LOCUS       NP_067330                376 aa            linear   ROD 24-JUN-2024
DEFINITION  fibromodulin precursor [Mus musculus].
ACCESSION   NP_067330 XP_983063
VERSION     NP_067330.1
DBSOURCE    REFSEQ: accession NM_021355.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 376)
  AUTHORS   Huang,X., Zhu,Z., Du,M., Wu,C., Fu,J., Zhang,J., Tan,W., Wu,B.,
            Liu,L. and Liao,Z.B.
  TITLE     FMOD Alleviates Depression-Like Behaviors by Targeting the
            PI3K/AKT/mTOR Signaling After Traumatic Brain Injury
  JOURNAL   Neuromolecular Med 26 (1), 24 (2024)
   PUBMED   38864941
  REMARK    GeneRIF: FMOD Alleviates Depression-Like Behaviors by Targeting the
            PI3K/AKT/mTOR Signaling After Traumatic Brain Injury.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 376)
  AUTHORS   Halasi,M., Talmon,A., Tal,Y., Yosipovitch,G. and Adini,I.
  TITLE     Dark pigmentation and related low FMOD expression increase IL-3 and
            facilitateplasmacytoid dendritic cell maturation
  JOURNAL   Clin Immunol 251, 109638 (2023)
   PUBMED   37149118
  REMARK    GeneRIF: Dark pigmentation and related low FMOD expression increase
            IL-3 and facilitateplasmacytoid dendritic cell maturation.
REFERENCE   3  (residues 1 to 376)
  AUTHORS   Castillo,V., Diaz-Astudillo,P., Corrales-Orovio,R., San Martin,S.
            and Egana,J.T.
  TITLE     Comprehensive Characterization of Tissues Derived from Animals at
            Different Regenerative Stages: A Comparative Analysis between Fetal
            and Adult Mouse Skin
  JOURNAL   Cells 12 (9), 1215 (2023)
   PUBMED   37174615
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 376)
  AUTHORS   Brutsch,S.M., Madzharova,E., Pantasis,S., Wustemann,T., Gurri,S.,
            Steenbock,H., Gazdhar,A., Kuhn,G., Angel,P., Bellusci,S.,
            Brinckmann,J., Auf dem Keller,U., Werner,S. and Bordoli,M.R.
  TITLE     Mesenchyme-derived vertebrate lonesome kinase controls lung
            organogenesis by altering the matrisome
  JOURNAL   Cell Mol Life Sci 80 (4), 89 (2023)
   PUBMED   36920550
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 376)
  AUTHORS   Chen,A., Liao,S., Cheng,M., Ma,K., Wu,L., Lai,Y., Qiu,X., Yang,J.,
            Xu,J., Hao,S., Wang,X., Lu,H., Chen,X., Liu,X., Huang,X., Li,Z.,
            Hong,Y., Jiang,Y., Peng,J., Liu,S., Shen,M., Liu,C., Li,Q.,
            Yuan,Y., Wei,X., Zheng,H., Feng,W., Wang,Z., Liu,Y., Wang,Z.,
            Yang,Y., Xiang,H., Han,L., Qin,B., Guo,P., Lai,G.,
            Munoz-Canoves,P., Maxwell,P.H., Thiery,J.P., Wu,Q.F., Zhao,F.,
            Chen,B., Li,M., Dai,X., Wang,S., Kuang,H., Hui,J., Wang,L.,
            Fei,J.F., Wang,O., Wei,X., Lu,H., Wang,B., Liu,S., Gu,Y., Ni,M.,
            Zhang,W., Mu,F., Yin,Y., Yang,H., Lisby,M., Cornall,R.J.,
            Mulder,J., Uhlen,M., Esteban,M.A., Li,Y., Liu,L., Xu,X. and Wang,J.
  TITLE     Spatiotemporal transcriptomic atlas of mouse organogenesis using
            DNA nanoball-patterned arrays
  JOURNAL   Cell 185 (10), 1777-1792 (2022)
   PUBMED   35512705
REFERENCE   6  (residues 1 to 376)
  AUTHORS   Ezura,Y., Chakravarti,S., Oldberg,A., Chervoneva,I. and Birk,D.E.
  TITLE     Differential expression of lumican and fibromodulin regulate
            collagen fibrillogenesis in developing mouse tendons
  JOURNAL   J Cell Biol 151 (4), 779-788 (2000)
   PUBMED   11076963
REFERENCE   7  (residues 1 to 376)
  AUTHORS   Neidhardt,L., Gasca,S., Wertz,K., Obermayr,F., Worpenberg,S.,
            Lehrach,H. and Herrmann,B.G.
  TITLE     Large-scale screen for genes controlling mammalian embryogenesis,
            using high-throughput gene expression analysis in mouse embryos
  JOURNAL   Mech Dev 98 (1-2), 77-94 (2000)
   PUBMED   11044609
REFERENCE   8  (residues 1 to 376)
  AUTHORS   Murphy,J.M., Heinegard,R., McIntosh,A., Sterchi,D. and Barry,F.P.
  TITLE     Distribution of cartilage molecules in the developing mouse joint
  JOURNAL   Matrix Biol 18 (5), 487-497 (1999)
   PUBMED   10601736
REFERENCE   9  (residues 1 to 376)
  AUTHORS   Svensson,L., Aszodi,A., Reinholt,F.P., Fassler,R., Heinegard,D. and
            Oldberg,A.
  TITLE     Fibromodulin-null mice have abnormal collagen fibrils, tissue
            organization, and altered lumican deposition in tendon
  JOURNAL   J Biol Chem 274 (14), 9636-9647 (1999)
   PUBMED   10092650
REFERENCE   10 (residues 1 to 376)
  AUTHORS   Aszodi,A., Chan,D., Hunziker,E., Bateman,J.F. and Fassler,R.
  TITLE     Collagen II is essential for the removal of the notochord and the
            formation of intervertebral discs
  JOURNAL   J Cell Biol 143 (5), 1399-1412 (1998)
   PUBMED   9832566
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154872.10 and AK032302.1.
            
            On May 4, 2006 this sequence version replaced XP_983063.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032302.1, BC064779.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.09 cM"
     Protein         1..376
                     /product="fibromodulin precursor"
                     /note="KSPG fibromodulin; collagen-binding 59 kDa protein;
                     keratan sulfate proteoglycan fibromodulin"
                     /calculated_mol_wt=41196
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1877
     mat_peptide     19..376
                     /product="Fibromodulin. /id=PRO_0000032740"
                     /note="propagated from UniProtKB/Swiss-Prot (P50608.1)"
                     /calculated_mol_wt=41196
     Site            19
                     /site_type="pyrrolidone-carboxylic-acid"
                     /note="Pyrrolidone carboxylic acid.
                     /evidence=ECO:0000250|UniProtKB:P13605; propagated from
                     UniProtKB/Swiss-Prot (P50608.1)"
     Site            20
                     /site_type="sulfatation"
                     /note="Sulfotyrosine. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (P50608.1)"
     Site            38
                     /site_type="sulfatation"
                     /note="Sulfotyrosine. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (P50608.1)"
     Site            53
                     /site_type="sulfatation"
                     /note="Sulfotyrosine. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (P50608.1)"
     Site            55
                     /site_type="sulfatation"
                     /note="Sulfotyrosine. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (P50608.1)"
     Site            63
                     /site_type="sulfatation"
                     /note="Sulfotyrosine. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (P50608.1)"
     Site            65
                     /site_type="sulfatation"
                     /note="Sulfotyrosine. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (P50608.1)"
     Region          75..109
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          105..167
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          106..127
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P50608.1)"
     Region          107..130
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            127
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) (keratan sulfate) asparagine.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P50608.1)"
     Region          130..151
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P50608.1)"
     Region          131..156
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <147..>356
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          156..176
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (P50608.1)"
     Region          157..177
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            166
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) (keratan sulfate) asparagine.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P50608.1)"
     Region          177..198
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (P50608.1)"
     Region          178..201
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          201..222
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (P50608.1)"
     Site            201
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) (keratan sulfate) asparagine.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P50608.1)"
     Region          202..224
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          224..245
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (P50608.1)"
     Region          225..245
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          246..269
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          246..266
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (P50608.1)"
     Region          269..289
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (P50608.1)"
     Region          270..314
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            291
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) (keratan sulfate) asparagine.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P50608.1)"
     Region          294..315
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (P50608.1)"
     Region          315..334
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          316..335
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (P50608.1)"
     Site            341
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P50608.1)"
     Region          344..367
                     /region_name="LRR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (P50608.1)"
     CDS             1..376
                     /gene="Fmod"
                     /gene_synonym="FM; SLRR2E"
                     /coded_by="NM_021355.4:338..1468"
                     /db_xref="CCDS:CCDS15301.1"
                     /db_xref="GeneID:14264"
                     /db_xref="MGI:MGI:1328364"
ORIGIN      
        1 mqwasvllla glcslsqgqy dedshwwiqy lrnqqstyyd pydpypyeps epypygveeg
       61 payaygappp peprdcpqec dcppnfptam ycdnrnlkyl pfvpsrmkyv yfqnnqisai
      121 qegvfdnatg llwvalhgnq itsdkvgrkv fsklrhlerl yldhnnltrm pgplprslre
      181 lhldhnqisr vpnnalegle nltalylhhn eiqevgssmr glrslilldl synhlrrvpd
      241 glpsaleqly lehnnvytvp dsyfrgspkl lyvrlshnsl tnnglatntf nssslleldl
      301 synqlqkipp vntnlenlyl qgnrinefsi ssfctvvdvm nfsklqvlrl dgneikrsam
      361 pvdaplclrl anliei
//
