LOCUS       NM_001161763            5202 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus flavin containing monooxygenase 5 (Fmo5), transcript
            variant 2, mRNA.
ACCESSION   NM_001161763
VERSION     NM_001161763.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5202)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5202)
  AUTHORS   Phillips,I.R., Veeravalli,S., Khadayate,S. and Shephard,E.A.
  TITLE     Metabolomic and transcriptomic analyses of Fmo5-/- mice reveal
            roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated
            oxidative stress response, unfolded protein response, lipid
            homeostasis, and carbohydrate and one-carbon metabolism
  JOURNAL   PLoS One 18 (6), e0286692 (2023)
   PUBMED   37267233
  REMARK    GeneRIF: Metabolomic and transcriptomic analyses of Fmo5-/- mice
            reveal roles for flavin-containing monooxygenase 5 (FMO5) in
            NRF2-mediated oxidative stress response, unfolded protein response,
            lipid homeostasis, and carbohydrate and one-carbon metabolism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5202)
  AUTHORS   Veeravalli,S., Phillips,I.R., Freire,R.T., Varshavi,D.,
            Everett,J.R. and Shephard,E.A.
  TITLE     Flavin-Containing Monooxygenase 1 Catalyzes the Production of
            Taurine from Hypotaurine
  JOURNAL   Drug Metab Dispos 48 (5), 378-385 (2020)
   PUBMED   32156684
REFERENCE   4  (bases 1 to 5202)
  AUTHORS   Chen,M., Guan,B., Xu,H., Yu,F., Zhang,T. and Wu,B.
  TITLE     The Molecular Mechanism Regulating Diurnal Rhythm of
            Flavin-Containing Monooxygenase 5 in Mouse Liver
  JOURNAL   Drug Metab Dispos 47 (11), 1333-1342 (2019)
   PUBMED   31515204
  REMARK    GeneRIF: Hepatic Fmo5 displayed diurnal rhythmicities in expression
            and activity in mice.
REFERENCE   5  (bases 1 to 5202)
  AUTHORS   Phillips,I.R. and Shephard,E.A.
  TITLE     Drug metabolism by flavin-containing monooxygenases of human and
            mouse
  JOURNAL   Expert Opin Drug Metab Toxicol 13 (2), 167-181 (2017)
   PUBMED   27678284
  REMARK    Review article
REFERENCE   6  (bases 1 to 5202)
  AUTHORS   Yu,Z., Mannik,J., Soto,A., Lin,K.K. and Andersen,B.
  TITLE     The epidermal differentiation-associated Grainyhead gene Get1/Grhl3
            also regulates urothelial differentiation
  JOURNAL   EMBO J 28 (13), 1890-1903 (2009)
   PUBMED   19494835
REFERENCE   7  (bases 1 to 5202)
  AUTHORS   Zhang,J., Cerny,M.A., Lawson,M., Mosadeghi,R. and Cashman,J.R.
  TITLE     Functional activity of the mouse flavin-containing monooxygenase
            forms 1, 3, and 5
  JOURNAL   J Biochem Mol Toxicol 21 (4), 206-215 (2007)
   PUBMED   17721934
  REMARK    GeneRIF: The functional activity of Fmo5 was determined.
REFERENCE   8  (bases 1 to 5202)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   9  (bases 1 to 5202)
  AUTHORS   Cherrington,N.J., Falls,J.G., Rose,R.L., Clements,K.M.,
            Philpot,R.M., Levi,P.E. and Hodgson,E.
  TITLE     Molecular cloning, sequence, and expression of mouse
            flavin-containing monooxygenases 1 and 5 (FMO1 and FMO5)
  JOURNAL   J Biochem Mol Toxicol 12 (4), 205-212 (1998)
   PUBMED   9580872
REFERENCE   10 (bases 1 to 5202)
  AUTHORS   Falls,J.G., Blake,B.L., Cao,Y., Levi,P.E. and Hodgson,E.
  TITLE     Gender differences in hepatic expression of flavin-containing
            monooxygenase isoforms (FMO1, FMO3, and FMO5) in mice
  JOURNAL   J Biochem Toxicol 10 (3), 171-177 (1995)
   PUBMED   7473608
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK162951.1, AK133675.1 and AC130541.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147040.1, SRR7345562.906336.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-895               AK162951.1         2-896
            896-2079            AK133675.1         961-2144
            2080-5202           AC130541.4         106799-109921
FEATURES             Location/Qualifiers
     source          1..5202
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.23 cM"
     gene            1..5202
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
                     /note="flavin containing monooxygenase 5"
                     /db_xref="GeneID:14263"
                     /db_xref="MGI:MGI:1310004"
     exon            1..98
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            99..275
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1742
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
                     /EC_number="1.14.13.8"
                     /EC_number="1.6.3.1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     dimethylaniline monooxygenase [N-oxide-forming] 5;
                     dimethylaniline oxidase 5; hepatic flavin-containing
                     monooxygenase 5; NAPDH oxidase; NADPH oxidase"
                     /codon_start=1
                     /product="flavin-containing monooxygenase 5 isoform 1"
                     /protein_id="NP_001155235.1"
                     /db_xref="CCDS:CCDS17656.1"
                     /db_xref="GeneID:14263"
                     /db_xref="MGI:MGI:1310004"
                     /translation="MAKKRIAVIGAGASGLTCIKCCLEEGLEPVCFERSGDIGGLWRF
                     QEAPEEGRASIYQSVVINTSKEMMCFSDYPIPDHYPNYMHNSQVLEYFRMYAKEFDLL
                     KYIQFKTTVCSVKKQPDFSTSGQWQVVTECEGKQQVDVFDGVLVCTGHHTDAHLPLES
                     FPGIEKFKGKYFHSRDYKNPVEFTGKRVIVIGIGNSGGDLAVEISHTAKQVFLSTRRG
                     AWILNRVGKHGYPIDLLLSSRIMYYLSRICGPSLKNNYMEKQMNQRFDHEMFGLKPKH
                     RALSQHPTVNDDLPNRIIAGLVKVKGNVKEFTETAAVFEDGSREDGIDVVIFATGYSF
                     AFPFLEDSVKVVKNKVSLYKKVFPPNLEKPTLAIIGLIQPLGAIMPISELQGRWATQV
                     FKGLKKLPSQSEMMAEINKAREEMAKRYVDSQRHTIQGDYIDTMEEIADLVGVRPNIL
                     PLVFTDPRLALRLLLGPCTPVQYRLQGPGKWAGARKTILTTEDRVRKPLMTRVVERDS
                     SGGSLVTVRVLMLAVAFFAVILAYF"
     exon            276..464
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            465..627
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            628..770
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            771..970
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1323
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1396
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..5202
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2440..2445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2466
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
     regulatory      2492..2497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2514
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
                     /note="major polyA site"
     regulatory      3603..3608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3627
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
     regulatory      4031..4036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4049
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
     regulatory      5180..5185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5200
                     /gene="Fmo5"
                     /gene_synonym="5033418D19Rik"
ORIGIN      
        1 ccctattggc ctctgctgtg tttatatgag gcgcggctgc tctgccctga gttacagccc
       61 tgcttagctc cgaactagtg tagcagcgcc ctgagctgga caagtgacgc agacccaacc
      121 agagaagcac tctggtgacc atggccaaaa aaaggattgc tgtaattgga gcaggagcta
      181 gcgggctcac ctgcatcaag tgctgcctgg aagagggctt ggaacctgtc tgctttgaaa
      241 ggtctggtga catcggagga ctgtggagat tccaggaagc ccctgaggaa ggcagggcca
      301 gtatttacca gtccgtggtc atcaacacct ccaaggaaat gatgtgtttc agtgactacc
      361 ccatcccaga tcattaccct aactacatgc acaactccca ggtcctagag tatttcagga
      421 tgtatgccaa agaatttgac cttctcaaat atatccaatt caagactaca gtgtgcagcg
      481 tgaagaagca gcctgatttc tctacctcgg gccaatggca ggtggtcact gagtgtgaag
      541 ggaaacagca ggtagacgtc ttcgatggag tcctggtgtg cacgggtcat cacacggatg
      601 ctcacctgcc cctggaaagc tttcctggaa ttgaaaagtt caaaggaaag tactttcaca
      661 gccgagacta taagaaccca gtggaattca ccgggaagag ggtcattgta attggcattg
      721 ggaattctgg aggggatctg gctgtagaga ttagccacac agccaagcag gtattcctca
      781 gtaccaggag aggagcttgg atcttgaacc gtgtaggcaa gcatggatat cctattgacc
      841 tgctactctc ttctcggatt atgtactact tgtcacgtat ctgtggtcca tcactaaaaa
      901 acaactatat ggaaaaacag atgaaccaaa ggtttgatca tgaaatgttt ggcctgaaac
      961 ctaaacacag ggctctgagt cagcatccaa cagtgaatga tgacctgccc aatcgtatca
     1021 ttgctggctt ggtgaaggtg aaaggaaatg tgaaggaatt cacagagaca gccgccgtat
     1081 ttgaggatgg ctccagggag gatggcattg atgtggtcat ctttgccaca ggctacagct
     1141 ttgcctttcc ttttcttgag gactctgtca aagtagtaaa aaacaaggtg tccttgtaca
     1201 aaaaggtctt tccacctaac ctggaaaaac caacacttgc aatcatcggc ttaattcagc
     1261 ccttgggagc cattatgccc atttcagagc tccaaggacg ctgggccact caagtgttca
     1321 aagggctaaa gaaattgccc tcacaaagtg aaatgatggc agaaataaat aaggctcgag
     1381 aggaaatggc aaaaaggtat gtggacagcc agcgtcatac catccaggga gactatatag
     1441 acaccatgga agagattgca gatttagtgg gtgtcaggcc caatatcctg cctctggtct
     1501 tcactgaccc caggctggca ttacggttac tactggggcc ctgtactcca gtccagtatc
     1561 gcctacaggg ccctggaaag tgggctggag cccggaaaac tattctcacc acggaagatc
     1621 gtgttcggaa gcctctgatg acaagagtgg tggaaagaga cagctctggg gggtcactgg
     1681 tgacagtgcg tgtcctcatg ctggctgttg ctttctttgc tgtcatcctg gcttattttt
     1741 agatgtggca gcgcagtact tgagctgcca ccggaaaacg ccatctagcc acaccttcag
     1801 aacctgatga gactgaacac agcttcatac tgcacaggaa tcaatcacaa tctctctctc
     1861 tctctctctc tctctctctc tctctctctc tctctctctc cctctccctc tccctccctc
     1921 actttctctc tctctcttct cccttcctcc ccctctctct cctccctcaa tcattaatcc
     1981 ttcttggttt tatttctgtg atattgggtt ttcactaatt gattcatctc cctccctcgt
     2041 gagccttttg tctctccctc tagtcattcc cagaccgtga gctcaggccc ccttcatcat
     2101 ctttgtatgt cattagcagg gttcttttaa tgcttgactc tgttgtgttt ctagcactgc
     2161 acagctagac ctcgctggat gataacccat cttgaaaaga ctgcttccat tatcaagcgc
     2221 atattggcag cacttgacct tataagcaga gcccacatat ctatttcagg aattcccaca
     2281 gagggcagtc cagaaagaag agccacttag tgctgaagac tgggagtcca aaatccaggg
     2341 tgcagacagt gaggcattcc tgtcttcatg attaatacag tgagggtatc acatgggcaa
     2401 aacagaaaat agctaagttc cggcatgtgg cacatgctga ataaatgctc gttgatatgt
     2461 atgaaataag gtgttatctc taagtcaatc taataaatgg ctaactctat agaactctta
     2521 atgtgatcca ttatcaattt taataacatt aattttataa attattttta taaattaact
     2581 agttattaat tttagtaact gaatatacct gtctttcaga tgggtggtgg gcatttaaac
     2641 tcaggtccac ttgccttcac agcaagtgct cttattcacc aagccatctt cctacctcct
     2701 gcttttatat tcttaaaaaa gaaactactg actgaacata gtggcacata cctgtaattc
     2761 cagaacttgg gagttcctgg caaaggatca ccacaagttc aaggccagcc tagttcccag
     2821 agtgagttcc aagccagcca ggtttgcata gcaagaactt ggctcaagca acaacaaaat
     2881 atacaaaatc agaaaaggat ttgctcttct aagtttgaaa gtcttttaaa taatttgccg
     2941 tcttccaata ggttgattaa agaacctgag gcttttagtt agctatcctg gcttaatctt
     3001 gaagggctag tgttaggatc cagctgaggc agtaagcaag tgctagcact ggaggtgggg
     3061 tcagcaagtg tgattattcc ctccccctgc cccgcccagc attgaggtgg ggtcagcaag
     3121 tgtgagtctc cccctgccca gctccctcct tccttcagag tctacataat aagaatcagt
     3181 aagctcttcc acgtcttaag ttagaactag tattagtatt aactaggggc attctgccta
     3241 gaccagttct tcctgtgtgt agttcagaaa ggcaggagtg gaactgaaat gcaagattta
     3301 agaagcattg gctgtcagaa gcacttgaac tccctaagga taatttgacc cgctgcagga
     3361 atggcatgag aataacacaa atacatgtaa gcagatacgt gagaattcaa actcctaatt
     3421 atacacggat ttgaacagct gcctaatatt ttacccagtg tactctctgt gaacttgagc
     3481 actgagccct ggttgggttt ctagggccct tttccttccg aaatccttta gcaactgaat
     3541 gtttgtcatt attaaaatgg gtctgggatt tttttttaat ctgaagattg ctttcgttca
     3601 aaaataaacg gaagctctgc atcttaactt ttcttctttt acaatgtaaa ggtcctctca
     3661 ttgagcttgt aaagatattg aagcactaca ctgccaagaa tgtaatctct acttatgggc
     3721 actaatacca caggcttctt tcaaagcctg tacttttaag tagcttcaac tctctcgttc
     3781 tgcttagaat atgcaaaact acaaaagcat cattgatttc taaaccaagc tgaaggtaag
     3841 gctaggatag gaccttgaac ttaaaacaac tgaagataca aagagtagtt actgatcgat
     3901 actgatcgat gatcgtgtgc tgattcacca attcatgcac tttgctcttc tggccatatt
     3961 aaaagattac gtcacttacc caactatgat aaatctgatg atccaaaaga tgtattcttg
     4021 caatgcaaag aataaagaaa tggcccaaat ggactgacta gctcatgtca aaggggtata
     4081 gaaatcattt caaagtggcc ccagtggcca aatttgaaat aaatgtcgag caataaataa
     4141 cctagtattg gattataacc tgaaacacaa agatacctga gtccatgcca ttataggtaa
     4201 atgattggaa acattatcag aatggaataa gtaaagcccc cacacagaat tctaaatatt
     4261 ttagttcttg cccctcaagg aaatgaagca aagctctctc agatgtactg catagattaa
     4321 cttcctttag aaatctagtg tgggaagggg tgagggataa ctgcagagga gaagtcagac
     4381 agactacctc agtcagatgc ccacatcaat acaagcattg gcaatcactg gtagttgtat
     4441 gcatgagatg acctctgtgg tgtttttcct tcagatgata gcccaggcta ggcaggagaa
     4501 aagtaccatg caggcagcct caggatgatc tacgaatacc ttactcccct ggaactgttg
     4561 aagtcatcaa aagccagtct gagagagaga gagcttccta gcatacagga gccttgagga
     4621 agtatccatg gtgagaattc aagaagagaa aaagagatac taagtaaaaa ttgaagaact
     4681 agtaacaatt gtgtactctg ggtaaagaat gatgtgtcaa tattggtgtt aaactaataa
     4741 atgcaccacc atgacatgtt ctcaggagga aaacaagcac gcagaacctc tctgtcgtct
     4801 ttgcaactta agtctaaaac cggtgcacaa gatttttgtt tgtttgagtt gttttaagtt
     4861 cagagtttga cctgaattac agtgtactaa aaacttctca gacgaatgtt ggatagtcga
     4921 agatggctcg ctcttgcaga ggacctgggt ttggttccca gaatccatat agtgcgtcac
     4981 aactgtctgt aactccactt ctagggtatc tgtctccctc ttctggccat cgtgagcact
     5041 gcatgtgtgt ggtgcacatg catgcatgca acagcactct ttaacagata aaataaatat
     5101 ttttttaaaa aaagaatata ggctgggacc atttgtttaa atgactgttt cttcaattgt
     5161 gctcagatta catcgctcta ataaaccata atataactta cg
//
