LOCUS       NM_001418161            2610 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus farnesyltransferase, CAAX box, beta (Fntb), transcript
            variant 2, mRNA.
ACCESSION   NM_001418161
VERSION     NM_001418161.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2610)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2610)
  AUTHORS   Jo,A., Lee,Y., Kam,T.I., Kang,S.U., Neifert,S.,
            Karuppagounder,S.S., Khang,R., Kang,H., Park,H., Chou,S.C., Oh,S.,
            Jiang,H., Swing,D.A., Ham,S., Pirooznia,S., Umanah,G.K.E., Mao,X.,
            Kumar,M., Ko,H.S., Kang,H.C., Lee,B.D., Lee,Y.I., Andrabi,S.A.,
            Park,C.H., Lee,J.Y., Kim,H., Kim,H., Kim,H., Cho,J.W., Paek,S.H.,
            Na,C.H., Tessarollo,L., Dawson,V.L., Dawson,T.M. and Shin,J.H.
  TITLE     PARIS farnesylation prevents neurodegeneration in models of
            Parkinson's disease
  JOURNAL   Sci Transl Med 13 (604) (2021)
   PUBMED   34321320
REFERENCE   3  (bases 1 to 2610)
  AUTHORS   Jeong,A., Cheng,S., Zhong,R., Bennett,D.A., Bergo,M.O. and Li,L.
  TITLE     Protein farnesylation is upregulated in Alzheimer's human brains
            and neuron-specific suppression of farnesyltransferase mitigates
            pathogenic processes in Alzheimer's model mice
  JOURNAL   Acta Neuropathol Commun 9 (1), 129 (2021)
   PUBMED   34315531
  REMARK    GeneRIF: Protein farnesylation is upregulated in Alzheimer's human
            brains and neuron-specific suppression of farnesyltransferase
            mitigates pathogenic processes in Alzheimer's model mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2610)
  AUTHORS   Su,W., Chapman,N.M., Wei,J., Zeng,H., Dhungana,Y., Shi,H.,
            Saravia,J., Zhou,P., Long,L., Rankin,S., Kc,A., Vogel,P. and Chi,H.
  TITLE     Protein Prenylation Drives Discrete Signaling Programs for the
            Differentiation and Maintenance of Effector Treg Cells
  JOURNAL   Cell Metab 32 (6), 996-1011 (2020)
   PUBMED   33207246
REFERENCE   5  (bases 1 to 2610)
  AUTHORS   Du,X., Zeng,H., Liu,S., Guy,C., Dhungana,Y., Neale,G., Bergo,M.O.
            and Chi,H.
  TITLE     Mevalonate metabolism-dependent protein geranylgeranylation
            regulates thymocyte egress
  JOURNAL   J Exp Med 217 (2) (2020)
   PUBMED   31722972
REFERENCE   6  (bases 1 to 2610)
  AUTHORS   Lee,R., Chang,S.Y., Trinh,H., Tu,Y., White,A.C., Davies,B.S.,
            Bergo,M.O., Fong,L.G., Lowry,W.E. and Young,S.G.
  TITLE     Genetic studies on the functional relevance of the protein
            prenyltransferases in skin keratinocytes
  JOURNAL   Hum Mol Genet 19 (8), 1603-1617 (2010)
   PUBMED   20106865
  REMARK    GeneRIF: Both Fntb and Pggt1b are required for the homeostasis of
            skin keratinocytes.
REFERENCE   7  (bases 1 to 2610)
  AUTHORS   Tkatchenko,T.V., Moreno-Rodriguez,R.A., Conway,S.J.,
            Molkentin,J.D., Markwald,R.R. and Tkatchenko,A.V.
  TITLE     Lack of periostin leads to suppression of Notch1 signaling and
            calcific aortic valve disease
  JOURNAL   Physiol Genomics 39 (3), 160-168 (2009)
   PUBMED   19723774
REFERENCE   8  (bases 1 to 2610)
  AUTHORS   Yang,S.H., Bergo,M.O., Farber,E., Qiao,X., Fong,L.G. and Young,S.G.
  TITLE     Caution! Analyze transcripts from conditional knockout alleles
  JOURNAL   Transgenic Res 18 (3), 483-489 (2009)
   PUBMED   19093225
REFERENCE   9  (bases 1 to 2610)
  AUTHORS   Mijimolle,N., Velasco,J., Dubus,P., Guerra,C., Weinbaum,C.A.,
            Casey,P.J., Campuzano,V. and Barbacid,M.
  TITLE     Protein farnesyltransferase in embryogenesis, adult homeostasis,
            and tumor development
  JOURNAL   Cancer Cell 7 (4), 313-324 (2005)
   PUBMED   15837621
  REMARK    GeneRIF: FTase is essential for embryonic development, but
            dispensable for adult homeostasis. Elimination of FTase during
            tumor progression had a limited but significant inhibitory effect
            on tumor development.
REFERENCE   10 (bases 1 to 2610)
  AUTHORS   Seldin,M.F., Hirohata,S. and Apte,S.S.
  TITLE     Chromosomal mapping of Adam9, Adam15 and Adam21
  JOURNAL   Matrix Biol 19 (2), 185-187 (2000)
   PUBMED   10842103
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132331.3 and AC124556.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784646.629170.1,
                                           SRR17253014.3904803.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               AC132331.3         27777-28012         c
            237-301             AC132331.3         2878-2942           c
            302-374             AC124556.4         140838-140910       c
            375-466             AC124556.4         139163-139254       c
            467-613             AC124556.4         126408-126554       c
            614-697             AC124556.4         126231-126314       c
            698-784             AC124556.4         116873-116959       c
            785-914             AC124556.4         107212-107341       c
            915-1047            AC124556.4         103943-104075       c
            1048-1159           AC124556.4         99555-99666         c
            1160-1274           AC124556.4         97758-97872         c
            1275-2610           AC124556.4         92872-94207         c
FEATURES             Location/Qualifiers
     source          1..2610
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 33.73 cM"
     gene            1..2610
                     /gene="Fntb"
                     /gene_synonym="2010013E13Rik"
                     /note="farnesyltransferase, CAAX box, beta"
                     /db_xref="GeneID:110606"
                     /db_xref="MGI:MGI:1861305"
     exon            1..236
                     /gene="Fntb"
                     /gene_synonym="2010013E13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1403
                     /gene="Fntb"
                     /gene_synonym="2010013E13Rik"
                     /EC_number="2.5.1.58"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein farnesyltransferase subunit beta; FTase-beta; CAAX
                     farnesyltransferase subunit beta; ras proteins
                     prenyltransferase subunit beta"
                     /codon_start=1
                     /product="protein farnesyltransferase subunit beta isoform
                     2"
                     /protein_id="NP_001405090.1"
                     /db_xref="GeneID:110606"
                     /db_xref="MGI:MGI:1861305"
                     /translation="MASSSSFTYYCPPSSSPVWSEPLYSLRPEHVRERLQDDSVETVT
                     SIEQAKVEEKIQEVFSSYKFNHLVPRLILQREKHFHYLKRGLRQLTDAYECLDASRPW
                     LCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNAL
                     CIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIIT
                     PDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQW
                     VTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQA
                     LQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDMVMGVPEN
                     VLPTHPVYNIGPEKVIQATTHFLQKPVPGFEECEDEVTSDPATD"
     exon            237..301
                     /gene="Fntb"
                     /gene_synonym="2010013E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            302..374
                     /gene="Fntb"
                     /gene_synonym="2010013E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            375..466
                     /gene="Fntb"
                     /gene_synonym="2010013E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            467..613
                     /gene="Fntb"
                     /gene_synonym="2010013E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            614..697
                     /gene="Fntb"
                     /gene_synonym="2010013E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            698..784
                     /gene="Fntb"
                     /gene_synonym="2010013E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            785..914
                     /gene="Fntb"
                     /gene_synonym="2010013E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1047
                     /gene="Fntb"
                     /gene_synonym="2010013E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1159
                     /gene="Fntb"
                     /gene_synonym="2010013E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1274
                     /gene="Fntb"
                     /gene_synonym="2010013E13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..2610
                     /gene="Fntb"
                     /gene_synonym="2010013E13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2589..2594
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fntb"
                     /gene_synonym="2010013E13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2610
                     /gene="Fntb"
                     /gene_synonym="2010013E13Rik"
                     /note="major polyA site"
ORIGIN      
        1 actttccgta gcgccttagc ccgctcgagt ttcaatgcgc gttgttgctg gatgaagctg
       61 agtcctatac agcgctcgca gctctcccga tcatggcttc ttcgagttcc ttcacctatt
      121 attgtcctcc atcttcctcc cctgtttggt cagaaccgct gtatagtctg agacctgagc
      181 acgtgcggga gcggttgcaa gacgactcag tggaaacagt cacatccata gaacaggcca
      241 aagtagaaga gaagatccag gaggtcttca gttcttacaa gtttaaccac cttgtaccaa
      301 ggctcatttt gcagagggag aagcacttcc attatctgaa aagaggcctt cgacaactga
      361 cagatgccta tgagtgtctg gatgccagcc gcccctggct ctgctactgg atcctgcaca
      421 gcctggagct ccttgacgaa cccatccccc agatagtggc cacagacgtg tgtcagttcc
      481 tggagctgtg tcagagtcca gacggtggct ttggaggggg ccccggtcag tacccacacc
      541 tcgcacccac ttatgcagcc gtcaatgcgc tgtgcatcat cggcacagag gaagcctaca
      601 acgtcattaa cagggagaaa ctccttcagt atttgtactc cctaaagcaa cccgacggct
      661 cttttctcat gcacgtcgga ggtgaggtgg acgtaaggag tgcatactgt gctgcctcgg
      721 tagcctctct caccaacatc atcactccag acctctttga aggcacggcc gaatggatag
      781 ccaggtgcca gaactgggaa ggcggcattg gtggggtgcc agggatggaa gcccacggtg
      841 gctacacctt ctgtggcttg gctgcgctgg ttatcctcaa gaaggaacgt tctttgaacc
      901 tgaagagctt gctacaatgg gtgacaagcc ggcagatgcg gtttgaagga ggctttcagg
      961 gccgctgcaa caagctggtg gacggctgct actccttctg gcaggcaggg ctcctgcccc
     1021 tgctgcaccg agccctccac gctcaaggtg accctgccct cagcatgagc cattggatgt
     1081 tccatcagca ggcgctgcag gagtacatcc tgatgtgctg ccagtgtcca gccggggggc
     1141 ttctggacaa gcctggcaag tcacgtgact tctatcatac ttgctactgc ctgagcggcc
     1201 tctccattgc ccagcatttc ggaagcggag ccatgttgca cgatatggtc atgggtgtgc
     1261 ccgaaaacgt tctgcccaca caccctgtgt acaacattgg acctgagaag gtgatccagg
     1321 ccaccacaca ctttctgcag aagccagtcc caggctttga ggaatgtgaa gatgaggtga
     1381 cctcagatcc tgccaccgac tagaggaccc cgtggctctc ccagctcccc cgtcagacaa
     1441 ggtttctcca tttgggtgtg tagcacgctc tgtgctactt gagcctcgac cactgtggag
     1501 ttgtggtttc tttgtccttt cctgtcaaac aaaacaaagc catcagctct gggttggaat
     1561 acacggtggt gtgattttta aaattatttt catacctgtc aagccaaaac tctgggagcc
     1621 gatgtagcaa gccaggttgg gagcagtgta tgctgggaag cagcagcgca cccccttctc
     1681 cccccccccc ccccaatgct gaaatggaag atatctgtga gtatctgcat cccagccact
     1741 gctgtgactc cacccacaca caccattcag tcaccagacc ggcatcctct ctggtataaa
     1801 tcttagctct gtgcaagggt ggggctgtgg gtccagccaa tacgagctct ggaagagagc
     1861 actgggctcc agtaggccat atttatgctt gtctctttca ccccagtcat ctgcaaagga
     1921 caggggtcgg gaatgaagaa ggctcttaga ttgagccctc cccataacct ggggaaaacc
     1981 gagtcacatc ctctccgagg ccacgtttgg tatgagtgag acttattttg tccttggtat
     2041 gatgactaca cccaggtaat caattatgag tggaaaacca acctctaggt caactctgtg
     2101 ccagaggaag cagcttcccc atgcccagcc cctgcctctc cccatcatgt accaggagag
     2161 gccctcctcc agctatgctg cggcccaggt tccttctccc cacccacccc tccaagacag
     2221 tgctgtcttt tctcatccag agtgttaaca ctactaaggc tttcacctta attgatcact
     2281 caggatttgt tcccgccctg tccactccag gcaggctggc tgctgccggg acagcagcct
     2341 caggtagtag ggctggcagt aatcctggaa ctgccctgca ccggcctggc acggtctgta
     2401 gggtgctgag tttgctcgtc catccactgc tacagtcaca gcgagctcgc ctcactgtcc
     2461 cagcctgtga gcaggcagac gggagcttgg agatgcagca tgaggctctt cccctaacca
     2521 ctggccattt gctgcctctg attccctgtt gctttggtgt actgggctat gtattacctc
     2581 cttgaaataa taaaagagta acattttcta
//
