LOCUS       NM_008035               1097 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus folate receptor beta (Folr2), transcript variant 2,
            mRNA.
ACCESSION   NM_008035
VERSION     NM_008035.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1097)
  AUTHORS   Alfar,R., Napoleon,J.V., Shahriar,I., Finnell,R., Walchle,C.,
            Johnson,A. and Low,P.S.
  TITLE     Selective reprogramming of regulatory T cells in solid tumors can
            strongly enhance or inhibit tumor growth
  JOURNAL   Front Immunol 14, 1274199 (2023)
   PUBMED   37928524
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1097)
  AUTHORS   Dick,S.A., Wong,A., Hamidzada,H., Nejat,S., Nechanitzky,R.,
            Vohra,S., Mueller,B., Zaman,R., Kantores,C., Aronoff,L., Momen,A.,
            Nechanitzky,D., Li,W.Y., Ramachandran,P., Crome,S.Q., Becher,B.,
            Cybulsky,M.I., Billia,F., Keshavjee,S., Mital,S., Robbins,C.S.,
            Mak,T.W. and Epelman,S.
  TITLE     Three tissue resident macrophage subsets coexist across organs with
            conserved origins and life cycles
  JOURNAL   Sci Immunol 7 (67), eabf7777 (2022)
   PUBMED   34995099
  REMARK    GeneRIF: Three tissue resident macrophage subsets coexist across
            organs with conserved origins and life cycles.
REFERENCE   3  (bases 1 to 1097)
  AUTHORS   Rodriguez-Garcia,A., Lynn,R.C., Poussin,M., Eiva,M.A., Shaw,L.C.,
            O'Connor,R.S., Minutolo,N.G., Casado-Medrano,V., Lopez,G.,
            Matsuyama,T. and Powell,D.J. Jr.
  TITLE     CAR-T cell-mediated depletion of immunosuppressive tumor-associated
            macrophages promotes endogenous antitumor immunity and augments
            adoptive immunotherapy
  JOURNAL   Nat Commun 12 (1), 877 (2021)
   PUBMED   33563975
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1097)
  AUTHORS   Schniering,J., Benesova,M., Brunner,M., Haller,S., Cohrs,S.,
            Frauenfelder,T., Vrugt,B., Feghali-Bostwick,C., Schibli,R.,
            Distler,O., Muller,C. and Maurer,B.
  TITLE     18F-AzaFol for Detection of Folate Receptor-beta Positive
            Macrophages in Experimental Interstitial Lung Disease-A
            Proof-of-Concept Study
  JOURNAL   Front Immunol 10, 2724 (2019)
   PUBMED   31824505
  REMARK    GeneRIF: (18)F-AzaFol for Detection of Folate Receptor-beta
            Positive Macrophages in Experimental Interstitial Lung Disease-A
            Proof-of-Concept Study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1097)
  AUTHORS   Meredith,M., MacNeil,A.H., Trasler,J.M. and Baltz,J.M.
  TITLE     Growing Mouse Oocytes Transiently Activate Folate Transport via
            Folate Receptors As They Approach Full Size
  JOURNAL   Biol Reprod 94 (6), 125 (2016)
   PUBMED   27122634
  REMARK    GeneRIF: The characteristics of folate transport in oocytes are
            consistent with folate receptor-mediated endocytosis, possibly by
            the FOLR2 isoform.
REFERENCE   6  (bases 1 to 1097)
  AUTHORS   Barber,R.C., Bennett,G.D., Greer,K.A. and Finnell,R.H.
  TITLE     Expression patterns of folate binding proteins one and two in the
            developing mouse embryo
  JOURNAL   Mol Genet Metab 66 (1), 31-39 (1999)
   PUBMED   9973545
REFERENCE   7  (bases 1 to 1097)
  AUTHORS   Shen,F., Zheng,X., Wang,J. and Ratnam,M.
  TITLE     Identification of amino acid residues that determine the
            differential ligand specificities of folate receptors alpha and
            beta
  JOURNAL   Biochemistry 36 (20), 6157-6163 (1997)
   PUBMED   9166787
REFERENCE   8  (bases 1 to 1097)
  AUTHORS   Brigle,K.E., Seither,R.L., Westin,E.H. and Goldman,I.D.
  TITLE     Increased expression and genomic organization of a folate-binding
            protein homologous to the human placental isoform in L1210 murine
            leukemia cell lines with a defective reduced folate carrier
  JOURNAL   J Biol Chem 269 (6), 4267-4272 (1994)
   PUBMED   8307991
REFERENCE   9  (bases 1 to 1097)
  AUTHORS   Brigle,K.E., Spinella,M.J., Westin,E.H. and Goldman,I.D.
  TITLE     Increased expression and characterization of two distinct folate
            binding proteins in murine erythroleukemia cells
  JOURNAL   Biochem Pharmacol 47 (2), 337-345 (1994)
   PUBMED   8304978
REFERENCE   10 (bases 1 to 1097)
  AUTHORS   Brigle,K.E., Westin,E.H., Houghton,M.T. and Goldman,I.D.
  TITLE     Characterization of two cDNAs encoding folate-binding proteins from
            L1210 murine leukemia cells. Increased expression associated with a
            genomic rearrangement
  JOURNAL   J Biol Chem 266 (26), 17243-17249 (1991)
   PUBMED   1894617
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ049116.1, AC159005.3 and
            BQ176722.1.
            
            On Nov 18, 2011 this sequence version replaced NM_008035.1.
            
            Summary: This gene encodes a receptor protein located on the plasma
            membrane that mediates folate uptake by cells. Mice lacking the
            product of this gene show no defects in embryonic development and
            grow normally into fertile adults. However, such mice were found to
            be highly susceptible to the teratogenic effects of arsenic.
            Alternate splicing of this gene results in multiple transcript
            variants. [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All variants (1-3) encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022108.1, CB587421.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-430               CJ049116.1         2-431
            431-471             AC159005.3         16125-16165
            472-607             AC159005.3         16251-16386
            608-1006            AC159005.3         16516-16914
            1007-1097           BQ176722.1         1-91                c
FEATURES             Location/Qualifiers
     source          1..1097
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.67 cM"
     gene            1..1097
                     /gene="Folr2"
                     /gene_synonym="FBP2; Folbp-2; Folbp2; FR-beta; FR-P3"
                     /note="folate receptor beta"
                     /db_xref="GeneID:14276"
                     /db_xref="MGI:MGI:95569"
     exon            1..128
                     /gene="Folr2"
                     /gene_synonym="FBP2; Folbp-2; Folbp2; FR-beta; FR-P3"
                     /inference="alignment:Splign:2.1.0"
     exon            129..285
                     /gene="Folr2"
                     /gene_synonym="FBP2; Folbp-2; Folbp2; FR-beta; FR-P3"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..894
                     /gene="Folr2"
                     /gene_synonym="FBP2; Folbp-2; Folbp2; FR-beta; FR-P3"
                     /note="folate binding protein 2; folate receptor 2
                     (fetal)"
                     /codon_start=1
                     /product="folate receptor beta precursor"
                     /protein_id="NP_032061.1"
                     /db_xref="CCDS:CCDS21516.1"
                     /db_xref="GeneID:14276"
                     /db_xref="MGI:MGI:95569"
                     /translation="MAWKQTPLLLLVYMVTTGSGRDRTDLLNVCMDAKHHKTKPGPED
                     KLHDQCSPWKKNACCSVNTSQELHKADSRLYFNWDHCGKMEPACKSHFIQDSCLYECS
                     PNLGPWIQQVDQSWRKERFLDVPLCKEDCHQWWEACRTSFTCKRDWHKGWDWSSGINK
                     CPNTAPCHTFEYYFPTPASLCEGLWSHSYKVSNYSRGSGRCIQMWFDSTQGNPNEDVV
                     KFYASFMTSGTVPHAAVLLVPSLAPVLSLWLPG"
     exon            286..471
                     /gene="Folr2"
                     /gene_synonym="FBP2; Folbp-2; Folbp2; FR-beta; FR-P3"
                     /inference="alignment:Splign:2.1.0"
     exon            472..607
                     /gene="Folr2"
                     /gene_synonym="FBP2; Folbp-2; Folbp2; FR-beta; FR-P3"
                     /inference="alignment:Splign:2.1.0"
     exon            608..1081
                     /gene="Folr2"
                     /gene_synonym="FBP2; Folbp-2; Folbp2; FR-beta; FR-P3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1050..1055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Folr2"
                     /gene_synonym="FBP2; Folbp-2; Folbp2; FR-beta; FR-P3"
                     /note="hexamer: AATAAA"
     polyA_site      1081
                     /gene="Folr2"
                     /gene_synonym="FBP2; Folbp-2; Folbp2; FR-beta; FR-P3"
                     /note="major polyA site"
ORIGIN      
        1 attccgtgct taccaaagct tctatgtggg gctgtggacg aagactgtag agactaccca
       61 gagtctgacc tagggagagg ccaactcgga tacccctatg tgcgctccca gaagctaagg
      121 acattgagac agaaagacat ggcctggaaa cagacaccac tcttgctttt ggtctacatg
      181 gtcacaacag gcagtggccg ggacagaaca gacctactca acgtttgcat ggatgccaaa
      241 caccataaga caaagccggg ccccgaggac aagctgcatg accagtgtag tccatggaag
      301 aaaaatgcct gttgctcagt caacaccagc caggagctac acaaggctga ctcccgtctg
      361 tacttcaact gggatcactg tggcaagatg gagcctgcct gtaagagtca cttcatccaa
      421 gactcctgcc tgtatgagtg ctcccccaac cttgggcctt ggatccagca agtggaccag
      481 agttggcgta aagagcgttt cctggatgtg cccttatgca aagaggactg tcaccagtgg
      541 tgggaagcct gtcgtacctc ctttacctgc aagagagact ggcataaagg ctgggactgg
      601 tcctcaggca ttaacaagtg cccaaacaca gcaccctgtc acacgtttga gtactacttc
      661 ccgacaccag ccagcctttg cgagggtctc tggagtcact cctacaaggt cagcaactac
      721 agcagaggga gtggccgctg catccagatg tggtttgact caacccaggg caatccgaat
      781 gaggacgtgg tgaagtttta tgcttccttt atgacatctg ggactgtgcc ccatgcagca
      841 gtacttcttg tgcccagcct ggccccagtg ctgtcattat ggctccctgg ctgagaggtc
      901 agtcttcctc tctagatttc tcctctatct acccttggtc tggttcaact cttcaaagaa
      961 taaggaagtc ttgagcctgc ttccacccct ctcctctgtc atccagttcc tgatccatgt
     1021 tgggggttgg ggtttctaca atcattttca ataaatctat gacacatctg ggcctaatga
     1081 aaaaaaaaaa aaaaaaa
//
