LOCUS       NM_001412432            1615 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus folate receptor alpha (Folr1), transcript variant 9,
            mRNA.
ACCESSION   NM_001412432
VERSION     NM_001412432.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1615)
  AUTHORS   Anton-Fernandez,A., Cuadros,R., Peinado-Cahuchola,R., Hernandez,F.
            and Avila,J.
  TITLE     Role of folate receptor alpha in the partial rejuvenation of
            dentate gyrus cells: Improvement of cognitive function in
            21-month-old aged mice
  JOURNAL   Sci Rep 14 (1), 6915 (2024)
   PUBMED   38519576
  REMARK    GeneRIF: Role of folate receptor alpha in the partial rejuvenation
            of dentate gyrus cells: Improvement of cognitive function in
            21-month-old aged mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1615)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1615)
  AUTHORS   Zhang,W., Zhang,R., Wu,L., Zhu,C., Zhang,C., Xu,C., Zhao,S.,
            Liu,X., Guo,T., Lu,Y., Gao,Z., Yu,X., Li,L., Chen,Z.J., Qin,Y. and
            Jiao,X.
  TITLE     NLRP14 deficiency causes female infertility with oocyte maturation
            defects and early embryonic arrest by impairing cytoplasmic UHRF1
            abundance
  JOURNAL   Cell Rep 42 (12), 113531 (2023)
   PUBMED   38060382
REFERENCE   4  (bases 1 to 1615)
  AUTHORS   Zhang,M., Salbaum,J.M., Jones,S., Burk,D. and Kappen,C.
  TITLE     Aberrant lipid accumulation in the mouse visceral yolk sac
            resulting from maternal diabetes and obesity
  JOURNAL   Front Cell Dev Biol 11, 1073807 (2023)
   PUBMED   36936697
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1615)
  AUTHORS   Xie,S., Louis Sam Titus,A.S.C. and Mohan,C.
  TITLE     Elevated expression of receptors for EGF, PDGF, transferrin and
            folate within murine and human lupus nephritis kidneys
  JOURNAL   Clin Immunol 246, 109188 (2023)
   PUBMED   36396012
  REMARK    GeneRIF: Elevated expression of receptors for EGF, PDGF,
            transferrin and folate within murine and human lupus nephritis
            kidneys.
REFERENCE   6  (bases 1 to 1615)
  AUTHORS   Shen,F., Zheng,X., Wang,J. and Ratnam,M.
  TITLE     Identification of amino acid residues that determine the
            differential ligand specificities of folate receptors alpha and
            beta
  JOURNAL   Biochemistry 36 (20), 6157-6163 (1997)
   PUBMED   9166787
REFERENCE   7  (bases 1 to 1615)
  AUTHORS   Taylor,L.E., Bennett,G.D. and Finnell,R.H.
  TITLE     Altered gene expression in murine branchial arches following in
            utero exposure to retinoic acid
  JOURNAL   J Craniofac Genet Dev Biol 15 (1), 13-25 (1995)
   PUBMED   7601910
REFERENCE   8  (bases 1 to 1615)
  AUTHORS   Brigle,K.E., Spinella,M.J., Westin,E.H. and Goldman,I.D.
  TITLE     Increased expression and characterization of two distinct folate
            binding proteins in murine erythroleukemia cells
  JOURNAL   Biochem Pharmacol 47 (2), 337-345 (1994)
   PUBMED   8304978
REFERENCE   9  (bases 1 to 1615)
  AUTHORS   Brigle,K.E., Westin,E.H., Houghton,M.T. and Goldman,I.D.
  TITLE     Insertion of an intracisternal A particle within the 5'-regulatory
            region of a gene encoding folate-binding protein in L1210 leukemia
            cells in response to low folate selection. Association with
            increased protein expression
  JOURNAL   J Biol Chem 267 (31), 22351-22355 (1992)
   PUBMED   1429588
REFERENCE   10 (bases 1 to 1615)
  AUTHORS   Brigle,K.E., Westin,E.H., Houghton,M.T. and Goldman,I.D.
  TITLE     Characterization of two cDNAs encoding folate-binding proteins from
            L1210 murine leukemia cells. Increased expression associated with a
            genomic rearrangement
  JOURNAL   J Biol Chem 266 (26), 17243-17249 (1991)
   PUBMED   1894617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167240.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR17784651.909893.1, SRR17784648.500804.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849385, SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-408               AC167240.5         154485-154892
            409-556             AC167240.5         155903-156050
            557-710             AC167240.5         156656-156809
            711-892             AC167240.5         161101-161282
            893-1081            AC167240.5         165653-165841
            1082-1217           AC167240.5         165975-166110
            1218-1615           AC167240.5         166463-166860
FEATURES             Location/Qualifiers
     source          1..1615
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.67 cM"
     gene            1..1615
                     /gene="Folr1"
                     /gene_synonym="FBP1; Folbp-1; Folbp1"
                     /note="folate receptor alpha"
                     /db_xref="GeneID:14275"
                     /db_xref="MGI:MGI:95568"
     exon            1..408
                     /gene="Folr1"
                     /gene_synonym="FBP1; Folbp-1; Folbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            409..556
                     /gene="Folr1"
                     /gene_synonym="FBP1; Folbp-1; Folbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..710
                     /gene="Folr1"
                     /gene_synonym="FBP1; Folbp-1; Folbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..892
                     /gene="Folr1"
                     /gene_synonym="FBP1; Folbp-1; Folbp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             731..1498
                     /gene="Folr1"
                     /gene_synonym="FBP1; Folbp-1; Folbp1"
                     /note="FR-alpha; folate-binding protein 1; folate receptor
                     1 (adult)"
                     /codon_start=1
                     /product="folate receptor alpha precursor"
                     /protein_id="NP_001399361.1"
                     /db_xref="GeneID:14275"
                     /db_xref="MGI:MGI:95568"
                     /translation="MAHLMTVQLLLLVMWMAECAQSRATRARTELLNVCMDAKHHKEK
                     PGPEDNLHDQCSPWKTNSCCSTNTSQEAHKDISYLYRFNWNHCGTMTSECKRHFIQDT
                     CLYECSPNLGPWIQQVDQSWRKERILDVPLCKEDCQQWWEDCQSSFTCKSNWHKGWNW
                     SSGHNECPVGASCHPFTFYFPTSAALCEEIWSHSYKLSNYSRGSGRCIQMWFDPAQGN
                     PNEEVARFYAEAMSGAGFHGTWPLLCSLSLVLLWVIS"
     exon            893..1081
                     /gene="Folr1"
                     /gene_synonym="FBP1; Folbp-1; Folbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1217
                     /gene="Folr1"
                     /gene_synonym="FBP1; Folbp-1; Folbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1615
                     /gene="Folr1"
                     /gene_synonym="FBP1; Folbp-1; Folbp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1596..1601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Folr1"
                     /gene_synonym="FBP1; Folbp-1; Folbp1"
                     /note="hexamer: AATAAA"
     polyA_site      1615
                     /gene="Folr1"
                     /gene_synonym="FBP1; Folbp-1; Folbp1"
                     /note="major polyA site"
ORIGIN      
        1 agtcagcagg ctgatctgga agtataaaca agaaaggagg ctgacggctc tagaagtccc
       61 caacctgttg tgatcttcag tagacaaaca ctcctggtgt gtcacaggat tcaggtacat
      121 ggcagtggcc agggcgaagg gtagcaagac agaaccaggg acctcctggg agcctgtctc
      181 tctttgtagg gccttgttct ttggctaatt ttcccccaga gtccaaattg cctcctctct
      241 ctccttcctc cttcccttct tccttgcctt ccttcccctc cttccttttc tctttctcct
      301 gacattcacc aatgtagtgg tctctactat ctcacttaaa tttcggttga gacagctccc
      361 acatctatgt ccaatttgga gccttcctct ggggccacac acgcacaggc cactaaacct
      421 cggccggctg tctcctggaa tgaagaaagc aaaggaagcc tagagtggag acaaagaagc
      481 ccgaggcact ctgagagctg ccatcttttc cttgtttgcc gcctgacact tctcagcagg
      541 atccacatac cctaagggag tggagagagg cctgggctgg gccaggtttt ctgggctttt
      601 tcctgtgctc cgagtaggtg ggttgtattt tacccagtag gagtggaaga ctccttggcg
      661 cttggtgctt caaccggact gacttcctgg gcctggagtt ggcgattaga ctctgccttc
      721 agggtctgac atggctcacc tgatgactgt gcagttgttg ctcctggtga tgtggatggc
      781 cgaatgtgct cagtccagag ctactcgggc caggactgaa cttctcaatg tctgcatgga
      841 tgccaaacac cacaaagaaa aaccgggccc tgaggacaat ttacacgacc agtgcagccc
      901 ctggaagacg aattcctgct gttccacgaa cacaagccag gaagcacata aggacatttc
      961 ctacctgtac cggttcaact ggaaccactg cggaactatg acatcggaat gcaaacggca
     1021 ctttatccaa gacacctgcc tctatgagtg ttccccgaac ttgggaccct ggatccagca
     1081 ggtggaccag agctggcgca aagagcggat ccttgatgtt cccctgtgca aagaggactg
     1141 tcagcagtgg tgggaggact gccagagctc ttttacctgc aagagcaatt ggcacaaggg
     1201 atggaactgg tcctcggggc ataacgagtg tcctgtggga gcctcctgcc atcccttcac
     1261 cttctacttc cccacatctg ctgctctgtg tgaggaaatc tggagtcact cctacaagct
     1321 cagcaactac agtcgaggga gcggccgctg cattcagatg tggttcgacc cagcccaggg
     1381 caaccccaac gaggaagtgg cgaggttcta tgccgaggcc atgagtggag ctgggtttca
     1441 tgggacctgg ccactcttgt gcagcctgtc cttagtgctg ctctgggtga tcagctgagc
     1501 tcctgtttta ccttcagttg tctggagcgc caccctgctt ggctcagcct cccagctccc
     1561 agcctccttt gtggtggggc tctgacagcc tctttaataa accagacatt ccaca
//
