LOCUS       NM_016770               3047 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus folate hydrolase 1 (Folh1), transcript variant 1,
            mRNA.
ACCESSION   NM_016770
VERSION     NM_016770.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3047)
  AUTHORS   Su,Y., Huang,M., Thomas,A.G., Maragakis,J., Huizar,K.D.J.,
            Zheng,Y., Wu,Y., Farah,M.H. and Slusher,B.S.
  TITLE     GCPII Inhibition Promotes Remyelination after Peripheral Nerve
            Injury in Aged Mice
  JOURNAL   Int J Mol Sci 25 (13), 6893 (2024)
   PUBMED   39000003
  REMARK    GeneRIF: GCPII Inhibition Promotes Remyelination after Peripheral
            Nerve Injury in Aged Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3047)
  AUTHORS   Sedlak,F., Kvasnicka,A., Maresova,B., Brumarova,R., Dobesova,D.,
            Dostalova,K., Sramkova,K., Pehr,M., Sacha,P., Friedecky,D. and
            Konvalinka,J.
  TITLE     Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient
            Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid
            Composition
  JOURNAL   ACS Chem Neurosci 15 (7), 1342-1355 (2024)
   PUBMED   38377674
  REMARK    GeneRIF: Parallel Metabolomics and Lipidomics of a PSMA/GCPII
            Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain
            Lipid Composition.
REFERENCE   3  (bases 1 to 3047)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3047)
  AUTHORS   Ji,T., Pang,Y., Cheng,M., Wang,R., Chen,X., Zhang,C., Liu,M.,
            Zhang,J. and Zhong,C.
  TITLE     Deletion of glutamate carboxypeptidase II (GCPII), but not GCPIII,
            provided long-term benefits in mice with traumatic brain injury
  JOURNAL   CNS Neurosci Ther 29 (12), 3786-3801 (2023)
   PUBMED   37349952
  REMARK    GeneRIF: Deletion of glutamate carboxypeptidase II (GCPII), but not
            GCPIII, provided long-term benefits in mice with traumatic brain
            injury.
REFERENCE   5  (bases 1 to 3047)
  AUTHORS   Wu,W., Xu,S., Wang,J., Zhang,K., Zhang,M., Cao,Y., Ren,H., Zheng,D.
            and Zhong,C.
  TITLE     Metabolite differences between glutamate carboxypeptidase II gene
            knockout mice and their wild-type littermates after traumatic brain
            injury: a 7-tesla 1H-MRS study
  JOURNAL   BMC Neurosci 19 (1), 75 (2018)
   PUBMED   30458729
  REMARK    GeneRIF: decrease in both glutamate and N-acetylaspartate levels in
            the ipsilateral hippocampus at 24 h post-traumatic brain injury
            (TBI); however, the reduction in glutamate and N-acetylaspartate
            levels was less marked in GCP II-KO mice than in WT mice. T2 MR
            data and brain water-content analysis demonstrated that the extent
            of cortical edema and brain swelling was less in KO than in WT mice
            after TBI .
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3047)
  AUTHORS   Tsai,G., Dunham,K.S., Drager,U., Grier,A., Anderson,C., Collura,J.
            and Coyle,J.T.
  TITLE     Early embryonic death of glutamate carboxypeptidase II (NAALADase)
            homozygous mutants
  JOURNAL   Synapse 50 (4), 285-292 (2003)
   PUBMED   14556233
REFERENCE   7  (bases 1 to 3047)
  AUTHORS   Schmittgen,T.D., Zakrajsek,B.A., Hill,R.E., Liu,Q., Reeves,J.J.,
            Axford,P.D., Singer,M.J. and Reed,M.W.
  TITLE     Expression pattern of mouse homolog of prostate-specific membrane
            antigen (FOLH1) in the transgenic adenocarcinoma of the mouse
            prostate model
  JOURNAL   Prostate 55 (4), 308-316 (2003)
   PUBMED   12712410
REFERENCE   8  (bases 1 to 3047)
  AUTHORS   Bacich,D.J., Ramadan,E., O'Keefe,D.S., Bukhari,N., Wegorzewska,I.,
            Ojeifo,O., Olszewski,R., Wrenn,C.C., Bzdega,T., Wroblewska,B.,
            Heston,W.D. and Neale,J.H.
  TITLE     Deletion of the glutamate carboxypeptidase II gene in mice reveals
            a second enzyme activity that hydrolyzes N-acetylaspartylglutamate
  JOURNAL   J Neurochem 83 (1), 20-29 (2002)
   PUBMED   12358725
REFERENCE   9  (bases 1 to 3047)
  AUTHORS   Bacich,D.J., Pinto,J.T., Tong,W.P. and Heston,W.D.
  TITLE     Cloning, expression, genomic localization, and enzymatic activities
            of the mouse homolog of prostate-specific membrane
            antigen/NAALADase/folate hydrolase
  JOURNAL   Mamm Genome 12 (2), 117-123 (2001)
   PUBMED   11210180
REFERENCE   10 (bases 1 to 3047)
  AUTHORS   Ohrt,C., Mirabelli-Primdahl,L., Karnasuta,C., Chantakulkij,S. and
            Kain,K.C.
  TITLE     Distinguishing Plasmodium falciparum treatment failures from
            reinfections by restrictions fragment length polymorphism and
            polymerase chain reaction genotyping
  JOURNAL   Am J Trop Med Hyg 57 (4), 430-437 (1997)
   PUBMED   9347959
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB872570.1, BC119605.1, AK002920.1 and BB179784.1.
            
            On Apr 29, 2009 this sequence version replaced NM_016770.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002920.1, BC119605.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BB872570.1         2-57
            57-1856             BC119605.1         1-1800
            1857-2424           AK002920.1         1824-2391
            2425-2740           BC119605.1         2369-2684
            2741-3036           AK002920.1         2708-3003
            3037-3047           BB179784.1         277-287
FEATURES             Location/Qualifiers
     source          1..3047
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 48.51 cM"
     gene            1..3047
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /note="folate hydrolase 1"
                     /db_xref="GeneID:53320"
                     /db_xref="MGI:MGI:1858193"
     exon            1..226
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     exon            227..335
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     exon            336..522
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     exon            523..624
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     exon            625..750
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     exon            751..937
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1031
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1130
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1216
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1336
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1419
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1483
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1551
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1643
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1734
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1999
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2081
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2174
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..3047
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2942..2947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /note="hexamer: AATATA"
     polyA_site      2957
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
                     /note="major polyA site"
     polyA_site      2966
                     /gene="Folh1"
                     /gene_synonym="GCP2; mopsm"
ORIGIN      
        1 gacttctatt tcccagggga atagcagtgg gaggaaattt taacccgcag aatctctgca
       61 gtggatgtag aagagaactg ctgaggaaaa ctaaagttgc cagagatgtg gaacgcactg
      121 caggacagag actccgcgga ggtcctggga caccgccagc gctggctccg tgttgggaca
      181 ctggtgctgg ctttaaccgg aaccttcctc attggcttcc tctttgggtg gtttataaaa
      241 ccttccaatg aagctactgg taatgtttcc cattctggca tgaagaagga gtttttgcat
      301 gaattgaagg ctgagaacat caaaaaattt ttatacaatt tcacacggac accacacttg
      361 gcaggaacac aaaataattt tgagcttgca aagcaaattc atgaccagtg gaaagaattt
      421 ggcctggatt tggttgagtt atcccattac gatgtcttgc tgtcctatcc aaataaaact
      481 catcctaact atatctcaat aattaatgaa gatggaaatg agattttcaa aacatcatta
      541 tctgaacagc cacccccagg atatgagaat atatcagatg tagtgccacc atacagtgcc
      601 ttctctccac aagggacacc agagggtgat ctagtgtatg tcaactatgc acgaactgaa
      661 gacttcttta aactggaacg ggaaatgaag atcagttgtt ctgggaagat tgtgattgcc
      721 agatatggga aagtgttcag aggaaatatg gttaaaaatg ctcaactggc aggggcaaaa
      781 ggaatgattc tgtactcaga ccctgctgac tactttgttc ctgcggtgaa gtcctatcca
      841 gatggctgga acctccctgg aggtggtgtc caacgtggaa atgtcttaaa tcttaatggt
      901 gcaggtgacc cgctcacacc aggttaccca gcaaatgaac atgcttatag gcatgagttg
      961 acaaacgctg ttggccttcc aagtattcct gtccatccta ttggatatga tgatgcacag
     1021 aaactcttag aacacatggg tggtccagca ccccctgaca gtagctggaa gggaggatta
     1081 aaagtgcctt acaacgtggg acctggcttt gctggaaact tttcaacaca aaaggtcaag
     1141 atgcatattc actcttacac taaagtgaca agaatctata atgtcattgg caccctcaaa
     1201 ggagctctgg aaccagacag atatgttatt cttggaggtc accgagatgc ttgggtattt
     1261 ggtggcattg accctcagag tggagcagct gttgttcatg aaattgtgcg gagctttgga
     1321 accctgaaga agaaaggacg gaggcctaga aggacaattt tgtttgcaag ctgggatgca
     1381 gaagaatttg gccttcttgg ttctactgag tgggcagagg aacattcaag actcctacaa
     1441 gagcgaggtg tggcttatat taatgctgat tcttccatag aaggaaatta cactctaaga
     1501 gttgattgca caccactgat gtacagctta gtgtacaacc taacaaaaga gctgcaaagc
     1561 ccagatgaag gttttgaagg aaaatctctt tatgacagct ggaaagaaaa gagtccttca
     1621 cctgagttca ttggaatgcc cagaattagc aagctggggt ctggcaatga ttttgaagtg
     1681 ttcttccaaa gacttggaat tgcttcaggc agagcccgat atactaaaaa ttggaaaact
     1741 aacaaagtca gcagctatcc tctctatcac agtgtctatg aaacatatga gctggtagta
     1801 aaattttatg acccaacatt taaataccac ctcactgtgg cccaggttcg aggagcgatg
     1861 gtatttgaac ttgccaattc tatagtgctt ccctttgact gccaaagtta tgctgtagct
     1921 ctgaagaagt atgctgacac tatctacaat atttcaatga aacatccaca agaaatgaag
     1981 gcttacatga tatcatttga ttcactgttt tctgcagtca ataattttac agatgttgca
     2041 tctaagttca atcagagact gcaagagtta gacaaaagca accccatatt actgagaatt
     2101 atgaatgacc agctgatgta tctggaacgt gcattcattg atcctttagg cttaccagga
     2161 aggcctttct acaggcatat catctatgct ccaagcagcc acaacaagta tgcaggagaa
     2221 tcattccctg ggatttatga tgcccttttt gatataagta gcaaagtcaa tgcttctaag
     2281 gcctggaacg aagtgaagag acagatttct attgcaacct ttacagtgca agctgcagca
     2341 gagactctga gggaagtagc ttaaacacat tctacagaat cacaaaatcc ctatggaact
     2401 atggagctta tatatatata tatacacatg catacatata ttcttatttt tttcatatgc
     2461 atcaaaaaat ccaaaagtgg ataatttatt ttttaaattt caacatgtat tcataaaatt
     2521 taaaattcaa ataagtatta aaactaaggt gaacagtcta ataaagtgat acatttgaca
     2581 gtatcagaca attatcagaa atataataca gccttcccag atctactctg tcatttcaat
     2641 aaaaacaagt atcaattcct tatggaacac agctggaata gttcacaagt ctgcttcatc
     2701 tgggggacta gatacactct ggccacgaaa ggctgggaag atcatattag ccacaatagc
     2761 tgacaagtta taatctattc tcatatcttg taaaactcag cactctgaat tataacgttt
     2821 aattatttag acttaggaaa atatcatttt atgaaaatgt ataaaatata aatgcacaac
     2881 caataattaa tttgtagtcc caataaccat gtacttctaa acaattgcat catttatatc
     2941 aaatataatc ctggtcttaa attttatgtt tatgatttcc ttgtttatat agaagtcatc
     3001 aaacatggct gtattcatta catatcttga atatatacat aattttg
//
