LOCUS       NM_027402               2779 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus fibronectin type III domain containing 5 (Fndc5),
            mRNA.
ACCESSION   NM_027402 XM_357394
VERSION     NM_027402.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2779)
  AUTHORS   Grzeszczuk,M., Mrozowska,M., Kmiecik,A., Rusak,A., Jablonska,K.,
            Ciesielska,U., Dziegiel,P. and Nowinska,K.
  TITLE     The Effect of Hypoxia on Irisin Expression in HL-1 Cardiomyocytes
  JOURNAL   In Vivo 38 (5), 2126-2133 (2024)
   PUBMED   39187335
  REMARK    GeneRIF: The Effect of Hypoxia on Irisin Expression in HL-1
            Cardiomyocytes.
REFERENCE   2  (bases 1 to 2779)
  AUTHORS   Ge,Y., Wu,X., Cai,Y., Hu,Q., Wang,J., Zhang,S., Zhao,B., Cui,W.,
            Wu,Y., Wang,Q., Feng,T., Liu,H., Qu,Y. and Ge,S.
  TITLE     FNDC5 prevents oxidative stress and neuronal apoptosis after
            traumatic brain injury through SIRT3-dependent regulation of
            mitochondrial quality control
  JOURNAL   Cell Death Dis 15 (5), 364 (2024)
   PUBMED   38802337
  REMARK    GeneRIF: FNDC5 prevents oxidative stress and neuronal apoptosis
            after traumatic brain injury through SIRT3-dependent regulation of
            mitochondrial quality control.
            Erratum:[Cell Death Dis. 2024 Jul 24;15(7):527. doi:
            10.1038/s41419-024-06901-5. PMID: 39048543]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2779)
  AUTHORS   Shimonty,A., Pin,F., Prideaux,M., Peng,G., Huot,J., Kim,H.,
            Rosen,C.J., Spiegelman,B.M. and Bonewald,L.F.
  TITLE     Deletion of FNDC5/irisin modifies murine osteocyte function in a
            sex-specific manner
  JOURNAL   Elife 12, 92263 (2024)
   PUBMED   38661340
  REMARK    GeneRIF: Deletion of FNDC5/irisin modifies murine osteocyte
            function in a sex-specific manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2779)
  AUTHORS   Dong,Q., Han,Z., Gao,M. and Tian,L.
  TITLE     FNDC5/irisin ameliorates bone loss of type 1 diabetes by
            suppressing endoplasmic reticulum stress-mediated ferroptosis
  JOURNAL   J Orthop Surg Res 19 (1), 205 (2024)
   PUBMED   38555440
  REMARK    GeneRIF: FNDC5/irisin ameliorates bone loss of type 1 diabetes by
            suppressing endoplasmic reticulum stress-mediated ferroptosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2779)
  AUTHORS   Hashemi,M.S., Ghaedi,K., Salamian,A., Karbalaie,K., Emadi-Baygi,M.,
            Tanhaei,S., Nasr-Esfahani,M.H. and Baharvand,H.
  TITLE     Fndc5 knockdown significantly decreased neural differentiation rate
            of mouse embryonic stem cells
  JOURNAL   Neuroscience 231, 296-304 (2013)
   PUBMED   23219938
  REMARK    GeneRIF: Fndc5 expression is required for the appropriate neural
            differentiation of mESCs. These data confirm the importance of
            Fndc5 in the generation and development of the nervous system.
REFERENCE   6  (bases 1 to 2779)
  AUTHORS   Bostrom,P., Wu,J., Jedrychowski,M.P., Korde,A., Ye,L., Lo,J.C.,
            Rasbach,K.A., Bostrom,E.A., Choi,J.H., Long,J.Z., Kajimura,S.,
            Zingaretti,M.C., Vind,B.F., Tu,H., Cinti,S., Hojlund,K., Gygi,S.P.
            and Spiegelman,B.M.
  TITLE     A PGC1-alpha-dependent myokine that drives brown-fat-like
            development of white fat and thermogenesis
  JOURNAL   Nature 481 (7382), 463-468 (2012)
   PUBMED   22237023
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2779)
  AUTHORS   Kuninger,D., Kuzmickas,R., Peng,B., Pintar,J.E. and Rotwein,P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
REFERENCE   8  (bases 1 to 2779)
  AUTHORS   Teufel,A., Malik,N., Mukhopadhyay,M. and Westphal,H.
  TITLE     Frcp1 and Frcp2, two novel fibronectin type III repeat containing
            genes
  JOURNAL   Gene 297 (1-2), 79-83 (2002)
   PUBMED   12384288
REFERENCE   9  (bases 1 to 2779)
  AUTHORS   Ferrer-Martinez,A., Ruiz-Lozano,P. and Chien,K.R.
  TITLE     Mouse PeP: a novel peroxisomal protein linked to myoblast
            differentiation and development
  JOURNAL   Dev Dyn 224 (2), 154-167 (2002)
   PUBMED   12112469
REFERENCE   10 (bases 1 to 2779)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL606977.28, BY265316.1,
            BE861837.1, AK005096.1, CX207206.1, BG088140.2, AA003587.1 and
            AI836596.1.
            
            [WARNING] On Jan 24, 2025 this sequence was replaced by
            NM_027402.5.
            
            On Jul 22, 2016 this sequence version replaced NM_027402.3.
            
            Summary: This gene encodes a type I transmembrane protein
            containing fibronectin type III repeat. The encoded transmembrane
            protein undergoes proteolytic processing to generate a soluble
            hormone named irisin that is secreted into the bloodstream. The
            expression of this gene followed by the secretion of irisin from
            skeletal muscle is induced by exercise. The ectopic expression of
            the encoded protein in mice causes an elevation of irisin in blood
            and improves metabolic health. [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ401376.1, AK005096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AL606977.28        83413-83525
            114-438             BY265316.1         1-325
            439-678             BE861837.1         91-330
            679-1468            AK005096.1         680-1469
            1469-1491           CX207206.1         159-181
            1492-2147           BG088140.2         1-656
            2148-2400           AA003587.1         203-455
            2401-2779           AI836596.1         1-379               c
FEATURES             Location/Qualifiers
     source          1..2779
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 62.93 cM"
     gene            1..2779
                     /gene="Fndc5"
                     /gene_synonym="1500001L03Rik; PeP; Pxp"
                     /note="fibronectin type III domain containing 5"
                     /db_xref="GeneID:384061"
                     /db_xref="MGI:MGI:1917614"
     exon            1..165
                     /gene="Fndc5"
                     /gene_synonym="1500001L03Rik; PeP; Pxp"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..710
                     /gene="Fndc5"
                     /gene_synonym="1500001L03Rik; PeP; Pxp"
                     /note="peroxisomal protein; fibronectin type III
                     domain-containing protein 5; fibronectin type III
                     repeat-containing protein 2"
                     /codon_start=1
                     /product="fibronectin type III domain-containing protein 5
                     preproprotein"
                     /protein_id="NP_081678.1"
                     /db_xref="CCDS:CCDS18683.1"
                     /db_xref="GeneID:384061"
                     /db_xref="MGI:MGI:1917614"
                     /translation="MPPGPCAWPPRAALRLWLGCVCFALVQADSPSAPVNVTVRHLKA
                     NSAVVSWDVLEDEVVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHV
                     QAISIQGQSPASEPVLFKTPREAEKMASKNKDEVTMKEMGRNQQLRTGEVLIIVVVLF
                     MWAGVIALFCRQYDIIKDNEPNNNKEKTKSASETSTPEHQGGGLLRSKI"
     exon            166..281
                     /gene="Fndc5"
                     /gene_synonym="1500001L03Rik; PeP; Pxp"
                     /inference="alignment:Splign:2.1.0"
     exon            282..480
                     /gene="Fndc5"
                     /gene_synonym="1500001L03Rik; PeP; Pxp"
                     /inference="alignment:Splign:2.1.0"
     exon            481..570
                     /gene="Fndc5"
                     /gene_synonym="1500001L03Rik; PeP; Pxp"
                     /inference="alignment:Splign:2.1.0"
     exon            571..704
                     /gene="Fndc5"
                     /gene_synonym="1500001L03Rik; PeP; Pxp"
                     /inference="alignment:Splign:2.1.0"
     exon            705..2763
                     /gene="Fndc5"
                     /gene_synonym="1500001L03Rik; PeP; Pxp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2742..2747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fndc5"
                     /gene_synonym="1500001L03Rik; PeP; Pxp"
                     /note="hexamer: AATAAA"
     polyA_site      2763
                     /gene="Fndc5"
                     /gene_synonym="1500001L03Rik; PeP; Pxp"
                     /note="major polyA site"
ORIGIN      
        1 ggggcggcgc ggggcggccg ggccgggagg gccgcgggct ggagcgtgag tgcgagcggt
       61 caccgggccc aggagtcgcc atgcccccag ggccgtgcgc ctggccgccc cgcgccgcgc
      121 tccgcctgtg gctaggctgc gtctgcttcg cgctggtgca ggcggacagc ccctcagccc
      181 ctgtgaacgt gaccgtccgg cacctcaagg ccaactctgc cgtggtcagc tgggatgtcc
      241 tggaggatga agtggtcatt ggctttgcca tctctcagca gaagaaggat gtgcggatgc
      301 tccggttcat tcaggaggtg aacaccacca cccggtcctg cgctctctgg gacctggagg
      361 aggacacaga atatatcgtc catgtgcagg ccatctccat ccagggacag agcccagcca
      421 gtgagcctgt gctcttcaag accccacgcg aggctgaaaa gatggcctca aagaacaaag
      481 atgaggtgac catgaaggag atggggagga accagcagct gcgaacgggg gaggtgctga
      541 tcattgttgt ggtcctcttc atgtgggcag gtgttatagc tctcttctgc cgccagtatg
      601 atatcatcaa ggacaacgag cccaataaca acaaggagaa aaccaagagc gcatcagaaa
      661 ccagcacacc ggagcatcag ggtgggggtc tcctccgcag caagatatga tgacacattt
      721 acagtgcttg ctctgagcag ctcagaagac agtagagaat gcgagaggac cttctgacgg
      781 tgattgtcca acatgcatct ggcccgctct gcggctcctc ccacctccat cttctcctat
      841 catcgggctt attatcctct ctcttggctt ctctctttct gatatcagtt cctgaagcct
      901 ctcactaacc cctagctcca ggagtacctc agcaatgtcc atggctgaag ctacacccag
      961 agacagagct gcagaatgag agagacccag ccggagggat gccattgctg cggggtagac
     1021 tgagtgccaa ggctcttggc acaggactca catctgggcc actcagcttg accgaaggct
     1081 gtgtgtgaaa ggggagaaag acgagacttc caggcagggc tattcttttt atttctgcga
     1141 gggacaagag tctggctttt aagctgcagc cccgctgttc cttttctcct ctgtcccatt
     1201 tcctacctta catgaaatcc attcaaccgg ctctggacac ttctcttatc tgttcccttc
     1261 ctggtttcca aagaagccct ctgtgaacat catcaaagca tgggtacccc catctgcaag
     1321 ggatgggctt catcctccgc tagtccctgt gtccttcctg ggcacggggt gagagctgta
     1381 gaagcggtgg gggcacagct agccacagtt tttccttttc cctaccttag tctgacagag
     1441 gaggttgaac tacaaaccca aattctgcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaat
     1501 caaataagcc acaaagctaa aagactgcgc cccattctga agaaggcaca agtacatggg
     1561 agagtcctgc cttacttctc ctggactggc ttcctctttg agaaaatgca caaagctctg
     1621 ggagaaagca gctaccaaga ctatctggaa ctgtgtctgt cagaccaatg gtaccaggga
     1681 ggctgcagtg ctgccagctt ttcaagggtc ctgactctgt cagacacttt ctggattcag
     1741 ccactaagga catctgtggt acaaggtgca cctttgcaaa tgtgtatgat gccagttgtt
     1801 tggactcttg gaaaacacca ctggagggct ttgctccaga atgcagaccg ctctgccaag
     1861 gcctccatgt ctgcttgcat ctagcttgca caaagataga tctttgtggt gagatcatct
     1921 gtgtggagtt ttaagaagct ctggaagaag gtactgcccg cgtttaaagg aagtgccttg
     1981 gctggggcag cagtgtcagc ttggataact gaaaacacct acatcctaca gcataaagaa
     2041 ctgctgagcg agctactgga aagccgttta caccagacag gcagagagca gagagcagcc
     2101 actgtcacta tcttgccatc tcattcaggg tcctctgaaa gttacccagg gctctcatct
     2161 acttccctag agcttgcagt gtaaagtgac agctagtgtg ctccctctct ccctccctcc
     2221 ccctcctctc ctctgcccct tactggttta aaaaaaaaaa ggtgcttgat gtggcagcag
     2281 acttcttgga gactgaagca cagtggctgc cagacgcctg cactggaaag gcgaacgaac
     2341 tctgtatctt ccatcggtgg ccaagggagt gtgggtggct gttcccagca catagtaggt
     2401 gcttggtaaa atatctgtgg tactgaatgt tgagcacagg tgcccaagtc agagagctga
     2461 aagccatcac ccaatgactg ccccttcatt cgggtctcta acagctctcc aagctgggtc
     2521 agccaccact gtgctcgctc caactgcggg tagcacagga gaggagggac ggataagggc
     2581 agatgtcagc aatactaagg gcttcctcct gggagggaat gaggttccac tcattgtctc
     2641 gtgacttcca tccctgctga acggggctgc aaggccaagg ctccttaagg gaggtcctta
     2701 cctccaatcc agttagagca ataaccactt tttaaatgta aaataaagac aaatgaaaag
     2761 gcaaaaaaaa aaaaaaaaa
//
