LOCUS       NM_018881               4112 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus flavin containing monooxygenase 2 (Fmo2), transcript
            variant 3, mRNA.
ACCESSION   NM_018881
VERSION     NM_018881.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4112)
  AUTHORS   Wang,L., Zha,H., Huang,J. and Shi,L.
  TITLE     Flavin containing monooxygenase 2 regulates renal tubular cell
            fibrosis and paracrine secretion via SMURF2 in AKI-CKD
            transformation
  JOURNAL   Int J Mol Med 52 (5) (2023)
   PUBMED   37800598
  REMARK    GeneRIF: Flavin containing monooxygenase 2 regulates renal tubular
            cell fibrosis and paracrine secretion via SMURF2 in AKI-CKD
            transformation.
REFERENCE   2  (bases 1 to 4112)
  AUTHORS   Yoshida,Y., Shimizu,I., Shimada,A., Nakahara,K., Yanagisawa,S.,
            Kubo,M., Fukuda,S., Ishii,C., Yamamoto,H., Ishikawa,T., Kano,K.,
            Aoki,J., Katsuumi,G., Suda,M., Ozaki,K., Yoshida,Y., Okuda,S.,
            Ohta,S., Okamoto,S., Minokoshi,Y., Oda,K., Sasaoka,T., Abe,M.,
            Sakimura,K., Kubota,Y., Yoshimura,N., Kajimura,S., Zuriaga,M.,
            Walsh,K., Soga,T. and Minamino,T.
  TITLE     Brown adipose tissue dysfunction promotes heart failure via a
            trimethylamine N-oxide-dependent mechanism
  JOURNAL   Sci Rep 12 (1), 14883 (2022)
   PUBMED   36050466
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4112)
  AUTHORS   AlOgayil,N., Bauermeister,K., Galvez,J.H., Venkatesh,V.S.,
            Zhuang,Q.K., Chang,M.L., Davey,R.A., Zajac,J.D., Ida,K., Kamiya,A.,
            Taketo,T., Bourque,G. and Naumova,A.K.
  TITLE     Distinct roles of androgen receptor, estrogen receptor alpha, and
            BCL6 in the establishment of sex-biased DNA methylation in mouse
            liver
  JOURNAL   Sci Rep 11 (1), 13766 (2021)
   PUBMED   34215813
  REMARK    Erratum:[Sci Rep. 2021 Nov 22;11(1):22975. doi:
            10.1038/s41598-021-02512-8.. PMID: 34811454]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4112)
  AUTHORS   Veeravalli,S., Phillips,I.R., Freire,R.T., Varshavi,D.,
            Everett,J.R. and Shephard,E.A.
  TITLE     Flavin-Containing Monooxygenase 1 Catalyzes the Production of
            Taurine from Hypotaurine
  JOURNAL   Drug Metab Dispos 48 (5), 378-385 (2020)
   PUBMED   32156684
REFERENCE   5  (bases 1 to 4112)
  AUTHORS   Miyai,M., Hamada,M., Moriguchi,T., Hiruma,J., Kamitani-Kawamoto,A.,
            Watanabe,H., Hara-Chikuma,M., Takahashi,K., Takahashi,S. and
            Kataoka,K.
  TITLE     Transcription Factor MafB Coordinates Epidermal Keratinocyte
            Differentiation
  JOURNAL   J Invest Dermatol 136 (9), 1848-1857 (2016)
   PUBMED   27208706
  REMARK    Review article
REFERENCE   6  (bases 1 to 4112)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4112)
  AUTHORS   Hernandez,D., Janmohamed,A., Chandan,P., Omar,B.A., Phillips,I.R.
            and Shephard,E.A.
  TITLE     Deletion of the mouse Fmo1 gene results in enhanced pharmacological
            behavioural responses to imipramine
  JOURNAL   Pharmacogenet Genomics 19 (4), 289-299 (2009)
   PUBMED   19262426
REFERENCE   8  (bases 1 to 4112)
  AUTHORS   Patel,S., Xi,Z.F., Seo,E.Y., McGaughey,D. and Segre,J.A.
  TITLE     Klf4 and corticosteroids activate an overlapping set of
            transcriptional targets to accelerate in utero epidermal barrier
            acquisition
  JOURNAL   Proc Natl Acad Sci U S A 103 (49), 18668-18673 (2006)
   PUBMED   17130451
REFERENCE   9  (bases 1 to 4112)
  AUTHORS   Lattard,V., Longin-Sauvageon,C., Krueger,S.K., Williams,D.E. and
            Benoit,E.
  TITLE     The FMO2 gene of laboratory rats, as in most humans, encodes a
            truncated protein
  JOURNAL   Biochem Biophys Res Commun 292 (2), 558-563 (2002)
   PUBMED   11906197
REFERENCE   10 (bases 1 to 4112)
  AUTHORS   Karoly,E.D. and Rose,R.L.
  TITLE     Sequencing, expression, and characterization of cDNA expressed
            flavin-containing monooxygenase 2 from mouse
  JOURNAL   J Biochem Mol Toxicol 15 (6), 300-308 (2001)
   PUBMED   11835629
  REMARK    GeneRIF: sequencing, expression, and characterization of cDNA
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117767.13.
            
            On Feb 17, 2018 this sequence version replaced NM_018881.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 all encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031415.1, SRR5189676.88740.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC117767.13        75628-75714         c
            88-225              AC117767.13        75130-75267         c
            226-414             AC117767.13        65652-65840         c
            415-577             AC117767.13        64524-64686         c
            578-720             AC117767.13        63265-63407         c
            721-920             AC117767.13        58946-59145         c
            921-1276            AC117767.13        57338-57693         c
            1277-1349           AC117767.13        54969-55041         c
            1350-4112           AC117767.13        51273-54035         c
FEATURES             Location/Qualifiers
     source          1..4112
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 70.34 cM"
     gene            1..4112
                     /gene="Fmo2"
                     /gene_synonym="2310008D08Rik; 2310042I22Rik"
                     /note="flavin containing monooxygenase 2"
                     /db_xref="GeneID:55990"
                     /db_xref="MGI:MGI:1916776"
     exon            1..87
                     /gene="Fmo2"
                     /gene_synonym="2310008D08Rik; 2310042I22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            88..225
                     /gene="Fmo2"
                     /gene_synonym="2310008D08Rik; 2310042I22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1701
                     /gene="Fmo2"
                     /gene_synonym="2310008D08Rik; 2310042I22Rik"
                     /EC_number="1.14.13.8"
                     /note="FMO 2; dimethylaniline oxidase 2; pulmonary
                     flavin-containing monooxygenase 2"
                     /codon_start=1
                     /product="dimethylaniline monooxygenase [N-oxide-forming]
                     2"
                     /protein_id="NP_061369.2"
                     /db_xref="CCDS:CCDS15425.1"
                     /db_xref="GeneID:55990"
                     /db_xref="MGI:MGI:1916776"
                     /translation="MAKKVVVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGLWRFK
                     ENVEDGRASIYRSVITNTSKEMSCFSDFPMPEDFPNFLHNSKLLEYFRIFAKKFDLLK
                     YIQFQTTVISVKKRPDFASSGQWEVYTQSNGKEQRTVFDAVMVCSGHHIQPHLPLKSF
                     PGIERFRGQYFHSREYKHPVGFEGKRILVVGIGNSAADIASELSKTAAQVFVSTRHGS
                     WVMSRISEDGYPWDMVFHTRFSSMLRNVLPRTVVKWMMEQQMNRWFNHENYGLVPQNK
                     YLMKEPVLNDDLPSRLLYGAIKVKTRVKELTETAVVFEDGTVEEDVDIIVFATGYTFS
                     FSFLEDSLVKVEDNRVSLYKAMFPPHLEKPTLACIGLIQPLGSIFPTVELQARWATRV
                     FKGLCSLPSETTMMADIVERNEKRVNLFGKSQSQILQTNYVDYLDELALEIGAKPDFV
                     SLFFKDPKLAVKLYFGPCNSYQYRLVGPGQWEGARNAILTQKQRILKPLKTRTLQSSD
                     SAPVSFLLKILGLLAVVLAFFFQLQGF"
     exon            226..414
                     /gene="Fmo2"
                     /gene_synonym="2310008D08Rik; 2310042I22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            415..577
                     /gene="Fmo2"
                     /gene_synonym="2310008D08Rik; 2310042I22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            578..720
                     /gene="Fmo2"
                     /gene_synonym="2310008D08Rik; 2310042I22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            721..920
                     /gene="Fmo2"
                     /gene_synonym="2310008D08Rik; 2310042I22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1276
                     /gene="Fmo2"
                     /gene_synonym="2310008D08Rik; 2310042I22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1349
                     /gene="Fmo2"
                     /gene_synonym="2310008D08Rik; 2310042I22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..4112
                     /gene="Fmo2"
                     /gene_synonym="2310008D08Rik; 2310042I22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4085..4090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fmo2"
                     /gene_synonym="2310008D08Rik; 2310042I22Rik"
                     /note="hexamer: AATAAA"
     regulatory      4092..4097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fmo2"
                     /gene_synonym="2310008D08Rik; 2310042I22Rik"
                     /note="hexamer: ATTACA"
     polyA_site      4108
                     /gene="Fmo2"
                     /gene_synonym="2310008D08Rik; 2310042I22Rik"
                     /note="major polyA site"
     polyA_site      4112
                     /gene="Fmo2"
                     /gene_synonym="2310008D08Rik; 2310042I22Rik"
ORIGIN      
        1 atctcttaaa tactcccatc tctccgcaca caaccctcag ggggaactct tctgccaaga
       61 ggacagtgct aagaagcaca aataaaggag acaatggcaa agaaggttgt ggtgattgga
      121 gcaggggtca gtggcctaat ctctctgaag tgctgcgtgg acgagggtct ggagcccacc
      181 tgcttcgaaa ggactgaaga tataggggga ctgtggagat tcaaagaaaa cgtggaagat
      241 ggccgcgcta gcatctaccg ctctgtcatt accaacacta gcaaagaaat gtcctgtttc
      301 agtgacttcc cgatgccgga ggacttcccc aacttcctgc acaactctaa actcctggaa
      361 tattttagga tctttgccaa gaaatttgat ctcctaaaat atattcagtt tcagaccact
      421 gtcattagtg tgaaaaaacg cccggacttc gcatcttctg ggcaatggga agtttatact
      481 cagagcaacg gaaaggagca acgcactgtc tttgacgctg ttatggtttg cagcggccat
      541 cacatccagc ctcacctgcc actcaagtca ttcccaggta ttgagaggtt ccgaggccag
      601 tatttccata gccgcgaata caagcaccca gtggggtttg aggggaaacg catcctggtg
      661 gttggaatag gaaactcagc tgcagatatt gcctctgaac tgagtaagac ggccgcgcag
      721 gtgtttgtca gcaccagaca tggatcctgg gtcatgagtc gaatctctga agatggctac
      781 ccttgggaca tggtgttcca cactagattt agctccatgc tccgaaatgt cctgccccgc
      841 acggtcgtca agtggatgat ggaacaacag atgaatcgat ggttcaacca tgaaaattat
      901 ggtctggtgc ctcagaacaa ataccttatg aaagaacctg tgctaaacga cgacctcccc
      961 agccgcctgc tgtacggagc catcaaagta aaaacacggg tgaaggagct cacggagaca
     1021 gctgtggtct tcgaggatgg cacggtggag gaagacgtgg atatcattgt ctttgccacg
     1081 gggtatacgt tctctttttc tttcctggaa gactcacttg ttaaagtgga ggataatagg
     1141 gtttccctgt acaaagccat gtttccccct cacctggaga agccaaccct tgcgtgcata
     1201 ggtctcatcc agcctctagg ctccatcttc ccaaccgtag agcttcaggc gcgctgggcg
     1261 acaagagttt tcaaaggctt gtgtagcttg ccttcggaga cgactatgat ggcagacatt
     1321 gttgaaagaa atgaaaaaag agttaacctg tttgggaaaa gccagagtca gatactgcag
     1381 accaactacg ttgactacct ggatgaactc gccttggaga taggtgcaaa gccagatttc
     1441 gtctctctct ttttcaaaga ccctaaactg gctgtgaaac tctacttcgg accctgtaat
     1501 tcctaccagt accgcctggt tggacctggg cagtgggaag gagccaggaa cgccatcctc
     1561 acccagaagc agaggatcct gaaaccctta aagacccgga ctctccagtc ctctgatagt
     1621 gccccagtgt ctttcctgct caagatcctg gggctgctcg ctgttgttct ggccttcttt
     1681 ttccaacttc aggggtttta atcagtcaca tgacagtttt ctccatcact gcctctttga
     1741 aagggaaact ggagaaattc catcctcatt ataattttac tttaggggaa taagtagggg
     1801 gactaattgt agggagatca gaaaacttag gtctagatat aaaactaagt taaggttaca
     1861 ggatgttctt atcattgttt ccccaaattc atcagtctcc acatggtatt ctataataac
     1921 accagcacag gtagatagta ctatcagcca tggcaggttt tgagttacaa gattaaaaaa
     1981 aaaatcaata aaattatgta gaataaaaag taagtcatag ttgagcatgt tagaacatgg
     2041 ctttaatctt agcacttgga aggcagatgg atctctgtga gttcaaagaa aaaaaaaagg
     2101 caagacactg aagaactgaa attgtagtag acatttcaca tcttgtacac tatgatgctc
     2161 agtgctgttc ctatgcatac tctggtcaca gttcccactt ctgatgcaaa aatgaaaaca
     2221 atattcccta gctacaacat atagatagat actgtttctc atagactaga cattgtgctg
     2281 tgtgtacatt atgtatttta ttggatttaa ttctcacagc aactgtgtga tgggtagagc
     2341 tatatatatc acccattcta cagatggcac tgaggagggg acattataga gcatatccta
     2401 aacagctggt cttgagatga ggcttcaatt gaagcccaat ttgttaaact cagaaactta
     2461 tgctcatgac ctccccatgc aatatgctta ttaatgaata gtccactctt gacgaagtac
     2521 ttcctaatca cttattttag tcattataaa ctcacacaat agctctattc attagcataa
     2581 agttttctaa gactattgta gaaaatggca ctttctttgc aaatagaatc tgtctaggtt
     2641 catttacaat attaggtctg tatgtccgct ggaatttaaa aagcacttgg gataaacaca
     2701 gtagtacaga cctttaatcc cagcactaag gagtcaagac aggcagatta ctaccagttt
     2761 gaggctgggt tgctctacat agcaaaatct gggccagcca gggctacatg gtgacaacct
     2821 gtctcaaaag aaaaataatt acaaagagat ttagtattaa aaatagctat gcagtgatat
     2881 ttaatcatca ccatgtgaaa gtataagaaa tgaagtgaag tgcatctccc aagcagatga
     2941 aactctacaa tggctgaggt tatagggtta acattatagg taagaaaagc aaatctcagc
     3001 aatgtcctgt ctttgtcatc tgataagggg cagggggagg ttgtcagtta tgagagacat
     3061 tttcttggaa cggaaaacta aaggagacac cagcagttta gtgtcaacaa acactgagca
     3121 acatagcaaa caccaggcta caaacactcc tgatagcatc tctttccatg aaccgcactg
     3181 caaaagataa gctatgccca gagaccagac cagagcctct gcagagggga caaaggccag
     3241 gatactgaag gtttaagtaa atagctcttc tttagccctc cgagcagtgg ttctcagttt
     3301 tcctaatgct acaccccctt aaaacaatcc ctcatgttgt ggtgaccctc aaccataaaa
     3361 gtatctcatt gctgcttcat aactgtaatt ttgctactct tatgaattgt tgtgcaaata
     3421 gctgatatgt gacccctgtg ggggtcttga cccactggtt gagaactact gcttcaaagc
     3481 tttgtgaaca ctgtctttaa accagcccct ctctccgttc tctcccctta ctctcctccc
     3541 cctttccagt ttgatggcaa tctcttccaa aggaaacttc tttcttctaa gcccactgaa
     3601 ttgggctgca gaattgcccg gttggcaagg ccttgtaagc ttaagaatct gaatttgagc
     3661 ttcaggaccc atattttaca agcccggtgt ggctgcacac acttctaatc ccagcattgg
     3721 ggagggagat gaaaacagta tcctgggtat cgctggccag cctcctctgt tttaatgagt
     3781 tccaggtcag tcagagaccc tgtctcagaa aacaaaagtg ggcgaatcct gaggagcaat
     3841 accagagtct cacctctggc ctatgtactc atgtttgtat atgtttccac ataaccctgc
     3901 aactgcacgc acttgaacac acacaaacat atatgcatac acatatatac atacaaaagt
     3961 tcactgatat tactacattt gcatttaaga ctcttgactg tacttataag caaattcctt
     4021 tcaaaagtta caaatgaaaa tgtattgtgt gcatctatga aattctcaaa cacatttttt
     4081 taaaaataaa aattacaagt gaaatgtata aa
//
