LOCUS       NM_008033               1924 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus farnesyltransferase, CAAX box, alpha (Fnta), mRNA.
ACCESSION   NM_008033 XM_912079 XM_922257
VERSION     NM_008033.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1924)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1924)
  AUTHORS   Jeong,A., Cheng,S., Zhong,R., Bennett,D.A., Bergo,M.O. and Li,L.
  TITLE     Protein farnesylation is upregulated in Alzheimer's human brains
            and neuron-specific suppression of farnesyltransferase mitigates
            pathogenic processes in Alzheimer's model mice
  JOURNAL   Acta Neuropathol Commun 9 (1), 129 (2021)
   PUBMED   34315531
  REMARK    GeneRIF: Protein farnesylation is upregulated in Alzheimer's human
            brains and neuron-specific suppression of farnesyltransferase
            mitigates pathogenic processes in Alzheimer's model mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1924)
  AUTHORS   Chen,J., Sun,Y., Ou,Z., Yeh,S., Huang,C.P., You,B., Tsai,Y.C.,
            Sheu,T.J., Zu,X. and Chang,C.
  TITLE     Androgen receptor-regulated circFNTA activates KRAS signaling to
            promote bladder cancer invasion
  JOURNAL   EMBO Rep 21 (4), e48467 (2020)
   PUBMED   32052578
  REMARK    GeneRIF: Androgen receptor-regulated circFNTA activates KRAS
            signaling to promote bladder cancer invasion.
REFERENCE   4  (bases 1 to 1924)
  AUTHORS   Hagemann,A., Muller,G., Manthey,I. and Bachmann,H.S.
  TITLE     Exploring the putative self-binding property of the human
            farnesyltransferase alpha-subunit
  JOURNAL   FEBS Lett 591 (21), 3637-3648 (2017)
   PUBMED   28948621
REFERENCE   5  (bases 1 to 1924)
  AUTHORS   Okamoto-Uchida,Y., Yu,R., Miyamura,N., Arima,N., Ishigami-Yuasa,M.,
            Kagechika,H., Yoshida,S., Hosoya,T., Nawa,M., Kasama,T., Asaoka,Y.,
            Alois,R.W., Elling,U., Penninger,J.M., Nishina,S., Azuma,N. and
            Nishina,H.
  TITLE     The mevalonate pathway regulates primitive streak formation via
            protein farnesylation
  JOURNAL   Sci Rep 6, 37697 (2016)
   PUBMED   27883036
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1924)
  AUTHORS   De Jager,P.L., Harvey,D., Polydorides,A.D., Zuo,J. and Heintz,N.
  TITLE     A high-resolution genetic map of the nervous locus on mouse
            chromosome 8
  JOURNAL   Genomics 48 (3), 346-353 (1998)
   PUBMED   9545640
REFERENCE   7  (bases 1 to 1924)
  AUTHORS   Porter,J.C. and Messer,A.
  TITLE     Genetic mapping of farnesyltransferase alpha(Fnta) to mouse
            chromosome 8
  JOURNAL   Mamm Genome 7 (8), 622-623 (1996)
   PUBMED   8678990
REFERENCE   8  (bases 1 to 1924)
  AUTHORS   Glass,D.J., Bowen,D.C., Stitt,T.N., Radziejewski,C., Bruno,J.,
            Ryan,T.E., Gies,D.R., Shah,S., Mattsson,K., Burden,S.J.,
            DiStefano,P.S., Valenzuela,D.M., DeChiara,T.M. and Yancopoulos,G.D.
  TITLE     Agrin acts via a MuSK receptor complex
  JOURNAL   Cell 85 (4), 513-523 (1996)
   PUBMED   8653787
REFERENCE   9  (bases 1 to 1924)
  AUTHORS   Shirasawa,H., Kinoshita,T., Shino,Y., Mori,K., Shimizu,K. and
            Simizu,B.
  TITLE     Cloning and sequencing of the murine farnesyltransferase
            alpha-encoding cDNA from a cell line which expresses the human
            papillomavirus type-16 E6 gene
  JOURNAL   Gene 164 (2), 373-374 (1995)
   PUBMED   7590362
REFERENCE   10 (bases 1 to 1924)
  AUTHORS   Seabra,M.C., Reiss,Y., Casey,P.J., Brown,M.S. and Goldstein,J.L.
  TITLE     Protein farnesyltransferase and geranylgeranyltransferase share a
            common alpha subunit
  JOURNAL   Cell 65 (3), 429-434 (1991)
   PUBMED   2018975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093366.9.
            
            On Feb 5, 2019 this sequence version replaced NM_008033.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010744.1, AK090346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               AC093366.9         148444-148673
            231-316             AC093366.9         150499-150584
            317-431             AC093366.9         152850-152964
            432-536             AC093366.9         154285-154389
            537-663             AC093366.9         156741-156867
            664-812             AC093366.9         159490-159638
            813-875             AC093366.9         163022-163084
            876-1047            AC093366.9         164114-164285
            1048-1924           AC093366.9         164490-165366
FEATURES             Location/Qualifiers
     source          1..1924
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 14.27 cM"
     gene            1..1924
                     /gene="Fnta"
                     /gene_synonym="FTA"
                     /note="farnesyltransferase, CAAX box, alpha"
                     /db_xref="GeneID:14272"
                     /db_xref="MGI:MGI:104683"
     exon            1..230
                     /gene="Fnta"
                     /gene_synonym="FTA"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1164
                     /gene="Fnta"
                     /gene_synonym="FTA"
                     /EC_number="2.5.1.59"
                     /EC_number="2.5.1.58"
                     /note="FTase-alpha; GGTase-I-alpha; CAAX
                     farnesyltransferase subunit alpha; ras proteins
                     prenyltransferase subunit alpha; type I protein
                     geranyl-geranyltransferase subunit alpha"
                     /codon_start=1
                     /product="protein
                     farnesyltransferase/geranylgeranyltransferase type-1
                     subunit alpha"
                     /protein_id="NP_032059.1"
                     /db_xref="CCDS:CCDS22205.1"
                     /db_xref="GeneID:14272"
                     /db_xref="MGI:MGI:104683"
                     /translation="MAATEGVGESAAGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAG
                     EAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSEKFRDVYDY
                     FRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYITAIIE
                     EQPKNYQVWHHRRVLVEWLKDPSQELEFIADILSQDAKNYHAWQHRQWVIQEFRLWDN
                     ELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESA
                     WNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDVYEDMLENQCDNKEDIL
                     NKALELCEILAKEKDTIRKEYWRYIGRSLQSKHCRESDIPASV"
     exon            231..316
                     /gene="Fnta"
                     /gene_synonym="FTA"
                     /inference="alignment:Splign:2.1.0"
     exon            317..431
                     /gene="Fnta"
                     /gene_synonym="FTA"
                     /inference="alignment:Splign:2.1.0"
     exon            432..536
                     /gene="Fnta"
                     /gene_synonym="FTA"
                     /inference="alignment:Splign:2.1.0"
     exon            537..663
                     /gene="Fnta"
                     /gene_synonym="FTA"
                     /inference="alignment:Splign:2.1.0"
     exon            664..812
                     /gene="Fnta"
                     /gene_synonym="FTA"
                     /inference="alignment:Splign:2.1.0"
     exon            813..875
                     /gene="Fnta"
                     /gene_synonym="FTA"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1047
                     /gene="Fnta"
                     /gene_synonym="FTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1924
                     /gene="Fnta"
                     /gene_synonym="FTA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1621..1626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fnta"
                     /gene_synonym="FTA"
                     /note="hexamer: AATAAA"
     polyA_site      1646
                     /gene="Fnta"
                     /gene_synonym="FTA"
                     /note="major polyA site"
     regulatory      1881..1886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fnta"
                     /gene_synonym="FTA"
                     /note="hexamer: ATTAAA"
     polyA_site      1924
                     /gene="Fnta"
                     /gene_synonym="FTA"
ORIGIN      
        1 accaccacct ctgctgcgga cggaggcgag atggcggcca ccgagggggt cggggaatct
       61 gcggcaggcg gcgagccggg acagccggag cagccgccgc ccccgcctcc gccgccgcca
      121 gcacagcagc cgcaggaaga agagatggcg gctgaggccg gggaagcggc ggcgtcccct
      181 atggacgacg ggtttctgag cctggactcg cccacctatg tcttgtacag ggacagagca
      241 gaatgggctg atatagaccc agtgccccag aatgacggcc ctaacccagt ggtccagatc
      301 atctacagtg aaaagtttag agatgtttat gattacttcc gagctgttct gcagcgcgat
      361 gagaggagcg aacgagcctt taagctcacc cgagacgcta ttgagttaaa tgcagccaac
      421 tacacagtgt ggcattttcg gagagttctc ttaaggtcgc ttcaaaagga tctacaagag
      481 gaaatgaact acatcactgc gataattgag gagcagccca aaaactatca agtttggcac
      541 cacaggcgag tattagtgga atggctgaaa gatccttctc aagagcttga attcattgcc
      601 gacattctta gtcaggatgc caagaattac catgcctggc agcatcgaca gtgggtcatt
      661 caggaattcc gactttggga taatgagctg cagtatgtag accagcttct caaagaggat
      721 gtgaggaata actctgtgtg gaaccaaaga cacttcgtca tttctaacac cactggctac
      781 agtgaccgcg cggtgttaga gcgagaagtc cagtatactc tggaaatgat caagttagtg
      841 ccgcataatg agagcgcatg gaactacctg aaagggattc tgcaggaccg tggtctttct
      901 agatacccta atctattaaa tcagttgctt gatttacaac caagccacag ttctccgtac
      961 ctgattgcct ttcttgtgga tgtctatgaa gacatgctag aaaaccagtg tgacaacaag
     1021 gaggacattc ttaataaagc actagagtta tgtgagatcc tagctaaaga aaaggacact
     1081 ataagaaagg aatattggag gtatattgga cggtcccttc agagtaaaca ctgcagagaa
     1141 agtgacatac cggcgagtgt atagcagcga gggcatccgg aagaagtgga cgatgctttc
     1201 taaggcctct tatgcaggag cgtagagtgg ttagagcggt catctcttgc ctgtgcgcta
     1261 aagctgtcca ggtgctgctt ttaacaagaa ctaagtatga ctcctgtgtg ctgacgctgt
     1321 tcagacgagc tctaagaatc cattttctaa agcaaagtca ttggagggga gggtgaggaa
     1381 agtttcccat aaaggaacta ctgcttttgt agtcttccca acatttagtc cagtcctgta
     1441 gaatccgctc ctcctgaaag atgtgtatgc aaggctgtgc gctgggagtg acgattgatt
     1501 tgcagtaacc tgaatctcgg tgcattatgc ggcaactgcg cctgttggtt agagctgctg
     1561 tgcgcactca caggatcttg ctatcactgt aaccaactaa tgccaaaaga aaggttttat
     1621 aataaagtca cattatctat aaacaattcc atagtgtttg atgtttaaca gtatataagg
     1681 gacaaacaag aagcccagtg cttgggaggc tgagacagga ggattgctgc aagtttgagc
     1741 cagtctggac tacatagaga ggtttgggcc agttcagaat atagagggta gccttctttg
     1801 aaaaaaaaaa aaaaaagtca aaaacttaaa aagaaaatat tactatacat tttgtgatta
     1861 tgggagggaa atgtgaattt attaaaaatg gaaattggtc ctgtttttct tgtcagcaac
     1921 aaaa
//
