LOCUS       NM_008036               3783 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus FBJ osteosarcoma oncogene B (Fosb), transcript variant
            1, mRNA.
ACCESSION   NM_008036
VERSION     NM_008036.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3783)
  AUTHORS   Deng,Y., Hahn,Q., Yu,L., Zhu,Z., Boyer,J.A., Wang,J., Kong,D.,
            Carey,L.M., Hepperla,A.J., Simon,J.M., Temple,B., Zhang,Z.,
            Zhang,Y., Santos,C., Frank,J.E., Herring,L.E., Wang,X.,
            Dokholyan,N.V., Campbell,S.L., Baldwin,A.S., Damania,B., Zhang,Q.
            and Liu,P.
  TITLE     2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB signaling
            in cell migration control independent of innate immunity
  JOURNAL   Sci Adv 10 (42), eado7024 (2024)
   PUBMED   39413198
  REMARK    GeneRIF: 2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB
            signaling in cell migration control independent of innate immunity.
            Erratum:[Sci Adv. 2025 Jan 17;11(3):eadv6581. doi:
            10.1126/sciadv.adv6581.. PMID: 39823348]
REFERENCE   2  (bases 1 to 3783)
  AUTHORS   Stephens,G.S., Park,J., Eagle,A., You,J., Silva-Perez,M., Fu,C.H.,
            Choi,S., Romain,C.P.S., Sugimoto,C., Buffington,S.A., Zheng,Y.,
            Costa-Mattioli,M., Liu,Y., Robison,A.J. and Chin,J.
  TITLE     Persistent FosB expression limits recurrent seizure activity and
            provides neuroprotection in the dentate gyrus of APP mice
  JOURNAL   Prog Neurobiol 237, 102612 (2024)
   PUBMED   38642602
  REMARK    GeneRIF: Persistent FosB expression limits recurrent seizure
            activity and provides neuroprotection in the dentate gyrus of APP
            mice.
REFERENCE   3  (bases 1 to 3783)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3783)
  AUTHORS   Sourty,M., Nasseef,M.T., Champagnol-Di Liberti,C., Mondino,M.,
            Noblet,V., Parise,E.M., Markovic,T., Browne,C.J., Darcq,E.,
            Nestler,E.J. and Kieffer,B.L.
  TITLE     Manipulating DeltaFOSB in D1-Type Medium Spiny Neurons of the
            Nucleus Accumbens Reshapes Whole-Brain Functional Connectivity
  JOURNAL   Biol Psychiatry 95 (3), 266-274 (2024)
   PUBMED   37517704
  REMARK    GeneRIF: Manipulating DeltaFOSB in D1-Type Medium Spiny Neurons of
            the Nucleus Accumbens Reshapes Whole-Brain Functional Connectivity.
REFERENCE   5  (bases 1 to 3783)
  AUTHORS   Yao,S.Q., Wang,M., Liang,J.J., Ng,T.K. and Cen,L.P.
  TITLE     Retinal transcriptome of neonatal mice after optic nerve injury
  JOURNAL   PLoS One 18 (5), e0286344 (2023)
   PUBMED   37252932
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3783)
  AUTHORS   Mondino,A., Whaley,C.D., DeSilva,D.R., Li,W., Jenkins,M.K. and
            Mueller,D.L.
  TITLE     Defective transcription of the IL-2 gene is associated with
            impaired expression of c-Fos, FosB, and JunB in anergic T helper 1
            cells
  JOURNAL   J Immunol 157 (5), 2048-2057 (1996)
   PUBMED   8757326
REFERENCE   7  (bases 1 to 3783)
  AUTHORS   Brown,J.R., Ye,H., Bronson,R.T., Dikkes,P. and Greenberg,M.E.
  TITLE     A defect in nurturing in mice lacking the immediate early gene fosB
  JOURNAL   Cell 86 (2), 297-309 (1996)
   PUBMED   8706134
REFERENCE   8  (bases 1 to 3783)
  AUTHORS   Gruda,M.C., van Amsterdam,J., Rizzo,C.A., Durham,S.K., Lira,S. and
            Bravo,R.
  TITLE     Expression of FosB during mouse development: normal development of
            FosB knockout mice
  JOURNAL   Oncogene 12 (10), 2177-2185 (1996)
   PUBMED   8668344
REFERENCE   9  (bases 1 to 3783)
  AUTHORS   Lazo,P.S., Dorfman,K., Noguchi,T., Mattei,M.G. and Bravo,R.
  TITLE     Structure and mapping of the fosB gene. FosB downregulates the
            activity of the fosB promoter
  JOURNAL   Nucleic Acids Res 20 (2), 343-350 (1992)
   PUBMED   1741260
REFERENCE   10 (bases 1 to 3783)
  AUTHORS   Zerial,M., Toschi,L., Ryseck,R.P., Schuermann,M., Muller,R. and
            Bravo,R.
  TITLE     The product of a novel growth factor activated gene, fos B,
            interacts with JUN proteins enhancing their DNA binding activity
  JOURNAL   EMBO J 8 (3), 805-813 (1989)
   PUBMED   2498083
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY337108.1, AC148988.5, CK795975.1, BU698478.1, BY547195.1,
            CF356426.1 and AI846927.1.
            
            On Jul 15, 2006 this sequence version replaced NM_008036.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.824469.1, BC137994.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN02415122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               BY337108.1         2-391
            391-740             AC148988.5         101261-101610       c
            741-915             AC148988.5         99221-99395         c
            916-1566            CK795975.1         17-667
            1567-2383           AC148988.5         96044-96860         c
            2384-2810           BU698478.1         75-501
            2811-2949           BY547195.1         238-376
            2950-3131           AC148988.5         95296-95477         c
            3132-3709           CF356426.1         1-578
            3710-3783           AI846927.1         10-83               c
FEATURES             Location/Qualifiers
     source          1..3783
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.56 cM"
     gene            1..3783
                     /gene="Fosb"
                     /note="FBJ osteosarcoma oncogene B"
                     /db_xref="GeneID:14282"
                     /db_xref="MGI:MGI:95575"
     exon            1..740
                     /gene="Fosb"
                     /inference="alignment:Splign:2.1.0"
     CDS             615..1631
                     /gene="Fosb"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein fosB; osteosarcoma oncoprotein B FosB;
                     transcription factor AP-1 subunit FosB"
                     /codon_start=1
                     /product="protein FosB isoform 1"
                     /protein_id="NP_032062.1"
                     /db_xref="CCDS:CCDS20897.1"
                     /db_xref="GeneID:14282"
                     /db_xref="MGI:MGI:95575"
                     /translation="MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQEC
                     AGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPAVDPYDMPGT
                     SYSTPGLSAYSTGGASGSGGPSTSTTTSGPVSARPARARPRRPREETLTPEEEEKRRV
                     RRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAH
                     KPGCKIPYEEGPGPGPLAEVRDLPGSTSAKEDGFGWLLPPPPPPPLPFQSSRDAPPNL
                     TASLFTHSEVQVLGDPFPVVSPSYTSSFVLTCPEVSAFAGAQRTSGSEQPSDPLNSPS
                     LLAL"
     exon            741..1061
                     /gene="Fosb"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1169
                     /gene="Fosb"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..3776
                     /gene="Fosb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3752..3757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fosb"
                     /note="hexamer: AATAAA"
     polyA_site      3776
                     /gene="Fosb"
                     /note="major polyA site"
ORIGIN      
        1 attcataaga ctggagcggc tacgccgggg acacgcggag ccggggcttg ctggacttga
       61 ctactggtga ctctttcttt ttcttcttct tggaggccgt gaaaaattta tatatatata
      121 tttatatata tttttaaact ggagagaaag ttttgtgggt ttcctttttg caagactctt
      181 tctagatcgt tcttccgatt cgtccggagg atagactttc tttctgtggg cttctggatc
      241 gcgcccctct gctctccctc atttcttggg acgcttcgac aggattggaa ctgcatctga
      301 agcgcacgct gcaccgcggc actgcccggc gggtttctgg gcggggagcg atccccgcgt
      361 cgccccccgt gaaaccgaca gagcctggac tttcaggagg tacagcggcg gtctgaaggg
      421 gatctgggat cttgcagagg gaacttgcat cgaaacttgg gcagttctcc gaaccggaga
      481 ctaagcttcc ccgagcagcg cactttggag acgtgtccgg tctactccgg actcgcatct
      541 cattccactc ggccatagcc ttggcttccc ggcgacctca gcgtggtcac aggggccccc
      601 ctgtgcccag ggaaatgttt caagcttttc ccggagacta cgactccggc tcccggtgta
      661 gctcatcacc ctccgccgag tctcagtacc tgtcttcggt ggactccttc ggcagtccac
      721 ccaccgccgc cgcctcccag gagtgcgccg gtctcgggga aatgcccggc tccttcgtgc
      781 caacggtcac cgcaatcaca accagccagg atcttcagtg gctcgtgcaa cccaccctca
      841 tctcttccat ggcccagtcc caggggcagc cactggcctc ccagcctcca gctgttgacc
      901 cttatgacat gccaggaacc agctactcaa ccccaggcct gagtgcctac agcactggcg
      961 gggcaagcgg aagtggtggg ccttcaacca gcacaaccac cagtggacct gtgtctgccc
     1021 gtccagccag agccaggcct agaagacccc gagaagagac acttacccca gaagaagaag
     1081 aaaagcgaag ggttcgcaga gagcggaaca agctggctgc agctaagtgc aggaaccgtc
     1141 ggagggagct gacagatcga cttcaggcgg aaactgatca gcttgaagag gaaaaggcag
     1201 agctggagtc ggagatcgcc gagctgcaaa aagagaagga acgcctggag tttgtcctgg
     1261 tggcccacaa accgggctgc aagatcccct acgaagaggg gccggggcca ggcccgctgg
     1321 ccgaggtgag agatttgcca gggtcaacat ccgctaagga agacggcttc ggctggctgc
     1381 tgccgccccc tccaccaccg cccctgccct tccagagcag ccgagacgca ccccccaacc
     1441 tgacggcttc tctctttaca cacagtgaag ttcaagtcct cggcgacccc ttccccgttg
     1501 ttagcccttc gtacacttcc tcgtttgtcc tcacctgccc ggaggtctcc gcgttcgccg
     1561 gcgcccaacg caccagcggc agcgagcagc cgtccgaccc gctgaactcg ccctcccttc
     1621 ttgctctgta aactctttag acaaacaaaa caaacaaacc cgcaaggaac aaggaggagg
     1681 aagatgagga ggagagggga ggaagcagtc cgggggtgtg tgtgtggacc ctttgactct
     1741 tctgtctgac cacctgccgc ctctgccatc ggacatgacg gaaggacctc ctttgtgttt
     1801 tgtgctccgt ctctggtttt ctgtgccccg gcgagaccgg agagctggtg actttgggga
     1861 cagggggtgg ggcggggatg gacacccctc ctgcatatct ttgtcctgtt acttcaaccc
     1921 aacttctggg gatagatggc tggctgggtg ggtagggtgg ggtgcaacgc ccacctttgg
     1981 cgtcttgcgt gaggctggag gggaaagggt gctgagtgtg gggtgcaggg tgggttgagg
     2041 tcgagctggc atgcacctcc agagagaccc aacgaggaaa tgacagcacc gtcctgtcct
     2101 tcttttcccc cacccaccca tccaccctca agggtgcagg gtgaccaaga tagctctgtt
     2161 ttgctccctc gggccttagc tgattaactt aacatttcca agaggttaca acctcctcct
     2221 ggacgaattg agcccccgac tgagggaagt cgatgccccc tttgggagtc tgctaacccc
     2281 acttcccgct gattccaaaa tgtgaacccc tatctgactg ctcagtcttt ccctcctggg
     2341 aaaactggct caggttggat ttttttcctc gtctgctaca gagccccctc ccaactcagg
     2401 cccgctccca cccctgtgca gtattatgct atgtccctct caccctcacc cccaccccag
     2461 gcgcccttgg ccgtcctcgt tgggccttac tggttttggg cagcaggggg cgctgcgacg
     2521 cccatcttgc tggagcgctt tatactgtga atgagtggtc ggattgctgg gtgcgccgga
     2581 tgggattgac ccccagccct ccaaaacttt ccctgggcct ccccttcttc cacttgcttc
     2641 ctccctcccc ttgacaggga gttagactcg aaaggatgac cacgacgcat cccggtggcc
     2701 ttcttgctca ggccccagac tttttctctt taagtccttc gccttcccca gcctaggacg
     2761 ccaacttctc cccaccctgg gagccccgca tcctctcaca gaggtcgagg caattttcag
     2821 agaagttttc agggctgagg ctttggctcc cctatcctcg atatttgaat ccccaaatat
     2881 ttttggacta gcatacttaa gagggggctg agttcccact atcccactcc atccaattcc
     2941 ttcagtccca aagacgagtt ctgtcccttc cctccagctt tcacctcgtg agaatcccac
     3001 gagtcagatt tctatttttt aatattgggg agatgggccc taccgcccgt cccccgtgct
     3061 gcatggaaca ttccataccc tgtcctgggc cctaggttcc aaacctaatc ccaaacccca
     3121 cccccagcta tttatccctt tcctggttcc caaaaagcac ttatatctat tatgtataaa
     3181 taaatatatt atatatgagt gtgcgtgtgt gtgcgtgtgc gtgcgtgcgt gcgtgcgtgc
     3241 gagcttcctt gttttcaagt gtgctgtgga gttcaaaatc gcttctgggg atttgagtca
     3301 gactttctgg ctgtcccttt ttgtcacttt tttgttgttg tctcggctcc tctggctgtt
     3361 ggagacagtc ccggcctctc cctttatcct ttctcaagtc tgtctcgctc agaccacttc
     3421 caacatgtct ccactctcaa tgactctgat ctccggtctg tctgttaatt ctggatttgt
     3481 cggggacatg caattttact tctgtaagta agtgtgactg ggtggtagat tttttacaat
     3541 ctatatcgtt gagaattctg ggtggaaatg tctgatcagg agaagggcct gccactgccg
     3601 accacaattc attgactcca tagccctcac ccaggctgta tttgtgattt ttttcatttt
     3661 gtttttttgt attttgcacc tgaccccggg ggtgctgggg cagtctagca ctgggcagct
     3721 cccctccccc ccttggttct gcactgtcgc caataaaaag cttttaaaaa actgtaaaaa
     3781 aaa
//
