LOCUS       NM_021355               3123 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus fibromodulin (Fmod), mRNA.
ACCESSION   NM_021355 XM_977969
VERSION     NM_021355.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3123)
  AUTHORS   Huang,X., Zhu,Z., Du,M., Wu,C., Fu,J., Zhang,J., Tan,W., Wu,B.,
            Liu,L. and Liao,Z.B.
  TITLE     FMOD Alleviates Depression-Like Behaviors by Targeting the
            PI3K/AKT/mTOR Signaling After Traumatic Brain Injury
  JOURNAL   Neuromolecular Med 26 (1), 24 (2024)
   PUBMED   38864941
  REMARK    GeneRIF: FMOD Alleviates Depression-Like Behaviors by Targeting the
            PI3K/AKT/mTOR Signaling After Traumatic Brain Injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3123)
  AUTHORS   Halasi,M., Talmon,A., Tal,Y., Yosipovitch,G. and Adini,I.
  TITLE     Dark pigmentation and related low FMOD expression increase IL-3 and
            facilitateplasmacytoid dendritic cell maturation
  JOURNAL   Clin Immunol 251, 109638 (2023)
   PUBMED   37149118
  REMARK    GeneRIF: Dark pigmentation and related low FMOD expression increase
            IL-3 and facilitateplasmacytoid dendritic cell maturation.
REFERENCE   3  (bases 1 to 3123)
  AUTHORS   Castillo,V., Diaz-Astudillo,P., Corrales-Orovio,R., San Martin,S.
            and Egana,J.T.
  TITLE     Comprehensive Characterization of Tissues Derived from Animals at
            Different Regenerative Stages: A Comparative Analysis between Fetal
            and Adult Mouse Skin
  JOURNAL   Cells 12 (9), 1215 (2023)
   PUBMED   37174615
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3123)
  AUTHORS   Brutsch,S.M., Madzharova,E., Pantasis,S., Wustemann,T., Gurri,S.,
            Steenbock,H., Gazdhar,A., Kuhn,G., Angel,P., Bellusci,S.,
            Brinckmann,J., Auf dem Keller,U., Werner,S. and Bordoli,M.R.
  TITLE     Mesenchyme-derived vertebrate lonesome kinase controls lung
            organogenesis by altering the matrisome
  JOURNAL   Cell Mol Life Sci 80 (4), 89 (2023)
   PUBMED   36920550
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3123)
  AUTHORS   Chen,A., Liao,S., Cheng,M., Ma,K., Wu,L., Lai,Y., Qiu,X., Yang,J.,
            Xu,J., Hao,S., Wang,X., Lu,H., Chen,X., Liu,X., Huang,X., Li,Z.,
            Hong,Y., Jiang,Y., Peng,J., Liu,S., Shen,M., Liu,C., Li,Q.,
            Yuan,Y., Wei,X., Zheng,H., Feng,W., Wang,Z., Liu,Y., Wang,Z.,
            Yang,Y., Xiang,H., Han,L., Qin,B., Guo,P., Lai,G.,
            Munoz-Canoves,P., Maxwell,P.H., Thiery,J.P., Wu,Q.F., Zhao,F.,
            Chen,B., Li,M., Dai,X., Wang,S., Kuang,H., Hui,J., Wang,L.,
            Fei,J.F., Wang,O., Wei,X., Lu,H., Wang,B., Liu,S., Gu,Y., Ni,M.,
            Zhang,W., Mu,F., Yin,Y., Yang,H., Lisby,M., Cornall,R.J.,
            Mulder,J., Uhlen,M., Esteban,M.A., Li,Y., Liu,L., Xu,X. and Wang,J.
  TITLE     Spatiotemporal transcriptomic atlas of mouse organogenesis using
            DNA nanoball-patterned arrays
  JOURNAL   Cell 185 (10), 1777-1792 (2022)
   PUBMED   35512705
REFERENCE   6  (bases 1 to 3123)
  AUTHORS   Ezura,Y., Chakravarti,S., Oldberg,A., Chervoneva,I. and Birk,D.E.
  TITLE     Differential expression of lumican and fibromodulin regulate
            collagen fibrillogenesis in developing mouse tendons
  JOURNAL   J Cell Biol 151 (4), 779-788 (2000)
   PUBMED   11076963
REFERENCE   7  (bases 1 to 3123)
  AUTHORS   Neidhardt,L., Gasca,S., Wertz,K., Obermayr,F., Worpenberg,S.,
            Lehrach,H. and Herrmann,B.G.
  TITLE     Large-scale screen for genes controlling mammalian embryogenesis,
            using high-throughput gene expression analysis in mouse embryos
  JOURNAL   Mech Dev 98 (1-2), 77-94 (2000)
   PUBMED   11044609
REFERENCE   8  (bases 1 to 3123)
  AUTHORS   Murphy,J.M., Heinegard,R., McIntosh,A., Sterchi,D. and Barry,F.P.
  TITLE     Distribution of cartilage molecules in the developing mouse joint
  JOURNAL   Matrix Biol 18 (5), 487-497 (1999)
   PUBMED   10601736
REFERENCE   9  (bases 1 to 3123)
  AUTHORS   Svensson,L., Aszodi,A., Reinholt,F.P., Fassler,R., Heinegard,D. and
            Oldberg,A.
  TITLE     Fibromodulin-null mice have abnormal collagen fibrils, tissue
            organization, and altered lumican deposition in tendon
  JOURNAL   J Biol Chem 274 (14), 9636-9647 (1999)
   PUBMED   10092650
REFERENCE   10 (bases 1 to 3123)
  AUTHORS   Aszodi,A., Chan,D., Hunziker,E., Bateman,J.F. and Fassler,R.
  TITLE     Collagen II is essential for the removal of the notochord and the
            formation of intervertebral discs
  JOURNAL   J Cell Biol 143 (5), 1399-1412 (1998)
   PUBMED   9832566
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154872.10 and AK032302.1.
            
            On Feb 14, 2018 this sequence version replaced NM_021355.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032302.1, BC064779.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               AC154872.10        132799-133059
            262-3120            AK032302.1         2-2860
            3121-3123           AC154872.10        143823-143825
FEATURES             Location/Qualifiers
     source          1..3123
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.09 cM"
     gene            1..3123
                     /gene="Fmod"
                     /gene_synonym="FM; SLRR2E"
                     /note="fibromodulin"
                     /db_xref="GeneID:14264"
                     /db_xref="MGI:MGI:1328364"
     exon            1..329
                     /gene="Fmod"
                     /gene_synonym="FM; SLRR2E"
                     /inference="alignment:Splign:2.1.0"
     exon            330..1316
                     /gene="Fmod"
                     /gene_synonym="FM; SLRR2E"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..1468
                     /gene="Fmod"
                     /gene_synonym="FM; SLRR2E"
                     /note="KSPG fibromodulin; collagen-binding 59 kDa protein;
                     keratan sulfate proteoglycan fibromodulin"
                     /codon_start=1
                     /product="fibromodulin precursor"
                     /protein_id="NP_067330.1"
                     /db_xref="CCDS:CCDS15301.1"
                     /db_xref="GeneID:14264"
                     /db_xref="MGI:MGI:1328364"
                     /translation="MQWASVLLLAGLCSLSQGQYDEDSHWWIQYLRNQQSTYYDPYDP
                     YPYEPSEPYPYGVEEGPAYAYGAPPPPEPRDCPQECDCPPNFPTAMYCDNRNLKYLPF
                     VPSRMKYVYFQNNQISAIQEGVFDNATGLLWVALHGNQITSDKVGRKVFSKLRHLERL
                     YLDHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLENLTALYLHHNEIQEVGSS
                     MRGLRSLILLDLSYNHLRRVPDGLPSALEQLYLEHNNVYTVPDSYFRGSPKLLYVRLS
                     HNSLTNNGLATNTFNSSSLLELDLSYNQLQKIPPVNTNLENLYLQGNRINEFSISSFC
                     TVVDVMNFSKLQVLRLDGNEIKRSAMPVDAPLCLRLANLIEI"
     exon            1317..3123
                     /gene="Fmod"
                     /gene_synonym="FM; SLRR2E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2981..2986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fmod"
                     /gene_synonym="FM; SLRR2E"
                     /note="hexamer: AATAAA"
     polyA_site      3003
                     /gene="Fmod"
                     /gene_synonym="FM; SLRR2E"
                     /note="major polyA site"
     regulatory      3089..3094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fmod"
                     /gene_synonym="FM; SLRR2E"
                     /note="hexamer: TATAAA"
     polyA_site      3117
                     /gene="Fmod"
                     /gene_synonym="FM; SLRR2E"
ORIGIN      
        1 gctaacttat tcagcagcaa gagacttcag gctgccaatg ctccagggaa gataacccag
       61 tggaaagaag gtggttttta cagcctgggt cggacggaat tttgcagagc tgagtgtgag
      121 ctccgcccct tacaggactg aaaaagccag cttaggctcc tcagcccctc tttgagatat
      181 ttgattagga atttgggggc gggccctggc ctggcacaga cttgcacact ctccgtaggc
      241 gctcactcct ctcttccctc tctgccacat tctccaaccc aaggagacca gacagaagga
      301 cgtggtcact ctgaacagtt caacccaaga gacaaaaatg cagtgggcct ccgtcctgct
      361 gctggctggg ctctgctcac tttcccaggg ccagtatgat gaagactctc actggtggat
      421 ccaatacctc cgaaaccagc agtccaccta ctacgacccc tatgaccctt acccctatga
      481 gccctctgag ccttacccct atggagtgga agaaggccca gcctatgcct atggtgcacc
      541 acctccacca gagccccgtg attgtcccca agaatgcgac tgtcccccca acttccccac
      601 agccatgtac tgtgacaacc gcaacctcaa gtacctgcct tttgtgccct cccgcatgaa
      661 gtacgtctac ttccagaaca accagatctc tgccatccag gaaggtgtct ttgacaatgc
      721 cactgggctc ctctgggtcg ctctacatgg caaccagatt accagtgaca aggtaggcag
      781 gaaagtcttc tccaagctga ggcacttgga gaggctgtac ttggaccaca acaacctgac
      841 ccggatgccc ggcccgctgc cccgatccct gagagagctc cacctggacc acaaccagat
      901 ctcacgggtc cccaacaatg ctttggaggg cctggagaac ctcacggcct tatatctcca
      961 ccacaatgag atccaggaag tggggagttc catgagaggc ctccggtccc tgatcctact
     1021 agacctgagt tataaccacc ttcggagggt acccgacggt ctgccctcag ccctggagca
     1081 gctgtaccta gaacacaaca atgtctacac cgtccctgac agctacttcc gggggtcacc
     1141 caagctgctg tacgtccggt tgtctcacaa cagtctcact aacaacggcc ttgctaccaa
     1201 caccttcaac tccagcagcc ttcttgagct agacttgtct tacaatcagc tgcagaagat
     1261 ccctcctgtc aacaccaacc tggagaatct ttacctccag ggcaacagga tcaatgagtt
     1321 ctccatcagc agcttctgca cggtggtgga cgtcatgaac ttctccaagc tgcaggtgct
     1381 acgcctggat gggaacgaga tcaagcgcag cgcaatgccg gtggacgccc cactctgcct
     1441 gcgcctcgcc aacctcatcg agatctgagg ggcctcgcct tgggctcctg gctccgggct
     1501 ccgagtaccg tgcaccgtgc accgggctcg gggtacatgc cctgccaccc cgctgcatgt
     1561 ttggcttttg ctggatggtc tgggacacgc atgtgacaga agtccacagg atcttattca
     1621 atctccttcc aacaggcaga gttaggtggg atcaggggcc aggccagttt ctgcaggggg
     1681 atgaatttgg tggtaaaaga aatatagcta tagagtctag ccccaaaatc ttcttgcttg
     1741 gacagtagca tataaccagt tccaatttga ccttttttga gctgtgctca acagcatggc
     1801 cagctgcttc tgcagttgct ctgggctcct gctctttgct cctcaaaaca tcacaacaca
     1861 cctcttgccc agtcacctcc tcccagcccc agctcaccct ctctgccctc tttcactggg
     1921 gcctcttcta atgtcttagg cagtcaggag acacccacac cctaagggca cactcttatc
     1981 tgaggctaaa cggatggcta aaatcacaca cttaccccca cctcacctgt ttaaagtcac
     2041 catattgaac accataatga tgagctgtta acatagggga taaccgactc tataatggag
     2101 gatctatcag aggagggaag tgtccagtgg tcattatcag tatccatagt aagatgggga
     2161 agagacacac ctcaggatag cagaactgaa ggggcagccc cctttccagt ttcatctgac
     2221 acaacatgat ctgcacccct tcttgggctt ttagtatcga aggggcaagc gtggttttca
     2281 aaacatgaga aagagcctct gctcatcctt tggtctagta tgaagggttg ttacgcaaat
     2341 ggcagaggca gactccaccc gccgaggacc tacccactaa cccagactag ggggtgatct
     2401 caatagctcg tttgtccata atgctagagc atcaggaacc agccctgtgg agatgctcac
     2461 tggggtgcaa gaagccctgc caggcccaag tcctgccgac actagacctg gcttcctctg
     2521 cattcacact atgcagtccg ccttatgccc agtggtgcct gtgatttgta gtttgtctaa
     2581 gaacagcccc atcttctcct ttttaaaggt gatattgcct aggtacaacc aacagcttct
     2641 tctagacccc actgggatag agccaccagg gtagcgagtg gcaagaagca gttgtaagat
     2701 gctagcctga ggtgggtccc tgccttagac ccctgactct gtgtgcactt gggagcaagc
     2761 ttctctggaa aggacagggt ggggcggggt gcttagactg tgctacgggt tccagaactg
     2821 caatccacaa aagccaaacc agcttgtttc aaccggggag tgccacctgc ggagcaaggc
     2881 tgccctggcc agggttcttg ggaagcacct gcatgtatca ccatcctgcc tctgaagagc
     2941 cctcagcatg aagcaagcat gaatggcggc caacctaacc aataaagtta ttttataagt
     3001 gcatctgcaa ggatggaatg gttggtggca gccctcggca tcgcctcggg gtacctagac
     3061 acacaggcct tgaaccgtgt cagctcttta taaagagtag cctatataaa aactcaagtt
     3121 agc
//
