LOCUS       NM_001378890            2094 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus fibronectin type III domain containing 4 (Fndc4),
            transcript variant 4, mRNA.
ACCESSION   NM_001378890 XM_011240762
VERSION     NM_001378890.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2094)
  AUTHORS   Xu,X., Peng,L., Xia,Y., Guo,Y., Qi,T., Li,C., Ding,F., Zhao,H.,
            Zhao,X., Liu,Q., Han,X., Xia,L., He,Y., Li,W., Liu,R., Xu,X.,
            Hai,C., Yan,W. and Tao,L.
  TITLE     Fibronectin type III domain containing 4 alleviates myocardial
            ischemia/reperfusion injury via the Nrf2-dependent antioxidant
            pathway
  JOURNAL   Free Radic Biol Med 224, 256-271 (2024)
   PUBMED   39197598
REFERENCE   2  (bases 1 to 2094)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2094)
  AUTHORS   Georgiadi,A., Lopez-Salazar,V., Merahbi,R.E., Karikari,R.A., Ma,X.,
            Mourao,A., Klepac,K., Buhler,L., Alfaro,A.J., Kaczmarek,I.,
            Linford,A., Bosma,M., Shilkova,O., Ritvos,O., Nakamura,N.,
            Hirose,S., Lassi,M., Teperino,R., Machado,J., Scheideler,M.,
            Dietrich,A., Geerlof,A., Feuchtinger,A., Blutke,A., Fischer,K.,
            Muller,T.D., Kessler,K., Schoneberg,T., Thor,D., Hornemann,S.,
            Kruse,M., Nawroth,P., Pivovarova-Ramich,O., Pfeiffer,A.F.H.,
            Sattler,M., Bluher,M. and Herzig,S.
  TITLE     Orphan GPR116 mediates the insulin sensitizing effects of the
            hepatokine FNDC4 in adipose tissue
  JOURNAL   Nat Commun 12 (1), 2999 (2021)
   PUBMED   34016966
  REMARK    GeneRIF: Orphan GPR116 mediates the insulin sensitizing effects of
            the hepatokine FNDC4 in adipose tissue.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2094)
  AUTHORS   Li,J., Wang,Y., Wang,Y., Yan,Y., Tong,H. and Li,S.
  TITLE     Fibronectin type III domain containing four promotes
            differentiation of C2C12 through the Wnt/beta-catenin signaling
            pathway
  JOURNAL   FASEB J 34 (6), 7759-7772 (2020)
   PUBMED   32298013
  REMARK    GeneRIF: Fibronectin type III domain containing four promotes
            differentiation of C2C12 through the Wnt/beta-catenin signaling
            pathway.
REFERENCE   5  (bases 1 to 2094)
  AUTHORS   Lv,Z.T., Liang,S., Chen,K., Zhang,J.M., Cheng,P., Guo,J.C.,
            Yang,Q., Zhou,C.H., Liao,H. and Chen,A.M.
  TITLE     FNDC4 Inhibits RANKL-Induced Osteoclast Formation by Suppressing
            NF-kappaB Activation and CXCL10 Expression
  JOURNAL   Biomed Res Int 2018, 3936257 (2018)
   PUBMED   29977911
  REMARK    GeneRIF: FNDC4 could suppress osteoclast formation via NF-kappaB
            pathway and downregulation of CXCL10
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2094)
  AUTHORS   Kole,C., Berdugo,N., Da Silva,C., Ait-Ali,N., Millet-Puel,G.,
            Pagan,D., Blond,F., Poidevin,L., Ripp,R., Fontaine,V., Wincker,P.,
            Zack,D.J., Sahel,J.A., Poch,O. and Leveillard,T.
  TITLE     Identification of an Alternative Splicing Product of the Otx2 Gene
            Expressed in the Neural Retina and Retinal Pigmented Epithelial
            Cells
  JOURNAL   PLoS One 11 (3), e0150758 (2016)
   PUBMED   26985665
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2094)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 2094)
  AUTHORS   Hildrestrand,G.A., Neurauter,C.G., Diep,D.B., Castellanos,C.G.,
            Krauss,S., Bjoras,M. and Luna,L.
  TITLE     Expression patterns of Neil3 during embryonic brain development and
            neoplasia
  JOURNAL   BMC Neurosci 10, 45 (2009)
   PUBMED   19426544
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2094)
  AUTHORS   Teufel,A., Malik,N., Mukhopadhyay,M. and Westphal,H.
  TITLE     Frcp1 and Frcp2, two novel fibronectin type III repeat containing
            genes
  JOURNAL   Gene 297 (1-2), 79-83 (2002)
   PUBMED   12384288
REFERENCE   10 (bases 1 to 2094)
  AUTHORS   Inoue,S., Sano,H. and Ohta,M.
  TITLE     Growth suppression of Escherichia coli by induction of expression
            of mammalian genes with transmembrane or ATPase domains
  JOURNAL   Biochem Biophys Res Commun 268 (2), 553-561 (2000)
   PUBMED   10679242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114619.9.
            
            On Mar 12, 2020 this sequence version replaced XM_011240762.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1520888.1,
                                           SRR11927932.3224014.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               AC114619.9         32408-32810
            404-548             AC114619.9         32986-33130
            549-664             AC114619.9         33222-33337
            665-869             AC114619.9         33509-33713
            870-959             AC114619.9         34150-34239
            960-1101            AC114619.9         34530-34671
            1102-1174           AC114619.9         34857-34929
            1175-2094           AC114619.9         35179-36098
FEATURES             Location/Qualifiers
     source          1..2094
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.27 cM"
     gene            1..2094
                     /gene="Fndc4"
                     /gene_synonym="2810430J06Rik; 6330410H20Rik; Fnmp1; FRCP1"
                     /note="fibronectin type III domain containing 4"
                     /db_xref="GeneID:64339"
                     /db_xref="MGI:MGI:1917195"
     exon            1..403
                     /gene="Fndc4"
                     /gene_synonym="2810430J06Rik; 6330410H20Rik; Fnmp1; FRCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            404..548
                     /gene="Fndc4"
                     /gene_synonym="2810430J06Rik; 6330410H20Rik; Fnmp1; FRCP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             428..1408
                     /gene="Fndc4"
                     /gene_synonym="2810430J06Rik; 6330410H20Rik; Fnmp1; FRCP1"
                     /note="isoform c precursor is encoded by transcript
                     variant 4; fibronectin type III repeat containing protein
                     1; fibronectin type III domain-containing protein 4"
                     /codon_start=1
                     /product="fibronectin type III domain-containing protein 4
                     isoform c precursor"
                     /protein_id="NP_001365819.1"
                     /db_xref="GeneID:64339"
                     /db_xref="MGI:MGI:1917195"
                     /translation="MPLAPPANSVETMASLMPLSPYLSPTVLLLVSCDLGFVRADRPP
                     SPVNVTVTHLRANSATVSWDVPEGNIVIGYSISQQRQNGPGQRVIREVNTTTRACALW
                     GLAEDSDYTVQVRSIGLRGESPPGPRVHFRTLKGSDRLPSNSSSPGDITVEGLDGERP
                     LQTGEVVIIVVVLLMWAAVIGLFCRQYDIIKDNDSNNNPKEKGKGPEQSPQGRPVGTT
                     RQVMWDQKSLHQSTPLMFDRMKNQNQKRGCTVLARGPMSPASGLLALTSCPYSLPLGL
                     REGCFCPGCPPSVSQKNLLGLEADAALHYSSVFHGASGAPPSPGSPSSCW"
     exon            549..664
                     /gene="Fndc4"
                     /gene_synonym="2810430J06Rik; 6330410H20Rik; Fnmp1; FRCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            665..869
                     /gene="Fndc4"
                     /gene_synonym="2810430J06Rik; 6330410H20Rik; Fnmp1; FRCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            870..959
                     /gene="Fndc4"
                     /gene_synonym="2810430J06Rik; 6330410H20Rik; Fnmp1; FRCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1101
                     /gene="Fndc4"
                     /gene_synonym="2810430J06Rik; 6330410H20Rik; Fnmp1; FRCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1174
                     /gene="Fndc4"
                     /gene_synonym="2810430J06Rik; 6330410H20Rik; Fnmp1; FRCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..2094
                     /gene="Fndc4"
                     /gene_synonym="2810430J06Rik; 6330410H20Rik; Fnmp1; FRCP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1432..1437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fndc4"
                     /gene_synonym="2810430J06Rik; 6330410H20Rik; Fnmp1; FRCP1"
                     /note="hexamer: AATAAA"
     polyA_site      1456
                     /gene="Fndc4"
                     /gene_synonym="2810430J06Rik; 6330410H20Rik; Fnmp1; FRCP1"
                     /note="major polyA site"
     regulatory      2054..2059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fndc4"
                     /gene_synonym="2810430J06Rik; 6330410H20Rik; Fnmp1; FRCP1"
                     /note="hexamer: AATAAA"
     polyA_site      2094
                     /gene="Fndc4"
                     /gene_synonym="2810430J06Rik; 6330410H20Rik; Fnmp1; FRCP1"
                     /note="major polyA site"
ORIGIN      
        1 gacggcggcg agacaggcca gcgcgtccca gcccggctgc agcggagcgc gccgggccag
       61 ctctgcagaa ggcggcggct ggctcgccgg gacggtcaca tcccgctgca ggggaccagc
      121 tttggccgcc gcactgtcct ctgcaccggg gacgcaggcc tcgctggcaa cgccccccgc
      181 tcagagtcag accacgcggg gcccttggga aggccggggg gccggcagac ccgccgcccg
      241 cggccactcc gcctctgccc tctctgcccg cagctcggcc gtcgctgccc gccttggcgg
      301 gccggtgtca gaatggggta gggccagcgc cagtctggcg atgggccgcc ctctgggcac
      361 cgagcggccc cccgaggcct gaccgaccac gaggacccgg gaggatcctc gtctggatgt
      421 caagcgaatg cctctggccc ctccagcgaa ctcggtggaa accatggctt ctttgatgcc
      481 tctttcccca tatctgagtc ccacggtcct cctgctggtc agctgtgacc tgggttttgt
      541 gcgagcagac cgacctccct ctcctgtgaa tgtgacggtc actcatctca gagccaactc
      601 agccactgtg tcctgggacg ttccagaagg caacatcgtc attggctact ccatttccca
      661 gcaacgacag aatggcccgg ggcagcgtgt aatcagagaa gtgaacacca ccaccagggc
      721 ctgcgctctc tggggcctgg ctgaagacag tgactacaca gtgcaggtta ggagcatcgg
      781 cctccgggga gagagccctc cagggccccg tgtgcacttc cgcacgctca agggttctga
      841 caggctgccc tccaacagct ccagtccagg tgatattaca gtggagggtc tggatggaga
      901 gcggccattg cagacagggg aagtcgtcat cattgtagtg gtattgctca tgtgggctgc
      961 tgtaatcggg ctattctgcc gtcagtatga catcatcaag gacaacgact ccaacaacaa
     1021 ccccaaggag aaggggaagg ggcctgaaca gagtcctcag ggaaggccag tggggacaac
     1081 aagacaggtg atgtgggacc aaaaaagtct ccatcaatca acaccattga tgtttgatcg
     1141 gatgaagaac cagaaccaga agagaggatg cactgtcctc gctaggggcc ccatgtcacc
     1201 tgcatcagga ctattggcac tcactagctg cccctacagc ttgcctctgg gcctcagaga
     1261 ggggtgtttc tgcccgggtt gccctccttc agtgagtcag aagaaccttc tgggcctaga
     1321 ggcagacgct gcattgcact attccagtgt cttccacgga gcctctgggg ctcctccctc
     1381 acctggcagc ccctccagct gctggtgatc tcacccctgg gacatttttc caataaaggt
     1441 tctggacaaa ctggaactga ctggttcctg tatggtatgc tgaagacatc tctacacctt
     1501 gtcagttctt ctcaggcctc caccaacctg aaaggacaga gtcttgataa gatgtttgcg
     1561 tcagtgtaac aatgtattca tctaagatgg gcggggaaag acaaaagggg aggggatgaa
     1621 agccaaaggc ctcccttctt tgtctttgct gaatgagaag agagaaaatg agaagtcaca
     1681 gttttcatac caacagaaac caggccatgt catataaaag ggccagtaga tttttttttt
     1741 atctttgttc aggaccttgt gcatactaag caaatattct actgttgcgc tatataacca
     1801 atcccttccc tgcacttttg actccagcac tcactttggg gaaatggtca gaagggctga
     1861 gctgtcttag gagctgacag gagagcagcc accactaatg tgcccttggt gccatgtgtt
     1921 ctcaccccgg gcacaccagt gcctcgtctt tgttttcttt ttcatctatg tctttgttca
     1981 ttcaaagtta ataataattg taatccataa atgagtttat atttatactc taacatatcc
     2041 agaggattct agaaataaag ctgaggggtt tggatgcccc tatcaaaaaa agta
//
