LOCUS       NM_008031               4368 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus fragile X messenger ribonucleoprotein 1 (Fmr1),
            transcript variant 1, mRNA.
ACCESSION   NM_008031 XM_907445
VERSION     NM_008031.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4368)
  AUTHORS   Tuma,J., Rana,A.N., Philip,T., Park,J.B. and Lee,H.Y.
  TITLE     Altered olfactory responses in Fmr1 KO mice
  JOURNAL   Sci Rep 15 (1), 2952 (2025)
   PUBMED   39848954
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4368)
  AUTHORS   Ohnami,S., Naito,M., Kawase,H., Higuchi,M., Hasebe,S., Takasu,K.,
            Kanemaru,R., Azuma,Y., Yokoyama,R., Kochi,T., Imado,E., Tahara,T.,
            Kotake,Y., Asano,S., Oishi,N., Takuma,K., Hashimoto,H., Ogawa,K.,
            Nakamura,A., Yamakawa,H. and Ago,Y.
  TITLE     Brain region-specific neural activation by low-dose opioid promotes
            social behavior
  JOURNAL   JCI Insight 9 (23), e182060 (2024)
   PUBMED   39641273
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4368)
  AUTHORS   Uneri,A., McArdle,C.J., Deng,Z., Barth,S.H., Keene,D., Craft,S. and
            Raab-Graham,K.F.
  TITLE     DJ-1-mediated repression of the RNA-binding protein FMRP is
            predicted to impact known Alzheimer's disease-related protein
            networks
  JOURNAL   J Alzheimers Dis 102 (3), 763-777 (2024)
   PUBMED   39610285
REFERENCE   4  (bases 1 to 4368)
  AUTHORS   Napier,M., Kumar,A., Szulist,N., Martin,D. and Scott,A.L.
  TITLE     P2X7 expression patterns in the developing Fmr1-knockout mouse
            hippocampus
  JOURNAL   Hippocampus 34 (11), 633-644 (2024)
   PUBMED   39269925
  REMARK    GeneRIF: P2X7 expression patterns in the developing Fmr1-knockout
            mouse hippocampus.
REFERENCE   5  (bases 1 to 4368)
  AUTHORS   McCarthy,D.M., Vied,C., Trupiano,M.X., Canekeratne,A.J., Wang,Y.,
            Schatschneider,C. and Bhide,P.G.
  TITLE     Behavioral, neurotransmitter and transcriptomic analyses in male
            and female Fmr1 KO mice
  JOURNAL   Front Behav Neurosci 18, 1458502 (2024)
   PUBMED   39308631
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4368)
  AUTHORS   Verheij,C., de Graaff,E., Bakker,C.E., Willemsen,R., Willems,P.J.,
            Meijer,N., Galjaard,H., Reuser,A.J., Oostra,B.A. and Hoogeveen,A.T.
  TITLE     Characterization of FMR1 proteins isolated from different tissues
  JOURNAL   Hum Mol Genet 4 (5), 895-901 (1995)
   PUBMED   7633450
REFERENCE   7  (bases 1 to 4368)
  AUTHORS   Khandjian,E.W., Fortin,A., Thibodeau,A., Tremblay,S., Cote,F.,
            Devys,D., Mandel,J.L. and Rousseau,F.
  TITLE     A heterogeneous set of FMR1 proteins is widely distributed in mouse
            tissues and is modulated in cell culture
  JOURNAL   Hum Mol Genet 4 (5), 783-789 (1995)
   PUBMED   7633436
REFERENCE   8  (bases 1 to 4368)
  AUTHORS   Laval,S.H., Blair,H.J., Hirst,M.C., Davies,K.E. and Boyd,Y.
  TITLE     Mapping of FMR1, the gene implicated in fragile X-linked mental
            retardation, on the mouse X chromosome
  JOURNAL   Genomics 12 (4), 818-821 (1992)
   PUBMED   1572655
REFERENCE   9  (bases 1 to 4368)
  AUTHORS   Faust,C.J., Verkerk,A.J., Wilson,P.J., Morris,C.P., Hopwood,J.J.,
            Oostra,B.A. and Herman,G.E.
  TITLE     Genetic mapping on the mouse X chromosome of human cDNA clones for
            the fragile X and Hunter syndromes
  JOURNAL   Genomics 12 (4), 814-817 (1992)
   PUBMED   1572654
REFERENCE   10 (bases 1 to 4368)
  AUTHORS   Mandel,J.L., Arveiler,B., Camerino,G., Hanauer,A., Heilig,R.,
            Koenig,M. and Oberle,I.
  TITLE     Genetic mapping of the human X chromosome: linkage analysis of the
            q26-q28 region that includes the fragile X locus and isolation of
            expressed sequences
  JOURNAL   Cold Spring Harb Symp Quant Biol 51 Pt 1, 195-203 (1986)
   PUBMED   3472716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC055766.31.
            
            On Sep 14, 2022 this sequence version replaced NM_008031.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079671.1, SRR13948564.2167652.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               AC055766.31        178436-178721       c
            287-339             AC055766.31        168969-169021       c
            340-433             AC055766.31        165709-165802       c
            434-505             AC055766.31        162218-162289       c
            506-654             AC055766.31        161666-161814       c
            655-748             AC055766.31        159542-159635       c
            749-865             AC055766.31        159339-159455       c
            866-1036            AC055766.31        157073-157243       c
            1037-1115           AC055766.31        156883-156961       c
            1116-1225           AC055766.31        153531-153640       c
            1226-1357           AC055766.31        151923-152054       c
            1358-1420           AC055766.31        151380-151442       c
            1421-1507           AC055766.31        149175-149261       c
            1508-1703           AC055766.31        146524-146719       c
            1704-1886           AC055766.31        144890-145072       c
            1887-1969           AC055766.31        143980-144062       c
            1970-4368           AC055766.31        139340-141738       c
FEATURES             Location/Qualifiers
     source          1..4368
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 34.83 cM"
     gene            1..4368
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /note="fragile X messenger ribonucleoprotein 1"
                     /db_xref="GeneID:14265"
                     /db_xref="MGI:MGI:95564"
     exon            1..286
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..2080
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /note="isoform 1 is encoded by transcript variant 1; FMRP
                     translational regulator 1; synaptic functional regulator
                     FMR1"
                     /codon_start=1
                     /product="fragile X messenger ribonucleoprotein 1 isoform
                     1"
                     /protein_id="NP_032057.2"
                     /db_xref="CCDS:CCDS30171.1"
                     /db_xref="GeneID:14265"
                     /db_xref="MGI:MGI:95564"
                     /translation="MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPERQIPF
                     HDVRFPPPVGYNKDINESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDAT
                     YNEIVTIERLRSVNPNKPATKDTFHKIKLEVPEDLRQMCAKESAHKDFKKAVGAFSVT
                     YDPENYQLVILSINEVTSKRAHMLIDMHFRSLRTKLSLILRNEEASKQLESSRQLASR
                     FHEQFIVREDLMGLAIGTHGANIQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKAR
                     SFLEFAEDVIQVPRNLVGKVIGKNGKLIQEIVDKSGVVRVRIEAENEKSVPQEEEIMP
                     PSSLPSNNSRVGPNSSEEKKHLDTKENTHFSQPNSTKVQRVLVVSSIVAGGPQKPEPK
                     AWQGMVPFVFVGTKDSIANATVLLDYHLNYLKEVDQLRLERLQIDEQLRQIGASSRPP
                     PNRTDKEKGYVTDDGQGMGRGSRPYRNRGHGRRGPGYTSGTNSEASNASETESDHRDE
                     LSDWSLAPTEEERESFLRRGDGRRRGGGGRGQGGRGRGGGFKGNDDHSRTDNRPRNPR
                     EAKGRTADGSLQSASSEGSRLRTGKDRNQKKEKPDSVDGLQPLVNGVP"
     exon            287..339
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            340..433
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            434..505
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            506..654
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            655..748
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            749..865
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1036
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1115
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1225
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1357
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1420
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1507
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1703
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1886
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1969
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..4368
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3849..3854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /note="hexamer: AATAAA"
     polyA_site      3875
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /note="major polyA site"
     regulatory      4285..4290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /note="hexamer: ATTAAA"
     polyA_site      4306
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
     regulatory      4338..4343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /note="hexamer: ATTAAA"
     polyA_site      4368
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /note="major polyA site"
ORIGIN      
        1 agtcagtcag gcgctgggga gcgtttcggt ttcacttccg gtgaggggcc gcgcctgaga
       61 gggcgggcag tgaagcaaac ggacggcgag cgcgggcggt ggcagtgacg gcggcgccgc
      121 tgccgggggg cgtgcggtaa cgcggcggcg gcggcggcgg cgacggcggc tgggcctcaa
      181 gcgcctgcag cccacctccc ggaggcgggc tcccggcgcg aggacggacg agaagatgga
      241 ggagctggtg gtggaagtgc ggggctccaa tggcgctttc tacaaggcat ttgtaaaaga
      301 tgtccatgaa gattctataa cagttgcttt tgaaaacaac tggcaaccag agagacagat
      361 tccattccat gatgtgagat tcccaccacc tgtaggttat aataaagata taaacgaaag
      421 tgatgaagtt gaggtttatt ccagagcaaa tgaaaaagag ccttgctgtt ggtggttagc
      481 taaagtgagg atgataaagg gtgagtttta tgtgatagaa tatgcagcat gtgatgctac
      541 gtataatgaa attgtcacaa ttgagcgtct acgatctgtt aatcccaaca aacctgctac
      601 aaaagatact ttccataaga tcaagctgga ggtgccagaa gatttacgac aaatgtgtgc
      661 caaagaatca gcacataagg attttaaaaa ggcagttggt gccttctctg taacttatga
      721 tccagaaaat tatcagctgg taattttgtc catcaatgaa gtcacctcaa agcgagccca
      781 catgttgatt gacatgcact ttcgaagtct gcgcaccaag ttgtctctta tactgagaaa
      841 tgaagaagcc agtaaacaac tggagagttc aaggcagctt gcctcaagat ttcatgaaca
      901 gtttatcgta cgagaagatc tgatgggttt agctattggt actcatggtg ctaatattca
      961 gcaagctaga aaagtgcctg gcgtcactgc tattgattta gatgaggata cctgcacatt
     1021 tcatatttat ggagaggatc aagatgcagt gaaaaaggct agaagctttc tggaatttgc
     1081 tgaagatgtc atacaggttc cacgaaactt agtaggcaaa gtaataggaa aaaatggaaa
     1141 gctgattcaa gagatcgtgg acaagtcagg agttgtgagg gtgaggattg aggctgaaaa
     1201 tgagaaaagt gtcccacaag aagaggaaat tatgccacca agttccctac cttccaataa
     1261 ttcaagggtt ggacctaact cctctgaaga aaagaaacat ttagatacaa aggaaaacac
     1321 ccatttttct caacctaaca gtacaaaagt ccagagggtg ttagtggttt catcaattgt
     1381 agcaggggga ccccagaaac ctgaacccaa ggcttggcag ggtatggtac catttgtttt
     1441 tgtgggaaca aaagacagca tcgctaatgc cactgttctt ttggattatc acctgaacta
     1501 tttaaaggaa gtagaccagt tgcgtttgga gagattacaa attgatgagc agttgcgaca
     1561 aattggagct agttctagac caccaccaaa tcgtacagat aaggaaaaag gctatgtgac
     1621 tgatgatggt caaggaatgg gtcgaggtag tagaccttac agaaataggg ggcacggcag
     1681 acgcggtcct ggatatactt caggaactaa ttctgaagca tcaaatgctt ctgaaacaga
     1741 atctgaccac agagacgaac tcagtgattg gtcattagct ccaacagagg aagagaggga
     1801 gagcttcctg cgcagaggag acggacggcg gcgtggagga ggaggaagag gacaaggagg
     1861 aagaggaaga ggaggaggct tcaaaggaaa cgacgatcat tcccgaacag ataatcgtcc
     1921 acgtaatcca agagaggcta aaggaagaac agctgatgga tccctgcaga gtgcctccag
     1981 tgaagggagc cggctgcgca cgggtaaaga tcgtaaccag aagaaggaaa agccagacag
     2041 cgtagatggg ctgcaaccgc tggtgaatgg agtaccctaa ataagctaca taattccgaa
     2101 gttatatttc ctctaccatt tccgtaattc ttactccatt ttagaaaact ttgttaggcc
     2161 aaagacaaat agtaggcaag atggcacagg gcatgaagtg aacacaaatt ctgcaaagaa
     2221 tttttttgat attggcaata atcaacaatc ttccagattt gcacaaaaag atcttgaaat
     2281 ttgatgcata acttttaagt acacttaaca cttcagggca ggattttact tttatttttt
     2341 aaaaatacta agcagtgatc tttattaact aggaccattt tcctgaattg gactatataa
     2401 ctcagcagta tgtttcagtc tttcggagta aatcacattt gtgataatca tactagatct
     2461 ctgtcttcag tctcatttaa agtcttcatg aaatgctgtg ccatttcatg tcctgtgtca
     2521 gtttatgttt tggtccactt ttccagtatt ttagtggacc ctgaaatgtg tgtgatgtga
     2581 catttgttat tttcattagc aaaaaaaaga gttgtatgat ctgtgccttt tttatatctt
     2641 ggcaggtagg aatattatat ttggatgcag agttcaggga agataagttg gaaacactaa
     2701 atgttaaaga tgtagcaaac cctgtcaaac attagtactt tttagaagaa tgcatgcttt
     2761 ccatattttt ttccttacat aaacatcagc ttaggcagta taaaaaatag gacttgtttt
     2821 ttgtttttgt tttgttgcac tgaagtatga caaatagtgt tattggaagg gatgtgtaat
     2881 ttttctgtat agacaggaga agaaataact atcttttcat ttgggagagg ctaaagatgt
     2941 tttcagctac ttgcaaatct tcctggtcga aagttagtag gatatgcctg ctctttggcc
     3001 tgatgacgaa tttcaacttt gaaacatttt cttttgtcct ccccaaattt tgtcaagttt
     3061 tttcattcat attttacatt aaagcttatt ttggggagat atgaaggtca tcttcataaa
     3121 tacataacaa ccctcaaaag tatataggta ctttgtctga gaaacattga aagcaggtta
     3181 aatgttttgt aactttgaaa tacaaagtct aatgcataag cagaaccgaa aagcagaccg
     3241 acaattggtt aacaaataat tctttttttt tcttttttga tgtgttgagt cttatttttg
     3301 tggggttttt ttctctcttt ttttttaaat gactgaaatt cactgaagaa aaatatgtga
     3361 aggaccttca ctctgagatg ttatattttt ttttaaaaat aactctgagt aggggtacca
     3421 ctgaatctgt acagagccgt acaaaccgaa gttctgcctc tgatgtactt tgtgaatttg
     3481 tttctttgaa ttttcatttt tcatttagtt ttccttgcat acaaataagc atataaaatg
     3541 gcaacaaact gcacatgatt tcacaaatat taaaatgtct tttaaaaagt attgccaaac
     3601 agtaatgttg atttctagtt atttattctg ggaatgtata gtatttgaaa acagaaattg
     3661 gtaccttgca cacatcatct gtaaactgtt cagtttaaaa tactgtagat aattaaccaa
     3721 ggtagaatga ccttgtaatg taactgctct tgggcaatat tctctgtaca tattagcgac
     3781 aacagattgg attttatgtt gacatttgtt tggttatagt gcaatatatt ttgtatgcaa
     3841 acagtttcaa taaagtttga tcttcctctg ctaaattgat gttgatgcaa tccttacaat
     3901 gattgctttt aaaattttaa gataggaaag aaatctatag aaagtgttct gttacaaaat
     3961 gtaactgtta ccattggaaa tttcacatgt caaaggaggt tagccgttat ttaccaactt
     4021 tcaagaacgt aatcttgttc aataaggtga aatatcaatg attggtacac agtcacaatg
     4081 taccgttaaa atatgcacta agtctctttt ttttacaaag gctgaattca gcaaggcgct
     4141 aacttgctta aatgtgaatt actaacttct aaaactgtaa tttgattcac atcttttcaa
     4201 atggagttgg agttgattca tattacaata tttgtgtgca aaatgtgtat gtttttcagt
     4261 ttaaagtcat gtttttaaaa tcttattaaa gtttcaaaaa tctgaagatt gtttatctta
     4321 tctagatgta aatttttatt aaaaagttgc acttatgaaa aagcaaaa
//
