcctggta tctgaaccac ggcggggacc tgagccacct ccccggccac
     1741 acgtttgcaa cccaacagca aactttcccc aacgtccggg agatgttcaa ctcgcaccgg
     1801 ctaggactgg acaactcgtc cctcggggag tcccaggtga gcaatgcgag ctgtcagctg
     1861 ccctatcgag ctacgccgtc cctctaccgc cacgcagccc cctactctta cgactgcacc
     1921 aaatactgag gctgtccagt ccgctccagc cccaggaccg caccggcttc gcctcctcca
     1981 tgggaacctt cttcgacgga gccgcagaaa gcgacggaaa gcgcccctct ctcagaacca
     2041 ggagcagaga gctccgtgca actcgcaggt aacttatccg cagctcagtt tgagatctca
     2101 gcgagtccct ctaaggggga tgcagcccag caaaacgaaa tacagatttt ttttttaatt
     2161 ccttccccta cccagatgct gcgcctgctc cccttggggc ttcatagatt agcttatgga
     2221 ccaaacccca tagggacccc taatgacttc tgtggagatt ctccacgggc gcaagaggtc
     2281 tctccggata aggtgccttc tgtaaacgag tgcggatttg taaccaggct attttgttct
     2341 tgcccagagc ctttaatata atatttaaag ttgtgtccac tggataaggt ttcgtcttgc
     2401 ccaactgtta ctgccaaatt gaattcaaga aacgtgtgtg ggtcttttct ccccacgtca
     2461 ccatgataaa ataggtccct ccccaaactg taggtctttt acaaaacaag aaaataattt
     2521 atttttttgt tgttgttgga taacgaaatt aagtatcgga tacttttaat ttaggaagtg
     2581 catggctttg tacagtagat gccatctggg gtattccaaa aacacaccaa aagactttaa
     2641 aatttcaatc tcacctgtgt ttgtcttatg tgatctcagt gttgtattta ccttaaaata
     2701 aacccgtgtt gtttttctgc ccaaaaaaaa aaaaaaaaa
//
