LOCUS       NP_061369                535 aa            linear   ROD 09-FEB-2025
DEFINITION  dimethylaniline monooxygenase [N-oxide-forming] 2 [Mus musculus].
ACCESSION   NP_061369
VERSION     NP_061369.2
DBSOURCE    REFSEQ: accession NM_018881.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 535)
  AUTHORS   Wang,L., Zha,H., Huang,J. and Shi,L.
  TITLE     Flavin containing monooxygenase 2 regulates renal tubular cell
            fibrosis and paracrine secretion via SMURF2 in AKI-CKD
            transformation
  JOURNAL   Int J Mol Med 52 (5) (2023)
   PUBMED   37800598
  REMARK    GeneRIF: Flavin containing monooxygenase 2 regulates renal tubular
            cell fibrosis and paracrine secretion via SMURF2 in AKI-CKD
            transformation.
REFERENCE   2  (residues 1 to 535)
  AUTHORS   Yoshida,Y., Shimizu,I., Shimada,A., Nakahara,K., Yanagisawa,S.,
            Kubo,M., Fukuda,S., Ishii,C., Yamamoto,H., Ishikawa,T., Kano,K.,
            Aoki,J., Katsuumi,G., Suda,M., Ozaki,K., Yoshida,Y., Okuda,S.,
            Ohta,S., Okamoto,S., Minokoshi,Y., Oda,K., Sasaoka,T., Abe,M.,
            Sakimura,K., Kubota,Y., Yoshimura,N., Kajimura,S., Zuriaga,M.,
            Walsh,K., Soga,T. and Minamino,T.
  TITLE     Brown adipose tissue dysfunction promotes heart failure via a
            trimethylamine N-oxide-dependent mechanism
  JOURNAL   Sci Rep 12 (1), 14883 (2022)
   PUBMED   36050466
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 535)
  AUTHORS   AlOgayil,N., Bauermeister,K., Galvez,J.H., Venkatesh,V.S.,
            Zhuang,Q.K., Chang,M.L., Davey,R.A., Zajac,J.D., Ida,K., Kamiya,A.,
            Taketo,T., Bourque,G. and Naumova,A.K.
  TITLE     Distinct roles of androgen receptor, estrogen receptor alpha, and
            BCL6 in the establishment of sex-biased DNA methylation in mouse
            liver
  JOURNAL   Sci Rep 11 (1), 13766 (2021)
   PUBMED   34215813
  REMARK    Erratum:[Sci Rep. 2021 Nov 22;11(1):22975. doi:
            10.1038/s41598-021-02512-8.. PMID: 34811454]
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 535)
  AUTHORS   Veeravalli,S., Phillips,I.R., Freire,R.T., Varshavi,D.,
            Everett,J.R. and Shephard,E.A.
  TITLE     Flavin-Containing Monooxygenase 1 Catalyzes the Production of
            Taurine from Hypotaurine
  JOURNAL   Drug Metab Dispos 48 (5), 378-385 (2020)
   PUBMED   32156684
REFERENCE   5  (residues 1 to 535)
  AUTHORS   Miyai,M., Hamada,M., Moriguchi,T., Hiruma,J., Kamitani-Kawamoto,A.,
            Watanabe,H., Hara-Chikuma,M., Takahashi,K., Takahashi,S. and
            Kataoka,K.
  TITLE     Transcription Factor MafB Coordinates Epidermal Keratinocyte
            Differentiation
  JOURNAL   J Invest Dermatol 136 (9), 1848-1857 (2016)
   PUBMED   27208706
  REMARK    Review article
REFERENCE   6  (residues 1 to 535)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 535)
  AUTHORS   Hernandez,D., Janmohamed,A., Chandan,P., Omar,B.A., Phillips,I.R.
            and Shephard,E.A.
  TITLE     Deletion of the mouse Fmo1 gene results in enhanced pharmacological
            behavioural responses to imipramine
  JOURNAL   Pharmacogenet Genomics 19 (4), 289-299 (2009)
   PUBMED   19262426
REFERENCE   8  (residues 1 to 535)
  AUTHORS   Patel,S., Xi,Z.F., Seo,E.Y., McGaughey,D. and Segre,J.A.
  TITLE     Klf4 and corticosteroids activate an overlapping set of
            transcriptional targets to accelerate in utero epidermal barrier
            acquisition
  JOURNAL   Proc Natl Acad Sci U S A 103 (49), 18668-18673 (2006)
   PUBMED   17130451
REFERENCE   9  (residues 1 to 535)
  AUTHORS   Lattard,V., Longin-Sauvageon,C., Krueger,S.K., Williams,D.E. and
            Benoit,E.
  TITLE     The FMO2 gene of laboratory rats, as in most humans, encodes a
            truncated protein
  JOURNAL   Biochem Biophys Res Commun 292 (2), 558-563 (2002)
   PUBMED   11906197
REFERENCE   10 (residues 1 to 535)
  AUTHORS   Karoly,E.D. and Rose,R.L.
  TITLE     Sequencing, expression, and characterization of cDNA expressed
            flavin-containing monooxygenase 2 from mouse
  JOURNAL   J Biochem Mol Toxicol 15 (6), 300-308 (2001)
   PUBMED   11835629
  REMARK    GeneRIF: sequencing, expression, and characterization of cDNA
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117767.13.
            
            On Jun 9, 2003 this sequence version replaced NP_061369.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 all encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031415.1, SRR5189676.88740.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..535
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 70.34 cM"
     Protein         1..535
                     /product="dimethylaniline monooxygenase [N-oxide-forming]
                     2"
                     /EC_number="1.14.13.8"
                     /note="FMO 2; dimethylaniline oxidase 2; pulmonary
                     flavin-containing monooxygenase 2"
                     /calculated_mol_wt=60844
     Region          2..532
                     /region_name="FMO-like"
                     /note="Flavin-binding monooxygenase-like; pfam00743"
                     /db_xref="CDD:395602"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P17635; propagated from
                     UniProtKB/Swiss-Prot (Q8K2I3.3)"
     Site            510..530
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K2I3.3)"
     CDS             1..535
                     /gene="Fmo2"
                     /gene_synonym="2310008D08Rik; 2310042I22Rik"
                     /coded_by="NM_018881.4:94..1701"
                     /db_xref="CCDS:CCDS15425.1"
                     /db_xref="GeneID:55990"
                     /db_xref="MGI:MGI:1916776"
ORIGIN      
        1 makkvvviga gvsglislkc cvdegleptc fertediggl wrfkenvedg rasiyrsvit
       61 ntskemscfs dfpmpedfpn flhnsklley frifakkfdl lkyiqfqttv isvkkrpdfa
      121 ssgqwevytq sngkeqrtvf davmvcsghh iqphlplksf pgierfrgqy fhsreykhpv
      181 gfegkrilvv gignsaadia selsktaaqv fvstrhgswv msrisedgyp wdmvfhtrfs
      241 smlrnvlprt vvkwmmeqqm nrwfnhenyg lvpqnkylmk epvlnddlps rllygaikvk
      301 trvkelteta vvfedgtvee dvdiivfatg ytfsfsfled slvkvednrv slykamfpph
      361 lekptlacig liqplgsifp tvelqarwat rvfkglcslp settmmadiv ernekrvnlf
      421 gksqsqilqt nyvdyldela leigakpdfv slffkdpkla vklyfgpcns yqyrlvgpgq
      481 wegarnailt qkqrilkplk trtlqssdsa pvsfllkilg llavvlafff qlqgf
//
