LOCUS       NM_010234               2109 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus FBJ osteosarcoma oncogene (Fos), mRNA.
ACCESSION   NM_010234
VERSION     NM_010234.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2109)
  AUTHORS   Gutierrez-Castellanos,N., Husain,B.F.A., Dias,I.C., Nomoto,K.,
            Duarte,M.A., Ferreira,L., Lacoste,B. and Lima,S.Q.
  TITLE     A hypothalamic node for the cyclical control of female sexual
            rejection
  JOURNAL   Neuron 113 (2), 277-290 (2025)
   PUBMED   39591968
REFERENCE   2  (bases 1 to 2109)
  AUTHORS   Lesuis,S.L., Park,S., Hoorn,A., Rashid,A.J., Mocle,A.J.,
            Salter,E.W., Vislavski,S., Gray,M.T., Torelli,A.M.,
            DeCristofaro,A., Driever,W.P.F., van der Stelt,M., Zweifel,L.S.,
            Collingridge,G.L., Lefebvre,J.L., Walters,B.J., Frankland,P.W.,
            Hill,M.N. and Josselyn,S.A.
  TITLE     Stress disrupts engram ensembles in lateral amygdala to generalize
            threat memory in mice
  JOURNAL   Cell 188 (1), 121-140 (2025)
   PUBMED   39549697
REFERENCE   3  (bases 1 to 2109)
  AUTHORS   Moya-Garzon,M.D., Wang,M., Li,V.L., Lyu,X., Wei,W., Tung,A.S.,
            Raun,S.H., Zhao,M., Coassolo,L., Islam,H., Oliveira,B., Dai,Y.,
            Spaas,J., Delgado-Gonzalez,A., Donoso,K., Alvarez-Buylla,A.,
            Franco-Montalban,F., Letian,A., Ward,C.P., Liu,L., Svensson,K.J.,
            Goldberg,E.L., Gardner,C.D., Little,J.P., Banik,S.M., Xu,Y. and
            Long,J.Z.
  TITLE     A beta-hydroxybutyrate shunt pathway generates anti-obesity ketone
            metabolites
  JOURNAL   Cell 188 (1), 175-186 (2025)
   PUBMED   39536746
REFERENCE   4  (bases 1 to 2109)
  AUTHORS   Lu,D., Uldry Lavergne,C.G., Choi,S., Park,J., Kim,J., Zhao,S.,
            Desimone,Q., Lendaro,E., Chen,B., Han,B.X., Wang,F. and
            Goldstein,N.
  TITLE     General anesthesia activates a central anxiolytic center in the
            BNST
  JOURNAL   Cell Rep 43 (11), 114909 (2024)
   PUBMED   39460938
REFERENCE   5  (bases 1 to 2109)
  AUTHORS   Chang,J., Li,Z., Yuan,H., Wang,X., Xu,J., Yang,P. and Qin,L.
  TITLE     Protective role of aconitate decarboxylase 1 in
            neuroinflammation-induced dysfunctions of the paraventricular
            thalamus and sleepiness
  JOURNAL   Commun Biol 7 (1), 1484 (2024)
   PUBMED   39523388
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2109)
  AUTHORS   Wang,Z.Q., Ovitt,C., Grigoriadis,A.E., Mohle-Steinlein,U.,
            Ruther,U. and Wagner,E.F.
  TITLE     Bone and haematopoietic defects in mice lacking c-fos
  JOURNAL   Nature 360 (6406), 741-745 (1992)
   PUBMED   1465144
REFERENCE   7  (bases 1 to 2109)
  AUTHORS   Johnson,R.S., Spiegelman,B.M. and Papaioannou,V.
  TITLE     Pleiotropic effects of a null mutation in the c-fos proto-oncogene
  JOURNAL   Cell 71 (4), 577-586 (1992)
   PUBMED   1423615
REFERENCE   8  (bases 1 to 2109)
  AUTHORS   Tomomura,M., Nakagawa,K. and Saheki,T.
  TITLE     Proto-oncogene c-jun and c-fos messenger RNAs increase in the liver
            of carnitine-deficient juvenile visceral steatosis (jvs) mice
  JOURNAL   FEBS Lett 311 (1), 63-66 (1992)
   PUBMED   1383034
REFERENCE   9  (bases 1 to 2109)
  AUTHORS   Field,S.J., Johnson,R.S., Mortensen,R.M., Papaioannou,V.E.,
            Spiegelman,B.M. and Greenberg,M.E.
  TITLE     Growth and differentiation of embryonic stem cells that lack an
            intact c-fos gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9306-9310 (1992)
   PUBMED   1329091
REFERENCE   10 (bases 1 to 2109)
  AUTHORS   Clarke,A.R., Maandag,E.R., van Roon,M., van der Lugt,N.M., van der
            Valk,M., Hooper,M.L., Berns,A. and te Riele,H.
  TITLE     Requirement for a functional Rb-1 gene in murine development
  JOURNAL   Nature 359 (6393), 328-330 (1992)
   PUBMED   1406937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159244.4.
            
            On Apr 11, 2018 this sequence version replaced NM_010234.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154418.1, BC029814.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               AC159244.4         180770-181060
            292-543             AC159244.4         181815-182066
            544-651             AC159244.4         182472-182579
            652-2109            AC159244.4         182697-184154
FEATURES             Location/Qualifiers
     source          1..2109
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.7 cM"
     gene            1..2109
                     /gene="Fos"
                     /gene_synonym="c-fos; cFos; D12Rfj1"
                     /note="FBJ osteosarcoma oncogene"
                     /db_xref="GeneID:14281"
                     /db_xref="MGI:MGI:95574"
     exon            1..291
                     /gene="Fos"
                     /gene_synonym="c-fos; cFos; D12Rfj1"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1293
                     /gene="Fos"
                     /gene_synonym="c-fos; cFos; D12Rfj1"
                     /note="proto-oncogene protein c-fos; proto-oncogene c-Fos;
                     cellular oncogene fos; transcription factor AP-1 subunit
                     c-Fos"
                     /codon_start=1
                     /product="protein c-Fos"
                     /protein_id="NP_034364.1"
                     /db_xref="CCDS:CCDS26059.1"
                     /db_xref="GeneID:14281"
                     /db_xref="MGI:MGI:95574"
                     /translation="MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPV
                     NTQDFCADLSVSSANFIPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGLPTQS
                     AGAYARAGMVKTVSGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRE
                     LTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSV
                     ASLDLTGGLPEASTPESEEAFTLPLLNDPEPKPSLEPVKSISNVELKAEPFDDFLFPA
                     SSRPSGSETSRSVPDVDLSGSFYAADWEPLHSNSLGMGPMVTELEPLCTPVVTCTPGC
                     TTYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL"
     exon            292..543
                     /gene="Fos"
                     /gene_synonym="c-fos; cFos; D12Rfj1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..651
                     /gene="Fos"
                     /gene_synonym="c-fos; cFos; D12Rfj1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..2109
                     /gene="Fos"
                     /gene_synonym="c-fos; cFos; D12Rfj1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2084..2089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fos"
                     /gene_synonym="c-fos; cFos; D12Rfj1"
                     /note="hexamer: AATAAA"
     polyA_site      2109
                     /gene="Fos"
                     /gene_synonym="c-fos; cFos; D12Rfj1"
                     /note="major polyA site"
ORIGIN      
        1 aaccgcgact gcagcgagca actgagaaga ctggatagag ccggcggttc cgcgaacgag
       61 cagtgaccgc gctcccaccc agctctgctc tgcagctccc accagtgtct acccctggac
      121 cccttgccgg gctttcccca aacttcgacc atgatgttct cgggtttcaa cgccgactac
      181 gaggcgtcat cctcccgctg cagtagcgcc tccccggccg gggacagcct ttcctactac
      241 cattccccag ccgactcctt ctccagcatg ggctctcctg tcaacacaca ggacttttgc
      301 gcagatctgt ccgtctctag tgccaacttt atccccacgg tgacagccat ctccaccagc
      361 ccagacctgc agtggctggt gcagcccact ctggtctcct ccgtggcccc atcgcagacc
      421 agagcgcccc atccttacgg actccccacc cagtctgctg gggcttacgc cagagcggga
      481 atggtgaaga ccgtgtcagg aggcagagcg cagagcatcg gcagaagggg caaagtagag
      541 cagctatctc ctgaagagga agagaaacgg agaatccgaa gggaacggaa taagatggct
      601 gcagccaagt gccggaatcg gaggagggag ctgacagata cactccaagc ggagacagat
      661 caacttgaag atgagaagtc tgcgttgcag actgagattg ccaatctgct gaaagagaag
      721 gaaaaactgg agtttatttt ggcagcccac cgacctgcct gcaagatccc cgatgacctt
      781 ggcttcccag aggagatgtc tgtggcctcc ctggatttga ctggaggtct gcctgaggct
      841 tccaccccag agtctgagga ggccttcacc ctgccccttc tcaacgaccc tgagcccaag
      901 ccatccttgg agccagtcaa gagcatcagc aacgtggagc tgaaggcaga accctttgat
      961 gacttcttgt ttccggcatc atctaggccc agtggctcag agacctcccg ctctgtgcca
     1021 gatgtggacc tgtccggttc cttctatgca gcagactggg agcctctgca cagcaattcc
     1081 ttggggatgg ggcccatggt cacagagctg gagcccctgt gtactcccgt ggtcacctgt
     1141 actccgggct gcactactta cacgtcttcc tttgtcttca cctaccctga agctgactcc
     1201 ttcccaagct gtgccgctgc ccaccgaaag ggcagcagca gcaacgagcc ctcctccgac
     1261 tccctgagct cacccacgct gctggccctg tgagcagtca gagaaggcaa ggcagccggc
     1321 atccagacgt gccactgccc gagctggtgc attacagaga ggagaaacac gtcttccctc
     1381 gaaggttccc gtcgacctag ggaggacctt acctgttcgt gaaacacacc aggctgtggg
     1441 cctcaaggac ttgcaagcat ccacatctgg cctccagtcc tcacctcttc cagagatgta
     1501 gcaaaaacaa aacaaaacaa aacaaaaaac cgcatggagt gtgttgttcc tagtgacacc
     1561 tgagagctgg tagttagtag agcatgtgag tcaaggcctg gtctgtgtct cttttctctt
     1621 tctccttagt tttctcatag cactaactaa tctgttgggt tcattattgg aattaacctg
     1681 gtgctggatt gtatctagtg cagctgattt taacaatacc tactgtgttc ctggcaatag
     1741 cgtgttccaa ttagaaacga ccaatattaa actaagaaaa gataggactt tattttccag
     1801 tagatagaaa tcaatagcta tatccatgta ctgtagtcct tcagcgtcaa tgttcattgt
     1861 catgttactg atcatgcatt gtcgaggtgg tctgaatgtt ctgacattaa cagttttcca
     1921 tgaaaacgtt tttattgtgt tttcaattta tttattaaga tggattctca gatatttata
     1981 tttttatttt atttttttct accctgaggt ctttcgacat gtggaaagtg aatttgaatg
     2041 aaaaatttta agcattgttt gcttattgtt ccaagacatt gtcaataaaa gcatttaagt
     2101 tgaatgcga
//
