LOCUS       NM_001291065            2070 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus forkhead box A2 (Foxa2), transcript variant 1, mRNA.
ACCESSION   NM_001291065 XM_006498785
VERSION     NM_001291065.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2070)
  AUTHORS   Trinh,L.T., Finnel,R.R., Osipovich,A.B., Musselman,J.R.,
            Sampson,L.L., Wright,C.V.E. and Magnuson,M.A.
  TITLE     Positive autoregulation of Sox17 is necessary for gallbladder and
            extrahepatic bile duct formation
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39745200
REFERENCE   2  (bases 1 to 2070)
  AUTHORS   Moldovan,G.E., Massri,N., Vegter,E.L., Pauneto-Delgado,I.N.,
            Burns,G.W., Joshi,N., Gu,B., Arora,R. and Fazleabas,A.T.
  TITLE     YAP1 and WWTR1 are required for murine pregnancy initiation
  JOURNAL   Reproduction 169 (1), e240355 (2025)
   PUBMED   39503541
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2070)
  AUTHORS   Amato,C.M., Xu,X. and Yao,H.H.
  TITLE     An extragenital cell population contributes to urethra closure
            during mouse penis development
  JOURNAL   Sci Adv 10 (49), eadp0673 (2024)
   PUBMED   39642224
REFERENCE   4  (bases 1 to 2070)
  AUTHORS   Arekatla,G., Skylaki,S., Corredor Suarez,D., Jackson,H.,
            Schapiro,D., Engler,S., Auler,M., Camargo Ortega,G., Hastreiter,S.,
            Reimann,A., Loeffler,D., Bodenmiller,B. and Schroeder,T.
  TITLE     Identification of an embryonic differentiation stage marked by Sox1
            and FoxA2 co-expression using combined cell tracking and high
            dimensional protein imaging
  JOURNAL   Nat Commun 15 (1), 7860 (2024)
   PUBMED   39251590
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2070)
  AUTHORS   Dumoulin,A., Wilson,N.H., Tucker,K.L. and Stoeckli,E.T.
  TITLE     A cell-autonomous role for primary cilium-mediated signaling in
            long-range commissural axon guidance
  JOURNAL   Development 151 (17) (2024)
   PUBMED   39157903
REFERENCE   6  (bases 1 to 2070)
  AUTHORS   Duyao,M.P., Auerbach,A.B., Ryan,A., Persichetti,F., Barnes,G.T.,
            McNeil,S.M., Ge,P., Vonsattel,J.P., Gusella,J.F., Joyner,A.L. et
            al.
  TITLE     Inactivation of the mouse Huntington's disease gene homolog Hdh
  JOURNAL   Science 269 (5222), 407-410 (1995)
   PUBMED   7618107
REFERENCE   7  (bases 1 to 2070)
  AUTHORS   Kondoh,Y., Ono,T., Kagiyama,N., Fujita,S., Momiyama,M., Hori,S.H.
            and Yoshida,M.C.
  TITLE     Simultaneous visualization of Q-bands and FISH signals using a
            novel fluorochrome
  JOURNAL   Cytogenet Cell Genet 71 (1), 96-98 (1995)
   PUBMED   7606937
REFERENCE   8  (bases 1 to 2070)
  AUTHORS   Cereghini,S., Ott,M.O., Power,S. and Maury,M.
  TITLE     Expression patterns of vHNF1 and HNF1 homeoproteins in early
            postimplantation embryos suggest distinct and sequential
            developmental roles
  JOURNAL   Development 116 (3), 783-797 (1992)
   PUBMED   1363228
REFERENCE   9  (bases 1 to 2070)
  AUTHORS   Avraham,K.B., Prezioso,V.R., Chen,W.S., Lai,E., Sladek,F.M.,
            Zhong,W., Darnell,J.E. Jr., Jenkins,N.A. and Copeland,N.G.
  TITLE     Murine chromosomal location of four hepatocyte-enriched
            transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and
            HNF-4
  JOURNAL   Genomics 13 (2), 264-268 (1992)
   PUBMED   1612587
REFERENCE   10 (bases 1 to 2070)
  AUTHORS   Lai,E., Prezioso,V.R., Tao,W.F., Chen,W.S. and Darnell,J.E. Jr.
  TITLE     Hepatocyte nuclear factor 3 alpha belongs to a gene family in
            mammals that is homologous to the Drosophila homeotic gene fork
            head
  JOURNAL   Genes Dev 5 (3), 416-427 (1991)
   PUBMED   1672118
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845297.15 and L10409.1.
            
            On Mar 22, 2014 this sequence version replaced XM_006498785.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L10409.1, AB231453.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AL845297.15        195548-195590       c
            44-2029             L10409.1           3-1988
            2030-2070           AL845297.15        192519-192559       c
FEATURES             Location/Qualifiers
     source          1..2070
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 73.38 cM"
     gene            1..2070
                     /gene="Foxa2"
                     /gene_synonym="Hnf-3b; HNF3-beta; Hnf3b; HNF3beta; Tcf-3b;
                     Tcf3b"
                     /note="forkhead box A2"
                     /db_xref="GeneID:15376"
                     /db_xref="MGI:MGI:1347476"
     exon            1..122
                     /gene="Foxa2"
                     /gene_synonym="Hnf-3b; HNF3-beta; Hnf3b; HNF3beta; Tcf-3b;
                     Tcf3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1433
                     /gene="Foxa2"
                     /gene_synonym="Hnf-3b; HNF3-beta; Hnf3b; HNF3beta; Tcf-3b;
                     Tcf3b"
                     /note="isoform a is encoded by transcript variant 1;
                     hepatocyte nuclear factor 3-beta; HNF-3-beta; forkhead box
                     protein A2; hepatocyte nuclear factor 3 beta (winged helix
                     transcription factor)"
                     /codon_start=1
                     /product="hepatocyte nuclear factor 3-beta isoform a"
                     /protein_id="NP_001277994.1"
                     /db_xref="CCDS:CCDS71157.1"
                     /db_xref="GeneID:15376"
                     /db_xref="MGI:MGI:1347476"
                     /translation="MHSASSMLGAVKMEGHEPSDWSSYYAEPEGYSSVSNMNAGLGMN
                     GMNTYMSMSAAAMGGGSGNMSAGSMNMSSYVGAGMSPSLAGMSPGAGAMAGMSGSAGA
                     AGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPKTYRRS
                     YTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLS
                     FNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCEKQLALKEAAGAA
                     SSGGKKTAPGSQASQAQLGEAAGSASETPAGTESPHSSASPCQEHKRGGLSELKGAPA
                     SALSPPEPAPSPGQQQQAAAHLLGPPHHPGLPPEAHLKPEHHYAFNHPFSINNLMSSE
                     QQHHHSHHHHQPHKMDLKAYEQVMHYPGGYGSPMPGSLAMGPVTNKAGLDASPLAADT
                     SYYQGVYSRPIMNSS"
     exon            123..2070
                     /gene="Foxa2"
                     /gene_synonym="Hnf-3b; HNF3-beta; Hnf3b; HNF3beta; Tcf-3b;
                     Tcf3b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2047..2052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxa2"
                     /gene_synonym="Hnf-3b; HNF3-beta; Hnf3b; HNF3beta; Tcf-3b;
                     Tcf3b"
                     /note="hexamer: ATTAAA"
     polyA_site      2070
                     /gene="Foxa2"
                     /gene_synonym="Hnf-3b; HNF3-beta; Hnf3b; HNF3beta; Tcf-3b;
                     Tcf3b"
                     /note="major polyA site"
ORIGIN      
        1 ggtcgtttgt tgtggctgtt aaattttaaa ccgccatgca ctcggcttcc agtatgctgg
       61 gagccgtgaa gatggaaggg cacgagccat ccgactggag cagctactac gcggagcccg
      121 agggctactc ttccgtgagc aacatgaacg ccggcctggg gatgaatggc atgaacacat
      181 acatgagcat gtccgcggct gccatgggcg gcggttccgg caacatgagc gcgggctcca
      241 tgaacatgtc atcctatgtg ggcgctggaa tgagcccgtc gctagctggc atgtccccgg
      301 gcgccggcgc catggcgggc atgagcggct cagccggggc ggccggcgtg gcgggcatgg
      361 gacctcacct gagtccgagt ctgagcccgc tcgggggaca ggcggccggg gccatgggtg
      421 gccttgcccc ctacgccaac atgaactcga tgagccccat gtacgggcag gccggcctga
      481 gccgcgctcg ggaccccaag acataccgac gcagctacac acacgccaaa cctccctact
      541 cgtacatctc gctcatcacc atggccatcc agcagagccc caacaagatg ctgacgctga
      601 gcgagatcta tcagtggatc atggacctct tccctttcta ccggcagaac cagcagcgct
      661 ggcagaactc catccgccac tctctctcct tcaacgactg ctttctcaag gtgccccgct
      721 cgccagacaa gcctggcaag ggctccttct ggaccctgca cccagactcg ggcaacatgt
      781 tcgagaacgg ctgctacctg cgccgccaga agcgcttcaa gtgtgagaag caactggcac
      841 tgaaggaagc cgcgggtgcg gccagtagcg gaggcaagaa gaccgctcct gggtcccagg
      901 cctctcaggc tcagctcggg gaggccgcgg gctcggcctc cgagactccg gcgggcaccg
      961 agtcccccca ttccagcgct tctccgtgtc aggagcacaa gcgaggtggc ctaagcgagc
     1021 taaagggagc acctgcctct gcgctgagtc ctcccgagcc ggcgccctcg cctgggcagc
     1081 agcagcaggc tgcagcccac ctgctgggcc cacctcacca cccaggcctg ccaccagagg
     1141 cccacctgaa gcccgagcac cattacgcct tcaaccaccc cttctctatc aacaacctca
     1201 tgtcgtccga gcagcaacat caccacagcc accaccacca tcagccccac aaaatggacc
     1261 tcaaggccta cgaacaggtc atgcactacc cagggggcta tggttccccc atgccaggca
     1321 gcttggccat gggcccagtc acgaacaaag cgggcctgga tgcctcgccc ctggctgcag
     1381 acacttccta ctaccaagga gtgtactcca ggcctattat gaactcatcc taagaagatg
     1441 gctttcaggc cctgctagct ctggtcactg gggacaaggg aaatgagagg ctgagtggag
     1501 actttgggag agctttgagg aaaagtagcc accacacttc aggcctcaag ggagcagtct
     1561 cacctgtctg tgtccctaaa tagatgggcc acagtgatct gtcattctaa atagggaagg
     1621 gaatggaaat atatatgtat acatataaac ttgttttaaa ggagcctttg gtctcctcta
     1681 tgtagactac tgcttctcaa gacatctgca gagtttgatt tttgttgttg ttctctattg
     1741 ctgttgttgc agaaaagtct gactttaaaa acaaacaaac aaacaaaaaa cttttgtgag
     1801 tgacttggtg taaaaccatg tagttttaac agaaaaccag agggttgtac tgatgttgaa
     1861 aagaggaaag aaaaataatg taagagtctg gtgtaccgga ccaggagaaa ggagaaaaac
     1921 acatcccatt ctggacatgg tgaaatccag gtctcgggtc tgatttaatt tatggtttct
     1981 gcgtgcttta tttatggctt ataaatgtgt gttctggcta gaatggccag aattccacaa
     2041 atctatatta aagtgttatt gccgatttta
//
