LOCUS       NP_001392095            1165 aa            linear   ROD 17-JUL-2024
DEFINITION  folliculin-interacting protein 2 isoform 2 [Mus musculus].
ACCESSION   NP_001392095 XP_006501657
VERSION     NP_001392095.1
DBSOURCE    REFSEQ: accession NM_001405166.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1165)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1165)
  AUTHORS   Shillingford,J.M. and Shayman,J.A.
  TITLE     Functional TFEB activation characterizes multiple models of renal
            cystic disease and loss of polycystin-1
  JOURNAL   Am J Physiol Renal Physiol 324 (4), F404-F422 (2023)
   PUBMED   36794754
REFERENCE   3  (residues 1 to 1165)
  AUTHORS   Fernandez,L.P., Deleyto-Seldas,N., Colmenarejo,G., Sanz,A.,
            Wagner,S., Plata-Gomez,A.B., Gomez-Patino,M., Molina,S.,
            Espinosa-Salinas,I., Aguilar-Aguilar,E., Ortega,S.,
            Grana-Castro,O., Loria-Kohen,V., Fernandez-Marcos,P.J., Efeyan,A.
            and Ramirez de Molina,A.
  TITLE     Folliculin-interacting protein FNIP2 impacts on overweight and
            obesity through a polymorphism in a conserved 3' untranslated
            region
  JOURNAL   Genome Biol 23 (1), 230 (2022)
   PUBMED   36316722
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1165)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1165)
  AUTHORS   Hasumi,H., Baba,M., Hasumi,Y., Lang,M., Huang,Y., Oh,H.F.,
            Matsuo,M., Merino,M.J., Yao,M., Ito,Y., Furuya,M., Iribe,Y.,
            Kodama,T., Southon,E., Tessarollo,L., Nagashima,K., Haines,D.C.,
            Linehan,W.M. and Schmidt,L.S.
  TITLE     Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles
            in kidney tumor suppression in cooperation with Flcn
  JOURNAL   Proc Natl Acad Sci U S A 112 (13), E1624-E1631 (2015)
   PUBMED   25775561
  REMARK    GeneRIF: Fnip1 and Fnip2 play critical roles in kidney tumor
            suppression in cooperation with Flcn
REFERENCE   6  (residues 1 to 1165)
  AUTHORS   Lim,T.H., Fujikane,R., Sano,S., Sakagami,R., Nakatsu,Y.,
            Tsuzuki,T., Sekiguchi,M. and Hidaka,M.
  TITLE     Activation of AMP-activated protein kinase by MAPO1 and FLCN
            induces apoptosis triggered by alkylated base mismatch in DNA
  JOURNAL   DNA Repair (Amst) 11 (3), 259-266 (2012)
   PUBMED   22209521
  REMARK    GeneRIF: The involvement of the AMPK-MAPO1-FLCN complex in the
            signaling pathway of apoptosis, is described.
REFERENCE   7  (residues 1 to 1165)
  AUTHORS   Komori,K., Takagi,Y., Sanada,M., Lim,T.H., Nakatsu,Y., Tsuzuki,T.,
            Sekiguchi,M. and Hidaka,M.
  TITLE     A novel protein, MAPO1, that functions in apoptosis triggered by
            O6-methylguanine mispair in DNA
  JOURNAL   Oncogene 28 (8), 1142-1150 (2009)
   PUBMED   19137017
REFERENCE   8  (residues 1 to 1165)
  AUTHORS   Hasumi,H., Baba,M., Hong,S.B., Hasumi,Y., Huang,Y., Yao,M.,
            Valera,V.A., Linehan,W.M. and Schmidt,L.S.
  TITLE     Identification and characterization of a novel
            folliculin-interacting protein FNIP2
  JOURNAL   Gene 415 (1-2), 60-67 (2008)
   PUBMED   18403135
REFERENCE   9  (residues 1 to 1165)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113945.26 and AC142502.3.
            
            On Apr 20, 2022 this sequence version replaced XP_006501657.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.3776.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1165
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 34.91 cM"
     Protein         1..1165
                     /product="folliculin-interacting protein 2 isoform 2"
                     /note="FNIP1-like protein; O6-methylguanine-induced
                     apoptosis 1 protein"
                     /calculated_mol_wt=128295
     Region          69..191
                     /region_name="FNIP_N"
                     /note="Folliculin-interacting protein N-terminus;
                     pfam14636"
                     /db_xref="CDD:464228"
     Region          350..583
                     /region_name="FNIP_M"
                     /note="Folliculin-interacting protein middle domain;
                     pfam14637"
                     /db_xref="CDD:434087"
     Region          978..1161
                     /region_name="FNIP_C"
                     /note="Folliculin-interacting protein C-terminus;
                     pfam14638"
                     /db_xref="CDD:464229"
     CDS             1..1165
                     /gene="Fnip2"
                     /gene_synonym="D630023B12Rik; mKIAA1450"
                     /coded_by="NM_001405166.1:1126..4623"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:329679"
                     /db_xref="MGI:MGI:2683054"
ORIGIN      
        1 mcggtadstn wpvgqqesar cltdttcgag rifktlvcak ipkcarggrd tnstvlnhsw
       61 scsefglsdi rllvyqdcer rgrqvmfdsr avqkmeeaaa qkaedvpikm sarccqesss
      121 ssgssssgss sshgfggslq hakqqlpkyq ytrpasdvsm lgemmfgsva msykgstlki
      181 hyirsppqlm iskvfsatmg sfcgstnnlq dsfeyinqdp qagklntnqy nlgpfrtgsn
      241 lgllqvcsgk llqglseggp lrltrsasff aahstpvdmp srgqnedrds giarsaslss
      301 llitpfpsps sstsssssyq rrwlrsqtts lengifprrs tdetfslaee tcssnpamvr
      361 rkkiaisiif slcereaaqr dfqdfffshf plfeshmnrl kgaiekamis crkisesslr
      421 vqfyvsrlme algefrgtiw nlysvpriae pvwltmmsnt leknqlcqrf lkefillieq
      481 vnknqffaal ltavltyhla wvptvmpvdh ppikafsekr tsqsvnmlak thpynplwaq
      541 lgdlygaigs pvrltrtvvi gkqkdlvqri lyvltyflrc selqenqlsw sgnpseddqv
      601 ingskiital ekgeveesey vvvtvssepa lvppilpqgt aerrspeptv vaeisegvnt
      661 selghkpekn rckrpeqnse assmgfqeae pdsswipqgi fcedkqndqe atqdcssspp
      721 scevprvrrr mdqqtlhskl hgetlkkrae qsaawpcpdr hsqedppvek vtfhigssis
      781 pesdfesrtk rmeerlkacg hfhgasasas ssmdtgltqe qqgsgcsfka dfekditpqd
      841 hssggegvse drglranmth avgqlsqvdg plahslcaae sgrrlleqtr dvqlkgykgp
      901 ssepvpnrcr qqgglliaad vpygdasgkg nyrsegdipr nesldsalgd sddeacvlal
      961 lelghscdrt eeslevelpl prsqstskan vrnfgrslla gycatympdl vlhgtssdek
     1021 lkqclaadlv htvhhpvlde piaeavciia dtdkwtvqva tsqrkvtdtm klgqdvlvss
     1081 qvssllqsil qlyklhlpad fcimhledrl qemylkskml seylrghtrv hvkelsvvlg
     1141 iesndlpllt aiasthspyv aqill
//
