LOCUS       NM_001408315            5520 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus formin-like 2 (Fmnl2), transcript variant 1, mRNA.
ACCESSION   NM_001408315 XM_006498333
VERSION     NM_001408315.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5520)
  AUTHORS   Pan,M.H., Zhang,K.H., Wu,S.L., Pan,Z.N., Sun,M.H., Li,X.H.,
            Ju,J.Q., Luo,S.M., Ou,X.H. and Sun,S.C.
  TITLE     FMNL2 regulates actin for endoplasmic reticulum and mitochondria
            distribution in oocyte meiosis
  JOURNAL   Elife 12, 92732 (2024)
   PUBMED   38747713
  REMARK    GeneRIF: FMNL2 regulates actin for endoplasmic reticulum and
            mitochondria distribution in oocyte meiosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5520)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5520)
  AUTHORS   Katsuno-Kambe,H., Parton,R.G., Yap,A.S. and Teo,J.L.
  TITLE     Caveolin-1 influences epithelial collective cell migration via
            FMNL2 formin
  JOURNAL   Biol Cell 113 (2), 107-117 (2021)
   PUBMED   33169848
  REMARK    GeneRIF: Caveolin-1 influences epithelial collective cell migration
            via FMNL2 formin.
REFERENCE   4  (bases 1 to 5520)
  AUTHORS   Kage,F., Steffen,A., Ellinger,A., Ranftler,C., Gehre,C.,
            Brakebusch,C., Pavelka,M., Stradal,T. and Rottner,K.
  TITLE     FMNL2 and -3 regulate Golgi architecture and anterograde transport
            downstream of Cdc42
  JOURNAL   Sci Rep 7 (1), 9791 (2017)
   PUBMED   28852060
  REMARK    GeneRIF: Our data thus link FMNL2/3 formins to actin
            assembly-dependent functions of Cdc42 in anterograde transport
            through the Golgi apparatus.
            Erratum:[Sci Rep. 2019 Nov 26;9(1):18008. doi:
            10.1038/s41598-019-54630-z. PMID: 31767955]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5520)
  AUTHORS   Kage,F., Winterhoff,M., Dimchev,V., Mueller,J., Thalheim,T.,
            Freise,A., Bruhmann,S., Kollasser,J., Block,J., Dimchev,G.,
            Geyer,M., Schnittler,H.J., Brakebusch,C., Stradal,T.E.,
            Carlier,M.F., Sixt,M., Kas,J., Faix,J. and Rottner,K.
  TITLE     FMNL formins boost lamellipodial force generation
  JOURNAL   Nat Commun 8, 14832 (2017)
   PUBMED   28327544
  REMARK    GeneRIF: force generation in lamellipodia strongly depends on FMNL
            formin activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5520)
  AUTHORS   Bugyi,B., Papp,G., Hild,G., Lorinczy,D., Nevalainen,E.M.,
            Lappalainen,P., Somogyi,B. and Nyitrai,M.
  TITLE     Formins regulate actin filament flexibility through long range
            allosteric interactions
  JOURNAL   J Biol Chem 281 (16), 10727-10736 (2006)
   PUBMED   16490788
  REMARK    GeneRIF: mDia1-FH2 has an effect on the conformation of actin
            filaments
REFERENCE   7  (bases 1 to 5520)
  AUTHORS   Cui,Y.Z., Peng,Y.F. and Tian,Q.
  TITLE     Expression of man, a formin homology domain-containing gene in the
            mouse limb
  JOURNAL   Sheng Li Xue Bao 57 (4), 433-438 (2005)
   PUBMED   16094489
REFERENCE   8  (bases 1 to 5520)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   9  (bases 1 to 5520)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 5520)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844859.5, AL844510.10 and AL845170.5.
            
            On Jun 15, 2022 this sequence version replaced XM_006498333.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777535.2663223.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               AL844859.5         111778-112283
            507-590             AL844510.10        119334-119417
            591-671             AL845170.5         21528-21608
            672-748             AL845170.5         27317-27393
            749-832             AL845170.5         36224-36307
            833-985             AL845170.5         39478-39630
            986-1094            AL845170.5         53526-53634
            1095-1171           AL845170.5         57234-57310
            1172-1265           AL845170.5         58664-58757
            1266-1340           AL845170.5         82295-82369
            1341-1451           AL845170.5         86450-86560
            1452-1601           AL845170.5         88681-88830
            1602-1703           AL845170.5         90503-90604
            1704-2016           AL845170.5         92377-92689
            2017-2223           AL845170.5         93276-93482
            2224-2348           AL845170.5         99136-99260
            2349-2551           AL845170.5         99879-100081
            2552-2786           AL845170.5         101864-102098
            2787-2855           AL845170.5         103211-103279
            2856-2936           AL845170.5         103388-103468
            2937-3066           AL845170.5         104984-105113
            3067-3230           AL845170.5         107512-107675
            3231-3332           AL845170.5         108496-108597
            3333-3431           AL845170.5         111037-111135
            3432-3555           AL845170.5         111877-112000
            3556-5520           AL845170.5         116864-118828
FEATURES             Location/Qualifiers
     source          1..5520
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 30.69 cM"
     gene            1..5520
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /note="formin-like 2"
                     /db_xref="GeneID:71409"
                     /db_xref="MGI:MGI:1918659"
     exon            1..506
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            507..590
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            591..671
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            672..748
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            749..832
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            833..985
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1094
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1171
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1265
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1340
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1451
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1601
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1703
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..2016
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2223
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2348
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2551
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2786
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2855
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..2936
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3066
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3230
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3332
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            3333..3431
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            3432..3555
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..5520
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5500..5505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /note="hexamer: AATAAA"
     polyA_site      5520
                     /gene="Fmnl2"
                     /gene_synonym="5430425K04Rik; Man"
                     /note="major polyA site"
ORIGIN      
        1 attgtgtcgg ccagccgtgc gcgaacgtcc gctcgctgtg gggccggggc tgaggtgtca
       61 gcgccgctgc ggccggggcg agaggcggac gagcaggagc gcgcaagcgg ccgcgggtgc
      121 cggcgggggc ggcgggagca ccatgcggat cggcgcccag cgccctgcag acccctcgcg
      181 aggcagagag gccggggcgg cgccggggcg gcggggagca tgaggacggc cggggaccgg
      241 ctgggttcgg agctctgcta ggaagcggcg tgcgctgagc actaaccggg acgcggcgga
      301 gggcgggagc caagcgcccg gggctgtggg cattttggac gcggacgcaa ggggcccgga
      361 gccagccggg gctccggcac gcagccgaca tgggcaacgc ggggagcatg gactcgcagc
      421 agaccgattt caaggcgcac aacgtgccat tgaagctgcc gatgcccgag ccaggtgaac
      481 tggaggagcg ctttgccatc gtgctgaatg ctatgaacct acctcctgac aaagccaggc
      541 tactgcggca gtatgacaat gagaaaaaat gggagctgat ctgtgatcag gagcgattcc
      601 aggtgaagaa ccctccccat acgtacatac agaagctcaa aggctacctg gacccagctg
      661 taaccaggaa gaaattcaga aggcgtgttc aagaatctac acaagtgcta agagaactgg
      721 aaatttcatt aagaaccaac cacattggat gggtcagaga gtttttgaat gaagaaaaca
      781 aaggccttga tgttcttgtg gagtatttgt cttttgcaca gtatgcagtc acttttgact
      841 ttgaaagtgt ggaaagtacc atggagagta cggtggacaa atcaaagccc tggagcaggt
      901 ccatcgagga cctgcacaga gggagcaacc tgccctcacc tgtgggcaac agtgtgtccc
      961 gctctggaag acattctgca cttcgatata atactttgcc aagcagaaga accctgaaaa
     1021 attcaagatt agtgagtaag aaggatgatg ttcacgtttg tatcatgtgt ttacgagcca
     1081 tcatgaatta ccagtatggc ttcaacatgg tcatgtctca tccacacgcc gtcaatgaga
     1141 ttgcactaag tctgaacaac aaaaatccca gaacaaaagc tcttgtcttg gagctgttgg
     1201 cagccgtttg tcttgtcaga ggcgggcatg aaataatttt atcagctttt gataacttca
     1261 aggaggtctg cggagaaaag cagcgttttg agaagctgat ggaacatttc aggaatgaag
     1321 ataataacat agattttatg gtggcctcta tgcagtttat taacattgta gtccattcag
     1381 tagaagacat gaacttcaga gttcatctac aatatgaatt caccaaatta ggcctggatg
     1441 aatacttgga taagctgaaa cacacagaga gcgacaagct gcaagtacag attcaggctt
     1501 acctggacaa tgtgtttgat gtgggagctc tgttggaaga cgcagaaacc aagaatgctg
     1561 ccttggagcg ggtggaggag ctggaagaaa acatctctca tttgtctgaa aagctgcagg
     1621 acacggagaa cgaagccatg tccaagatcg tggaactgga aaagcaactt atgcagagga
     1681 ataaggaact ggatgttgtc cgggaaatct acaaagatgc aaatacccaa gttcacacgt
     1741 taagaaaaat ggtcaaagaa aaggaagaag ccattcaaag acagtctacc ctggaaaaaa
     1801 agattcacga actggagaaa caagggacca ttaaaattca gaagaaaggg gatggggaca
     1861 ttgccatact gccagtcatg gcctctggca cgttgtccac ggggtcagaa ctagcagtgg
     1921 gtaactatgt gggatcagtt ccaggggcca ccacctcagg accctcagtc cctcctcccc
     1981 caccactacc tccatcatca gacacatctg aagcagcaca aaatggaaca gcatcgccac
     2041 ctatgtcccc acctcctccc ccaccccctc caccccctcc cccaccccct ccaccccctc
     2101 cactcccagg ccctgcagct gagacttcac cagctcctcc tctgccacca cccccacctc
     2161 cctctgcacc cccgctgcct gggacttctt cacctacagt ggttttcaac tcaggattag
     2221 cagctgtgaa aattaagaag ccaatcaaga cgaagttccg aatgccagtg tttaactggg
     2281 tcgccctgaa gcccaatcag atcaacggca cagtcttcaa tgaaatcgat gatgagcgga
     2341 tcctagagga cttaaatgtg gacgaatttg aagaaatatt caagacaaaa gcccaaggtc
     2401 ctgccattga tctttcttca agcaagcaga aaataacaca gaaggcatca agtaaagtga
     2461 cattattaga agcaaatcga gccaaaaatc ttgccataac tttaaggaaa gctgggaagt
     2521 ctgcggatga gatatgtaaa gctattcatg tgtttgactt gaagacgcta ccggttgact
     2581 ttgttgagtg tttgatgagg ttcttgccaa ctgagaatga ggtcaaagtg cttcggctgt
     2641 atgagcgaga gaggaagccc ttggagaact tgtcagacga ggaccgtttc atgatgcagt
     2701 tcagtaagat tgagcggctg ctgcagaaga tgaccatcat ggccttcatt gggaacttca
     2761 cagagagcat tcagatgctg actcctcaac ttcacgcaat tatagcagca tccgtctcta
     2821 tcaagtcatc tcaaaagctc aagaagattc tggagatcat cttggccctt ggaaactata
     2881 tgaatagcag caaacgagga gcagtctatg gatttaaact tcagagttta gatctgctct
     2941 tagatacaaa gtcgacagac cgaaagcaaa cactgttgca ctatatatca aatgtggtaa
     3001 aagaaaaata tcaacaagtt actctgtttt ataatgagct tcattacgtg gaaaaagctg
     3061 ctgcagtctc cctggagaac gttctgctgg atgtgaagga gctgcagagg gggatggatt
     3121 taaccaagag agagtatacc atgcatgacc acaacaccct gctgaaagag ttcctccttc
     3181 acaacgaggg caagctgaag aaactgcagg aggacgcgaa gattgctcag gatgcctttg
     3241 atgatgtggt gaaatatttt ggcgaaaatc ccaagacaac tccaccctcc gtgttcttcc
     3301 ctgtctttgt tcgatttgtg aaagcctaca agcaagcaga agaggaaaat gagctgagga
     3361 aaaagcagga acaagctctt atggaaaaac tgctagagca agaagccctg atggagcagc
     3421 aggatgcaaa gtctccttcc cataaatcaa agaggcagca gcaagagtta attgcggaat
     3481 taagaaggcg acaagttaaa gataacagac atgtatacga gggaaaagat ggcgccattg
     3541 aagacattat cacagatctt agaaaccaac cctacagacg agccgatgcg gtgagacgaa
     3601 gtgtgagacg gcgcttcgat gatcagaacc tgcgttctgt taatggtgcc gaaataacaa
     3661 tgtgactgga gaccaccttc atgagagggt gtccaagaaa ctgccattcc agccttcact
     3721 acagatgaaa tactctcaag ggctcagatt taacaaacac ataggaattt taaagtgatg
     3781 ggttctcttt ttaacccctg ttaacaagtg cctaaaattg gaagtaactt gctcagatta
     3841 atcaaagcaa taggtttgac ttaaatcttt ttacatcagt atgttactca gttttttaac
     3901 caaaatgtaa acttcatatt aaattcatta tttgccattt tgattgtcca ttgtggccca
     3961 ccctgatttc ctggtaatct gtaaataacg gatgtgtgtg ctatgggtat cctttgctga
     4021 gaggtcttct aagaaatttt gtgttcgagc catattcacc aactcctaac aagggactgg
     4081 aaacgggaga tggaagctgg catacaatta catccttctt tagtctcagc aaagtacaag
     4141 caggatgcaa ctgcagtgcc actccaagtc attcgatttt atcctatttc atgttgtttc
     4201 tgtgcaaggc tgccatgcac aaaggcattc acttgtatga cttcaagatg gcataaaaca
     4261 ttgaagactt atttgcagaa ctgtgttaag ctagaggcag cttttaataa cgcaaaggtt
     4321 tcttaattag cactaaaatt aatgtctcag tattctgatt tttgaggacc attatgggtg
     4381 aatccttaaa atagaaattg gtgccttgtt agtcagggag atttttacca caagctctat
     4441 cagtaagcat tcaaaaatta catgtattaa tgtaatgttg ggaacctggc cttattctct
     4501 tctgacaatc gaagggtcct tttttttttt tcttcccttt gtaaattata ctgatacagt
     4561 tgacattaag ttatcagggc tgaattgctt tatgcatttc ttacttatgg gaaattccca
     4621 ttaaattaac attgagatta agtttaaatt atccgcgata gggttaaatg gttgactaag
     4681 tcactcacct ttacttcctc actgacaagg catttccatc tttcccaaag tcaaagactg
     4741 gactgaagct aaatttgtac ttttcataat atatattctg cttctggctt accttgttgg
     4801 tacatcagta tattaattgt aaaaattatt gtatagtatt taaccaccaa atctgtgttc
     4861 atgtgaaccc cttggtgaag gccccctttt catggatgtg tagttatatg atctttaaaa
     4921 tgtacagata ttttgctata agattggtgc agttttttat ggtttttaca cttctcttta
     4981 attcctacct aagcctttag gtactactgt aaatattgtt ttaaaatgca tcagcctatg
     5041 ctacacaatc tgaatgttac tttaacttat agtttgtttt ctgaaatata tatatattta
     5101 actacaagga cagtttaaaa gtcagttacc acatttcaca gtagtatgcc tatttacaga
     5161 tcccttttaa actgccactt gctgtcacac tcataaatgt gtagtttaaa aagaacatgc
     5221 caagattgtc gtcttgttga gtcaatatcc atcttggtga gtatattaat ttgatcatga
     5281 tatcagaaaa atatgtggac ctccttcaca caaatcagct gctttccaaa ggcgtgcatt
     5341 tgcttaaagc aaactgccca tttcccagtg tacaaatgga caataatgtt ggcatattct
     5401 tctgtctgtc tagtaatggc cctgcttctt agcaatatta gaaatgtttt ataaaagcaa
     5461 tccatgttac ttttctggtc ttttcatgcc atttgagcaa ataaactatt tacactacta
//
