LOCUS       NM_008030               2048 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus flavin containing monooxygenase 3 (Fmo3), mRNA.
ACCESSION   NM_008030
VERSION     NM_008030.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2048)
  AUTHORS   Huang,M., Duan,S., Zhang,Q., Guo,L., Qin,Z. and Yang,J.
  TITLE     Deciphering the diurnal rhythm regulating mechanism of
            flavin-containing monooxygenase 3 in mouse liver
  JOURNAL   Int J Biochem Cell Biol 169, 106538 (2024)
   PUBMED   38320728
  REMARK    GeneRIF: Deciphering the diurnal rhythm regulating mechanism of
            flavin-containing monooxygenase 3 in mouse liver.
REFERENCE   2  (bases 1 to 2048)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2048)
  AUTHORS   Luo,T., Guo,Z., Liu,D., Guo,Z., Wu,Q., Li,Q., Lin,R., Chen,P.,
            Ou,C. and Chen,M.
  TITLE     Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO
            production via manipulating gut microbiota and flavin monooxygenase
            3
  JOURNAL   Gut Microbes 14 (1), 2077602 (2022)
   PUBMED   35613310
  REMARK    GeneRIF: Deficiency of PSRC1 accelerates atherosclerosis by
            increasing TMAO production via manipulating gut microbiota and
            flavin monooxygenase 3.
REFERENCE   4  (bases 1 to 2048)
  AUTHORS   AlOgayil,N., Bauermeister,K., Galvez,J.H., Venkatesh,V.S.,
            Zhuang,Q.K., Chang,M.L., Davey,R.A., Zajac,J.D., Ida,K., Kamiya,A.,
            Taketo,T., Bourque,G. and Naumova,A.K.
  TITLE     Distinct roles of androgen receptor, estrogen receptor alpha, and
            BCL6 in the establishment of sex-biased DNA methylation in mouse
            liver
  JOURNAL   Sci Rep 11 (1), 13766 (2021)
   PUBMED   34215813
  REMARK    Erratum:[Sci Rep. 2021 Nov 22;11(1):22975. doi:
            10.1038/s41598-021-02512-8.. PMID: 34811454]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2048)
  AUTHORS   Shimizu,M., Uehara,S., Suemizu,H. and Yamazaki,H.
  TITLE     In vivo drug interactions of itopride and trimethylamine mediated
            by flavin-containing monooxygenase 3 in humanized-liver mice
  JOURNAL   Drug Metab Pharmacokinet 37, 100369 (2021)
   PUBMED   33513464
  REMARK    GeneRIF: In vivo drug interactions of itopride and trimethylamine
            mediated by flavin-containing monooxygenase 3 in humanized-liver
            mice.
REFERENCE   6  (bases 1 to 2048)
  AUTHORS   Falls,J.G., Cherrington,N.J., Clements,K.M., Philpot,R.M.,
            Levi,P.E., Rose,R.L. and Hodgson,E.
  TITLE     Molecular cloning, sequencing, and expression in Escherichia coli
            of mouse flavin-containing monooxygenase 3 (FMO3): comparison with
            the human isoform
  JOURNAL   Arch Biochem Biophys 347 (1), 9-18 (1997)
   PUBMED   9344459
REFERENCE   7  (bases 1 to 2048)
  AUTHORS   Falls,J.G., Ryu,D.Y., Cao,Y., Levi,P.E. and Hodgson,E.
  TITLE     Regulation of mouse liver flavin-containing monooxygenases 1 and 3
            by sex steroids
  JOURNAL   Arch Biochem Biophys 342 (2), 212-223 (1997)
   PUBMED   9186481
REFERENCE   8  (bases 1 to 2048)
  AUTHORS   Kawamoto,S., Matsumoto,Y., Mizuno,K., Okubo,K. and Matsubara,K.
  TITLE     Expression profiles of active genes in human and mouse livers
  JOURNAL   Gene 174 (1), 151-158 (1996)
   PUBMED   8863742
REFERENCE   9  (bases 1 to 2048)
  AUTHORS   Falls,J.G., Blake,B.L., Cao,Y., Levi,P.E. and Hodgson,E.
  TITLE     Gender differences in hepatic expression of flavin-containing
            monooxygenase isoforms (FMO1, FMO3, and FMO5) in mice
  JOURNAL   J Biochem Toxicol 10 (3), 171-177 (1995)
   PUBMED   7473608
REFERENCE   10 (bases 1 to 2048)
  AUTHORS   Lawton,M.P., Cashman,J.R., Cresteil,T., Dolphin,C.T., Elfarra,A.A.,
            Hines,R.N., Hodgson,E., Kimura,T., Ozols,J., Phillips,I.R. et al.
  TITLE     A nomenclature for the mammalian flavin-containing monooxygenase
            gene family based on amino acid sequence identities
  JOURNAL   Arch Biochem Biophys 308 (1), 254-257 (1994)
   PUBMED   8311461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050123.1, AK149440.1 and D18023.1.
            
            On Aug 25, 2015 this sequence version replaced NM_008030.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149440.1, U87147.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AK050123.1         3-3
            2-1706              AK149440.1         2-1706
            1707-2045           AK149440.1         1717-2055
            2046-2048           D18023.1           185-187
FEATURES             Location/Qualifiers
     source          1..2048
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 70.34 cM"
     gene            1..2048
                     /gene="Fmo3"
                     /note="flavin containing monooxygenase 3"
                     /db_xref="GeneID:14262"
                     /db_xref="MGI:MGI:1100496"
     exon            1..58
                     /gene="Fmo3"
                     /inference="alignment:Splign:2.1.0"
     exon            59..196
                     /gene="Fmo3"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1669
                     /gene="Fmo3"
                     /EC_number="1.14.13.8"
                     /EC_number="1.14.13.148"
                     /EC_number="1.14.13.32"
                     /note="dimethylaniline monooxygenase [N-oxide-forming] 3;
                     dimethylaniline oxidase 3; hepatic flavin-containing
                     monooxygenase 3; trimethylamine monooxygenase"
                     /codon_start=1
                     /product="flavin-containing monooxygenase 3"
                     /protein_id="NP_032056.1"
                     /db_xref="CCDS:CCDS15426.1"
                     /db_xref="GeneID:14262"
                     /db_xref="MGI:MGI:1100496"
                     /translation="MKKKVAIIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGLWKFS
                     DHIEEGRASIYQSVFTNSSKEMMCFPDFPYPDDFPNFMHHSKLQEYITSFAKEKNLLK
                     YIQFETPVTSINKCPNFSTTGKWEVTTEKHGKKETAVFDATMICSGHHIFPHVPKDSF
                     PGLNRFKGKCFHSRDYKEPGIWKGKRVLVIGLGNSGCDIAAELSHVAQKVTISSRSGS
                     WVMSRVWDDGYPWDMVVLTRFQTFLKNNLPTAISDWWYTRQMNARFKHENYGLVPLNR
                     TLRKEPVFNDELPARILCGMVTIKPNVKEFTETSAVFEDGTMFEAIDCVIFATGYGYA
                     YPFLDDSIIKSRNNEVTLYKGVFPPQLEKPTMAVIGLVQSLGATIPITDLQARWAAQV
                     IKGTCTLPSVNDMMDDIDEKMGEKFKWYGNSTTIQTDYIVYMDELASFIGAKPNLLWL
                     FLKDPRLAVEVFFGPCSPYQFRLVGPGKWSGARNAILTQWDRSLKPMKTRVVSKVQKS
                     CSHFYSRLLRLLAVPVLLIALFLVLI"
     exon            197..385
                     /gene="Fmo3"
                     /inference="alignment:Splign:2.1.0"
     exon            386..548
                     /gene="Fmo3"
                     /inference="alignment:Splign:2.1.0"
     exon            549..691
                     /gene="Fmo3"
                     /inference="alignment:Splign:2.1.0"
     exon            692..891
                     /gene="Fmo3"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1247
                     /gene="Fmo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1320
                     /gene="Fmo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..2048
                     /gene="Fmo3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagagtcccc agaagactag gggtttaaac acagagaaga aaggaagaca aagaaaaggc
       61 acccatgaag aagaaagtgg ccatcattgg agctggtgtc agtggcctgg ctgccatcag
      121 gagctgtctg gaggaggggc tggagcccac atgctttgag aggagtgatg atgttggggg
      181 cctgtggaaa ttctcagacc atatagaaga gggcagggcc agcatttacc aatcggtctt
      241 caccaactct tccaaagaga tgatgtgttt tccagacttc ccctatcccg atgactttcc
      301 caacttcatg catcacagca agctccaaga atacatcact tcatttgcca aggaaaagaa
      361 cctcctgaaa tacatacagt ttgagacacc tgtaaccagt ataaataaat gtcctaattt
      421 ctcaactact ggcaaatggg aagtcaccac tgaaaagcac ggtaaaaaag aaacagctgt
      481 ctttgatgct acaatgattt gttctgggca tcacatattt ccccatgtac caaaagactc
      541 ctttccagga ctgaaccgtt ttaaaggcaa atgcttccac agcagggact ataaggaacc
      601 aggaatatgg aagggaaaac gagtcctggt gattggcctg gggaactcag gctgtgacat
      661 tgctgcagaa ctcagccatg tagctcagaa ggtcaccatc agctctagaa gtggttcttg
      721 ggtgatgagt cgagtctggg acgatggcta cccttgggac atggtggtgc tcacacggtt
      781 tcaaactttc ctcaaaaaca acttacccac cgccatctct gactggtggt acacaaggca
      841 gatgaatgcc agattcaagc acgaaaacta tggtttggtg cctttaaaca gaacactcag
      901 gaaagagccc gtgttcaatg atgagctccc agcccgcatc ctgtgtggca tggtgaccat
      961 caagcctaat gtaaaggagt tcacagagac gtccgctgtg tttgaggatg ggaccatgtt
     1021 tgaggccatt gactgtgtca tctttgccac aggctatggt tatgcctacc ccttcctgga
     1081 tgactctatt atcaaaagca gaaataatga ggtcactttg tacaaaggtg tcttccctcc
     1141 tcaactagag aaaccaacca tggcagtgat tggcctggtc cagtccctgg gtgccaccat
     1201 ccccataact gacctgcagg cacgctgggc agcacaagta ataaaaggaa cttgcacttt
     1261 gccttctgta aacgacatga tggatgacat tgatgagaaa atgggggaaa agttcaaatg
     1321 gtatggcaat agcaccacca tccagacaga ttacattgtt tatatggatg aactggcctc
     1381 cttcattggt gcaaagccca atctcctatg gctgtttctc aaggatccca ggttggctgt
     1441 agaagtgttc tttggccctt gcagccccta ccagttccgg ctggtaggcc caggaaagtg
     1501 gtcaggagcc cggaacgcca tcctaacaca gtgggaccga tcactgaagc ctatgaagac
     1561 gcgtgtcgtc agtaaagttc agaagtcttg ctctcacttc tattcccgtt tgctcaggct
     1621 cctggctgtt cccgttctgc tcattgcttt gttccttgtg ttgatctgat cgtgagtccc
     1681 tctagaattt ctgagagtca ctgacaacaa ccagacaaga actttgctat ttaaaaatta
     1741 agatttttca cacctctccc tttcctgttc aagatctttt gccagaactc tagacgttaa
     1801 ttagtaagca agacaatgtt ttgttctggc tttgtaacta agcccctttc agaatcatgt
     1861 tgatctgcag tgggcataag tccctttctc tttaagttcc accaacaatt tgtaaggaga
     1921 atggtatttt tatggacaac ttgtatcatc tcttggaaca gttggacatg attccttttc
     1981 tcttttaaac aatgcttgaa agatatactt cagattcaga cagtgaataa aatagagtat
     2041 ttagaata
//
