LOCUS       NM_008592               3990 bp    mRNA    linear   ROD 26-OCT-2024
DEFINITION  Mus musculus forkhead box C1 (Foxc1), mRNA.
ACCESSION   NM_008592 XM_993078
VERSION     NM_008592.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3990)
  AUTHORS   Havrylov,S., Chrystal,P., van Baarle,S., French,C.R.,
            MacDonald,I.M., Avasarala,J., Rogers,R.C., Berry,F.B., Kume,T.,
            Waskiewicz,A.J. and Lehmann,O.J.
  TITLE     Pleiotropy in FOXC1-attributable phenotypes involves altered
            ciliation and cilia-dependent signaling
  JOURNAL   Sci Rep 14 (1), 20278 (2024)
   PUBMED   39217245
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3990)
  AUTHORS   Almubarak,A., Zhang,Q., Zhang,C.H., Abdelwahab,N., Kume,T.,
            Lassar,A.B. and Berry,F.B.
  TITLE     FOXC1 and FOXC2 regulate growth plate chondrocyte maturation
            towards hypertrophy in the embryonic mouse limb skeleton
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39012257
  REMARK    GeneRIF: FOXC1 and FOXC2 regulate growth plate chondrocyte
            maturation towards hypertrophy in the embryonic mouse limb
            skeleton.
REFERENCE   3  (bases 1 to 3990)
  AUTHORS   Ju,H., Yu,M., Du,X., Xue,S., Ye,N., Sun,L., Wu,X., Xu,H. and
            Shen,Q.
  TITLE     Gestational diabetes mellitus induces congenital anomalies of the
            kidney and urinary tract in mice by altering RET/MAPK/ERK pathway
  JOURNAL   Biochem Biophys Res Commun 714, 149959 (2024)
   PUBMED   38657443
REFERENCE   4  (bases 1 to 3990)
  AUTHORS   Bhakuni,T., Norden,P.R., Ujiie,N., Tan,C., Lee,S.K., Tedeschi,T.,
            Hsieh,Y.W., Wang,Y., Liu,T., Fawzi,A.A. and Kume,T.
  TITLE     FOXC1 regulates endothelial CD98 (LAT1/4F2hc) expression in retinal
            angiogenesis and blood-retina barrier formation
  JOURNAL   Nat Commun 15 (1), 4097 (2024)
   PUBMED   38755144
  REMARK    GeneRIF: FOXC1 regulates endothelial CD98 (LAT1/4F2hc) expression
            in retinal angiogenesis and blood-retina barrier formation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3990)
  AUTHORS   Wei,W., Li,B., Li,F., Sun,K., Jiang,X. and Xu,R.
  TITLE     Variants in FOXC1 and FOXC2 identified in patients with conotruncal
            heart defects
  JOURNAL   Genomics 116 (3), 110840 (2024)
   PUBMED   38580085
REFERENCE   6  (bases 1 to 3990)
  AUTHORS   Gruneberg,H. and Wickramaratne,G.A.
  TITLE     A re-examination of two skeletal mutants of the mouse,
            vestigial-tail (vt) and congenital hydrocephalus (ch)
  JOURNAL   J Embryol Exp Morphol 31 (1), 207-222 (1974)
   PUBMED   4819561
REFERENCE   7  (bases 1 to 3990)
  AUTHORS   Breen,M., Richardson,R., Bondareff,W. and Weinstein,H.G.
  TITLE     Acidic glycosaminoglycans in developing sterno-costal cartilage of
            the hydrocephalic (ch+-ch+) mouse
  JOURNAL   Biochim Biophys Acta 304 (3), 828-836 (1973)
   PUBMED   4269479
REFERENCE   8  (bases 1 to 3990)
  AUTHORS   Raimondi,A.J., Bailey,O.T., McLone,D.G., Lawson,R.F. and
            Echeverry,A.
  TITLE     The pathophysiology and morphology of murine hydrocephalus in Hy-3
            and Ch mutants
  JOURNAL   Surg Neurol 1 (1), 50-55 (1973)
   PUBMED   4784576
REFERENCE   9  (bases 1 to 3990)
  AUTHORS   Gruneberg,H.
  TITLE     Exocrine glands and the Chievitz organ of some mouse mutants
  JOURNAL   J Embryol Exp Morphol 25 (2), 247-261 (1971)
   PUBMED   5088022
REFERENCE   10 (bases 1 to 3990)
  AUTHORS   Green,M.C.
  TITLE     The developmental effects of congenital hydrocephalus (ch) in the
            mouse
  JOURNAL   Dev Biol 23 (4), 585-608 (1970)
   PUBMED   5500588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645783.13.
            
            On or before May 4, 2006 this sequence version replaced
            XM_993078.1, NM_008592.1.
            
            Sequence Note: This RefSeq record was created using sequences from
            two different strains, C57BL/6J and C57BL/6, because no single
            transcript from the same strain was available for the full length
            of the gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3990              AL645783.13        33981-37970
FEATURES             Location/Qualifiers
     source          1..3990
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.52 cM"
     gene            1..3990
                     /gene="Foxc1"
                     /gene_synonym="ch; fkh-1; Fkh1; FREAC3; frkhda; Mf1; Mf4"
                     /note="forkhead box C1"
                     /db_xref="GeneID:17300"
                     /db_xref="MGI:MGI:1347466"
     exon            1..3990
                     /gene="Foxc1"
                     /gene_synonym="ch; fkh-1; Fkh1; FREAC3; frkhda; Mf1; Mf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             563..2224
                     /gene="Foxc1"
                     /gene_synonym="ch; fkh-1; Fkh1; FREAC3; frkhda; Mf1; Mf4"
                     /note="MF-1; FREAC-3; transcription factor FKH-1;
                     forkhead-related protein FKHL7; forkhead-related
                     transcription factor 3; congenital hydrocephalus;
                     mesoderm/mesenchyme forkhead 1"
                     /codon_start=1
                     /product="forkhead box protein C1"
                     /protein_id="NP_032618.2"
                     /db_xref="CCDS:CCDS26425.1"
                     /db_xref="GeneID:17300"
                     /db_xref="MGI:MGI:1347466"
                     /translation="MQARYSVSSPNSLGVVPYLGGEQSYYRAAAAAAGGGYTAMPAPM
                     SVYSHPAHAEQYPGSMARAYGPYTPQPQPKDMVKPPYSYIALITMAIQNAPDKKITLN
                     GIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYN
                     MFENGSFLRRRRRFKKKDAVKDKEEKGRLHLQEPPPPQAGRQPAPAPPEQAEGSAPGP
                     QPPPVRIQDIKTENGTCPSPPQPLSPAAALGSGSAATVPKIESPDSSSSSLSSGSSPP
                     GSLPSARPLSLDAAEPAPPPQPAPPPHHSQGFSVDNIMTSLRGSPQGSAAELGSGLLA
                     SAAASSRAGIAPPLALGAYSPGQSSLYSSPCSQSSSAGSSGGGGGGGGGGGGSSSAAG
                     TGGAATYHCNLQAMSLYAAGERGGHLQGPAGGAGSAAVDDPLPDYSLPPATSSSSSSL
                     SHGGGGQEASHHPASHQGRLTSWYLNQAGGDLGHLASAAAAAAAAGYPGQQQNFHSVR
                     EMFESQRIGLNNSPVNGNSSCQMAFPASQSLYRTSGAFVYDCSKF"
     regulatory      2903..2908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxc1"
                     /gene_synonym="ch; fkh-1; Fkh1; FREAC3; frkhda; Mf1; Mf4"
                     /note="hexamer: AATAAA"
     polyA_site      2930
                     /gene="Foxc1"
                     /gene_synonym="ch; fkh-1; Fkh1; FREAC3; frkhda; Mf1; Mf4"
ORIGIN      
        1 gaagttttcc caatgcttcc ttaagcggcc ggcgcaagag actgagaaaa ggtgacgcgg
       61 gggcccggga aggcggccgg cgcgctgccc ccgcccctgg ttatttggcc gccttagcca
      121 gcagccccga gcagtgtctc ctggaaggcg caggcagtgg cgagcagggc gccttatttt
      181 ttttatttgt ttttgttttt tttttttttt aatttttttt taacttttgt ctcttttttt
      241 gccccgactg cgcctggaag ttgatccgaa cgttcctccg aggcggcttg cagcgtcctg
      301 gtctggccct ctccgggtgc agcgaccctc cctcgccgcc cgcgcgggaa ctgagtgggc
      361 tgcgaggcgc caggcgagcg cagggagagg ccgagcggcc cagggcgcaa ggaggcggcc
      421 gcggccggga cagacgcagc gcggaggggc ccgcggtagc tcggcgcggc ccggactcgg
      481 actcggcggc cggtgcggcg cggcccggcc cgagcgaggg tggggggcgg cgggctgcgc
      541 ctggcggcgg cgagccgggg ccatgcaggc gcgctactcg gtgtccagcc ccaactccct
      601 gggagtggtg ccctacctcg gcggcgagca gagctactat cgcgctgccg cggcggcggc
      661 cgggggcggc tacaccgcca tgccggcccc tatgagcgtg tactcgcacc ctgctcacgc
      721 cgagcagtac ccgggcagca tggcgcgcgc ctacgggcct tatacgccgc agccgcagcc
      781 caaggacatg gtgaagccgc cctacagcta catcgctctt atcaccatgg ccatccagaa
      841 tgccccggac aagaagatca ctctgaatgg catctaccag ttcatcatgg accgcttccc
      901 cttctatcgg gacaataagc agggctggca gaacagcata cggcacaacc tctcgctcaa
      961 cgagtgcttc gtcaaggtgc cccgcgacga caagaagcca ggcaagggca gctactggac
     1021 gctcgacccg gactcctaca acatgttcga gaacggcagc ttcctgcggc ggcggcggcg
     1081 cttcaagaag aaggacgcag tgaaggacaa ggaggagaag ggccggctgc acctccaaga
     1141 accgccaccg ccgcaggccg gccgccagcc cgcgcccgcg cccccggagc aggccgaggg
     1201 ctccgctccc gggccacagc cgccgcccgt gcgcatccag gacatcaaga cggagaacgg
     1261 tacgtgtccc tcgcctcccc agcccctgtc cccggctgcc gccctaggca gcggcagcgc
     1321 cgccacagtg cccaaaatcg agagccccga cagcagcagc agcagcttgt cgagcgggag
     1381 cagccccccg ggcagcctgc cgtcggcgcg gccgctcagc ctggacgctg cagaacccgc
     1441 gccgccgcca cagcctgcgc cgccgccgca tcacagccag ggcttcagcg tggacaacat
     1501 catgacgtcg ctgcgggggt cgccgcaggg ttcggccgct gagctcggtt ccggcctcct
     1561 ggcctcggcg gctgcgtcct cgcgcgcggg catcgcgccc ccgctggcgc tgggtgccta
     1621 ctctccgggc cagagctccc tctacagctc cccctgcagc cagagctcca gtgcgggcag
     1681 ttcgggcggc gggggtggcg gcggcggcgg aggcggcggc agcagcagcg ctgcgggtac
     1741 ggggggcgcc gccacttacc actgcaacct gcaggctatg agcctgtacg cggcgggcga
     1801 gcgtggcggc cacttgcagg gtccggcggg aggcgcgggc agcgcggcgg tggacgaccc
     1861 cctgcccgac tactcgctgc ctccagcgac cagcagcagc tcttcgtccc tgagtcatgg
     1921 cgggggcggc caggaggcca gccaccaccc tgcatcccac cagggccgac tcacctcgtg
     1981 gtacctgaac caggcaggtg gagacctggg ccacttggcg agcgcggcgg cggctgcggc
     2041 ggccgcaggc taccctggcc agcagcagaa cttccactcg gtgcgggaaa tgttcgagtc
     2101 tcagcggatc ggcttgaaca actccccggt gaatgggaat agtagctgtc agatggcttt
     2161 ccctgccagt cagtctctgt accgcacgtc gggggctttc gtctatgact gtagcaaatt
     2221 ctgaccctat tcccggcact cttagagcca aatggaatgg aaccccagag caggaacagt
     2281 aaaagaatcc agcaatgcaa aatcgaaact aaaaacatac aaattttaaa acttgagaag
     2341 attcctcaca ccagcgaaca gaatctctcc tgaaattcag ctcaccagca tcagctcaaa
     2401 gaaaacctat tttcctaaaa gattaatgca gaacctcctc catttttgcc ttatctaagt
     2461 aagcaaaacc gtaaactatt ttgtacagac aacaaaatca tggtttatta aaggacagtt
     2521 tactccagat accacgtaag tttcttgcgt tcagagactc gctttcctgc tcattcgtct
     2581 tgcccctctg cctctgcctt gcctctcacc tgtaagatat tttatcctat gtcgaaagaa
     2641 cgggaaagta cctgtttatg aaaatcgctt tctttttatt catggacttg tttttaaatg
     2701 taaattgcaa catagtaatt tatttttaat ttgtagttgg atgttacgga ccaaacacca
     2761 gaaagtgttc caaaagcttt tcaagttaaa ttgcctgaaa cttttaaaat gtgccttttc
     2821 tctcattata aaaagggaaa ctgtattaat ctccttctat catccttttc tttttgttga
     2881 tcatatccat tgtttgttta ttaataaatt gccattcagt ttgaataaga cctatatgtc
     2941 tgaatacttt aatacagctt taatagaaaa gatttcagag cggaaattgt aggagttccc
     3001 tagtctctgt cagatttttt aaatgtggag aaaacttcta ggtgatgtca aatttcgcta
     3061 aactcagttt ttaaaattgt taagtagatt ttttttcccc ctacagcgtt ttctgcaaaa
     3121 catactatct agtcaacttg ctttgtggct attaaaagga taatttccta agtagatctg
     3181 agttggcaca tgaacaaata cttttcttca gtaactacag aacatgattt ggcgattttt
     3241 aagtccatga atcagcacca gtgttaccac agtggtgcct gtacgcagag aagcaaatgt
     3301 acccggagat actaacagat ggagatcagc ctatgtgtcc cacatagatt gcaatgagta
     3361 ttatacgtac ctgtgagcca gatgccaaat agtttttttt ctattaattt cattcctttc
     3421 ttagaggaga agtaaactag ttttaaaatg tatgtatata actcactcac agttacaatt
     3481 ctttatgcat tacacagaag gattaaattt ttaaaaatac aaatatactg tgggttggaa
     3541 atagatattt aatcttgggg aaacttttag aagatatatt tgtagaacaa tttgtttttg
     3601 aagacttaca gcaataacca gaaggaagag taagaaggca ggaaaaaaaa aaaaaacatt
     3661 agtctggggt ggtttctttt caaaccaatt tttcttgtta atttacagtt aaacctaggg
     3721 ggcaatccgg attggccctc cccccttttg taaataaccc aggaaatgta ataaattcat
     3781 tatcttaggg tgatctgccc tgtcaatcag acttggggag atggcggttt gattacagat
     3841 attcaggcct tcagtttgtt ttcgagataa agcaggttcc tatctgccgc tcctatctag
     3901 aggcaacact taagcagtaa ttgctgttgc ttgttgtcaa aatttgatca ttgttaaagg
     3961 attgctgcaa ataaatacac tctaatttca
//
