LOCUS       NM_010231               2404 bp    mRNA    linear   ROD 27-DEC-2022
DEFINITION  Mus musculus flavin containing monooxygenase 1 (Fmo1), transcript
            variant 1, mRNA.
ACCESSION   NM_010231
VERSION     NM_010231.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2404)
  AUTHORS   Li B, Yang S, Ye J, Chu S, Chen N and An Z.
  TITLE     Flavin-containing monooxygenase 1 deficiency promotes
            neuroinflammation in dopaminergic neurons in mice
  JOURNAL   Neurosci Lett 764, 136222 (2021)
   PUBMED   34500002
REFERENCE   2  (bases 1 to 2404)
  AUTHORS   Veeravalli S, Phillips IR, Freire RT, Varshavi D, Everett JR and
            Shephard EA.
  TITLE     Flavin-Containing Monooxygenase 1 Catalyzes the Production of
            Taurine from Hypotaurine
  JOURNAL   Drug Metab Dispos 48 (5), 378-385 (2020)
   PUBMED   32156684
  REMARK    GeneRIF: Flavin-Containing Monooxygenase 1 Catalyzes the Production
            of Taurine from Hypotaurine.
REFERENCE   3  (bases 1 to 2404)
  AUTHORS   Huang X, Balmer S, Yang F, Fidalgo M, Li D, Guallar D,
            Hadjantonakis AK and Wang J.
  TITLE     Zfp281 is essential for mouse epiblast maturation through
            transcriptional and epigenetic control of Nodal signaling
  JOURNAL   Elife 6, e33333 (2017)
   PUBMED   29168693
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2404)
  AUTHORS   Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K,
            Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre
            A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt
            AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,
            Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S,
            Wohnoutka P, Hawrylycz MJ, Puelles L and Jones AR.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 2404)
  AUTHORS   Janmohamed A, Phillips lR and Shephard EA.
  TITLE     Determination of cellular localization of expression of
            flavin-containing monooxygenase genes in mouse tissues by in situ
            hybridization
  JOURNAL   Methods Mol Biol 320, 295-305 (2006)
   PUBMED   16719401
REFERENCE   6  (bases 1 to 2404)
  AUTHORS   Janmohamed A, Hernandez D, Phillips IR and Shephard EA.
  TITLE     Cell-, tissue-, sex- and developmental stage-specific expression of
            mouse flavin-containing monooxygenases (Fmos)
  JOURNAL   Biochem Pharmacol 68 (1), 73-83 (2004)
   PUBMED   15183119
  REMARK    GeneRIF: Fmo1, 2, 3, 4 and 5 exhibit distinct cell-, tissue-, sex-
            and developmental stage-specific patterns of expression.
REFERENCE   7  (bases 1 to 2404)
  AUTHORS   Cherrington NJ, Falls JG, Rose RL, Clements KM, Philpot RM, Levi PE
            and Hodgson E.
  TITLE     Molecular cloning, sequence, and expression of mouse
            flavin-containing monooxygenases 1 and 5 (FMO1 and FMO5)
  JOURNAL   J Biochem Mol Toxicol 12 (4), 205-212 (1998)
   PUBMED   9580872
REFERENCE   8  (bases 1 to 2404)
  AUTHORS   Falls JG, Ryu DY, Cao Y, Levi PE and Hodgson E.
  TITLE     Regulation of mouse liver flavin-containing monooxygenases 1 and 3
            by sex steroids
  JOURNAL   Arch Biochem Biophys 342 (2), 212-223 (1997)
   PUBMED   9186481
REFERENCE   9  (bases 1 to 2404)
  AUTHORS   Itoh K, Nakamura K, Kimura T, Itoh S and Kamataki T.
  TITLE     Molecular cloning of mouse liver flavin containing monooxygenase
            (FMO1) cDNA and characterization of the expression product:
            metabolism of the neurotoxin, 1,2,3,4-tetrahydroisoquinoline (TIQ)
  JOURNAL   J Toxicol Sci 22 (1), 45-56 (1997)
   PUBMED   9076656
REFERENCE   10 (bases 1 to 2404)
  AUTHORS   Falls JG, Blake BL, Cao Y, Levi PE and Hodgson E.
  TITLE     Gender differences in hepatic expression of flavin-containing
            monooxygenase isoforms (FMO1, FMO3, and FMO5) in mice
  JOURNAL   J Biochem Toxicol 10 (3), 171-177 (1995)
   PUBMED   7473608
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117767.13, D16215.1, AC118643.6 and BU755220.1.
            
            [WARNING] On Apr 26, 2023 this sequence was replaced by
            NM_010231.4.
            
            On Aug 24, 2016 this sequence version replaced NM_010231.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011229.1, U87456.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC117767.13        43328-43566         c
            240-2298            D16215.1           68-2126
            2299-2387           AC118643.6         15017-15105
            2388-2404           BU755220.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2404
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 70.34 cM"
     gene            1..2404
                     /gene="Fmo1"
                     /note="flavin containing monooxygenase 1"
                     /db_xref="GeneID:14261"
                     /db_xref="MGI:MGI:1310002"
     exon            1..372
                     /gene="Fmo1"
                     /inference="alignment:Splign:2.1.0"
     exon            373..510
                     /gene="Fmo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             379..1977
                     /gene="Fmo1"
                     /EC_number="1.14.13.8"
                     /EC_number="1.14.13.148"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dimethylaniline monooxygenase [N-oxide-forming] 1;
                     trimethylamine monooxygenase; dimethylaniline oxidase 1;
                     hepatic flavin-containing monooxygenase 1"
                     /codon_start=1
                     /product="flavin-containing monooxygenase 1 isoform 1"
                     /protein_id="NP_034361.1"
                     /db_xref="CCDS:CCDS15424.1"
                     /db_xref="GeneID:14261"
                     /db_xref="MGI:MGI:1310002"
                     /translation="MVKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRFT
                     EHVEEGRASLYKSVVSNSSREMSCYPDFPFPEDYPNFVPNSLFLEYLKLYSTQFNLQR
                     CIYFNTKVCSITKRPDFAVSGQWEVVTVTNGKQNSAIFDAVMVCTGFLTNPHLPLDSF
                     PGILTFKGEYFHSRQYKHPDIFKDKRVLVVGMGNSGTDIAVEASHLAKKVFLSTTGGA
                     WVISRVFDSGYPWDMIFMTRFQNMLRNLLPTPIVSWLISKKMNSWFNHVNYGVAPEDR
                     TQLREPVLNDELPGRIITGKVFIKPSIKEVKENSVVFNNTPKEEPIDIIVFATGYTFA
                     FPFLDESVVKVEDGQASLYKYIFPAHLPKPTLAVIGLIKPLGSMVPTGETQARWVVQV
                     LKGATTLPPPSVMMEEVNERKKNKHSGFGLCYCKALQTDYITYIDDLLTSINAKPDLR
                     AMLLTDPRLALSIFFGPCTPYHFRLTGPGKWEGARKAILTQWDRTVKVTKTRTIQESP
                     SSFETLLKLFSFLALLIAVFLIFL"
     exon            511..699
                     /gene="Fmo1"
                     /inference="alignment:Splign:2.1.0"
     exon            700..862
                     /gene="Fmo1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1005
                     /gene="Fmo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1205
                     /gene="Fmo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1561
                     /gene="Fmo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1634
                     /gene="Fmo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..2388
                     /gene="Fmo1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgcttctta tctcttagac caggctcatc ctgtgtgcag ggaactccca aacactggct
       61 caaaacaatt ttgattgtta ctagctctgg gatcctaatt gtgtcagggc cactggaatg
      121 agcaattaca gctacttaga gtcagtaacc ccataaaaat ctccgattcc tctgggtgaa
      181 gaaggtggag ctgagttttt cctgtttttt cttattgtac atcagagagg agtcgtctca
      241 acagaacaca gctccctcca cgagtgaccc tgggggaatt tttcgaccat cccttgctcc
      301 aacgtaagga acagaacttg agaccttgtc acaggaacat aaagtcagat tgctaaactt
      361 ctgcatttac tgagaaacat ggtgaagcga gtggcaattg tgggagctgg ggtcagcggc
      421 ctggcctcca tcaagtgctg cctggaagag gggctggagc ccacctgctt cgagaggagc
      481 agtgacctgg ggggactttg gagattcacg gaacatgttg aagaagggag agccagtctt
      541 tacaagtctg tggtttctaa cagcagcagg gagatgtcgt gttacccaga ttttcctttt
      601 ccagaagact atccaaactt tgtgccaaat tctctattcc tggaatatct caaactctac
      661 tcaacccagt tcaaccttca gagatgcatt tatttcaata ccaaagtgtg cagtataaca
      721 aaacgcccgg attttgctgt ctctggacag tgggaagtgg tcactgtcac aaacgggaag
      781 caaaactcag ccatctttga tgctgtcatg gtctgcactg gttttctaac taacccacat
      841 ctgcccctgg attccttccc aggtatacta acttttaagg gggagtactt ccacagccga
      901 cagtataaac atccagacat atttaaggac aagcgagtcc ttgtagttgg aatggggaat
      961 tctggcacag atattgccgt ggaggccagc cacttagcaa aaaaggtgtt cctcagcact
     1021 actggagggg catgggtgat cagccgagtc tttgattcag ggtacccatg ggacatgata
     1081 ttcatgacac gatttcagaa catgctcaga aatcttctcc caactccaat tgtgagttgg
     1141 ttgatatcaa aaaagatgaa cagctggttc aaccacgtga attacggtgt agctccagaa
     1201 gacaggactc agctgagaga gcctgtgcta aatgatgagc tcccaggccg catcatcact
     1261 gggaaagtgt ttatcaagcc cagcatcaag gaggtaaagg aaaactctgt cgtgttcaac
     1321 aacacaccaa aggaggagcc cattgacatc atcgtctttg cgactggata tacttttgcg
     1381 ttccccttcc tcgatgaatc cgtagtgaaa gttgaggatg gccaggcatc actgtacaag
     1441 tacatcttcc ctgcgcatct gccaaaacca actctggctg tgattggcct catcaagccc
     1501 ctgggctcca tggtacccac aggagagaca caagctcgat gggttgttca ggtcctaaaa
     1561 ggtgcaacta cattaccacc gccaagtgtc atgatggagg aagttaatga acggaagaaa
     1621 aacaagcata gcgggtttgg cttgtgctac tgcaaggctt tgcaaacaga ttatataaca
     1681 tacatagatg acctcctgac ctctatcaac gcaaaaccgg atctgcgggc catgctcctg
     1741 actgacccac gactggctct gagcatcttc tttggcccat gtacccctta ccatttccgc
     1801 ctgactggtc caggaaaatg ggaaggagcc agaaaggcca tcttgaccca gtgggaccga
     1861 acagtgaaag tcaccaaaac tcgaaccata caagaatccc catcttcctt tgaaactttg
     1921 ctgaaactct ttagttttct ggctttgctc atagctgtct tcttgatttt cctgtaagtg
     1981 aaagatctaa ctggcttttc aaatgtatgg agtataacgt tccaactcct ctaatgtaac
     2041 aactttgtct tcataatcat aaaccatatc caaagaatga aaccctaccc cctccccttt
     2101 ccggttcacc tcactggcag cttggtattg ctgggtctct tgcagctcca ttaggtttaa
     2161 tgccagaaga taaggtccag cacttttgtt cacttaaaat gttggaagga tccaggccct
     2221 tttcaggaag aagctgcccc cagagaatac tctgagcatt ctttcgccct aaaaaagcaa
     2281 gtttcctaga tcttaatgaa aagcccaacc ttgtggaata ttggtctaca ctaaaatagt
     2341 tctctgtgta ttagctgact acaaataaaa tggaagagac tacatgtaaa aaaaaaaaaa
     2401 aaaa
//
