LOCUS       NM_008260               2039 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus forkhead box A3 (Foxa3), mRNA.
ACCESSION   NM_008260
VERSION     NM_008260.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2039)
  AUTHORS   Li,J., Li,R., Bai,X., Zhang,W., Nie,Y. and Hu,S.
  TITLE     Direct reprogramming of fibroblasts into functional hepatocytes via
            CRISPRa activation of endogenous Gata4 and Foxa3
  JOURNAL   Chin Med J (Engl) 137 (11), 1351-1359 (2024)
   PUBMED   38721807
  REMARK    GeneRIF: Direct reprogramming of fibroblasts into functional
            hepatocytes via CRISPRa activation of endogenous Gata4 and Foxa3.
REFERENCE   2  (bases 1 to 2039)
  AUTHORS   Bell,N., Bhagat,S., Muruganandan,S., Kim,R., Ho,K., Pierce,R.,
            Kozhemyakina,E., Lassar,A.B., Gamer,L., Rosen,V. and Ionescu,A.M.
  TITLE     Overexpression of transcription factor FoxA2 in the developing
            skeleton causes an enlargement of the cartilage hypertrophic zone,
            but it does not trigger ectopic differentiation in immature
            chondrocytes
  JOURNAL   Bone 160, 116418 (2022)
   PUBMED   35398294
REFERENCE   3  (bases 1 to 2039)
  AUTHORS   Xu,J., Xu,L., Sui,P., Chen,J., Moya,E.A., Hume,P., Janssen,W.J.,
            Duran,J.M., Thistlethwaite,P., Carlin,A., Gulleman,P.,
            Banaschewski,B., Goldy,M.K., Yuan,J.X., Malhotra,A., Pryhuber,G.,
            Crotty-Alexander,L., Deutsch,G., Young,L.R. and Sun,X.
  TITLE     Excess neuropeptides in lung signal through endothelial cells to
            impair gas exchange
  JOURNAL   Dev Cell 57 (7), 839-853 (2022)
   PUBMED   35303432
REFERENCE   4  (bases 1 to 2039)
  AUTHORS   Monica Shih,M.C., Huang,C.C., Chu,H.P., Hsu,N.C. and Chung,B.C.
  TITLE     Embryonic Steroids Control Developmental Programming of Energy
            Balance
  JOURNAL   Endocrinology 162 (12) (2021)
   PUBMED   34599818
REFERENCE   5  (bases 1 to 2039)
  AUTHORS   AlOgayil,N., Bauermeister,K., Galvez,J.H., Venkatesh,V.S.,
            Zhuang,Q.K., Chang,M.L., Davey,R.A., Zajac,J.D., Ida,K., Kamiya,A.,
            Taketo,T., Bourque,G. and Naumova,A.K.
  TITLE     Distinct roles of androgen receptor, estrogen receptor alpha, and
            BCL6 in the establishment of sex-biased DNA methylation in mouse
            liver
  JOURNAL   Sci Rep 11 (1), 13766 (2021)
   PUBMED   34215813
  REMARK    Erratum:[Sci Rep. 2021 Nov 22;11(1):22975. doi:
            10.1038/s41598-021-02512-8. PMID: 34811454]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2039)
  AUTHORS   Kaestner,K.H., Lee,K.H., Schlondorff,J., Hiemisch,H., Monaghan,A.P.
            and Schutz,G.
  TITLE     Six members of the mouse forkhead gene family are developmentally
            regulated
  JOURNAL   Proc Natl Acad Sci U S A 90 (16), 7628-7631 (1993)
   PUBMED   7689224
REFERENCE   7  (bases 1 to 2039)
  AUTHORS   Clevidence,D.E., Overdier,D.G., Tao,W., Qian,X., Pani,L., Lai,E.
            and Costa,R.H.
  TITLE     Identification of nine tissue-specific transcription factors of the
            hepatocyte nuclear factor 3/forkhead DNA-binding-domain family
  JOURNAL   Proc Natl Acad Sci U S A 90 (9), 3948-3952 (1993)
   PUBMED   7683413
REFERENCE   8  (bases 1 to 2039)
  AUTHORS   Avraham,K.B., Prezioso,V.R., Chen,W.S., Lai,E., Sladek,F.M.,
            Zhong,W., Darnell,J.E. Jr., Jenkins,N.A. and Copeland,N.G.
  TITLE     Murine chromosomal location of four hepatocyte-enriched
            transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and
            HNF-4
  JOURNAL   Genomics 13 (2), 264-268 (1992)
   PUBMED   1612587
REFERENCE   9  (bases 1 to 2039)
  AUTHORS   Flower,D.R., North,A.C. and Attwood,T.K.
  TITLE     Mouse oncogene protein 24p3 is a member of the lipocalin protein
            family
  JOURNAL   Biochem Biophys Res Commun 180 (1), 69-74 (1991)
   PUBMED   1834059
REFERENCE   10 (bases 1 to 2039)
  AUTHORS   Lai,E., Prezioso,V.R., Tao,W.F., Chen,W.S. and Darnell,J.E. Jr.
  TITLE     Hepatocyte nuclear factor 3 alpha belongs to a gene family in
            mammals that is homologous to the Drosophila homeotic gene fork
            head
  JOURNAL   Genes Dev 5 (3), 416-427 (1991)
   PUBMED   1672118
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC170864.2.
            
            On Nov 17, 2006 this sequence version replaced NM_008260.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X74938.1, BC037083.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AC170864.2         63423-63613
            192-2039            AC170864.2         71832-73679
FEATURES             Location/Qualifiers
     source          1..2039
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.46 cM"
     gene            1..2039
                     /gene="Foxa3"
                     /gene_synonym="Hnf-3g; Hnf3g; Tcf-3g; Tcf3g"
                     /note="forkhead box A3"
                     /db_xref="GeneID:15377"
                     /db_xref="MGI:MGI:1347477"
     exon            1..191
                     /gene="Foxa3"
                     /gene_synonym="Hnf-3g; Hnf3g; Tcf-3g; Tcf3g"
                     /inference="alignment:Splign:2.1.0"
     exon            192..2039
                     /gene="Foxa3"
                     /gene_synonym="Hnf-3g; Hnf3g; Tcf-3g; Tcf3g"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2018..2023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxa3"
                     /gene_synonym="Hnf-3g; Hnf3g; Tcf-3g; Tcf3g"
                     /note="hexamer: ATTAAA"
     polyA_site      2038
                     /gene="Foxa3"
                     /gene_synonym="Hnf-3g; Hnf3g; Tcf-3g; Tcf3g"
                     /note="major polyA site"
ORIGIN      
        1 gcgggactcc cgggctgtgt gcctcaggtc ggaactcggg gctagtgcct gtagagagac
       61 cgaagcactc ggttccccca ggggggcctc agcctgggtg tgtgggggcg caggccccgg
      121 ggatgctggg ctcagtgaag atggaggctc atgacctggc cgagtggagc tactacccgg
      181 aggcgggcga ggtgtattct ccagtgaatc ctgtgcccac catggcccct ctcaactcct
      241 acatgacctt gaacccactc agctctccct accctcccgg agggcttcag gcctccccac
      301 tgcctacagg acccctggca cccccagccc ccactgcgcc cttggggccc accttcccaa
      361 gcttgggcac tggtggcagc accggaggca gtgcttccgg gtatgtagcc ccagggcccg
      421 ggcttgtaca tggaaaagag atggcaaagg ggtaccggcg gccactggcc cacgccaaac
      481 caccatattc ctacatctct ctcataacca tggctattca gcaggctcca ggcaagatgc
      541 tgaccctgag tgaaatctac caatggatca tggacctctt cccgtactac cgggagaacc
      601 agcaacgttg gcagaactcc atccggcatt cgctgtcctt caatgactgc ttcgtcaagg
      661 tggcacgctc cccagacaag ccaggcaaag gctcctactg ggccttgcat cccagctctg
      721 ggaacatgtt tgagaacggc tgctatctcc gccggcagaa gcgcttcaag ctggaggaga
      781 aggcaaagaa aggaaacagc gccacatcgg ccagcaggaa tggtactgcg gggtcagcca
      841 cctctgccac cactacagct gccactgcag tcacctcccc ggctcagccc cagcctacgc
      901 catctgagcc cgaggcccag agtggggatg atgtgggggg tctggactgc gcctcacctc
      961 cttcgtccac accttatttc agcggcctgg agctcccggg ggaactaaag ttggatgcgc
     1021 cctataactt caaccaccct ttctctatca acaacctgat gtcagaacag acatcgacac
     1081 cttccaaact ggatgtgggg tttgggggct acggggctga gagtggggag cctggagtct
     1141 actaccagag cctctattcc cgctctctgc ttaatgcatc ctagcagcgc aattgggaac
     1201 gccatgatgg gcgtgggctg caacgttctt gggctctgat ctttctggtt acactttgct
     1261 tgtcccatta attaacatct tatttggtct attactgtga tatgacccat tggctactgt
     1321 ggtaactgcc atggactctt tggtaggcct agggttgggg tattaggaag gcagatgcgt
     1381 ttggaagtgc tgcgaaggtg gtcatgttgg acatattgtg aaggcagtta gactggtgta
     1441 ctatgaaagc tgccatatta agtgaagcca ttgggtgatt gatccactgg gtgcctgatg
     1501 gtcgtgatgt tggatgacac atgtctggtc ctttggatga tgtgttggac atcttgattg
     1561 accttttgag tatgtgacag aacacatctt ctttggctca ttttatcctg ggatcgcctc
     1621 ttttttttcc tcttcttttt ctttttcttt ttcttttttt cttttccttt tttctttttt
     1681 ttttcttttt tggcagactt cttggttcag cagatgccaa attggccacc atatcacatg
     1741 gtgtcttttt tgacattctg gatgcatgga aggtcactgt attggcaagg tgacatctca
     1801 gcatgctgct atgcaccaag atagatggtt accacaggcc tgccatcacc atctccttgg
     1861 tggaggttgg gtgaggggaa gaggtgagca gaccctatga gttttctctg aagcccatcc
     1921 ccaccctgtc tgtgagaaag ggctagtgtg ggtgtcggga gttcctactg aggtcaagtt
     1981 cttgtctggg gcttgggaat actgcctgtg tttggccatt aaaaaggcac catctccat
//
