LOCUS       NP_032618                553 aa            linear   ROD 12-JUN-2025
DEFINITION  forkhead box protein C1 [Mus musculus].
ACCESSION   NP_032618 XP_998172
VERSION     NP_032618.2
DBSOURCE    REFSEQ: accession NM_008592.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 553)
  AUTHORS   Como,C.N., O'Rourke,R., Winkler,C., Mitchell,D., Tran,L.,
            Lorberbaum,D., Sussel,L., Franco,S. and Siegenthaler,J.
  TITLE     Meningeal-derived retinoic acid regulates neurogenesis via
            suppression of Notch and Sox2
  JOURNAL   Cell Rep 44 (5), 115637 (2025)
   PUBMED   40310723
REFERENCE   2  (residues 1 to 553)
  AUTHORS   Havrylov,S., Chrystal,P., van Baarle,S., French,C.R.,
            MacDonald,I.M., Avasarala,J., Rogers,R.C., Berry,F.B., Kume,T.,
            Waskiewicz,A.J. and Lehmann,O.J.
  TITLE     Pleiotropy in FOXC1-attributable phenotypes involves altered
            ciliation and cilia-dependent signaling
  JOURNAL   Sci Rep 14 (1), 20278 (2024)
   PUBMED   39217245
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 553)
  AUTHORS   Almubarak,A., Zhang,Q., Zhang,C.H., Abdelwahab,N., Kume,T.,
            Lassar,A.B. and Berry,F.B.
  TITLE     FOXC1 and FOXC2 regulate growth plate chondrocyte maturation
            towards hypertrophy in the embryonic mouse limb skeleton
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39012257
  REMARK    GeneRIF: FOXC1 and FOXC2 regulate growth plate chondrocyte
            maturation towards hypertrophy in the embryonic mouse limb
            skeleton.
REFERENCE   4  (residues 1 to 553)
  AUTHORS   Ju,H., Yu,M., Du,X., Xue,S., Ye,N., Sun,L., Wu,X., Xu,H. and
            Shen,Q.
  TITLE     Gestational diabetes mellitus induces congenital anomalies of the
            kidney and urinary tract in mice by altering RET/MAPK/ERK pathway
  JOURNAL   Biochem Biophys Res Commun 714, 149959 (2024)
   PUBMED   38657443
REFERENCE   5  (residues 1 to 553)
  AUTHORS   Bhakuni,T., Norden,P.R., Ujiie,N., Tan,C., Lee,S.K., Tedeschi,T.,
            Hsieh,Y.W., Wang,Y., Liu,T., Fawzi,A.A. and Kume,T.
  TITLE     FOXC1 regulates endothelial CD98 (LAT1/4F2hc) expression in retinal
            angiogenesis and blood-retina barrier formation
  JOURNAL   Nat Commun 15 (1), 4097 (2024)
   PUBMED   38755144
  REMARK    GeneRIF: FOXC1 regulates endothelial CD98 (LAT1/4F2hc) expression
            in retinal angiogenesis and blood-retina barrier formation.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 553)
  AUTHORS   Gruneberg,H. and Wickramaratne,G.A.
  TITLE     A re-examination of two skeletal mutants of the mouse,
            vestigial-tail (vt) and congenital hydrocephalus (ch)
  JOURNAL   J Embryol Exp Morphol 31 (1), 207-222 (1974)
   PUBMED   4819561
REFERENCE   7  (residues 1 to 553)
  AUTHORS   Breen,M., Richardson,R., Bondareff,W. and Weinstein,H.G.
  TITLE     Acidic glycosaminoglycans in developing sterno-costal cartilage of
            the hydrocephalic (ch+-ch+) mouse
  JOURNAL   Biochim Biophys Acta 304 (3), 828-836 (1973)
   PUBMED   4269479
REFERENCE   8  (residues 1 to 553)
  AUTHORS   Raimondi,A.J., Bailey,O.T., McLone,D.G., Lawson,R.F. and
            Echeverry,A.
  TITLE     The pathophysiology and morphology of murine hydrocephalus in Hy-3
            and Ch mutants
  JOURNAL   Surg Neurol 1 (1), 50-55 (1973)
   PUBMED   4784576
REFERENCE   9  (residues 1 to 553)
  AUTHORS   Gruneberg,H.
  TITLE     Exocrine glands and the Chievitz organ of some mouse mutants
  JOURNAL   J Embryol Exp Morphol 25 (2), 247-261 (1971)
   PUBMED   5088022
REFERENCE   10 (residues 1 to 553)
  AUTHORS   Green,M.C.
  TITLE     The developmental effects of congenital hydrocephalus (ch) in the
            mouse
  JOURNAL   Dev Biol 23 (4), 585-608 (1970)
   PUBMED   5500588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645783.13.
            
            On or before May 4, 2006 this sequence version replaced
            XP_998172.1, NP_032618.1.
            
            Sequence Note: This RefSeq record was created using sequences from
            two different strains, C57BL/6J and C57BL/6, because no single
            transcript from the same strain was available for the full length
            of the gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..553
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.52 cM"
     Protein         1..553
                     /product="forkhead box protein C1"
                     /note="MF-1; FREAC-3; transcription factor FKH-1;
                     forkhead-related protein FKHL7; forkhead-related
                     transcription factor 3; congenital hydrocephalus;
                     mesoderm/mesenchyme forkhead 1"
                     /calculated_mol_wt=56809
     Region          1..51
                     /region_name="Required for transcriptional activation.
                     /evidence=ECO:0000250|UniProtKB:Q12948"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61572.3)"
     Region          73..165
                     /region_name="FH_FOXC1"
                     /note="Forkhead (FH) domain found in Forkhead box protein
                     C1 (FOXC1) and similar proteins; cd20044"
                     /db_xref="CDD:410818"
     Region          78..93
                     /region_name="Nuclear localization signal 1 (NLS 1).
                     /evidence=ECO:0000250|UniProtKB:Q12948"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61572.3)"
     Site            order(83,101..102,105,124..125,127..128,131,138,148..150,
                     152)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410818"
     Region          168..176
                     /region_name="Nuclear localization signal 2 (NLS 2).
                     /evidence=ECO:0000250|UniProtKB:Q12948"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61572.3)"
     Region          173..326
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61572.3)"
     Region          217..366
                     /region_name="Required for transcriptional inhibition.
                     /evidence=ECO:0000250|UniProtKB:Q12948"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61572.3)"
     Site            237
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:22493429,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61572.3)"
     Site            243
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:22493429,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61572.3)"
     Site            274
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12948; propagated from
                     UniProtKB/Swiss-Prot (Q61572.3)"
     Site            320
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:22493429; propagated from
                     UniProtKB/Swiss-Prot (Q61572.3)"
     Region          356..393
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61572.3)"
     Region          420..466
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61572.3)"
     Region          466..553
                     /region_name="Required for transcriptional activation.
                     /evidence=ECO:0000250|UniProtKB:Q12948"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61572.3)"
     Site            521
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:22493429; propagated from
                     UniProtKB/Swiss-Prot (Q61572.3)"
     CDS             1..553
                     /gene="Foxc1"
                     /gene_synonym="ch; fkh-1; Fkh1; FREAC3; frkhda; Mf1; Mf4"
                     /coded_by="NM_008592.2:563..2224"
                     /db_xref="CCDS:CCDS26425.1"
                     /db_xref="GeneID:17300"
                     /db_xref="MGI:MGI:1347466"
ORIGIN      
        1 mqarysvssp nslgvvpylg geqsyyraaa aaagggytam papmsvyshp ahaeqypgsm
       61 araygpytpq pqpkdmvkpp ysyialitma iqnapdkkit lngiyqfimd rfpfyrdnkq
      121 gwqnsirhnl slnecfvkvp rddkkpgkgs ywtldpdsyn mfengsflrr rrrfkkkdav
      181 kdkeekgrlh lqeppppqag rqpapappeq aegsapgpqp ppvriqdikt engtcpsppq
      241 plspaaalgs gsaatvpkie spdsssssls sgssppgslp sarplsldaa epapppqpap
      301 pphhsqgfsv dnimtslrgs pqgsaaelgs gllasaaass ragiapplal gayspgqssl
      361 ysspcsqsss agssgggggg ggggggsssa agtggaatyh cnlqamslya agergghlqg
      421 paggagsaav ddplpdyslp patssssssl shggggqeas hhpashqgrl tswylnqagg
      481 dlghlasaaa aaaaagypgq qqnfhsvrem fesqriglnn spvngnsscq mafpasqsly
      541 rtsgafvydc skf
//
