LOCUS       NM_008259               3181 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus forkhead box A1 (Foxa1), mRNA.
ACCESSION   NM_008259 XM_915825
VERSION     NM_008259.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3181)
  AUTHORS   Zou,D., Liao,J., Xiao,M., Liu,L., Dai,D. and Xu,M.
  TITLE     Impaired SUMOylation of FoxA1 promotes nonalcoholic fatty liver
            disease through down-regulation of Sirt6
  JOURNAL   Cell Death Dis 15 (9), 674 (2024)
   PUBMED   39277582
  REMARK    GeneRIF: Impaired SUMOylation of FoxA1 promotes nonalcoholic fatty
            liver disease through down-regulation of Sirt6.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3181)
  AUTHORS   Zhou,B.R., Feng,H., Huang,F., Zhu,I., Portillo-Ledesma,S., Shi,D.,
            Zaret,K.S., Schlick,T., Landsman,D., Wang,Q. and Bai,Y.
  TITLE     Structural insights into the cooperative nucleosome recognition and
            chromatin opening by FOXA1 and GATA4
  JOURNAL   Mol Cell 84 (16), 3061-3079 (2024)
   PUBMED   39121853
  REMARK    GeneRIF: Structural insights into the cooperative nucleosome
            recognition and chromatin opening by FOXA1 and GATA4.
REFERENCE   3  (bases 1 to 3181)
  AUTHORS   Swisa,A., Kieckhaefer,J., Daniel,S.G., El-Mekkoussi,H., Kolev,H.M.,
            Tigue,M., Jin,C., Assenmacher,C.A., Dohnalova,L., Thaiss,C.A.,
            Karlsson,N.G., Bittinger,K. and Kaestner,K.H.
  TITLE     The evolutionarily ancient FOXA transcription factors shape the
            murine gut microbiome via control of epithelial glycosylation
  JOURNAL   Dev Cell 59 (16), 2069-2084 (2024)
   PUBMED   38821056
  REMARK    GeneRIF: The evolutionarily ancient FOXA transcription factors
            shape the murine gut microbiome via control of epithelial
            glycosylation.
REFERENCE   4  (bases 1 to 3181)
  AUTHORS   Liu,J., Fan,Y., Chen,J., Zhao,M. and Jiang,C.
  TITLE     FOXA1 Suppresses Endoplasmic Reticulum Stress, Oxidative Stress,
            and Neuronal Apoptosis in Parkinson's Disease by Activating PON2
            Transcription
  JOURNAL   Neurotox Res 42 (4), 31 (2024)
   PUBMED   38935306
  REMARK    GeneRIF: FOXA1 Suppresses Endoplasmic Reticulum Stress, Oxidative
            Stress, and Neuronal Apoptosis in Parkinson's Disease by Activating
            PON2 Transcription.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3181)
  AUTHORS   Gao,B., Wu,X., Bu,L., Jiang,Q., Wang,L., Liu,H., Zhang,X., Wu,Y.,
            Li,X., Li,J., Liang,Y., Xu,L., Xie,W. and Guo,J.
  TITLE     Atypical inflammatory kinase IKBKE phosphorylates and inactivates
            FoxA1 to promote liver tumorigenesis
  JOURNAL   Sci Adv 10 (6), eadk2285 (2024)
   PUBMED   38324694
  REMARK    GeneRIF: Atypical inflammatory kinase IKBKE phosphorylates and
            inactivates FoxA1 to promote liver tumorigenesis.
REFERENCE   6  (bases 1 to 3181)
  AUTHORS   Qian,X., Samadani,U., Porcella,A. and Costa,R.H.
  TITLE     Decreased expression of hepatocyte nuclear factor 3 alpha during
            the acute-phase response influences transthyretin gene
            transcription
  JOURNAL   Mol Cell Biol 15 (3), 1364-1376 (1995)
   PUBMED   7862129
REFERENCE   7  (bases 1 to 3181)
  AUTHORS   Faust,C., Schumacher,A., Holdener,B. and Magnuson,T.
  TITLE     The eed mutation disrupts anterior mesoderm production in mice
  JOURNAL   Development 121 (2), 273-285 (1995)
   PUBMED   7768172
REFERENCE   8  (bases 1 to 3181)
  AUTHORS   Kaestner,K.H., Lee,K.H., Schlondorff,J., Hiemisch,H., Monaghan,A.P.
            and Schutz,G.
  TITLE     Six members of the mouse forkhead gene family are developmentally
            regulated
  JOURNAL   Proc Natl Acad Sci U S A 90 (16), 7628-7631 (1993)
   PUBMED   7689224
REFERENCE   9  (bases 1 to 3181)
  AUTHORS   Avraham,K.B., Prezioso,V.R., Chen,W.S., Lai,E., Sladek,F.M.,
            Zhong,W., Darnell,J.E. Jr., Jenkins,N.A. and Copeland,N.G.
  TITLE     Murine chromosomal location of four hepatocyte-enriched
            transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and
            HNF-4
  JOURNAL   Genomics 13 (2), 264-268 (1992)
   PUBMED   1612587
REFERENCE   10 (bases 1 to 3181)
  AUTHORS   Lai,E., Prezioso,V.R., Tao,W.F., Chen,W.S. and Darnell,J.E. Jr.
  TITLE     Hepatocyte nuclear factor 3 alpha belongs to a gene family in
            mammals that is homologous to the Drosophila homeotic gene fork
            head
  JOURNAL   Genes Dev 5 (3), 416-427 (1991)
   PUBMED   1672118
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123067.4.
            
            On Apr 11, 2018 this sequence version replaced NM_008259.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096524.1, U44752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-448               AC123067.4         41951-42398         c
            449-3181            AC123067.4         36915-39647         c
FEATURES             Location/Qualifiers
     source          1..3181
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 24.7 cM"
     gene            1..3181
                     /gene="Foxa1"
                     /gene_synonym="Hnf-3a; Hnf3a; Tcf-3a; Tcf3a"
                     /note="forkhead box A1"
                     /db_xref="GeneID:15375"
                     /db_xref="MGI:MGI:1347472"
     exon            1..448
                     /gene="Foxa1"
                     /gene_synonym="Hnf-3a; Hnf3a; Tcf-3a; Tcf3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..1783
                     /gene="Foxa1"
                     /gene_synonym="Hnf-3a; Hnf3a; Tcf-3a; Tcf3a"
                     /note="fork head domain; HNF-3-alpha; forkhead box protein
                     A1; hepatocyte nuclear factor 3 alpha (winged helix
                     transcription factor)"
                     /codon_start=1
                     /product="hepatocyte nuclear factor 3-alpha"
                     /protein_id="NP_032285.2"
                     /db_xref="CCDS:CCDS25926.1"
                     /db_xref="GeneID:15375"
                     /db_xref="MGI:MGI:1347472"
                     /translation="MLGTVKMEGHESNDWNSYYADTQEAYSSVPVSNMNSGLGSMNSM
                     NTYMTMNTMTTSGNMTPASFNMSYANTGLGAGLSPGAVAGMPGASAGAMNSMTAAGVT
                     AMGTALSPGGMGSMGAQPATSMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAK
                     TFKRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSI
                     RHSLSFNDCFVKVARSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCEKQPGAGG
                     GSGGGGSKGGPESRKDPSGPGNPSAESPLHRGVHGKASQLEGAPAPGPAASPQTLDHS
                     GATATGGASELKSPASSSAPPISSGPGALASVPPSHPAHGLAPHESQLHLKGDPHYSF
                     NHPFSINNLMSSSEQQHKLDFKAYEQALQYSPYGATLPASLPLGSASVATRSPIEPSA
                     LEPAYYQGVYSRPVLNTS"
     exon            449..3181
                     /gene="Foxa1"
                     /gene_synonym="Hnf-3a; Hnf3a; Tcf-3a; Tcf3a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3155..3160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Foxa1"
                     /gene_synonym="Hnf-3a; Hnf3a; Tcf-3a; Tcf3a"
                     /note="hexamer: AATAAA"
     polyA_site      3178
                     /gene="Foxa1"
                     /gene_synonym="Hnf-3a; Hnf3a; Tcf-3a; Tcf3a"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgagcgt ctttgtgcgg cggacaaatg gggagaggac gaggaggtgg gcactccggc
       61 gacgtaagat ccacatcagc tcaactgcac tcgcttcgca caggccgccc gctcacttcc
      121 cgcggaggcg ctgccgggcg ccgcgctccg cggccgcctc ctgtccccgg cgctgccccc
      181 tcccgccgcg ccgcgccgcc gccgccgcgc acgccgcgcc ccgcagcgcc gggcttcctc
      241 ctcgcccggg tggcgctggg ccctcgagcg ctccggtgac cgcagcggct ccgcgcccct
      301 cccccgcccc gagcagcgca cccgcccgtc gctccgcaca gggttggatg gttgtgtcgg
      361 ccgggctggc tccaggatgt tagggactgt gaagatggaa gggcatgaga gcaacgactg
      421 gaacagctac tacgcggaca cgcaggaggc ctactcctct gtccctgtca gcaacatgaa
      481 ctccggcctg ggctctatga actccatgaa cacctacatg accatgaaca ccatgaccac
      541 gagcggcaac atgaccccgg cttccttcaa catgtcctac gccaacacgg gcttaggggc
      601 cggcctgagt cccggtgctg tggctggcat gccaggggcc tctgcaggcg ccatgaacag
      661 catgactgcg gcgggcgtca cggccatggg tacggcgctg agcccgggag gcatgggctc
      721 catgggcgcg cagcccgcca cctccatgaa cggcctgggt ccctacgccg ccgccatgaa
      781 cccgtgcatg agtcccatgg cgtacgcgcc gtccaacctg ggccgcagcc gcgcgggggg
      841 cggcggcgac gccaagacat tcaagcgcag ctaccctcac gccaagccgc cttactccta
      901 catctcgctc atcacgatgg ccatccagca ggcgcccagc aagatgctca cgctgagcga
      961 gatctaccag tggatcatgg acctcttccc ctattaccgc cagaaccagc agcgctggca
     1021 gaactccatc cgccactcgc tgtccttcaa cgattgtttc gtcaaggtgg cacgatcccc
     1081 ggacaagcca ggcaagggct cctactggac gctgcacccg gactccggca acatgttcga
     1141 gaacggctgc tacttgcgcc gccaaaagcg cttcaagtgt gagaagcagc cgggggccgg
     1201 aggtgggagt gggggcggcg gctccaaagg gggcccagaa agtcgcaagg acccctcagg
     1261 cccggggaac cccagcgccg agtcacccct tcaccggggt gtgcacggaa aggctagcca
     1321 gctagagggc gcgccggccc cagggcccgc cgccagcccc cagactctgg accacagcgg
     1381 ggccacggcg acagggggcg cttcggagtt gaagtctcca gcgtcttcat ctgcgccccc
     1441 cataagctcc gggccagggg cgctagcatc tgtacccccc tctcacccgg ctcacggcct
     1501 ggcaccccac gaatctcagc tgcatctgaa aggggatccc cactactcct ttaatcaccc
     1561 cttctccatc aacaacctca tgtcctcctc cgagcaacag cacaagctgg acttcaaggc
     1621 atacgagcag gcgctgcagt actctcctta tggcgctacc ttgcccgcca gtctgcccct
     1681 tggcagcgcc tcagtggcca cgaggagccc catcgagccc tcagccctgg agccagccta
     1741 ctaccaaggt gtgtattcca gacccgtgct aaatacttcc tagctcccag aactgagggt
     1801 tttgtctgca tggccaacct ggtagcagga gagaaaaacc aacagcaaac aaacaaaacc
     1861 acacacacac acacagacac acacacacca aaccaaccac ataataaaat tccaaatagt
     1921 tttatttttc acgcacaatt ttccccagtt caaaggactg ttactttatt attgtattca
     1981 acactcattg tgtgtattac cacaaatact accgactcca taccaacact tttttttttc
     2041 tggcaacatt taatgatcca caaatgtata tatagaaaat cttcctcccc tttctccctt
     2101 tcactccttc ccctgcggac acattctagt tcctgcaggg cttatttaaa aagaagatgg
     2161 tcaagtttgt aaaatatttg ttcgtgctct ttttgttgtt gttgttgttg ttaggcccac
     2221 cacacgagtt tacaggtctg tggcaatact cttaactcag taaagatgga agtggtaaag
     2281 aaaccaagta gacagtaggg gctcttgaga gtattgaaag gcagtgctgc ctttatgcag
     2341 gaaggtataa accggttatg cacattggag ccctttgctt tcaccttaca ttctggatgc
     2401 attcagatct cggacgtcct taagtgaaat gaatatacat gtctatggac ttaatatcat
     2461 gcccagatat gaagacctcg ttcaactttg cataacacgt agaggtaata gctaggtgat
     2521 agacattttc aaaaattgcc tgactggcca agttacaagg atgcctctcc acacttgtcc
     2581 tctctaccca cctacgctgg aaatccagtt cttcaggaac tgccttcctc cctaattctg
     2641 ctcttgcttt tcagagagcc atcatggtca tgtcatgctg aggtcacatg tataaaatta
     2701 gcttttgtgt atgtataccg tttaaaggat tcccccaccc ccactccagg gggaaaaaag
     2761 gaagtatcat actattgaga gagaagttat aagaaatgca tttcaaaatt tggtcccgaa
     2821 ttccaaaatc ccaattgtgg ccattttagt tcttgccatc ctattcttgg ctcatccagt
     2881 gttaatgcac tttccacagt tggacgtggt gttagtttta gacaaacggg tttcattatt
     2941 attcctcttt gccttctcaa tgttaattta ttgcatggtt tactcctttt ctttacagcc
     3001 gaaattgctt taagtgatgg ttaaattgac aaattaagat gttaattttt atcgatgtga
     3061 tttgtaatta agatattttg atttcaataa caaaaataat acaagagttt aatctgtgga
     3121 ttatgttcct gatcatttgc agttaaggaa tttaaataaa tcacatgtta acgacaaaga
     3181 a
//
