LOCUS       NM_173182               6915 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus fibronectin type III domain containing 3B (Fndc3b),
            transcript variant 1, mRNA.
ACCESSION   NM_173182
VERSION     NM_173182.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6915)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6915)
  AUTHORS   You,Y., Liu,C., Liu,T., Tian,M., Wu,N., Yu,Z., Zhao,F., Qi,J. and
            Zhu,Q.
  TITLE     FNDC3B protects steatosis and ferroptosis via the AMPK pathway in
            alcoholic fatty liver disease
  JOURNAL   Free Radic Biol Med 193 (Pt 2), 808-819 (2022)
   PUBMED   36336231
  REMARK    GeneRIF: FNDC3B protects steatosis and ferroptosis via the AMPK
            pathway in alcoholic fatty liver disease.
REFERENCE   3  (bases 1 to 6915)
  AUTHORS   Garikipati,V.N.S., Verma,S.K., Cheng,Z., Liang,D., Truongcao,M.M.,
            Cimini,M., Yue,Y., Huang,G., Wang,C., Benedict,C., Tang,Y.,
            Mallaredy,V., Ibetti,J., Grisanti,L., Schumacher,S.M., Gao,E.,
            Rajan,S., Wilusz,J.E., Goukassian,D., Houser,S.R., Koch,W.J. and
            Kishore,R.
  TITLE     Circular RNA CircFndc3b modulates cardiac repair after myocardial
            infarction via FUS/VEGF-A axis
  JOURNAL   Nat Commun 10 (1), 4317 (2019)
   PUBMED   31541092
  REMARK    GeneRIF: Findings highlight a physiological role for circRNAs in
            cardiac repair and indicate that modulation of circFndc3b
            expression may represent a potential strategy to promote cardiac
            function and remodeling after MI.
            Erratum:[Nat Commun. 2020 May 1;11(1):2234. doi:
            10.1038/s41467-020-15382-x.. PMID: 32358483]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6915)
  AUTHORS   Peng,Y., Li,H., Li,X., Yu,S., Xiang,H., Peng,J. and Jiang,S.
  TITLE     MicroRNA-215 impairs adipocyte differentiation and co-represses
            FNDC3B and CTNNBIP1
  JOURNAL   Int J Biochem Cell Biol 79, 104-112 (2016)
   PUBMED   27521659
  REMARK    GeneRIF: miR-215-5p is a negative regulator of adipocyte
            differentiation through post-transcriptional regulation of FNDC3B
            and CTNNBIP1 during early adipogenesis
REFERENCE   5  (bases 1 to 6915)
  AUTHORS   Katoh,D., Nishizuka,M., Osada,S. and Imagawa,M.
  TITLE     FAD104, a Regulator of Adipogenesis and Osteogenesis, Interacts
            with the C-Terminal Region of STAT3 and Represses Malignant
            Transformation of Melanoma Cells
  JOURNAL   Biol Pharm Bull 39 (5), 849-855 (2016)
   PUBMED   26948083
  REMARK    GeneRIF: fad104 suppressed anchorage-independent growth of melanoma
            cells, and the N-terminal region of FAD104 is essential for
            inhibiting malignant transformation and STAT3 activity
REFERENCE   6  (bases 1 to 6915)
  AUTHORS   Kishimoto,K., Kato,A., Osada,S., Nishizuka,M. and Imagawa,M.
  TITLE     Fad104, a positive regulator of adipogenesis, negatively regulates
            osteoblast differentiation
  JOURNAL   Biochem Biophys Res Commun 397 (2), 187-191 (2010)
   PUBMED   20493170
  REMARK    GeneRIF: fad104 reciprocally regulates differentiation of
            adipocytes and osteoblast; functions as a positive regulator in
            adipocyte differentiation and as a negative regulator in osteoblast
            differentiation.
REFERENCE   7  (bases 1 to 6915)
  AUTHORS   Nishizuka,M., Kishimoto,K., Kato,A., Ikawa,M., Okabe,M., Sato,R.,
            Niida,H., Nakanishi,M., Osada,S. and Imagawa,M.
  TITLE     Disruption of the novel gene fad104 causes rapid postnatal death
            and attenuation of cell proliferation, adhesion, spreading and
            migration
  JOURNAL   Exp Cell Res 315 (5), 809-819 (2009)
   PUBMED   19138685
  REMARK    GeneRIF: Fad104 is essential for the survival of newborns just
            after birth and important for cell proliferation, adhesion,
            spreading and migration.
REFERENCE   8  (bases 1 to 6915)
  AUTHORS   Obholz,K.L., Akopyan,A., Waymire,K.G. and MacGregor,G.R.
  TITLE     FNDC3A is required for adhesion between spermatids and Sertoli
            cells
  JOURNAL   Dev Biol 298 (2), 498-513 (2006)
   PUBMED   16904100
REFERENCE   9  (bases 1 to 6915)
  AUTHORS   Tominaga,K., Kondo,C., Johmura,Y., Nishizuka,M. and Imagawa,M.
  TITLE     The novel gene fad104, containing a fibronectin type III domain,
            has a significant role in adipogenesis
  JOURNAL   FEBS Lett 577 (1-2), 49-54 (2004)
   PUBMED   15527760
REFERENCE   10 (bases 1 to 6915)
  AUTHORS   Imagawa,M., Tsuchiya,T. and Nishihara,T.
  TITLE     Identification of inducible genes at the early stage of adipocyte
            differentiation of 3T3-L1 cells
  JOURNAL   Biochem Biophys Res Commun 254 (2), 299-305 (1999)
   PUBMED   9918832
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140372.3, AK220297.1 and AW491305.1.
            
            On Oct 13, 2017 this sequence version replaced NM_173182.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220297.1, AB098596.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC140372.3         96729-96741         c
            14-6888             AK220297.1         1-6875
            6889-6915           AW491305.1         16-42               c
FEATURES             Location/Qualifiers
     source          1..6915
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 10.91 cM"
     gene            1..6915
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /note="fibronectin type III domain containing 3B"
                     /db_xref="GeneID:72007"
                     /db_xref="MGI:MGI:1919257"
     exon            1..107
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            108..246
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..3759
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /note="HCV NS5A-binding protein 37; factor for adipocyte
                     differentiation 104"
                     /codon_start=1
                     /product="fibronectin type III domain-containing protein
                     3B"
                     /protein_id="NP_775274.2"
                     /db_xref="CCDS:CCDS17274.1"
                     /db_xref="GeneID:72007"
                     /db_xref="MGI:MGI:1919257"
                     /translation="MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGEAAQQVILVQVN
                     PGETFTIRAEDGTLQCIQGPAEVPMMSPNGSIPPIHVPPGYISQVIEDSTGVRRVVVT
                     PQSPECYPPSYPSAMSPTHHLPPYLTHHPHFIQNSHTAYYPPVTVPGDMPPQFFPQPH
                     LPPTIYSEPEIIPLYGMSSYVTREDQYSKPPHKKLKDRQIDRQNRLNSPPSTIYKNSC
                     ATVYNGYGKGHSGGSSGGGGGGSGGGPGIKKTERRARSSPKSSDSDLQEYELEVKRVQ
                     DILSGIEKPQVSNIQARAVVLSWAPPVGLSCGPHGGLSFPYSYEVALSDKGRDGKYKI
                     IYSGEELECNLKDLRPATDYHVRVYAVYNSVKGSCSEPVSFTTHSCAPECPFPPKLAH
                     RSKSSLTLQWKAPIDNGSKITSYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGY
                     TFRLAARNDIGTSGYSQEVVCYTLGNIPQMPLAPRLVRAGVTWITLQWSRPEGCSPEE
                     VITYTLDIQEDENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNMEGKSCPSEVL
                     VCTTSPDRPGPPTRPLIKGPVTSHGFSVKWDAPKDNGGSEILKYLLEITDGTSEAGQW
                     EVAYSGSATEYVFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSLAPGQCRPPRV
                     LGRPKHKGVHLEWDVPASESGCEVSEYSVEMTEPENVASEVYHGPELECTVGNLLPGT
                     VYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCRAPRVSFTPDGCVLVGWESPASPGA
                     DISEYRLEWGEDEQSLELVYHGPDTCFEMRDLLPAAQYCCRLQAFNPAGAGPYSELVH
                     CQTPASAPDPVSTLCVLEEEPPSAHPDSPSVCLVLNWEEPCNNGSEILAYNIDLGDSC
                     ITVGNTTTHVMKNLLPETTYRIRIQAINEIGVGPFSQFIKAKTRPLPPSPPRLECAAS
                     GPQSLKLKWGDSNSKTHAAGDMVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYS
                     FRIQAMSEAGEGPYSETYTFSTTKSVPPTLKAPRVTQLEGNSCEIFWETVPPMRGDPV
                     SYVLQVLVGRDSEYKQVYKGEEATFQISGLQSNTDYRFRVCACRRCVDTSQELSGAFS
                     PSAAFMLQQREVMLTGDLGGMEEAKMKGMMPTDEQFAALIVLGFATLSILFAFILQYF
                     LMK"
     exon            247..322
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            323..399
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            400..643
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            644..934
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            935..993
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1145
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1205
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1344
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1398
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1523
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1698
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1785
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1924
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..1996
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2115
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2221
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2394
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2508
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2658
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2939
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..3152
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3319
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            3320..3447
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..6915
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6866..6871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /note="hexamer: AATAAA"
     polyA_site      6889
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
                     /note="major polyA site"
     polyA_site      6915
                     /gene="Fndc3b"
                     /gene_synonym="1600019O04Rik; Fad104; mKIAA4164"
ORIGIN      
        1 ggccgcggct ggactcggcg agccaggcgg ctgcaggctc gggcggggga gcggggcgcg
       61 gcgggaagca gaggacgacc cggtgcgtgt gggccagcgg agcgcgggta gcaggttgag
      121 ggcaattctc catgaatgta cgtcaccatg atgatgaccg accagatccc cctggaattg
      181 ccacctctgc tcaatgggga ggtggccatg atgccccact tggtgaacgg agaagcagct
      241 cagcaggtca ttcttgtcca agtgaaccca ggtgagacct ttaccatcag agccgaggat
      301 gggacacttc agtgcatcca aggacctgct gaagttccca tgatgtcacc caatgggtcc
      361 attcctccta tccatgtgcc tccaggttat atctcacagg tgattgaaga cagcaccgga
      421 gtccgccggg tggtggtcac accgcagtct cctgagtgct acccaccgag ttatccctca
      481 gccatgtctc caacccatca cctgccccct tatctgaccc accatccaca cttcatccag
      541 aactcgcaca ccgcctacta cccgcccgtc accgtgcctg gagatatgcc accccagttt
      601 ttcccccagc ctcaccttcc tcccacaata tatagcgagc cagaaattat ccccctgtat
      661 ggaatgtcga gctacgtcac ccgagaagac cagtacagca agcctccaca taagaagctg
      721 aaggaccgcc agatcgaccg ccagaaccgc ctcaacagcc caccttccac catctacaag
      781 aacagctgcg ccacagtgta caatggctac gggaaaggcc acagtggagg gagcagtgga
      841 ggtgggggag gtggcagcgg cggtggacct gggatcaaga agacagagcg aagagcgagg
      901 agcagcccaa aatccagtga ttctgacctg caagagtatg agttggaagt aaagagggtg
      961 caagacattc tttcgggaat agagaaacca caggtgtcta atatccaggc aagagcagtt
     1021 gtgctgtctt gggcaccccc tgtcggactg tcctgtggac cccatggtgg tctttccttc
     1081 ccttacagct atgaggtcgc cttatctgac aaagggcgag atgggaaata caagatcatt
     1141 tacagtggag aagagttgga gtgtaacctg aaagatctca ggcctgccac ggattaccat
     1201 gtgagggtat atgccgtgta caattctgtc aagggatcct gctccgagcc agtcagcttc
     1261 accacccata gctgcgcacc agaatgtccc ttccctccca agctggcaca caggagcaaa
     1321 agttcactta ccctgcagtg gaaggctcca attgacaatg gttcaaaaat caccagctac
     1381 cttttagaat gggatgaggg aaagagaaac agtggtttca gacagtgttt ctttggaagc
     1441 cagaagcact gcaaactgac aaagctctgt ccagccatgg gctacacgtt caggctcgct
     1501 gctcggaacg acatcggcac cagtggttac agccaggagg tcgtgtgcta cacgttggga
     1561 aacatcccgc agatgccctt ggcaccccgg cttgtccgag ccggcgtcac ctggatcacc
     1621 ctgcagtgga gcaggccaga aggctgctcg cctgaggaag tgataaccta caccctggac
     1681 attcaggagg atgagaacga tagccatttc cacccaaaat acactggaga ggacctaacc
     1741 tgtactgtga aaaatctcaa gcgaagcaca cagtataaat tcaggctgac tgcttccaac
     1801 atggagggga agagctgccc aagtgaagtc ctggtttgta caaccagccc cgacagacct
     1861 ggccctccaa ccagacccct cattaaagga cctgtcacat cacatggctt cagtgtcaag
     1921 tgggatgctc caaaggacaa cggtggctca gaaatcctga agtatctgct ggagatcacg
     1981 gatggaactt ctgaagctgg gcagtgggaa gtggcctaca gtggatcggc tacagagtat
     2041 gtctttaccc atttgaaacc aggcactttg tacaaactgc gagcgtgctg catcagtacc
     2101 ggtgggcaca gtcagtgttc tgaaagtctc cctgtccgca cactaagcct tgcaccaggt
     2161 cagtgccgac caccgagggt tttgggtaga ccaaagcaca aaggagtcca cttagagtgg
     2221 gatgtgcctg cgtctgaaag tggctgtgag gtctcagaat acagtgtgga aatgacggaa
     2281 cccgagaatg tcgcctcaga ggtgtaccat gggcctgagc tggagtgcac ggttggcaac
     2341 ctgctgcctg gaactgtgta ccgcttcaga gtgcgagctc tgaatgacgg agggtacggt
     2401 ccctactctg atgtgtcaga aatcaccact gccgcagggc cccctgggca gtgcagagca
     2461 ccgcgtgtct ccttcacgcc tgacggatgc gtcctggtgg gctgggagag ccctgcgagc
     2521 cctggtgccg acatctccga atacaggttg gagtggggag aagatgaaca gtccttagaa
     2581 ctcgtttatc atggtccaga cacctgcttt gagatgcgag atctgttgcc tgctgcacag
     2641 tattgctgca gactacaggc cttcaatcca gcaggcgcag ggccatatag tgagcttgtc
     2701 cactgccaga caccagcctc tgcccccgac cctgtctcca ctctgtgtgt cctggaggag
     2761 gagcccccca gtgcccaccc agactcaccc tctgtgtgcc ttgtactgaa ctgggaagag
     2821 ccgtgcaata atgggtctga aatccttgct tataacatcg atctgggaga cagctgcatt
     2881 actgtgggca acactaccac acacgtgatg aagaacctcc ttccagaaac gacataccgg
     2941 atcagaattc aggctatcaa tgaaattgga gttggaccat ttagtcagtt cattaaagca
     3001 aaaactcggc cattaccgcc ttcgcctcct aggcttgagt gtgctgcgtc tggtcctcag
     3061 agcctgaagc tcaagtgggg agacagtaac tccaagacac atgctgctgg tgacatggtg
     3121 tacacactac agctggaaga caggaacaag aggtttatct caatctaccg aggacccagc
     3181 cacacctaca aggtccagag actgacagag tttacctgct actccttcag gatccaggca
     3241 atgagcgagg caggggaggg gccttactca gaaacctaca ccttcagcac aaccaaaagc
     3301 gtgcctccca ccctcaaagc acctcgagtg acgcagttag aagggaattc ctgtgaaatc
     3361 ttctgggaga cggtaccacc gatgagaggc gaccctgtga gctacgttct acaggtgctg
     3421 gttggaagag actctgagta caagcaggtg tacaagggag aagaagccac attccaaatc
     3481 tcaggcctcc agagcaacac agattacagg ttccgcgtgt gtgcctgccg ccgctgtgtg
     3541 gacacgtctc aggagctcag tggcgcgttc agcccctctg cggctttcat gttacaacag
     3601 cgtgaggtta tgcttacagg ggacctggga ggcatggaag aggccaagat gaagggcatg
     3661 atgcccaccg acgaacagtt tgctgcactc atcgtgcttg gcttcgcgac cctgtccatt
     3721 ttgtttgcct ttatattaca gtacttctta atgaagtaaa tccagcaggc cagtggtatg
     3781 ctcggaacgc cacacgtttt aatacacatt tactcagagc ctcccctttt tacgctgttt
     3841 cgttctttga tttatacgct tctcttgttt tacacattta gctaggggaa agagtttggc
     3901 tgcacctatt tgagatgcaa aactaggaag aggttaaact ggattttttt ttaaacaata
     3961 ataaataaag gaataaagaa gagaaggaag cggcgggcaa gctccagaca ccgagagcca
     4021 gtgtgcccaa cgagcttgcc ttgtcgggct tccccgtgtg cttctggtct gttcccactg
     4081 atgtctttcg caagcctttg atcatcttgt gtgttacagt tcagtaattt atattcacag
     4141 tcatttcttg atcatctata cctgttaaca gaatcacagt gtatgtagtt cagggctggg
     4201 attccggtgt tgtcagagta ttgccacatg agaatattca gtgtgccttc ggaggaggcc
     4261 acctcgacca tccttacgtc actcagttac gtaactgtgt tagctcatct aagtcaaagt
     4321 gtgtacttta atctaaaatg ttttattact ctgtatccct tatgatttta acactatgag
     4381 ttgcctgtct aagaagtcac ataaccaaat gcgcctataa atgatagagc attgtagatt
     4441 ttcacatcgg tccatagcag taactttaag agggcattgt gcaatagtta gttgtttctt
     4501 gttcggctac tttaaaagct gctttaactt gtctgtctgt ctttgtacat aactacttct
     4561 aatataatca ctagagttat tatattctgt tatgtttgac cggaattatg tgacgagagc
     4621 tcatggcagt tgtgaactgt ctccttacat gttggcccat catatttgaa agacttgcct
     4681 ttggctattc tttggggtgt cagtgacgtg aatgaagttg aataccatat ttcagtgccc
     4741 atgatactaa tgtagcagta gatagaaatc ttactgataa agcccaccac aagggaacca
     4801 tttacatttg tcctgtttct gggggcttca tctggccgca tggagagagg gagtggaaac
     4861 tggctgtgag catgagatgt ttgggggcca aagagcctac tagattctct ccctgggtct
     4921 gtcactaatt tgctttgtga cctctctgtg cctgttttcc catgcatgag taatcaaatc
     4981 aaatggggat tcaatacctg taagtgctaa gagaccttgg atccaccggt gctatgtaag
     5041 tgcggagaat cactctcacg gattcactta gagtcatgag gtaatgagtt ctaacccaaa
     5101 gtcattggat ccctcaacca agtccacaat gttcaagtac ctcagggaca cttaagagtt
     5161 ggaggtgcaa ctgtattcca aaagggtgcg acagacacag ccgattcccc tcttcctgtt
     5221 tttttgtata tttttgctcc ttggtttttc ttgatcatag ctactttgtg cttggtctat
     5281 gttgtctatg atgcagtaag taccctgtac tagcttatac tattcccata ccaaagtcat
     5341 ggggaaacca acattatttt gttttgggtt tatttatact ctattctgca tacagtactt
     5401 taaatgccaa tgacagtgca atctttattt attgtaatgt taaatgtact tattactaat
     5461 gtgccctcct agcatgttat attttgtgtg ttttatactt tttgtaattt taggtcagtt
     5521 tagttccttg gcaacatctg tagtattagc cttctgacat ctttcttgtg tttttaaaga
     5581 taagagcatc taactcatta aatgccaaaa aaaaaaaaaa tccattacca gtgattgaaa
     5641 ggtttacatg tacccagaaa ccatattcat ctcctggaag agtgctaaga tcaatgcatt
     5701 gtcgcgtgcc tatattgata gagttatgca ctagagagtt ctgtattttg ttatcgacta
     5761 tggtgattag tgtaattaga cgtgtacact gatggtatca aggtaaatct atttttgcca
     5821 aagctctggc cttcggaagc tcatccttcc atcgaagtgt gtcttttggc ccactgtgac
     5881 gtcacttctg cattccctgc ggcagtcaca ggcgggtgaa ggcagatgca gtggaatggt
     5941 ttttaaggct attcattcac agggagagtc tttttttaaa aaaaaaacaa aacacttcag
     6001 cactgctgct gtaaagaatt ccctgaattg ttgaattgtt acaaaggaaa ttatacttca
     6061 ggccaaaaac ccctttgatc ttgcagagat tccgatactc ggtaactctc agaatgctga
     6121 agcgtgtgac acacgagccg acagcacttt attctctcgc tcgccattat ttgctattca
     6181 ttatagtctc ttcagtcagg aagttattcc tctacatggc actattctct atcacatatc
     6241 tgtatatgtg ctatggatat ataactatat atattgccat ttcaaaggaa caataaaacc
     6301 aagtgttctg ttgaccttgt ctgtgccctt tgccatacgt aggaatgagt gagtggcttt
     6361 ccgatgttct gatgcgtctc tgtgtgtcac atgcatccct gacacaggaa attccaggca
     6421 tctgaagcaa actgcccttt gtcctcaaag aaaatgttta aaaagaaaac tttttaaaag
     6481 gctattttgc atattatctg ccttgttctt atcacacttg agatgttgac attttctgac
     6541 cctgtgtctt tggctacaat cattcagtat ttgtgtcaaa tttgacaagt gccctaatag
     6601 aatgtgtttg aatgttatcc ttgcacaatt ctttaaattg aaagacaaaa tgttttacct
     6661 cactgttgga catacattcc aggcttttcg actttaggag aaaaaaaaaa ttaatcatat
     6721 gttttcctgt cttgtaaatt ttagattatt tcatatacat tgtattaaaa ctgccatatc
     6781 aattttaatg tatagatttt gcaaatacta tgctatatgt aatacctaac tgtatctgta
     6841 gtgtatatgt aatatattta tgcccaataa atgttttaat tctttctgac ttaagtaggg
     6901 ttcttcagcc ttgaa
//
