LOCUS       NM_144878               1787 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus flavin containing monooxygenase 4 (Fmo4), mRNA.
ACCESSION   NM_144878
VERSION     NM_144878.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1787)
  AUTHORS   Veeravalli,S., Phillips,I.R., Freire,R.T., Varshavi,D.,
            Everett,J.R. and Shephard,E.A.
  TITLE     Flavin-Containing Monooxygenase 1 Catalyzes the Production of
            Taurine from Hypotaurine
  JOURNAL   Drug Metab Dispos 48 (5), 378-385 (2020)
   PUBMED   32156684
REFERENCE   2  (bases 1 to 1787)
  AUTHORS   Veeravalli,S., Omar,B.A., Houseman,L., Hancock,M., Gonzalez
            Malagon,S.G., Scott,F., Janmohamed,A., Phillips,I.R. and
            Shephard,E.A.
  TITLE     The phenotype of a flavin-containing monooyxgenase knockout mouse
            implicates the drug-metabolizing enzyme FMO1 as a novel regulator
            of energy balance
  JOURNAL   Biochem Pharmacol 90 (1), 88-95 (2014)
   PUBMED   24792439
  REMARK    GeneRIF: Data indicate that in contrast to FMO2 and FMO4, FMO1 is
            highly expressed in metabolic tissues, including liver, kidney,
            white adipose tissue (WAT) and brown adipose tissue (BAT).
REFERENCE   3  (bases 1 to 1787)
  AUTHORS   Novick,R.M., Mitzey,A.M., Brownfield,M.S. and Elfarra,A.A.
  TITLE     Differential localization of flavin-containing monooxygenase (FMO)
            isoforms 1, 3, and 4 in rat liver and kidney and evidence for
            expression of FMO4 in mouse, rat, and human liver and kidney
            microsomes
  JOURNAL   J Pharmacol Exp Ther 329 (3), 1148-1155 (2009)
   PUBMED   19307449
  REMARK    GeneRIF: Data show a compelling visual demonstration of the
            isoform-specific localization patterns of FMO1, -3, and -4 in the
            rat liver and kidney and the first evidence for expression of FMO4
            at the protein level in mouse and human liver and kidney
            microsomes.
REFERENCE   4  (bases 1 to 1787)
  AUTHORS   Hernandez,D., Janmohamed,A., Chandan,P., Omar,B.A., Phillips,I.R.
            and Shephard,E.A.
  TITLE     Deletion of the mouse Fmo1 gene results in enhanced pharmacological
            behavioural responses to imipramine
  JOURNAL   Pharmacogenet Genomics 19 (4), 289-299 (2009)
   PUBMED   19262426
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF461145.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF461145.1, BC106858.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1787
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129/Sv"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 70.34 cM"
     gene            1..1787
                     /gene="Fmo4"
                     /gene_synonym="D1Ertd532e"
                     /note="flavin containing monooxygenase 4"
                     /db_xref="GeneID:226564"
                     /db_xref="MGI:MGI:2429497"
     exon            1..21
                     /gene="Fmo4"
                     /gene_synonym="D1Ertd532e"
                     /inference="alignment:Splign:2.1.0"
     exon            22..161
                     /gene="Fmo4"
                     /gene_synonym="D1Ertd532e"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1712
                     /gene="Fmo4"
                     /gene_synonym="D1Ertd532e"
                     /EC_number="1.14.13.8"
                     /note="FMO 4; dimethylaniline oxidase 4; hepatic
                     flavin-containing monooxygenase 4"
                     /codon_start=1
                     /product="dimethylaniline monooxygenase [N-oxide-forming]
                     4"
                     /protein_id="NP_659127.1"
                     /db_xref="CCDS:CCDS15423.1"
                     /db_xref="GeneID:226564"
                     /db_xref="MGI:MGI:2429497"
                     /translation="MAKKVAVIGAGVSGLSSIKCCLDENLEPTCFERTSDFGGLWKFA
                     DTSEDGMTRVYRSLVTNVCKEMSCYSDFPFREDYPNFMSHEKFWDYLREFAEHFGLLR
                     YIRFKTTVLSVTKRPDFSETGQWDVVTETEGKRDRAVFDAVMVCTGQFLSPHLPLESF
                     PGIHKFKGQILHSQEYRIPDAFRGKRILVVGLGNTGGDIAVELSEIAAQVFLSTRTGT
                     WVLSRSSPGGYPFNMIQTRWLNFLVRVLPSRFINWTHERKMNKILNHENYGLSIAKGK
                     KPKFIVNDELPTCILCGKVTMKTSVKDFTESSVIFEDGTTEANIDVVIFTTGYEFSFP
                     FFEEPLKSLCTKKIILYKRVFPPNLERATLAIIGLISLNGSILVGTEFQARWATRVFK
                     GLCSIPPSQKLMAEATKTEQLIKRGVIKDTSQDKLDFITYMDELTQCIGAKPSIPLLF
                     IKDPRLAWEVFFGPCTPYQYRLVGPGRWDGARNAILTQWDRTLKPLKTRIVPKSPEPT
                     SLSHYLIAWGAPVLLVSLLLIYKSSHFLELVQGKLPRRFPPYRLLWYMPQNS"
     exon            162..350
                     /gene="Fmo4"
                     /gene_synonym="D1Ertd532e"
                     /inference="alignment:Splign:2.1.0"
     exon            351..513
                     /gene="Fmo4"
                     /gene_synonym="D1Ertd532e"
                     /inference="alignment:Splign:2.1.0"
     exon            514..656
                     /gene="Fmo4"
                     /gene_synonym="D1Ertd532e"
                     /inference="alignment:Splign:2.1.0"
     exon            657..853
                     /gene="Fmo4"
                     /gene_synonym="D1Ertd532e"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1206
                     /gene="Fmo4"
                     /gene_synonym="D1Ertd532e"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1276
                     /gene="Fmo4"
                     /gene_synonym="D1Ertd532e"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1787
                     /gene="Fmo4"
                     /gene_synonym="D1Ertd532e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaactcaag ggaactcaca gagcgcacca tggccaagaa ggtggcagtg attggagctg
       61 gcgtaagtgg cctgtcctct atcaagtgct gcttggacga gaacctggag cccacctgct
      121 ttgagagaac tagcgacttt ggcggactgt ggaagtttgc tgacacttcc gaggatggga
      181 tgaccagggt ttacaggtca ctagtgacaa atgtctgcaa agaaatgtca tgttacagtg
      241 acttcccatt ccgagaagat taccccaact tcatgagcca tgagaaattc tgggactatc
      301 tcagagaatt tgctgagcac tttggcctgc tgagatatat tcggtttaag acaactgtgc
      361 tcagtgtaac aaagcgccca gacttctctg aaactggcca gtgggatgtt gtcacagaga
      421 cagaaggcaa acgggacagg gcagtatttg acgctgttat ggtttgcact gggcaattcc
      481 tgagcccaca tttacctctg gagtcctttc ctggaatcca taagtttaaa ggacagatcc
      541 tgcacagcca agagtacagg attccagatg ccttccgggg caagcgcatc ctggtggttg
      601 gtcttggaaa cactggcggg gacatagcag tagagctcag tgaaatagca gctcaggtgt
      661 ttctcagcac tagaactggc acctgggtcc taagccgctc ctcacctggt ggctaccctt
      721 tcaatatgat acaaacaaga tggctcaatt tccttgtacg agttctgcct tcacgtttta
      781 taaactggac tcacgagagg aaaatgaata aaatacttaa ccatgagaat tatggattaa
      841 gcattgcaaa agggaaaaaa ccaaaattta ttgtaaatga tgaactacca acctgtatac
      901 tttgtgggaa agtcaccatg aaaaccagcg tgaaggattt tacagaatct tctgtcatct
      961 ttgaagatgg tacaacagaa gccaacattg atgtagtgat cttcactaca ggatatgaat
     1021 tttcttttcc cttttttgaa gaacctctca aaagcctttg tacaaagaag atcatcctat
     1081 acaagcgagt ctttccccca aatttggaga gagcaacatt agccattatt ggcctgatca
     1141 gccttaatgg gtcgatctta gtgggcacag agttccaagc acgatgggcc acaagagtat
     1201 tcaaaggact ctgtagcata cctccatctc agaaactgat ggccgaagcc actaaaacgg
     1261 agcagctcat taaaaggggt gtgattaaag ataccagcca agacaaactg gacttcatta
     1321 cctacatgga cgagctcact cagtgcatag gcgcgaagcc cagcattcca cttttgttca
     1381 ttaaggatcc aagattggct tgggaagttt tctttggacc atgtacccct taccaatacc
     1441 gcctagtggg ccctggaaga tgggatggag ccagaaatgc catcctgaca cagtgggaca
     1501 ggactctgaa accattaaaa actcgaattg ttcctaagtc ccccgagcct acctccctct
     1561 cacattactt aatagcttgg ggggcacctg tcctgcttgt ctctctttta cttatctaca
     1621 aatcttcaca ttttcttgaa ttggtacaag gtaagctacc gagaagattt cccccttacc
     1681 gattactgtg gtacatgccc cagaactcat gagttggtct ccagtttacc aatggaggaa
     1741 ggtgtctggg acaccctctt taaacagatt ggtgctgctc tcaacac
//
