LOCUS       NM_022014               1006 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus fructosamine 3 kinase (Fn3k), transcript variant 1,
            mRNA.
ACCESSION   NM_022014
VERSION     NM_022014.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1006)
  AUTHORS   Huang,S., Reed,C., Ilsley,M., Magor,G., Tallack,M., Landsberg,M.,
            Mitchell,H., Gillinder,K. and Perkins,A.
  TITLE     Mutations in linker-2 of KLF1 impair expression of membrane
            transporters and cytoskeletal proteins causing hemolysis
  JOURNAL   Nat Commun 15 (1), 7019 (2024)
   PUBMED   39147774
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1006)
  AUTHORS   Sanghvi,V.R., Leibold,J., Mina,M., Mohan,P., Berishaj,M., Li,Z.,
            Miele,M.M., Lailler,N., Zhao,C., de Stanchina,E., Viale,A.,
            Akkari,L., Lowe,S.W., Ciriello,G., Hendrickson,R.C. and Wendel,H.G.
  TITLE     The Oncogenic Action of NRF2 Depends on De-glycation by
            Fructosamine-3-Kinase
  JOURNAL   Cell 178 (4), 807-819 (2019)
   PUBMED   31398338
  REMARK    GeneRIF: FN3K is a targetable modulator of NRF2 activity in cancer.
REFERENCE   3  (bases 1 to 1006)
  AUTHORS   Dunmore,S.J., Al-Derawi,A.S., Nayak,A.U., Narshi,A., Nevill,A.M.,
            Hellwig,A., Majebi,A., Kirkham,P., Brown,J.E. and Singh,B.M.
  TITLE     Evidence That Differences in Fructosamine-3-Kinase Activity May Be
            Associated With the Glycation Gap in Human Diabetes
  JOURNAL   Diabetes 67 (1), 131-136 (2018)
   PUBMED   29066600
  REMARK    GeneRIF: Data conclude that FN3K may play a key role in the GGap
            and thus diabetes complications such that FN3K may be a potential
            predictor of the risk of diabetes complications. Pharmacological
            modifications of its activity may provide a novel approach to their
            prevention.
REFERENCE   4  (bases 1 to 1006)
  AUTHORS   Pascal,S.M., Veiga-da-Cunha,M., Gilon,P., Van Schaftingen,E. and
            Jonas,J.C.
  TITLE     Effects of fructosamine-3-kinase deficiency on function and
            survival of mouse pancreatic islets after prolonged culture in high
            glucose or ribose concentrations
  JOURNAL   Am J Physiol Endocrinol Metab 298 (3), E586-E596 (2010)
   PUBMED   20009024
  REMARK    GeneRIF: We conclude that, despite its ability to reduce the
            glycation of intracellular islet proteins, FN3K is neither required
            for the maintenance of beta-cell survival and function under
            control conditions.
REFERENCE   5  (bases 1 to 1006)
  AUTHORS   Veiga da-Cunha,M., Jacquemin,P., Delpierre,G., Godfraind,C.,
            Theate,I., Vertommen,D., Clotman,F., Lemaigre,F., Devuyst,O. and
            Van Schaftingen,E.
  TITLE     Increased protein glycation in fructosamine 3-kinase-deficient mice
  JOURNAL   Biochem J 399 (2), 257-264 (2006)
   PUBMED   16819943
  REMARK    GeneRIF: These data indicate that FN3K serves as a protein repair
            enzyme and also in the metabolism of endogenously produced free
            fructose-epsilon-lysine.
REFERENCE   6  (bases 1 to 1006)
  AUTHORS   Delplanque,J., Delpierre,G., Opperdoes,F.R. and Van Schaftingen,E.
  TITLE     Tissue distribution and evolution of fructosamine 3-kinase and
            fructosamine 3-kinase-related protein
  JOURNAL   J Biol Chem 279 (45), 46606-46613 (2004)
   PUBMED   15331600
  REMARK    GeneRIF: fructosamine 3-kinase and fructosamine 3-kinase-related
            protein have roles in repairing damage caused by ribose 5-phosphate
REFERENCE   7  (bases 1 to 1006)
  AUTHORS   Delpierre,G., Rider,M.H., Collard,F., Stroobant,V., Vanstapel,F.,
            Santos,H. and Van Schaftingen,E.
  TITLE     Identification, cloning, and heterologous expression of a mammalian
            fructosamine-3-kinase
  JOURNAL   Diabetes 49 (10), 1627-1634 (2000)
   PUBMED   11016445
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY142714.1, AA058133.1, BU571242.1 and AI464555.1.
            
            On Jul 15, 2009 this sequence version replaced NM_022014.3.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010151.1, AJ404616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               BY142714.1         3-351
            350-496             AA058133.1         306-452
            497-741             BU571242.1         126-370
            742-1006            AI464555.1         1-265               c
FEATURES             Location/Qualifiers
     source          1..1006
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 85.38 cM"
     gene            1..1006
                     /gene="Fn3k"
                     /gene_synonym="2310074G21Rik"
                     /note="fructosamine 3 kinase"
                     /db_xref="GeneID:63828"
                     /db_xref="MGI:MGI:1926834"
     exon            1..177
                     /gene="Fn3k"
                     /gene_synonym="2310074G21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..966
                     /gene="Fn3k"
                     /gene_synonym="2310074G21Rik"
                     /EC_number="2.7.1.172"
                     /EC_number="2.7.1.171"
                     /note="isoform a is encoded by transcript variant 1;
                     protein-psicosamine 3-kinase FN3K; protein-ribulosamine
                     3-kinase FN3K"
                     /codon_start=1
                     /product="fructosamine-3-kinase isoform a"
                     /protein_id="NP_071297.1"
                     /db_xref="CCDS:CCDS25776.1"
                     /db_xref="GeneID:63828"
                     /db_xref="MGI:MGI:1926834"
                     /translation="MEQLLRAQLHTTTLRAFGSSGGGCISEGYAYYTDSGPVFVKVNR
                     RTQARQMFEGEMASLEALRNTGLVRVPKPMKVIDLPGGGAVFVMEHLKMKSLSSQASK
                     LGEQMADLHLYNQKLREKSKTRQNTVGCGAEGAEPQGVTKFGFHTVTCCGFIPQVNEW
                     QEDWPTFFTRHRLQAQLDLIEKDYADRETQELWSRLQVKIPDLFAGIEIVPALLHGDL
                     WSGNVAEDDQGPVIYDPASFYGHSEFELAIASMFGGFPRSFFTAYHRKIPKAPGFDKR
                     LLLYQLFNYLNHWNHFGREYRSPSLGVMRKLLR"
     exon            178..329
                     /gene="Fn3k"
                     /gene_synonym="2310074G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            330..421
                     /gene="Fn3k"
                     /gene_synonym="2310074G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            422..504
                     /gene="Fn3k"
                     /gene_synonym="2310074G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            505..627
                     /gene="Fn3k"
                     /gene_synonym="2310074G21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            628..1006
                     /gene="Fn3k"
                     /gene_synonym="2310074G21Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcgtcacct gaccgcattc tgcacctcaa ctctccatgg agcagctgct gcgcgcccag
       61 cttcacacca caacactgcg ggcctttggg agctccggag ggggctgcat cagcgagggc
      121 tatgcctact acactgacag tggccccgtg tttgtcaagg tcaatcgcag gacacaggcc
      181 cggcagatgt ttgagggaga gatggcgagc ctggaggccc tccgcaacac tggcttggtg
      241 cgggttccta agcccatgaa ggtgattgac ttgccaggag gtggggctgt ctttgtgatg
      301 gagcacttga agatgaagag ccttagcagt caggcatcaa agctcgggga acagatggca
      361 gacctgcacc tttacaatca gaagctcagg gagaagtcca agactcggca gaacacagtg
      421 ggctgtgggg cggagggtgc tgagccccag ggtgtgacca agtttggctt tcacacagtg
      481 acatgctgtg gctttatccc acaggtgaat gaatggcagg aggactggcc gaccttcttc
      541 actcgacacc ggctccaagc tcagttggat ctcattgaaa aggactatgc tgaccgagag
      601 acacaagagc tgtggtcaag gctacaggtg aagatcccgg atctgtttgc gggtatagag
      661 attgtccctg ccctgctcca tggagacctc tggtctggaa atgtggctga ggatgaccag
      721 ggacccgtaa tttatgatcc agcctccttc tatggccatt ctgagtttga actggccatt
      781 gcatcgatgt ttggggggtt ccccagatcc ttcttcactg cctaccatcg gaagatccca
      841 aaggctccag ggttcgacaa gcgcctgctg ctgtaccagc tctttaacta cctaaaccac
      901 tggaaccact ttggacggga gtacagaagc ccgtccctgg gggtgatgag gaagctgctc
      961 aggtagcaga gggctggacc taataaaatg tcaaactaga tcccta
//
