LOCUS       NM_008037               5886 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus fos-like antigen 2 (Fosl2), mRNA.
ACCESSION   NM_008037
VERSION     NM_008037.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5886)
  AUTHORS   Zerad,L., Gacem,N., Gayda,F., Day,L., Sinigaglia,K., Richard,L.,
            Parisot,M., Cagnard,N., Mathis,S., Bole-Feysot,C., O'Connell,M.A.,
            Pingault,V., Dambroise,E., Keegan,L.P., Vallat,J.M. and
            Bondurand,N.
  TITLE     Overexpression of Egr1 Transcription Regulator Contributes to
            Schwann Cell Differentiation Defects in Neural Crest-Specific Adar1
            Knockout Mice
  JOURNAL   Cells 13 (23), 1952 (2024)
   PUBMED   39682701
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5886)
  AUTHORS   Liu,Y., Li,X. and Yang,Y.
  TITLE     BACH1 transcriptionally upregulates FOSL2 to induce M2 macrophages
            phenotype by activating TGFbeta/SMAD signaling to promote the
            transformation of lung fibroblasts into myofibroblasts
  JOURNAL   Tissue Cell 88, 102407 (2024)
   PUBMED   38776730
  REMARK    GeneRIF: BACH1 transcriptionally upregulates FOSL2 to induce M2
            macrophages phenotype by activating TGFbeta/SMAD signaling to
            promote the transformation of lung fibroblasts into myofibroblasts.
REFERENCE   3  (bases 1 to 5886)
  AUTHORS   Bakiri,L., Hasenfuss,S.C., Guio-Carrion,A., Thomsen,M.K.,
            Hasselblatt,P. and Wagner,E.F.
  TITLE     Liver cancer development driven by the AP-1/c-Jun Fra-2 dimer
            through c-Myc
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2404188121 (2024)
   PUBMED   38657045
REFERENCE   4  (bases 1 to 5886)
  AUTHORS   Chen,J., Wen,Y., Lin,L., Cui,Y., Chen,Z., Gao,J., Zhuang,Y. and
            Chen,Q.
  TITLE     Fosl2 Deficiency Predisposes Mice to Osteopetrosis, Leading to Bone
            Marrow Failure
  JOURNAL   J Immunol 212 (7), 1081-1093 (2024)
   PUBMED   38380993
  REMARK    GeneRIF: Fosl2 Deficiency Predisposes Mice to Osteopetrosis,
            Leading to Bone Marrow Failure.
REFERENCE   5  (bases 1 to 5886)
  AUTHORS   Ai,Y., Kong,Y., Zou,Z., Chen,L. and Liang,G.
  TITLE     Long non-coding RNA MIR17HG impedes FOSL2-mediated transcription
            activation of HIC1 to maintain a pro-inflammatory phenotype of
            microglia during intracerebral haemorrhage
  JOURNAL   Eur J Neurosci 58 (10), 4107-4122 (2023)
   PUBMED   37846812
  REMARK    GeneRIF: Long non-coding RNA MIR17HG impedes FOSL2-mediated
            transcription activation of HIC1 to maintain a pro-inflammatory
            phenotype of microglia during intracerebral haemorrhage.
REFERENCE   6  (bases 1 to 5886)
  AUTHORS   Suzukawa,K. and Colburn,N.H.
  TITLE     AP-1 transrepressing retinoic acid does not deplete coactivators or
            AP-1 monomers but may target specific Jun or Fos containing dimers
  JOURNAL   Oncogene 21 (14), 2181-2190 (2002)
   PUBMED   11948401
  REMARK    GeneRIF: AP-1 transrepressing retinoic acid does not deplete
            coactivators or AP-1 monomers but may target specific Jun or Fos
            containing dimers
REFERENCE   7  (bases 1 to 5886)
  AUTHORS   Herdegen,T. and Leah,J.D.
  TITLE     Inducible and constitutive transcription factors in the mammalian
            nervous system: control of gene expression by Jun, Fos and Krox,
            and CREB/ATF proteins
  JOURNAL   Brain Res Brain Res Rev 28 (3), 370-490 (1998)
   PUBMED   9858769
  REMARK    Review article
REFERENCE   8  (bases 1 to 5886)
  AUTHORS   Poirier,C., Lalouette,A., Foletta,V.C., Cohen,D.R. and Guenet,J.L.
  TITLE     The gene encoding the Fos-related antigen 2 (Fosl2) maps to mouse
            chromosome 5
  JOURNAL   Mamm Genome 8 (3), 223 (1997)
   PUBMED   9069127
REFERENCE   9  (bases 1 to 5886)
  AUTHORS   Carrasco,D. and Bravo,R.
  TITLE     Tissue-specific expression of the fos-related transcription factor
            fra-2 during mouse development
  JOURNAL   Oncogene 10 (6), 1069-1079 (1995)
   PUBMED   7700631
REFERENCE   10 (bases 1 to 5886)
  AUTHORS   Foletta,V.C., Sonobe,M.H., Suzuki,T., Endo,T., Iba,H. and
            Cohen,D.R.
  TITLE     Cloning and characterisation of the mouse fra-2 gene
  JOURNAL   Oncogene 9 (11), 3305-3311 (1994)
   PUBMED   7936655
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY785312.1 and BC065131.1.
            
            On May 7, 2009 this sequence version replaced NM_008037.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065131.1, AK089371.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                BY785312.1         1-62
            63-4732             BC065131.1         1-4670
            4733-5886           BC065131.1         4672-5825
FEATURES             Location/Qualifiers
     source          1..5886
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.33 cM"
     gene            1..5886
                     /gene="Fosl2"
                     /gene_synonym="Fra-2"
                     /note="fos-like antigen 2"
                     /db_xref="GeneID:14284"
                     /db_xref="MGI:MGI:102858"
     exon            1..334
                     /gene="Fosl2"
                     /gene_synonym="Fra-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1213
                     /gene="Fosl2"
                     /gene_synonym="Fra-2"
                     /codon_start=1
                     /product="fos-related antigen 2"
                     /protein_id="NP_032063.2"
                     /db_xref="CCDS:CCDS19190.1"
                     /db_xref="GeneID:14284"
                     /db_xref="MGI:MGI:102858"
                     /translation="MYQDYPGNFDTSSRGSSGSPAHAESYSSGGGGQQKFRVDMPGSG
                     SAFIPTINAITTSQDLQWMVQPTVITSMSNPYPRSHPYSPLPGLASVPGHMALPRPGV
                     IKTIGTTVGRRRRDEQLSPEEEEKRRIRRERNKLAAAKCRNRRRELTEKLQAETEELE
                     EEKSGLQKEIAELQKEKEKLEFMLVAHGPVCKISPEERRSPPTSGLQSLRGTGSAVGP
                     VVVKQEPPEEDSPSSSAGMDKTQRSVIKPISIAGGGFYGEEPLHTPIVVTSTPAITPG
                     TSNLVFTYPNVLEQESPSSPSESCSKAHRRSSSSGDQSSDSLNSPTLLAL"
     exon            335..586
                     /gene="Fosl2"
                     /gene_synonym="Fra-2"
                     /inference="alignment:Splign:2.1.0"
     exon            587..694
                     /gene="Fosl2"
                     /gene_synonym="Fra-2"
                     /inference="alignment:Splign:2.1.0"
     exon            695..5864
                     /gene="Fosl2"
                     /gene_synonym="Fra-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1717..1722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fosl2"
                     /gene_synonym="Fra-2"
                     /note="hexamer: AGTAAA"
     polyA_site      1739
                     /gene="Fosl2"
                     /gene_synonym="Fra-2"
                     /note="major polyA site"
     regulatory      5746..5751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fosl2"
                     /gene_synonym="Fra-2"
                     /note="hexamer: ATTAAA"
     polyA_site      5768
                     /gene="Fosl2"
                     /gene_synonym="Fra-2"
                     /note="major polyA site"
     regulatory      5843..5848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fosl2"
                     /gene_synonym="Fra-2"
                     /note="hexamer: AATAAA"
     polyA_site      5864
                     /gene="Fosl2"
                     /gene_synonym="Fra-2"
                     /note="major polyA site"
ORIGIN      
        1 ggttccgcgg agcttgcaga gcagaaacga agtgcggtgc gcggcgatcg ggggggtcac
       61 ttcccgagtg tcgctgcctc ctgtctgcct tggttagggg acatcccggg agcgaaaagc
      121 ccagcccgtg gccgggccgg tggaccagcg agcgcgcagc agactgtgcg cggccgcggc
      181 gagggcgggg aagaaaacca ccctgtttcc tctccggccc ccaccgcgga tcatgtacca
      241 ggattatccc gggaactttg acacctcgtc ccggggcagc agcggctctc ctgcgcacgc
      301 cgagtcctac tccagcggtg gcggcggcca gcagaagttc cgggtagata tgcctggctc
      361 gggcagtgcc ttcatcccca caatcaacgc catcaccacc agccaggacc tgcagtggat
      421 ggtacagccc acagtgatca cctccatgtc caatccctat ccacgctcac atccctacag
      481 tcccctgcca ggcctggctt cagtccctgg gcacatggct ctccccagac ctggagtgat
      541 caagaccatc ggtaccaccg tgggccgcag aaggagagat gagcagctgt ctcctgagga
      601 ggaggagaag cgtcgaatcc ggagggagag aaacaagcta gctgcagcca agtgtcggaa
      661 ccgtcgccgg gagctgacag agaagctgca ggcggagacc gaggagctgg aagaggagaa
      721 gtctgggctg cagaaagaga ttgctgagct gcagaaggag aaggagaagc tagagttcat
      781 gttggtggct cacggccccg tgtgcaaaat cagccccgag gaacgccgat cgccccccac
      841 ctccgggctg cagtccttgc gcggtacggg cagtgccgtt ggccccgtgg tggtgaagca
      901 ggagcctccc gaagaggaca gcccctcttc ctcagcaggg atggacaaga cccagcgctc
      961 tgtcatcaag cccatcagca tcgccggggg tggtttctac ggggaagagc ctctgcacac
     1021 ccccatcgtg gtgacctcca cgcctgccat cactcccggc acttcaaacc ttgtcttcac
     1081 ctaccccaat gtcctggagc aggagtcgcc ttcgtcgccc tcagagtcct gctccaaggc
     1141 tcaccgcaga agcagtagca gtggggacca gtcatcagac tccttgaact cccccacact
     1201 tctagccctg taaccctgtg ctcctctggc cagctctgga ggaatcctca tccatcatta
     1261 ccacaccctt cccagggacc agcaccttta agcactccag ggccttgagg gaataagggg
     1321 cccctggctc tggggaccca cccggtggga cttagtggtg agacactggt tgatctctta
     1381 gaagccctgg gacacgccct ccctcattca tcttgcaagc gaagcgaatc ctttttcttg
     1441 agaagcctca gagaacttgg tttgtggact cagacgcgcc tgcggctacc cccacctcac
     1501 cccacccccc cctcttctga agccccgccc cctggagctg gcccggatgg tttctgtccc
     1561 tttgttatcc gttgtctctg aagtggacag tatcctttcc tgccccgcca agcatgctca
     1621 gtgccttttg gtttcccctc cttcccctag attcagtttt gctccctctg ggtttttata
     1681 agatttgcca tgacatttca tctgggtggt ccagatagta aagcgctttt atttctggag
     1741 ctggggaagc agatgactct tccactgggg cggaaggggc acccactgtg tcccgaaggg
     1801 gcagtcaaag tgcaatatta ttgaaacttc cctccctaca cacccagtgc gctgtggtta
     1861 cagaccgtgg gctccctgag ttctgccggt gagctgccgt cactgggatg cgccaaggac
     1921 ctttcctccc cggtctcaga gatgcacatc tctttgagga tcggcttggc tggaagacag
     1981 ggtgtgagtg cgacaacagg ggcacaggtt gggtttgcca aacgtctaat taccaagcca
     2041 ggatttgtgc caacaaagcc acatggctgt cctagtgagc ttcctttctt acctgtcttg
     2101 agctgggcgt ctctttaatt actgcctctg ccccggaccc ttctctctag acttgggaag
     2161 cactccttcc tagaagccac acatcactcc aaggctcagc tgggcgctgc tcatccccaa
     2221 ctctcatagt gacatcacct gtggatattt aatgagtgtg ggatgcgggg tctgcggtag
     2281 agatggtttc tggcagccgc agcagcccca ggtacctagc ctcccctggc tgctctcctg
     2341 tcagtgagat gcaggagccg ccctctgctc tcagtggtct ctgctactga tgaatccagt
     2401 gggtttcctt tcatattctc ctggccaact ccagagtggc ctcctaaccc agcaggccca
     2461 cccctctggg agtcgttggt ctccaccagt tttgttaggc tttgagtgtc tattcggttc
     2521 ctatcaaagc tagtgtgtat tcctttccac tacagaagaa ccatcactct catgggtgtc
     2581 ccagcctcca gcaagggcac agctctgtcc cctgcctttc tctccctttg tccccactgc
     2641 atgttgacac aagtatggaa gtggagcctg gttagaactt gtttctagtg ctaatgctct
     2701 gacctagtat ttccattgga gatcactgtc cagccatcta aagccctgtt attcgagtca
     2761 agcttatccc catttttgag agagaagggg taccttcaca gaccgatgcc cttcttaccc
     2821 caagttccca taaacacttg catgcagaag cacacaggac acagggacca tgtgggaagc
     2881 atgctcagcc tagcagagct gaaaggagca ggcttggctt ggtagagagg ggggcagaaa
     2941 ggagataatc tcaatgtgtt ctttcctgta tgccttggct ctaactctgc tgctctggtc
     3001 tcccagagcc tctaggggca ggggagtgct ccacaaggtg gtttgctggc ttcagagccc
     3061 tagaagcaca agacagtgga gccagcggag ccgggactag aggagttggg cagtctcagt
     3121 tgagaagctt tatcgcctca agccaagtgg gagctctctc cctcatgcct gtgggtattt
     3181 ctgaaatgaa gctgcgccct gttctgtcct ttcccaaagc ccccttctgc ccatagcatg
     3241 gatccaaccc aggtcacagg cctgggactt ggtaccctgg ttggacactc ctgagactcc
     3301 aagtctggct ttcagttcag ttttcatctg tgttgacatc ggggccagaa agcacagcca
     3361 gctaaatggg cctctgaggt caccttccct tccggcctgc ttgctttgtc ttacaagact
     3421 tcttggcttt tccaaagaca gagatttctg gggggaagcc gaatatttct acctaaactc
     3481 tgggtgtgac ctcagctcgc tttcctctga tccactgtcc aagttgggtc acaaacatgt
     3541 cactcatgca tgcctgcact ccagagtcag gtgccaagct tgcttgtcct tccctgcctc
     3601 caggtcaggg agcagctgca gtgagggtgg ggaggtgagg gctttgtaca cgtgtgtcct
     3661 ctgctgtcat gaacttgggc tggactgtga gcagctctgg gttaatacag ggcaggcaat
     3721 ccttaaacag ctagcatgaa acagttttgt cgtggccacc aggcttctgt gggaacagtc
     3781 cttctctggc tggctagcta ggcacagcta cggcactgga aagagtagag cccaggtgaa
     3841 gcttaggaaa ttgggagcta acaccaagca actggttccg tgggggaagg ttttagggag
     3901 ctcagactgc tgctttcata ggcaaagtgt gcccatgggg gccagtcatg ggaacatgtc
     3961 aaagccaaca ggaagcagaa cctgtagctt tctctggcat tagggagaga gaaccctgct
     4021 tgcttccact taactcctgg tggaagaggg gcaggcacgt tcgaagcttc tggattcatt
     4081 tttcctccac tttcctgaga gaccaaaagt gttccttgag atgtcaccat ttgtctttca
     4141 cagtgacttc cttccctgag caaacattca tgtggcttcg ctggggagga aaaaaataag
     4201 cacctactgt gtgccaggca ctatgaggca cttttctatt tatcctcttt taagatagga
     4261 ctaagagttc atctccttct agaaggcccc caggttaaat aaaaacactt gggggtaaga
     4321 gggctttctt cagagactcc caggtgggag tgcctctagt ctggtggtcc tcaaagactc
     4381 atccacagca gcatctgccc atcccaggct cctctctcct cagactcctc ctatctggct
     4441 tgtgctcctc aggtggctga aggggccacc ttagttctca tagaaattgt ggaccaatag
     4501 gatatgtgct gtgtataact ttctttttaa actgtaagta aagggtcttg cagctttgtg
     4561 cttgtgttat cttagcattt atcttcaaac cagcatctca ctatttattg acagtggtgt
     4621 gtgtgtgtgt gtgtgtgtgt ttctgcgtgt gcacatatgt gtgcacacat gtgcgtgtgt
     4681 gtgttcatgt gtgtgcatgc ttgtgtcttt ccacagcttt tttttttttt ttaaggatca
     4741 tcctactgct aagtccgtgt ctcttcttgc ttctagtgtt ttggccacgc ctcaccaaat
     4801 gtctgtaatg acccagtact cacaacatgt tcaggaggag ctgggtcaga ttttgacaga
     4861 gggtatggga agggaaaggg gagaagaaat tgacatttat tttattattt attttaaatg
     4921 tttacatttc tttgtgttgt tccaagcctg aatagaaaca gatagcatta aagtacttcc
     4981 ttcccactcc tttctctggc tctctctccc ccacttgttc tgacttagga taatgatctc
     5041 tattttgttt gtttctcaag tgacttgtgg acttgtgctg tataaactgt attaaaaagg
     5101 ctctgttttt aaagatcaat tgtcattcct gtggggacag tggctactga gaaatctaca
     5161 ttgtaagaga agacaatgaa agaccctggc cctgtctctc aaaacttaac tttctctgta
     5221 tgattttttt tttaaaaaaa tattccattt attttacttt gtggttactt gattttgagg
     5281 aagaaaatat tcagctttgt ataaagacta ggtatcagat tccttttgca gtgggaggtg
     5341 tatatatcgt attttggtat agagtaggac ccaagcttca tgcatctgta tttggtatat
     5401 gtcaatgacg tggagtgaaa tttgctatta gatcctggag gcaaatgggt tgtacaaggt
     5461 tttatggctc cgcggggaat ttaatttcct ttctgggcac cttttgtccc ctacttttaa
     5521 attaacggtg aaacggccct aggagggtcg ctctagttga actctccagg caggacctta
     5581 tgctcagaaa tctttgtata gttttaaatt tttgaggagt atctctgctc ggaagcatct
     5641 gtggtggtgt gatgtgttgt tctgtgtact gtatgtgaca caagcctaca ggatttgcac
     5701 taagaaaagc ttggtaggag cttgctgcta tggaggaaag aacatattaa aaacttattt
     5761 tccctcgggt ttgttctcgt tttatgtttt tgttgttgtt gttttgttag ctttcctact
     5821 tccactgagt agcattttgt agaataaaat taatcaagaa caaaaaaaaa aaaaaaaaaa
     5881 aaaaaa
//
