LOCUS       NM_010233               8425 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus fibronectin 1 (Fn1), transcript variant 1, mRNA.
ACCESSION   NM_010233 XM_129845
VERSION     NM_010233.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8425)
  AUTHORS   Wang,M., Liu,H., Zhang,M., Niu,X., Sun,M., Wang,F., Ni,Y., Hong,T.,
            Zhang,W. and Dang,S.
  TITLE     The secreted protease ADAMTS18 links early isoform transformation
            and maturation of glomerular basement membrane macromolecules to
            the integrity of the glomerular filtration barrier
  JOURNAL   Biochem Biophys Res Commun 750, 151386 (2025)
   PUBMED   39879696
REFERENCE   2  (bases 1 to 8425)
  AUTHORS   Zhang,J., Gao,J., Zeng,X., Wang,Z., Chen,C., Rong,C., Li,S.,
            Cai,L., Wang,L., Zhang,L. and Tian,Z.
  TITLE     A novel Cdc42-YAP-fibronectin signaling axis regulates ameloblast
            differentiation during early enamel formation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (2), 167570 (2025)
   PUBMED   39547518
REFERENCE   3  (bases 1 to 8425)
  AUTHORS   Eibach,Y., Kreher,S., Poetsch,M.S., Kho,A.L., Gaertner,U.,
            Clemen,C.S., Schroder,R., Guo,K., Milting,H., Meder,B., Potente,M.,
            Richter,M., Schneider,A., Meiners,S., Gautel,M. and Braun,T.
  TITLE     The deubiquitinase USP5 prevents accumulation of protein aggregates
            in cardiomyocytes
  JOURNAL   Sci Adv 11 (4), eado3852 (2025)
   PUBMED   39841822
REFERENCE   4  (bases 1 to 8425)
  AUTHORS   Arriagada,C., Lin,E., Schonning,M. and Astrof,S.
  TITLE     Mesodermal fibronectin controls cell shape, polarity, and
            mechanotransduction in the second heart field during cardiac
            outflow tract development
  JOURNAL   Dev Cell 60 (1), 62-84 (2025)
   PUBMED   39413783
REFERENCE   5  (bases 1 to 8425)
  AUTHORS   Siegerist,F., Kliewe,F., Hammer,E., Schakau,P., Chi Soh,J.E.,
            Weber,C., Lindenmeyer,M., Reichelt-Wurm,S., Drenic,V.,
            Chatziantoniou,C., Chadjichristos,C.E., Zhang,Y., Simm,S.,
            Banas,M.C., Nauck,M., Volker,U. and Endlich,N.
  TITLE     The role of the tricellular junction protein ILDR2 in
            glomerulopathies: Expression patterns and functional insights
  JOURNAL   iScience 27 (12), 111329 (2024)
   PUBMED   39640577
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8425)
  AUTHORS   Saga,Y., Yagi,T., Ikawa,Y., Sakakura,T. and Aizawa,S.
  TITLE     Mice develop normally without tenascin
  JOURNAL   Genes Dev 6 (10), 1821-1831 (1992)
   PUBMED   1383086
REFERENCE   7  (bases 1 to 8425)
  AUTHORS   Khandjian,E.W., Salomon,C., Leonard,N., Tremblay,S. and Turler,H.
  TITLE     Fibronectin gene expression in proliferating, quiescent, and
            SV40-infected mouse kidney cells
  JOURNAL   Exp Cell Res 202 (2), 464-470 (1992)
   PUBMED   1327855
REFERENCE   8  (bases 1 to 8425)
  AUTHORS   Vidal,S.M., Epstein,D.J., Malo,D., Weith,A., Vekemans,M. and
            Gros,P.
  TITLE     Identification and mapping of six microdissected genomic DNA probes
            to the proximal region of mouse chromosome 1
  JOURNAL   Genomics 14 (1), 32-37 (1992)
   PUBMED   1358796
REFERENCE   9  (bases 1 to 8425)
  AUTHORS   Malo,D., Schurr,E., Epstein,D.J., Vekemans,M., Skamene,E. and
            Gros,P.
  TITLE     The host resistance locus Bcg is tightly linked to a group of
            cytoskeleton-associated protein genes that include villin and
            desmin
  JOURNAL   Genomics 10 (2), 356-364 (1991)
   PUBMED   1676979
REFERENCE   10 (bases 1 to 8425)
  AUTHORS   Wartiovaara,J., Leivo,I. and Vaheri,A.
  TITLE     Expression of the cell surface-associated glycoprotein,
            fibronectin, in the early mouse embryo
  JOURNAL   Dev Biol 69 (1), 247-257 (1979)
   PUBMED   376373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ098561.1, CN534124.1, CF166960.1, CK638401.1, CK637170.1,
            CN538894.1, CN694596.1, CF727068.1, CN460535.1, AK133868.1 and
            AC124821.5.
            
            On Feb 9, 2013 this sequence version replaced NM_010233.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090135.1, AK090130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-461               CJ098561.1         2-462
            462-1082            CN534124.1         93-713
            1083-1479           CF166960.1         92-488
            1480-2166           CK638401.1         36-722
            2167-2699           CK637170.1         284-816
            2700-3359           CN538894.1         176-835
            3360-3864           CN694596.1         10-514
            3865-4416           CF727068.1         61-612
            4417-4518           CN460535.1         52-153
            4519-8376           AK133868.1         1-3858
            8377-8425           AC124821.5         29434-29482         c
FEATURES             Location/Qualifiers
     source          1..8425
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 36.05 cM"
     gene            1..8425
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /note="fibronectin 1"
                     /db_xref="GeneID:14268"
                     /db_xref="MGI:MGI:95566"
     exon            1..403
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..7686
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="fibronectin isoform a precursor"
                     /protein_id="NP_034363.1"
                     /db_xref="CCDS:CCDS15031.1"
                     /db_xref="GeneID:14268"
                     /db_xref="MGI:MGI:95566"
                     /translation="MLRGPGPGRLLLLAVLCLGTSVRCTEAGKSKRQAQQIVQPQSPV
                     AVSQSKPGCFDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEPEETCFDKY
                     TGNTYKVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDKWRRPHE
                     TGGYMLECLCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLG
                     EGNGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKCERHAL
                     QSASAGSGSFTDVRTAIYQPQTHPQPAPYGHCVTDSGVVYSVGMQWLKSQGNKQMLCT
                     CLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNY
                     EQDQKYSFCTDHAVLVQTRGGNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQ
                     NYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWAC
                     IPYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQCQDSET
                     RTFYQIGDSWEKFVHGVRYQCYCYGRGIGEWHCQPLQTYPGTTGPVQVIITETPSQPN
                     SHPIQWNAPEPSHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLI
                     SIQQYGHREVTRFDFTTSASTPVTSNTVTGETAPYSPVVATSESVTEITASSFVVSWV
                     SASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGKQ
                     SLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELN
                     LPETANSVTLSDLQPGVQYNITIYAVEENQESTPVFIQQETTGTPRSDNVPPPTDLQF
                     VELTDVKVTIMWTPPDSVVSGYRVEVLPVSLPGEHGQRLPVNRNTFAEITGLSPGVTY
                     LFKVFAVHQGRESNPLTAQQTTKLDAPTNLQFVNETDRTVLVTWTPPRARIAGYRLTA
                     GLTRGGQPKQYNVGPLASKYPLRNLQPGSEYTVTLVAVKGNQQSPKATGVFTTLQPLR
                     SIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGV
                     EYTYTIQVLRDGQERDAPIVNRVVTPLSPPTNLHLEANPDTGVLTVSWERSTTPDITG
                     YRITTTPTNGQQGTSLEEVVHADQSSCTFENLNPGLEYNVSVYTVKDDKESAPISDTV
                     VPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSVG
                     YYTVTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNIGPDTMRVTWA
                     PPPSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHE
                     SIPLRGRQKTGLDSPTGFDSSDITANSFTVHWVAPRAPITGYIIRHHAEHSVGRPRQD
                     RVPPSRNSITLTNLNPGTEYVVSIIAVNGREESPPLIGQQATVSDIPRDLEVIASTPT
                     SLLISWEPPAVSVRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYA
                     VTGRGDSPASSKPVSINYKTEIDKPSQMQVTDVQDNSISVRWLPSTSPVTGYRVTTTP
                     KNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNGESQPLVQTAVTNIDRPK
                     GLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIRELFPAPDGEDDTAELQGLRP
                     GSEYTVSVVALHDDMESQPLIGIQSTAIPAPTNLKFSQVTPTSFTAQWIAPSVQLTGY
                     RVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTLTSRPAQGVITT
                     LENVSPPRRARVTDATETTITISWRTKTETITGFQVDAIPANGQTPVQRSISPDVRSY
                     TITGLQPGTDYKIHLYTLNDNARSSPVIIDASTAIDAPSNLRFLTTTPNSLLVSWQAP
                     RARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEP
                     LIGRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFITNPGYDTENGIQLPGTTHQ
                     QPSVGQQMIFEEHGFRRTTPPTAATPVRLRPRPYLPNVDEEVQIGHVPRGDVDYHLYP
                     HVPGLNPNASTGQEALSQTTISWTPFQESSEYIISCQPVGTDEEPLQFQVPGTSTSAT
                     LTGLTRGVTYNIIVEALQNQRRHKVREEVVTVGNAVSEGLNQPTDDSCFDPYTVSHYA
                     IGEEWERLSDAGFKLTCQCLGFGSGHFRCDSSKWCHDNGVNYKIGEKWDRQGENGQRM
                     SCTCLGNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDN
                     CRRPGAAEPSPDGTTGHTYNQYTQRYNQRTNTNVNCPIECFMPLDVQADRDDSRE"
     exon            404..532
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..670
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..802
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..940
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1096
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1288
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1468
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1645
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1798
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1927
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2071
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2193
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2371
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2548
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2677
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2767
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2962
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3235
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3502
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3503..3597
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3598..3766
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3767..3853
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3854..4045
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4046..4318
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4319..4501
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4502..4591
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4592..4861
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4862..4978
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4979..5143
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5144..5299
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5300..5413
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5414..5683
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5684..5871
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5872..5959
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5960..6136
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6137..6226
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6227..6406
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6407..6496
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6497..6963
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6964..7102
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            7103..7267
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            7268..7393
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            7394..7500
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            7501..7614
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            7615..8425
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8356..8361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /note="hexamer: AATAAA"
     polyA_site      8376
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /note="major polyA site"
ORIGIN      
        1 agggcctcgt ggggggcggg aaggtactgt cccatataag cctctgctct tggggctcaa
       61 ccgctcgcac ccgctgcgct gcacaggggg agaaaaggag cccagggtgt gagccggaca
      121 acttctggtc ctctccttcc atctccttac cggcgtcccc acctcaggac ttttcccgca
      181 ggctgcgagg ggacccacag ttcgtggcca cttgcctcct ggggagggcg actctcctcc
      241 catccactca agatgctcag gggtccggga cccgggcggc tgctgctgct ggcagtcctg
      301 tgcctgggga cctcggtgcg ctgcaccgaa gccgggaaga gcaagaggca ggctcagcaa
      361 atcgtgcagc ctcaatcccc ggtggctgtc agtcagagca agcctggctg ttttgacaat
      421 gggaagcact atcagataaa tcagcagtgg gaacggacct acctaggcaa cgccctggtt
      481 tgtacctgct atggaggaag ccggggtttt aactgcgaga gcaagcctga gcctgaagag
      541 acttgctttg acaaatacac tgggaacact tacaaagtgg gtgacactta tgagcgccct
      601 aaagattcca tgatctggga ctgtacctgc atcggggctg ggagaggcag gatcagctgt
      661 accattgcaa atcgctgcca tgaagggggt cagtcctaca agattggcga caagtggagg
      721 aggccacatg agactggtgg ctacatgtta gagtgtctgt gtctgggaaa tggaaaaggg
      781 gaatggacct gcaaacctat agctgagaag tgttttgatc atgctgctgg gacgtcctac
      841 gtcgtggggg agacctggga aaagccctac caaggctgga tgatggtgga ctgtacttgt
      901 ctaggcgaag gcaatggacg catcacctgt acctccagaa acagatgcaa cgatcaggac
      961 acccggacat cctataggat tggagacacg tggagcaaga aggacaaccg aggaaacctg
     1021 cttcagtgtg tctgcacagg caatggcaga ggggagtgga agtgtgagcg acatgctcta
     1081 caaagtgctt cagccggatc tggctccttc actgatgtcc gaacagctat ttaccaaccg
     1141 cagactcacc cccagcccgc tccctacggc cactgtgtca ccgacagtgg tgtggtctac
     1201 tctgtgggaa tgcagtggct gaagtcgcaa ggaaacaagc aaatgctgtg cacgtgcctg
     1261 ggcaatggcg tcagctgcca ggagacagcc gtgacccaga cttatggtgg caattcaaac
     1321 ggggagccct gtgtcctccc gttcacctac aacggtagga ccttctattc ctgcaccacc
     1381 gaagggcggc aagacggaca tctgtggtgt agcacaactt ccaattacga acaagaccag
     1441 aagtattcct tctgcacaga ccatgcggtt ttggttcaga ctcgaggcgg aaattccaat
     1501 ggtgctctgt gccacttccc cttcctgtac aacaaccgga attacaccga ctgtacttct
     1561 gagggtcgca gggacaacat gaaatggtgc ggcaccaccc agaactacga tgccgatcag
     1621 aagtttggat tctgcccaat ggctgcccac gaggagatct gcacaaccaa tgaaggggtc
     1681 atgtatcgca ttggggatca gtgggataag cagcatgacc tgggccacat gatgaggtgc
     1741 acgtgtgtgg ggaacggtcg tggagaatgg gcctgcatcc cctactccca gctccgagac
     1801 cagtgcatcg ttgatgacat tacttacaat gtgaacgaca cgttccacaa gcgtcacgag
     1861 gagggacata tgctgaactg tacctgcttt ggtcagggcc ggggcagatg gaagtgtgac
     1921 cccattgacc agtgccaaga ttcagagacc cggacatttt accagattgg tgactcctgg
     1981 gagaagtttg tgcatggtgt ccgataccag tgttactgct acggccgtgg catcggggag
     2041 tggcactgtc aacctctgca gacctaccca ggcacaactg gacctgtcca agtaattatc
     2101 acggagaccc ccagccagcc caattcccac cccatccagt ggaatgcccc ggagccttca
     2161 cacatcacca agtacattct cagatggaga cctaaaacct ctacgggtcg ctggaaggaa
     2221 gctaccattc ctggccacct taactcctat accatcaaag gcctgacccc aggtgtgatc
     2281 tatgagggac agctcatcag catccagcag tatggccaca gagaagtgac acgcttcgac
     2341 ttcaccacca gcgccagcac ccctgtgacc agcaacacgg tgaccggaga gactgcgccc
     2401 tactctcctg ttgtggccac ttctgaatct gtaactgaaa tcacagccag cagctttgtg
     2461 gtctcatggg tctcagcctc cgacaccgtg tcaggcttcc gggtggagta tgagctgagc
     2521 gaggagggag atgaaccaca gtaccttgat ctcccaagca cggccacttc cgtgaacatt
     2581 cctgacctgc tcccgggcag aaagtacatt gtcaatgtct atcagatatc tgaggaggga
     2641 aaacagagct tgatcctgtc tacctcacag actacagcac ctgacgctcc tccagaccct
     2701 accgtggacc aggttgatga tacttccatt gttgttcggt ggagtagacc ccaggcacct
     2761 atcacagggt atagaattgt ctattcacct tcagtagaag gcagtagcac agagctcaac
     2821 ctccctgaaa cggccaactc cgtcaccctc agcgacctgc agcccggtgt tcagtacaac
     2881 atcactatct atgctgtgga ggagaaccag gagagcacac ccgttttcat ccaacaagag
     2941 accactggca ccccaagatc tgataacgtc ccccctccga cggacctaca gtttgtggaa
     3001 ctgactgatg tgaaagtcac catcatgtgg acccctcctg atagtgtggt gtctggatac
     3061 cgtgtggagg tcctgcctgt cagcctgccc ggggaacatg ggcagaggct gcctgtcaac
     3121 agaaatacct ttgctgaaat cactgggctg tcccctgggg tcacgtacct cttcaaagtc
     3181 tttgctgtgc accagggcag ggaaagcaat cctctgacgg cacaacagac caccaaactc
     3241 gacgctccca ctaacctcca gtttgtcaat gaaactgaca gaacagttct ggtaacgtgg
     3301 actccacctc gagcccgtat agcaggctac cgactgaccg cgggcctgac ccgaggaggc
     3361 cagcccaagc agtacaatgt gggacccttg gcctccaagt atcccctgag aaatctgcag
     3421 cctgggtctg agtacaccgt gaccttggtg gctgtgaaag ggaaccagca gagtcccaaa
     3481 gccaccggag tctttactac cctgcagcct ctgcgctcca ttccacctta caacaccgag
     3541 gtgacagaga ccacaattgt gatcacctgg acccccgctc caaggattgg cttcaagctg
     3601 ggtgtacgac cgagccaggg aggtgaggca ccccgagaag tgacttcaga ctctgggagc
     3661 attgttgtgt ctggcttgac tccaggcgtg gaatacactt acaccatcca agtcctgcga
     3721 gatggccagg agagagatgc accgattgtc aacagagtag tgacaccgct gtctccaccg
     3781 accaacttgc atctggaggc aaaccctgac actggagtgc ttactgtctc ctgggagagg
     3841 agcactaccc cagatatcac tggctacaga ataactacta cccccacgaa cgggcagcag
     3901 gggacctctc tggaagaagt ggtccatgct gatcagagtt cctgcacttt tgagaacctg
     3961 aatcctggcc tggagtacaa cgtcagtgtt tacactgtca aagatgacaa ggaaagtgcc
     4021 cctatctctg ataccgttgt cccagaggtg ccccagctca ctgacctaag ctttgttgat
     4081 ataactgatt caagcatcgg cctgaggtgg accccgctaa actcttccac cattatcggg
     4141 taccgaatca cagtagttgc ggcaggagaa gggatcccta tttttgaaga ttttgtggac
     4201 tcctcagtag gatactacac agttacaggg ctggagcctg gcattgacta tgacatcagc
     4261 gttatcactc tcattaatgg cggagagagt gcccctacta cactgacaca gcaaacggct
     4321 gtccctcctc ccacggatct gcgattcacc aatatcggtc cagacacgat gcgggtcact
     4381 tgggccccgc ctccgtccat cgagctgacc aacctcttgg tgcgctactc acccgtgaag
     4441 aatgaagagg acgttgcaga gctatccatt tcaccttcag acaatgccgt ggtcctaaca
     4501 aatctcctgc ctgggacaga atacttagtc agtgtctcca gtgtctacga acaacatgag
     4561 agcatccctc tccggggaag gcagaaaaca ggtctcgatt ccccaactgg ttttgattct
     4621 tctgatatca ccgccaactc attcactgtc cactgggtgg ctcctcgggc ccccatcacc
     4681 ggctacatca tccgccatca cgccgagcat tctgtcggaa gacccaggca ggatcgagtg
     4741 ccgccctcgc ggaattccat caccctcacc aaccttaatc cgggcaccga gtacgttgtc
     4801 agcatcattg ctgttaatgg cagagaggag agcccgccac tgattggcca gcaagccaca
     4861 gtttctgata ttccgagaga tctggaggtc attgcctcca cccccaccag cctgctcatc
     4921 agttgggaac cccctgccgt ctctgtgcgc tattacagaa tcacctacgg agagacagga
     4981 ggaaatagcc ctgtccagga gttcactgtg cccggaagca agtccacagc caccatcaac
     5041 aacattaaac caggagcaga ctacaccatc accctgtatg ctgtcactgg ccgtggggac
     5101 agtccagcaa gcagcaagcc agtttccatc aattataaaa cagaaattga caagccgtcc
     5161 cagatgcagg tgacagatgt ccaggacaac agcatcagtg tcaggtggct gccttcaact
     5221 tctcctgtga caggctacag agtgaccacc actcccaaaa atggcctagg accatcaaaa
     5281 actaaaactg ccagtccaga tcaaacagaa atgaccattg aaggtttgca acccactgtg
     5341 gagtacgtgg ttagtgttta tgctcagaac cggaacggag aaagccagcc cctggttcaa
     5401 actgcagtga ccaacattga tcgccctaaa ggactggcat tcactgatgt ggatgtcgat
     5461 tccatcaaaa ttgcttggga aagcccacag gggcaagttt ccaggtacag ggtgacctac
     5521 tcgagccctg aggatggaat ccgggagctt ttccctgcac ctgatggtga agacgacact
     5581 gcagagctgc agggcctcag gccggggtct gagtacacag tcagtgtggt tgccttgcac
     5641 gatgatatgg agagccagcc cctgattgga atccagtcca cagccattcc tgcgcccacc
     5701 aatctgaagt tcagtcaggt gacacccacc agctttactg cccagtggat agcacccagt
     5761 gttcagctca ctggctaccg ggtgcgggtg aacccgaaag agaagacagg accaatgaaa
     5821 gaaatcaacc tttctccaga cagctcatcg gtgattgtgt caggactcat ggtggccact
     5881 aaatacgaag tcagtgtcta tgctctcaag gacacactga caagcagacc agcccaggga
     5941 gtcatcacta ctctggagaa tgttagccct ccaagaaggg cccgtgtgac ggacgctaca
     6001 gagaccacca tcactattag ctggagaaca aagacagaga caatcactgg cttccaagtc
     6061 gatgccatcc cagccaatgg ccagacccca gttcagagga gcatcagccc ggatgttaga
     6121 agctacacca ttacaggttt acagccaggc actgactaca agatccacct gtacactctg
     6181 aacgacaatg cccggagctc gcccgtgatc atcgatgcct ccaccgccat cgacgcacca
     6241 tccaacctgc ggttcctgac caccacaccc aactccttgc tggtgtcatg gcaggcgccc
     6301 cgtgccagga ttactggcta cattatcaag tatgagaagc ctggatcccc tcccagagaa
     6361 gtggtccctc ggccccgccc tggtgtcacg gaggccacca ttactggtct ggagccagga
     6421 accgagtaca ccatctacgt cattgccctg aagaacaatc agaagagtga gcccctgatt
     6481 gggaggaaga agacagatga gcttccccaa ctggttaccc ttccacaccc caatcttcat
     6541 ggaccagaga tcttggatgt tccctccaca gttcaaaaga cccccttcat caccaaccct
     6601 gggtatgaca ccgaaaatgg tattcagctt cctggcacaa cccaccagca acccagtgtt
     6661 gggcaacaaa tgatctttga ggaacatggc tttaggcgga caacgccacc cactgcggcc
     6721 acccccgtca ggcttaggcc aagaccatac ctgccgaatg tagatgagga ggtccaaatc
     6781 ggtcatgttc ccaggggaga cgtagactac cacctctatc ctcatgttcc gggcctcaat
     6841 ccaaatgcct ctacaggaca ggaagctctc tctcagacaa ccatctcttg gacgccgttc
     6901 caggagagtt ctgagtacat catttcatgc caaccagttg gcaccgacga agagccctta
     6961 cagttccaag ttcctggaac ttctaccagt gcgactctga ctggccttac cagaggggtc
     7021 acctacaaca tcatagtgga ggcactgcag aaccagagga ggcacaaggt tcgggaagag
     7081 gttgtgactg tgggcaacgc tgtcagcgaa ggcctgaacc agcctacaga tgactcatgc
     7141 tttgaccctt acacggtttc ccattacgcc attggagagg agtgggagcg gttgtctgac
     7201 gctggcttta agctcacatg ccagtgcttg ggctttggca gtggtcattt cagatgcgat
     7261 tcatctaaat ggtgccatga caacggtgtc aactacaaga tcggagagaa gtgggatcgg
     7321 cagggagaaa atggccagcg gatgagctgc acatgcctcg ggaatggaaa gggagaattc
     7381 aagtgtgatc cccatgaagc aacgtgctat gacgatggga agacctacca tgtaggagaa
     7441 cagtggcaga aagaatatct cggagccatt tgctcctgca cgtgtttcgg aggccagcgg
     7501 ggctggcgct gtgacaactg ccgtagacct ggggctgctg aacccagtcc cgatggcacc
     7561 accggccaca cctacaacca gtatacacag agatacaatc agagaacaaa cactaacgta
     7621 aattgcccca ttgagtgctt catgccgcta gatgtgcaag ctgacagaga cgattctcga
     7681 gagtaatctt tccagcccca ccctacaagt gtctctctac caaggtcaat ccacacccca
     7741 gtgatgttag cagaccctcc atctttgagt ggtcctttca cccttaagcc ttttgctctg
     7801 gagccatgtt ctcagcttca gcacaattta cagcttctcc aagcatcgcc ccgtgggatg
     7861 ttttgagact tctctcctca atggtgacag ttggtcaccc tgttctgctt cagggtttca
     7921 gtactgctca gtgttgttta agagaatcaa aagttcttat ggtttggtct gggatcaata
     7981 gggaaacaca ggtagccaac taggaggaaa tgtactgaat gctagtaccc aagaccttga
     8041 gcaggaaagt cacccagaca cctctgcttt cttttgccat ctgacctgca gcactgtcag
     8101 gacatggcct gtggctgtgt gttcaaacac ccctcccaca ggactcactt tgtcccaaca
     8161 attcagattg cctagaaata cctttctctt acctgtttgt tatttatcaa tttttcccag
     8221 tatttttata cggaaaaaat tgtattgaag acactttgta tgcagttgat aagaggaatt
     8281 cagtataatt atggttggtg attattttta taagcacatg ccaacgcttt actactgtgg
     8341 aaagacaagt gttttaataa aaagatttac attccatgat gtggacgtca tttctttttt
     8401 tttttaacat catgtgtttg gagag
//
