LOCUS       NM_018828               4503 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus formin binding protein 4 (Fnbp4), transcript variant
            1, mRNA.
ACCESSION   NM_018828
VERSION     NM_018828.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4503)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   2  (bases 1 to 4503)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
REFERENCE   3  (bases 1 to 4503)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   4  (bases 1 to 4503)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 4503)
  AUTHORS   Ruivenkamp,C.A., van Wezel,T., Zanon,C., Stassen,A.P., Vlcek,C.,
            Csikos,T., Klous,A.M., Tripodis,N., Perrakis,A., Boerrigter,L.,
            Groot,P.C., Lindeman,J., Mooi,W.J., Meijjer,G.A., Scholten,G.,
            Dauwerse,H., Paces,V., van Zandwijk,N., van Ommen,G.J. and
            Demant,P.
  TITLE     Ptprj is a candidate for the mouse colon-cancer susceptibility
            locus Scc1 and is frequently deleted in human cancers
  JOURNAL   Nat Genet 31 (3), 295-300 (2002)
   PUBMED   12089527
REFERENCE   6  (bases 1 to 4503)
  AUTHORS   Zucconi,A., Dente,L., Santonico,E., Castagnoli,L. and Cesareni,G.
  TITLE     Selection of ligands by panning of domain libraries displayed on
            phage lambda reveals new potential partners of synaptojanin 1
  JOURNAL   J Mol Biol 307 (5), 1329-1339 (2001)
   PUBMED   11292345
REFERENCE   7  (bases 1 to 4503)
  AUTHORS   Bedford,M.T., Sarbassova,D., Xu,J., Leder,P. and Yaffe,M.B.
  TITLE     A novel pro-Arg motif recognized by WW domains
  JOURNAL   J Biol Chem 275 (14), 10359-10369 (2000)
   PUBMED   10744724
REFERENCE   8  (bases 1 to 4503)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 4503)
  AUTHORS   Chan,D.C., Bedford,M.T. and Leder,P.
  TITLE     Formin binding proteins bear WWP/WW domains that bind proline-rich
            peptides and functionally resemble SH3 domains
  JOURNAL   EMBO J 15 (5), 1045-1054 (1996)
   PUBMED   8605874
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL714026.13.
            
            On Feb 20, 2019 this sequence version replaced NM_018828.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U40750.2, AK084018.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               AL714026.13        26566-26834
            270-362             AL714026.13        27704-27796
            363-499             AL714026.13        32076-32212
            500-686             AL714026.13        32440-32626
            687-834             AL714026.13        33827-33974
            835-955             AL714026.13        34078-34198
            956-1306            AL714026.13        38344-38694
            1307-1517           AL714026.13        39302-39512
            1518-1642           AL714026.13        44429-44553
            1643-1747           AL714026.13        46838-46942
            1748-1881           AL714026.13        48416-48549
            1882-2066           AL714026.13        49524-49708
            2067-2383           AL714026.13        56913-57229
            2384-2528           AL714026.13        57339-57483
            2529-2884           AL714026.13        58573-58928
            2885-3042           AL714026.13        60207-60364
            3043-4503           AL714026.13        60569-62029
FEATURES             Location/Qualifiers
     source          1..4503
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.35 cM"
     gene            1..4503
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /note="formin binding protein 4"
                     /db_xref="GeneID:55935"
                     /db_xref="MGI:MGI:1860513"
     exon            1..269
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..3133
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /note="isoform 1 is encoded by transcript variant 1;
                     formin binding protein 30"
                     /codon_start=1
                     /product="formin-binding protein 4 isoform 1"
                     /protein_id="NP_061298.2"
                     /db_xref="CCDS:CCDS16414.2"
                     /db_xref="GeneID:55935"
                     /db_xref="MGI:MGI:1860513"
                     /translation="MGKKSRAVPGRRPILQLSPPGPRSSTPGRDPDPDPDPEADSTAA
                     ATSQSAPAAATAAAATSPAVPASAAPEDSPSEDEQEVVVEVPNVVQNPPTPVMTTRPT
                     AVKATGGLCLLGAYADSDDDESDVSEKTAQSKEANGNQATDIDSTLANFLAEIDAITA
                     PQPAAPVVASAPPPTPPRPEPKEAATPALSPTASNGSDTAQTPGWHYDTQCSLAGVEI
                     EMGDWQEVWDENTGCYYYWNTQTNEVTWELPQYLATQVQGLQHYQPSSVTGTEAAFVV
                     NTDMYTKERTTAASSSKSGPVITKREVKKEVNEGIQALSNSEEERKGVAAALLAPLLP
                     EGVKEEEERWRRKVICKEADPVSETKETSTASEETGPSIKPPEVMMDGTEDPSQEELC
                     SVVQSGESEEEEEEEEQDTLELELALERKKAELRALEEGDGSVSGSSPRSDISQPASQ
                     DGVRRIMSKRGKWKMFVRATSPESTSRSSSKTGRDSPENGETAIGAEDSEKIDEISDK
                     ETEVEESSEKIKVQLAPKVEEEQDLKFQIGELANTLTSKFEFLGINRQSISNFHMLLL
                     QTETRIADWREGALNGNYLKRKLQDAAEQLKQYEINATPKGWSCHWDRDHRRYFYVNE
                     QSGESQWEFPDGEEEEESQTKEVRDESLPKLTVKDKTCTDPNSTESSENPTGSLCKES
                     FSGQVSSSLMPLTPFWTLLQSNVPVLQPPLPLEMPPPPPPPPESPPPPPPPPPPPPPL
                     EDGEIQEVEMEDEGSEEPPAPGTEEDTPLKPSTQTTAVTSQSLVDSTASSPPSNKAVK
                     RKAPEMSTSVVQRSATIGSSPVLYSQSAIAAGHQAVGMAHQAVGMAHQAVSASHAAAA
                     GVGHQARGMSLQSNYLGLAAAPALMSYAECSVPIGVTTPSLQPAQARGTMAAPAVVEP
                     PPPPPPPPTPTPPPPPPAPKVPPPEKTRKGKKDKAKKSKTKMPSLVKKWQSIQRELDE
                     EDNSSSSEEDRESTAQKRIEEWKQQQLVSGLAERNANFEALPEDWRARLKRRKMAPST
                     "
     exon            270..362
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /inference="alignment:Splign:2.1.0"
     exon            363..499
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /inference="alignment:Splign:2.1.0"
     exon            500..686
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /inference="alignment:Splign:2.1.0"
     exon            687..834
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /inference="alignment:Splign:2.1.0"
     exon            835..955
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1306
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1517
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1642
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1747
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1881
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2066
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2383
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2528
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2884
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..3042
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..4503
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3933..3938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /note="hexamer: AATAAA"
     polyA_site      3957
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /note="major polyA site"
     regulatory      4477..4482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /note="hexamer: AATAAA"
     polyA_site      4503
                     /gene="Fnbp4"
                     /gene_synonym="FBP30; Fnbp30; mKIAA1014"
                     /note="major polyA site"
ORIGIN      
        1 actaatctgc cgtcgttcgc tgctcgcgct ccggctcatg atggggaaga agtcccgggc
       61 ggtacccggc cgcaggccta tcctgcagct ctctccaccg ggtcctcgga gcagcacccc
      121 gggccgggat cccgaccccg atccggatcc cgaggcagat tcgactgcgg cggcgacaag
      181 ccagtcagcg ccggcagcag cgacggcggc ggccgcgacg tcgcccgcgg tgcctgcctc
      241 cgctgcccca gaggactcgc cttcagaaga tgaacaagaa gtggtggtgg aggtccccaa
      301 cgttgttcag aaccctccaa caccagtcat gaccaccaga ccgacagccg tcaaggcaac
      361 aggaggtctg tgcttacttg gtgcttatgc tgacagcgat gacgatgaga gtgatgtgtc
      421 tgagaaaaca gcccaatcca aagaggccaa cggaaaccag gccactgaca ttgacagcac
      481 actggccaac ttcctagcgg agatagacgc cataacagca cctcagcctg cagctcctgt
      541 ggtagcttct gctccacctc caactccacc tcgaccagaa ccaaaagaag cggcaacacc
      601 tgccctttct cccaccgcat caaatggatc agacactgcc cagacgccag ggtggcatta
      661 tgacactcag tgttcattgg caggagttga aattgagatg ggagattggc aagaagtctg
      721 ggatgagaac acaggttgct attattattg gaacacacaa acaaatgaag tgacttggga
      781 gttaccccaa taccttgcta cacaggttca gggattacaa cattaccagc ccagttctgt
      841 aacaggtacc gaggctgctt ttgtggtaaa tacagacatg tatacaaagg agaggacaac
      901 tgctgcttcc agtagtaaaa gtggaccagt catcaccaaa cgagaagtta aaaaggaagt
      961 gaatgaagga atccaagccc tttccaacag tgaggaggag aggaaagggg tagcagctgc
     1021 attgctcgct cctttactgc ctgaaggggt aaaagaggag gaagaaagat ggagaagaaa
     1081 agtaatttgt aaagaagcag atccggtgtc agagactaag gaaacaagca cagcttcgga
     1141 ggagacgggc ccgagtataa agccaccgga agtgatgatg gacggcacag aagacccttc
     1201 tcaggaggag ctctgcagtg tcgttcaatc tggagaaagt gaggaggagg aggaagagga
     1261 ggagcaagac acccttgagc tggagctagc tttggaaagg aaaaaggcag agttacgagc
     1321 cttggaggaa ggagatggta gtgtgtcagg gtctagtcca cgttctgaca tcagccagcc
     1381 agcatctcag gacggagtgc gtaggattat gtctaaaaga ggaaaatgga agatgtttgt
     1441 tcgagccacc agtccagaat ccaccagccg aagttctagt aaaactggac gagattctcc
     1501 agaaaatgga gaaactgcaa ttggtgctga agattccgaa aaaatagatg aaatttcaga
     1561 caaagaaacg gaagtagaag agtcttctga gaagatcaaa gtccagctag cacctaaagt
     1621 ggaggaagag caggacctga aatttcagat tggagaactg gcaaataccc tgacaagtaa
     1681 atttgaattc ctagggatta ataggcagtc catctccaac tttcacatgc tgctcttaca
     1741 gactgagact cgaattgcag actggcggga aggggctctc aatggaaatt acctaaaacg
     1801 aaagcttcag gatgctgcag aacagctaaa acagtatgaa ataaacgcca ctcctaaagg
     1861 ctggtcctgc cactgggaca gggatcatag acgatatttc tatgtaaacg aacagtcggg
     1921 cgagtctcaa tgggaattcc cagatggtga ggaggaggaa gaaagccaaa caaaggaagt
     1981 tagagatgag agtctgccta agctgaccgt gaaggacaaa acctgcactg atccaaactc
     2041 tacagaatcc tctgagaacc cgacaggttc tctttgtaaa gaatcatttt ctggtcaagt
     2101 ttcttcatca ctcatgccac ttactccatt ctggaccctc ctccaatcaa atgtacctgt
     2161 gcttcaacct ccattacctc tggaaatgcc gccacctcca cctccacccc cggagtctcc
     2221 acctccacct cctccacctc ctcctccacc cccaccatta gaagatggtg agattcagga
     2281 ggtagaaatg gaggacgagg gaagtgagga gcctcctgcc cccggaacag aggaggacac
     2341 tcctttgaaa ccttcaacac agaccacagc tgtaaccagc cagagtctag ttgattctac
     2401 tgcctctagt cctccatcca ataaagcagt aaagaggaag gctccagaaa tgagtacttc
     2461 ggtagttcag agatcagcca ctattggtag ttctccagtt ctctatagcc agtcagctat
     2521 agctgcaggt caccaagctg ttgggatggc acaccaggct gttgggatgg cacaccaagc
     2581 agtatctgct agccatgcag cagcagcagg agtgggtcat caggcccgag ggatgagcct
     2641 gcagtcaaat tacctcggcc tagcagcagc acctgcgctg atgagttatg ctgaatgttc
     2701 tgtcccaatt ggagtgacta ctccatcgct gcagccagct caggctcgag gaactatggc
     2761 agcacctgct gttgtagaac cacctccacc tccacctcct ccccctacac ctacaccacc
     2821 accgccacca ccagctccca aagtgccacc gcccgagaag acgagaaaag ggaagaaaga
     2881 taaggcaaag aaaagtaaaa ctaaaatgcc atccttggta aagaaatggc agagtatcca
     2941 gcgggagtta gatgaagaag ataattcaag ttccagtgaa gaagaccggg aatcgactgc
     3001 acagaagcgg attgaggaat ggaaacagca gcagctggtg agtggcctgg cagaaagaaa
     3061 tgctaatttt gaagcccttc ctgaggattg gcgagcaaga ctgaagagaa ggaaaatggc
     3121 tcccagcaca tagttttcat tttgttttat gttcagtctt aaccagattt aaactgttgt
     3181 caaatgaact gtaaaatgtt atgaggaaga acatatacat ttcctgggca aggatgcgtg
     3241 catacaaagt tgtccattta tgaagtgtag tttttctgtt tgctgaatga ggaattgctt
     3301 tgacctggct gtctttattc tcacactggc aaacttagca tgttagatag gagtcagaca
     3361 tgtgagtcat gggcacgaaa tctctgtata ggacttgctg gcaaaagtga agggctttcc
     3421 tgcccagtag aggcttgttt agttctagtg tggcactctc cctcccttct cctccaaaca
     3481 agtgcaatta aggcagctct gtatcctccc ttgcttgacc atcaggatct ctatctgacc
     3541 tcctcaaagt ctgctcgcct gaagtgttga tctgtgctga tggccacaca caccctagaa
     3601 tgctcgcttt gcagcacagg caggagcagc agcaagcagc aggtgtttag atccttggtt
     3661 ttgagaaatt cccccctaag tatgtggcaa taagtataag ccactttgtg tattgtcttc
     3721 attgtcttac ccacttcaga aatacccctt ccttctatgt gtggacatgt tctccataag
     3781 attccagtat ttaagacacg ttcactgttg tgtactttct gttgtatcac aatcaggaaa
     3841 ggtcacttta aactgaaggg aaaagcaaat tgtgtcttaa agctgtttgt atttctccag
     3901 tttctgacat tgtaaatttg tatatataca ccaataaagc tctttttata cttctcattg
     3961 gttatccttt tgctcttcta agcatgttac cctacataac taggacttag tgtgtgccca
     4021 ttcttagttg ttccaatcag acttagtgca gaacatgcac tgacatttga acatcgggaa
     4081 agtgatggct tggggatata ggaagacagg gttttaagaa acatacacag tttccgataa
     4141 gatggtgcca ttttctggag cttgtaccct gttaataata tacctgatat ttgacctact
     4201 taagtcctag aaacaatgta atatggggga gaaaggtgct ttatagcttt ttattaagta
     4261 atacaaagct gattatggaa agtaatagat atttaagatt ataatcacaa tagttaacca
     4321 aagataatag tttgaatttt attctagtat attcctatgc agttcaattt tttttacttg
     4381 tattacagtg tattagattt tatttatcat gcgctgttgg gatgcccatt ttgtacataa
     4441 aattgttttg taatttgcat agagtaaatt tctacaaata aagattatca aatagctgtt
     4501 aaa
//
