LOCUS       NM_010230              11925 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus formin 1 (Fmn1), transcript variant 1, mRNA.
ACCESSION   NM_010230 XM_978556
VERSION     NM_010230.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11925)
  AUTHORS   Monzo,P., Crestani,M., Chong,Y.K., Ghisleni,A., Hennig,K., Li,Q.,
            Kakogiannos,N., Giannotta,M., Richichi,C., Dini,T., Dejana,E.,
            Maiuri,P., Balland,M., Sheetz,M.P., Pelicci,G., Ang,B.T., Tang,C.
            and Gauthier,N.C.
  TITLE     Adaptive mechanoproperties mediated by the formin FMN1 characterize
            glioblastoma fitness for invasion
  JOURNAL   Dev Cell 56 (20), 2841-2855 (2021)
   PUBMED   34559979
  REMARK    GeneRIF: Adaptive mechanoproperties mediated by the formin FMN1
            characterize glioblastoma fitness for invasion.
REFERENCE   2  (bases 1 to 11925)
  AUTHORS   Malkmus,J., Ramos Martins,L., Jhanwar,S., Kircher,B., Palacio,V.,
            Sheth,R., Leal,F., Duchesne,A., Lopez-Rios,J., Peterson,K.A.,
            Reinhardt,R., Onimaru,K., Cohn,M.J., Zuniga,A. and Zeller,R.
  TITLE     Spatial regulation by multiple Gremlin1 enhancers provides digit
            development with cis-regulatory robustness and evolutionary
            plasticity
  JOURNAL   Nat Commun 12 (1), 5557 (2021)
   PUBMED   34548488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11925)
  AUTHORS   Takemon,Y., Wright,V., Davenport,B., Gatti,D.M., Sheehan,S.M.,
            Letson,K., Savage,H.S., Lennon,R. and Korstanje,R.
  TITLE     Uncovering Modifier Genes of X-Linked Alport Syndrome Using a Novel
            Multiparent Mouse Model
  JOURNAL   J Am Soc Nephrol 32 (8), 1961-1973 (2021)
   PUBMED   34045313
  REMARK    GeneRIF: Uncovering Modifier Genes of X-Linked Alport Syndrome
            Using a Novel Multiparent Mouse Model.
REFERENCE   4  (bases 1 to 11925)
  AUTHORS   Fang,Q., Zhang,Y., Da,P., Shao,B., Pan,H., He,Z., Cheng,C., Li,D.,
            Guo,J., Wu,X., Guan,M., Liao,M., Zhang,Y., Sha,S., Zhou,Z.,
            Wang,J., Wang,T., Su,K., Chai,R. and Chen,F.
  TITLE     Deletion of Limk1 and Limk2 in mice does not alter cochlear
            development or auditory function
  JOURNAL   Sci Rep 9 (1), 3357 (2019)
   PUBMED   30833597
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11925)
  AUTHORS   Dutta,P. and Maiti,S.
  TITLE     Expression of multiple formins in adult tissues and during
            developmental stages of mouse brain
  JOURNAL   Gene Expr Patterns 19 (1-2), 52-59 (2015)
   PUBMED   26272686
REFERENCE   6  (bases 1 to 11925)
  AUTHORS   Jackson-Grusby,L., Kuo,A. and Leder,P.
  TITLE     A variant limb deformity transcript expressed in the embryonic
            mouse limb defines a novel formin
  JOURNAL   Genes Dev 6 (1), 29-37 (1992)
   PUBMED   1339380
REFERENCE   7  (bases 1 to 11925)
  AUTHORS   Oettinger,M.A., Stanger,B., Schatz,D.G., Glaser,T., Call,K.,
            Housman,D. and Baltimore,D.
  TITLE     The recombination activating genes, RAG 1 and RAG 2, are on
            chromosome 11p in humans and chromosome 2p in mice
  JOURNAL   Immunogenetics 35 (2), 97-101 (1992)
   PUBMED   1735560
REFERENCE   8  (bases 1 to 11925)
  AUTHORS   Vogt,T.F., Jackson-Grusby,L., Wynshaw-Boris,A.J., Chan,D.C. and
            Leder,P.
  TITLE     The same genomic region is disrupted in two transgene-induced limb
            deformity alleles
  JOURNAL   Mamm Genome 3 (8), 431-437 (1992)
   PUBMED   1643305
REFERENCE   9  (bases 1 to 11925)
  AUTHORS   Maas,R.L., Jepeal,L.I., Elfering,S.L., Holcombe,R.F., Morton,C.C.,
            Eddy,R.L., Byers,M.G., Shows,T.B. and Leder,P.
  TITLE     A human gene homologous to the formin gene residing at the murine
            limb deformity locus: chromosomal location and RFLPs
  JOURNAL   Am J Hum Genet 48 (4), 687-695 (1991)
   PUBMED   1673046
REFERENCE   10 (bases 1 to 11925)
  AUTHORS   Glaser,T., Lane,J. and Housman,D.
  TITLE     A mouse model of the aniridia-Wilms tumor deletion syndrome
  JOURNAL   Science 250 (4982), 823-827 (1990)
   PUBMED   2173141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY288387.1, AK135758.1, AL691466.15, AL691437.7, CK391697.1,
            AL672253.7, CO814739.2, AV256854.2, CN832512.1 and AK142145.1.
            
            On Aug 19, 2006 this sequence version replaced NM_010230.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1, also known as IA).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X53599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BY288387.1         2-38
            38-449              AK135758.1         4-415
            450-2090            AL691466.15        37642-39282
            2091-2266           AL691466.15        103090-103265
            2267-2384           AL691437.7         15726-15843
            2385-2446           AL691437.7         50286-50347
            2447-3237           AL691437.7         96535-97325
            3238-3388           AL691437.7         100697-100847
            3389-3964           CK391697.1         21-596
            3965-4072           AL672253.7         57436-57543
            4073-4226           CO814739.2         522-675
            4227-4286           AL672253.7         94632-94691
            4287-4338           AL672253.7         145976-146027
            4339-4351           AL672253.7         150876-150888
            4352-4561           AV256854.2         1-210
            4562-4890           CN832512.1         154-482
            4891-10366          AL672253.7         167600-173075
            10367-11925         AK142145.1         1226-2784
FEATURES             Location/Qualifiers
     source          1..11925
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 57.3 cM"
     gene            1..11925
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /note="formin 1"
                     /db_xref="GeneID:14260"
                     /db_xref="MGI:MGI:101815"
     exon            1..96
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            97..2090
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..4618
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /note="isoform 1 is encoded by transcript variant 1; limb
                     deformity protein"
                     /codon_start=1
                     /product="formin-1 isoform 1"
                     /protein_id="NP_034360.2"
                     /db_xref="CCDS:CCDS16559.1"
                     /db_xref="GeneID:14260"
                     /db_xref="MGI:MGI:101815"
                     /translation="MEGTHCTLQLHNPIAELCYISFYLPKGEVRGFSYKGTVTLDRSN
                     NAFHNCYQVREGPDITSLSQQPNEHPGDIFFKQTPTKNILTELYKLTAEKERLLDSLL
                     RSDNILGVSMGSQEGKLQELSVILATGDEYFQSAGNWRRELPVSSLIRRSTQENKKPR
                     RSGRRRESPEELRQKRTRRKGRGCQESAFQMGKDQVCSSSSLSFRARPNLRLLEERGN
                     LVPRGTLTSSLRRRESCPANILRTPDADLAFGNSGRTSEDTDLEGPLSPDSSPTEVGD
                     ADVGGQLKSSHQQEPPQPNVSESHGKHAGAERWSSRTRKSKSLERTCSKKPVSKVVAK
                     IQEPSAPVKRIVRAHHDGKGRVAYGPETQTEFIPKADFLTLPGGETETHSSGRLEEEQ
                     PGIKSLRSSAPERASITKEPASTEAAVNKVLRKVIESEKLDEATEGKRLGFSLNTRAT
                     HTFPETRSQRKAGLPQSGHKFLLLDLPHTVGPDSPQPKCDEKKPTPQVPTALGMVFNN
                     SSPQSSAHKRLSPVPSPLSPRCPSPQQHHRILLLPPLPSEGEVVFNEYPSRKNDVSSG
                     FPSADTLEPSSTTKVTETKGASPTSLRASQTWLVSEEASEKGLGPEKITAPPQHQLPP
                     GIASEGFPCDNFKEQTAKDLPNKDGGVWVPGYRAGPPCPFLLHEEKEKTSRSELYLDL
                     NPDQSPTEQDDRTPGRLQAVWPPPKTKDTEEKVGLKYTEAEYQAAILHLKREHKEEIE
                     TLQAQFELKTFHIRGEHALVTARLEEAIENLKQQLGKRREGCEEMRDVCISTDDDCSP
                     KAFRNVCIQTDRETFLKPCDAESKATRSSQIVPKKLTISLTQLSPSKDSKDIHAPFQT
                     REGTSSSSQHKISPPAPPTPPPLPPPLIPPPPPLPPGLGPLPPAPPIPPVCPVSPPPP
                     PPPPPPTPVPPSDGPPPPPPPPPPLPNVLALPNSGGPPPPPPPPPPGLAPPPPPGLSF
                     GLSSSSSQYPRKPAIEPSCPMKPLYWTRIQINDKSQDAAPTLWDSLEEPHIRDTSEFE
                     YLFSKDTTQQKKKPLSEAYEKKNKVKKIIKLLDGKRSQTVGILISSLHLEMKDIQQAI
                     FTVDDSVVDLETLAALYENRAQEDELTKIRKYYETSKEEDLKLLDKPEQFLHELAQIP
                     NFAERAQCIIFRAVFSEGITSLHRKVEIVTRASKGLLHMKSVKDILALILAFGNYMNG
                     GNRTRGQADGYSLEILPKLKDVKSRDNGMNLVDYVVKYYLRYYDQCKHHDQEASCRGK
                     DLFSLYFHIAVHPQRKSGLELKQEAGTDKSVFPLPEPQDFFLASQVKFEDLLKDLRKL
                     KRQLEASEQQMKLVCKESPREYLQPFKDKLEEFFKKAKKEHKMEESHLENAQKSFETT
                     VGYFGMKPKTGEKEVTPSYVFMVWFEFCSDFKTIWKRESKNISKERLKMAQASVSKLT
                     SEKKVETKKINPTASLKERLRQKEASVATN"
     exon            2091..2266
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2384
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2446
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..3237
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            3238..3388
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            3389..3476
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..3538
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3627
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            3628..3757
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            3758..3904
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            3905..3964
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            3965..4072
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            4073..4193
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            4194..4286
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            4287..4338
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            4339..4488
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            4489..4573
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            4574..11925
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4871..4876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
                     /note="hexamer: AATAAG"
     polyA_site      4892
                     /gene="Fmn1"
                     /gene_synonym="Fmn; formin-1; ld"
ORIGIN      
        1 ggtggaaggc acagcgaccg cttcaccgct ctggctcggt actggagcgc ggaggcatcc
       61 ctcgcagcag ctgctcccgc tgctgcacct ggtcaggcag cctcattgcg ggagaggact
      121 gtcagctgcc tgctctgcct agccatcatc acatgcctcc tgactggaac tgacctcaga
      181 ccagcatctc cacagcatga ataattaggt aggcataatg gaaggcactc actgcaccct
      241 ccagctgcat aaccccattg ccgaactctg ctatatcagc ttctatcttc caaaagggga
      301 agtcagagga ttttcataca agggcactgt aactctagac agatccaata acgctttcca
      361 taactgctac caagtcaggg aggggccaga catcaccagc ctcagccagc agccaaacga
      421 acatccaggc gacatatttt tcaaacagac tcccacaaaa aacatcctga cagagctata
      481 caagctcaca gcagagaagg agaggctgct ggacagtctg ctgaggtcag acaacatcct
      541 cggtgtttca atggggagcc aggagggaaa gttgcaggag ctgtcagtaa tccttgccac
      601 tggggatgag tatttccaga gtgctggcaa ctggcgcaga gaactccctg tgagctctct
      661 cattaggagg agcacccaag agaacaaaaa gccccggagg tctggcagga ggagagagag
      721 cccggaggag ctccggcaga agagaaccag gaggaaaggg cgtggctgcc aggagtcagc
      781 atttcagatg gggaaggacc aggtctgttc cagtagctcc ctttcttttc gagctcggcc
      841 taatctccgg ctcctagaag aaagaggaaa tttagttcct cggggaacgc ttacctcttc
      901 gctacggaga agagagagct gcccagccaa catcctcagg acaccggatg cagacctggc
      961 cttcggaaac tctgggagaa cctcagagga cactgatctt gaaggacctc tgtcccctga
     1021 cagcagcccc actgaggtag gagatgctga tgtgggaggg cagctcaaga gttctcacca
     1081 gcaggagccc ccacaaccaa atgtgtctga aagccatggg aaacatgcag gggcagagag
     1141 gtggagcagc aggactcgga agtcaaagtc attggagagg acttgcagta agaaacctgt
     1201 ttccaaagtg gtggccaaga ttcaggaacc atctgcccca gtaaaacgaa tagttagggc
     1261 gcatcatgac ggcaagggaa gggttgccta tggcccagag acccaaactg agtttatccc
     1321 aaaagctgac ttcctcaccc tcccaggagg tgaaactgag actcatagtt ccgggaggct
     1381 ggaggaggag cagccaggga tcaagtcatt gcggtcctca gccccagaaa gagcctccat
     1441 taccaaagaa ccagccagca ccgaggccgc tgtgaacaag gttctccgca aggtgataga
     1501 gagtgagaag ttagacgaag ctacagaggg gaaaaggttg ggcttctctc tcaacacaag
     1561 ggccacccac actttcccag aaactcgaag ccaaaggaag gctgggctac cgcagagtgg
     1621 ccataaattc ttgcttctgg atctgccgca cacggtaggt cctgattccc cacaacccaa
     1681 atgcgatgag aagaagccaa ccccccaggt tccaacagct cttggcatgg tatttaataa
     1741 ttcatcgcct cagtccagcg cacacaaacg gctgtcacct gttccctcgc ctctgtctcc
     1801 aaggtgtccc agtccacagc agcatcatag gatccttctg ctcccaccac tgcctagtga
     1861 gggagaagtt gtttttaatg agtaccctag tagaaagaac gacgtctcct ctgggttccc
     1921 ctctgctgac accttggagc catcatctac tacgaaggtc acggagacca aaggagccag
     1981 cccgacttcc ctcagagcaa gccaaacttg gctggtgtct gaggaagctt ccgaaaaagg
     2041 cttggggcca gagaagatca cagctccacc ccagcaccag ttgccaccag gtattgcctc
     2101 tgaaggcttt ccctgtgaca acttcaaaga gcagacggca aaagaccttc ccaataagga
     2161 tggaggggtt tgggtccctg gttacagagc cggaccaccc tgtccatttc tgctccatga
     2221 agagaaagag aagacaagta gaagtgaatt gtacttggat ctcaaccctg accagagccc
     2281 cacagagcag gacgacagga ctccaggcag actccaagct gtctggccac ccccaaagac
     2341 aaaggacaca gaagaaaaag tgggactgaa gtacactgaa gcagaatacc aggctgctat
     2401 cctacatctg aagagggagc acaaagaaga aatcgaaacc ctgcaggctc agtttgaact
     2461 caagacattt cacatccggg gtgagcacgc attagtaaca gcaagacttg aagaagccat
     2521 tgaaaatctc aagcaacagt taggaaagcg ccgggaagga tgtgaagaga tgagagatgt
     2581 gtgcatttcc acagatgatg actgctctcc aaaggctttc agaaatgtgt gcatccagac
     2641 agacagagag accttcctca agccctgtga tgctgaaagc aaagcaacca gaagcagcca
     2701 gatagtaccc aagaagctga ctatctcctt aacccagctc tctccctcaa aagacagcaa
     2761 agacatccac gccccattcc agacaagaga aggcacctcc tcatctagtc agcataagat
     2821 atcccctcca gctcccccca cgccaccacc actccctcca cctctcattc ctccacctcc
     2881 gcccctccca cctggacttg gacctttgcc tccagcacca cccataccac ctgtgtgtcc
     2941 tgtgtcgcca ccgccacctc ctccgcctcc tcctccaact cccgtgcctc caagtgatgg
     3001 accaccacca ccaccacctc ctccaccacc acttcccaat gtcctagctc ttcctaacag
     3061 tggaggtcct cctcctcctc cacctcctcc tccgccagga cttgcacccc cacctcctcc
     3121 tggactgtcc tttggactca gctcttcttc cagccagtat cctcgtaaac cagccattga
     3181 gcccagctgt cctatgaaac ctttgtattg gaccagaata caaataaatg ataaaagcca
     3241 agacgccgca ccaactttat gggactcctt agaagagcct catattaggg acacaagtga
     3301 atttgaatat ttattctcca aggacacaac tcaacagaag aaaaaacccc tgtcagaggc
     3361 ctacgaaaag aagaacaaag tcaaaaagat catcaagtta ttggatggaa agcgatctca
     3421 aactgtggga atcttgatat ctagtttaca tctagaaatg aaagatattc aacaggccat
     3481 atttactgtg gatgactccg tggttgacct ggagacctta gcagccttat atgaaaatcg
     3541 agcccaggag gatgaactga ctaaaataag aaagtactat gagacatcca aagaagaaga
     3601 cttgaaactg ctggacaaac ctgaacaatt tttgcatgag ttagcccaga ttcccaattt
     3661 tgccgaacgt gcccagtgca taatcttcag ggctgtattt tctgagggta tcacatcctt
     3721 acatcgaaaa gtagagattg tcacacgggc ctcgaagggc ttgttgcaca tgaagagtgt
     3781 gaaggatatc ttagctctca ttctggcttt tggaaactac atgaatggag gaaacaggac
     3841 gcgagggcaa gcagacggat atagtttaga aattctgccc aaactcaaag acgtcaaaag
     3901 tcgggacaat gggatgaatc tggtggacta tgttgtgaag tactacctgc gatactatga
     3961 tcagtgcaaa catcatgacc aagaagcaag ttgcagagga aaggatttat tcagcttata
     4021 cttccacatt gctgttcatc cccaaaggaa gtcaggactg gaactcaagc aggaagctgg
     4081 aacagacaag agtgttttcc cgctgcctga accacaggat ttcttcctgg cctctcaagt
     4141 caagtttgaa gacctcctaa aggatttgag gaagctgaag cgtcaactag aagcaagtga
     4201 gcaacagatg aagctggtgt gcaaggagtc cccaagggag tacctgcagc ctttcaagga
     4261 caaactggag gagttcttca agaaagccaa aaaagagcac aagatggaag aaagtcactt
     4321 ggagaatgca cagaaaagtt ttgaaacaac agtgggatat tttggaatga agccaaagac
     4381 tggagagaag gaggtcaccc ccagctatgt gtttatggtg tggtttgagt tctgcagtga
     4441 cttcaagacc atttggaagc gggagagtaa gaacatatct aaagaaagat tgaaaatggc
     4501 tcaggcatcc gtcagcaaac tgacatcaga gaagaaagtg gagacaaaga aaatcaatcc
     4561 caccgctagt ctgaaagaaa gactgcgtca gaaggaagcc agcgtggcca ccaactaaga
     4621 tgaaaacaga aggaagttac aatatgaaag acagcacctc actgctcctg cagacacaag
     4681 ggccaccggg gagttcctga aagactagtt agggacattt gctcatctcc ttctgaggcc
     4741 atctgcagaa agtcccctgt gccttctttg ggaagtctct tgtcaatcca caagaacaat
     4801 gcaaagttat gtttgggaac actacaggaa tatgtaattg tttcttgcag aagtcttaag
     4861 tccacccaat aataagatca gaagatattt aattcttttc acattttatt tatttaaagt
     4921 ggaaattcta agccttccag tatataccct tgtcatgaga aaagaggtac atggtgatcc
     4981 ccaagagaac tcaagcctta ttcctcacac actacagttt gtattgatct taatttttat
     5041 cctgttatac tgagatccta ttgcattttc accaaaaata ttgaaactta ccagaattga
     5101 ttttgaagag gtttaatact gtgtatctcc cagactagca aaatgatttt tgaggagaag
     5161 aatgatggtg gtggtggtga tgatggggat gataatgatg atgatataat gaaatggaca
     5221 ggattgaaat ctcacatggg tggaaaggga ataataacca taaaccttaa tctggagaag
     5281 aagttttgat gctggaagtg agcatcagct attgagatag gcctgctcag ttaatatggc
     5341 ttcctggcca gtaggcattc tgtaccaact tctaatagaa atgaggcaag gacaaacttg
     5401 gatcaagagg acccatttgg gtgagggacc aggtggtttc caatccagtg tggacagcaa
     5461 atgaatgcta tgcaggcatg cagatgagat ctgtactata gtctacaatt tgtatcctgt
     5521 ctctcccacc acccccggca gtgtccagac aggagagcag atgccactct ccccttttac
     5581 catgaccttg acacatgagc acatgaagga aggtagccag ggggcatttg ctgtccaaaa
     5641 aaatgttatg agcagaagag atttttacag taacataaaa gcagaattct tatgttgata
     5701 ttaacctgca aatggactgt cagcaccagg tggtgtcttc taactctggt ccttacatca
     5761 cagagaaaag ccaccttgcc cgtttttcct ccattctgtg aacttccctg gtgagagaag
     5821 aaggaggact gggcatgaac tgaggattgt attgaagact gtggttttta agcctcgctg
     5881 taaagaaagg ccatgctttt gtgttagtgg agacagtcta gagttgctca gaatcttgta
     5941 gggttttctg atctggttac ctctagctgc catgtggggt ccacctcttg cctcagcaac
     6001 tttccaggac ctttgaactt gccagatacc ttaagtgtct tcccagaatc tgcccacctg
     6061 tcatcagccc cccagccccc caccactcag ggacactctg ctaatagaca caagctaagg
     6121 aaagcagcac cgtagcctga catagtgcag accttgtaaa gcaagagtag ctggcatctc
     6181 ttaagtcact gatgccattt catacaggtg ctagctgtct ttctgtggtt tgaaggaaag
     6241 ttattgtcac gtggtttgtt ttcctcaaaa tgaagggata ggacaaaaga gacaatcaaa
     6301 tatggagctt agcatagcta gaatggcatg atgtcactgt tcttttcctg tggcttttta
     6361 ttgttgtttc tcatcattct cacctcgagg aagagcaaga gacttaacca gcagggcaaa
     6421 ttccacttgc agacatcctt tactctgtgg tcccttgtta gtaccgaagt gcaaaaaaga
     6481 aatgcagttc tgtgtttgga acaagaagca tctcagcatt ctgtgagatc tgcatggatc
     6541 ctgtgggtgg agtcagcagg aacaaagggt tttccatggt attgatgcta cctcaggtct
     6601 ctaagatgca catgagtcag cacaggtggc actgtctctc ccttggtcct tcaggaccat
     6661 agcagatcct gcaggttgac acgaagtaga ccataatgtt gtgtgttggg attggggcag
     6721 gggagggggc tctttgttgg gttaagggtg ctgcagagat ggcttgaggg tcaggagtac
     6781 aaagccttcc tgtagatggc cagagtttgg attctagtgc tcgtgctgag tggcacacac
     6841 tcaaacatta ctctctcttg ggagtctgac atcctccact gtcctccatg ggcacccgtg
     6901 ctcacatgca cagacgcaaa cacagttgtc atacatgcca ccacacaaag acatacacat
     6961 atgcacataa ttaaaaacta aaaatgaatc ataaaaaaca aatgggtaca tgatatggta
     7021 agataaatga gggggaaaaa aactaaaaat atgcttttgt cccaaatatc tcattttaca
     7081 aggtagttta aattgtgtta aaatcactag caagaagtat atattttctt tgatttttat
     7141 tttcattttc ctttgcctgt atttatcaaa gaaaaagacc aaaagatgat ggtaaaacct
     7201 ctgtttctat agatttattt ttatacatgt ttaattattg aatcataaaa tggggacata
     7261 tcatcaaatc caaagtggta acagtgctaa ataagcatgt atgaaattga atggttgtga
     7321 tggctggtgg gcgggggcaa agagcctacc atctctgcct gagacatcag tttataccag
     7381 accattttta ctatggaatt tcaagagtta aggattgtct tgggaaacgt agtctagaaa
     7441 aagccacgta gagaataacg tgatgttcta gagttgtatg tgtctgggtt cttcctatga
     7501 gatctaaggg gacgttataa gtgagcagaa tatcagaaga ccatgaatat ggcaattcat
     7561 agttgagctg tgttggcttg agggatgctg ctgctaagta gggtggactg ggcaaagcaa
     7621 tgaactttca ggcattcgag ctacttcatc tgcataagga aatcctcaat gtaggtgagt
     7681 caggtctgtt ccccaactga aagggctgta aaagaatgga ttaatgttta gctctcacaa
     7741 agagagataa ccttggatac atcttcatct tctagctata taaagaaaca atccagctgc
     7801 ttagaagctg tgactaatac agagttgact ttaaaaaaaa gcccctccaa aaactcaact
     7861 cagcatctct ccccctatgg acttaaccca agtgttttta atgctggtag cagttggatc
     7921 caggcacaac cagacttagt tgcacaactg tatgtgacca aaagacacat tttgtgtcac
     7981 tcctgctttc ctgtcagctg ttgacacctt ggtaggagct ctcattatta cattctccat
     8041 tctccatttc cctcttcaag gatgggcaat ctaccaaaat ccctcaagat aaccctttgc
     8101 taggaagtgg tgaatctaaa agctgaagca cgtttcatat gaagccagtt cagtggcctt
     8161 gtttatttca agacaatgcc ttatatcaca ttggaggagt ttgaatactt aacaggttct
     8221 ttgtcaacat ggagacatta acatggtagc tcactgactg ggtctcttca gctgtcatca
     8281 ggcttccacc agaagaacaa acaacaacaa aaaaagccaa tgaagccatg tgctgtcctt
     8341 aggcagacgt acttgtctcc actccccact ccatctcagc ccaactccag acaccctagg
     8401 gctgaccagc tccattgaga ccctgttatt tctctgcttt tctctttcct tgcgcccgta
     8461 gcccgcagga gccctccact ttatcccata tttttgctgt caaattctta gtctagagga
     8521 gactgagcta acttcagctt gcttgcttgc ttgcttgctt gcttgcttgc ttgcttgccc
     8581 ttaaagaaca gatcaagcct acatactcca tacactatac ttcatactac aagctccatc
     8641 tgtcctcaga taattgtctg acttttttta gtcttaagta tagagggaat cccctaaagg
     8701 ctgatccaac tgcttctgtg gttccacggt atttttcatg gttcatgtga aacgtgatat
     8761 cactgggctg ccaaagcaca aatgagtcag tattcttggg cagaagtgaa catcccaagg
     8821 attcaacagg gaataaacag gctctagcac attaaggatg tggcctaggc tgagtgttac
     8881 cttaaaatgc cttgtggtct ccacctctaa agctataaaa gtgtcttaga gagaatactc
     8941 atctagtaaa tagtgtgagt ttccaatgta ttatcttata tcaagtaaga aatcaagtat
     9001 atatcagcag aggcttacca aagtcatacc tgctctcctc cactattctc ttccagagtt
     9061 ttcttcaact tccatcttat aaaccaaggt atttaaattg ttcatcttag ttgactttcc
     9121 caagccatac ttctaaaaca aaacaccagc cccatagacc actgagcacc tagggaggtt
     9181 tctctgccta gccatagcat cattaataga tgtccaaaaa tgagcaattc tgggaatcac
     9241 gcagtgggtt ttaaggtagt taatatctat ggtatattaa aaggagcagt catcatatac
     9301 tactgcattt ccactgaaga gccaaaaggc atttaatata tatgttcatg aaacatacct
     9361 ttttcctctt taaaaaaaaa gatatactca tttttttatt ttatgtgtat gactgtttgc
     9421 ctacgtgtat atatgtgcac cacctgtgtg cctggtgtct gtagaagcca gcaggaggct
     9481 gttagatctc ctgggccggg cgttccaaac agttgtgagc tactgtgtga gtgctaggag
     9541 caaacctgga tcctctgcaa gagcaacgaa tactggtaac ccctgaacca tttctccagc
     9601 cccctttgcc tatcatccat ctcaagatag aacctaagta tttcacgtct gaccagcagt
     9661 ctctgtggtt ctgcacagat tttggaaggt cttcactact cttggaaaca aacccatgaa
     9721 tgaagaagaa actcttaaaa tggttctgtc tgcactgatt caaagaggat ttgtgggaaa
     9781 gaaaactaaa ggcatgggtt tcgtccaaaa atcatgaatt tttctaattc tactatttta
     9841 caacttgctg agacacaaat actgtgccct tcctgtccta ctgaccactg ggtatgtaat
     9901 ctttgaggga tatgcgcttt taggaaaaag gatttccctt taagggagca atctaagata
     9961 gtctctgaaa ggcagaaagt ttacaaatta gacactgggt attttttaag aaccttcagt
    10021 ggaagcatgt catcaattca tcacaggcct ttcctgtctt tgaattagaa tccagactag
    10081 tgtgggaagc agtctctctg gactttgatt tagggatcat gttttggcct ggaaaataag
    10141 cattggcctg cgtgtttaga agctccctga aatcagttag catcctaata cgagtcagat
    10201 gctgcagaaa tgtaaggcac ttcaagtcac ttatgggttg gcttggtttg gtttttctta
    10261 gcaccacctg ggatcacaga ggctcctaag atacatgaga cctttgcagt gttttctctc
    10321 caccttctga gacagaggga agcaaggaaa caggggagaa aaaaaagagt gaacaaattc
    10381 agtgcagtgt tttacacagc ttggtaccat gatagtacca gggacaggtt ttaatagaaa
    10441 tttaagctat ttgtattacg aacataggag tgtccacatg ttgttgtaac tctgtcctgc
    10501 aagagcaggt attccaatga cactggcctg tgcttagctg aggaacttcc agcttcagat
    10561 tctgttacaa gtgtcacttg ccaaaggacc ttactgttcc ttctaagcat cccagcacct
    10621 ggtgtgatct agctttcctc cacccatact ttgtcttcag cttccccttc cctcacatat
    10681 cacagccctt ctctcccaaa gggacctttg cagcttctat tggacccaga taccctttac
    10741 ctctacagca tagacaccaa atgtcccata gtcctctcac accctgtgtt ccagccttca
    10801 gtgtttggac agagcaccac tgtcaccaag gagcctgtgt gagacacact gctgagactg
    10861 cctcttgtta atgtcaccat cacctcatca ctcaggcaaa gaggggaaaa tccataaaag
    10921 aggtggaaaa tgcatttagt tttttcattt tgttctactt tattaaaaag gttgggtgtt
    10981 ctagttcttg gtttctcata gatttttaaa ctatctaatt agagaacact tttgatccat
    11041 cacagcaggt caccagccat gacaaggctc aatctaggac tctcagcttc ctgcgctgct
    11101 ggacacattg acctctgtgc aaacattgta gacttcttat tgctactcaa ttcttgctac
    11161 tgctcatgat tcaaatgtct accacaatct gaattgggat gttgacattt tgtggttatt
    11221 ttcagattaa tagtaattgt tatgctctta aaagcactca tagaaagtgt aagcatgtgt
    11281 aagcatgtcc tgaatagctt actattctgt catggtaaaa cacagccttt ctgttcaaat
    11341 attaggccaa tctgtaggtg gaaaaattaa ccaataaaat aaagacagct ttggaaagga
    11401 gaaggcactt taaagacatg aaacctctta ttacatgctc ttgtatgttt ttaagcataa
    11461 taagctaact ggatttgggt atatgccctt taagttaaaa ataatatgta tttctaattt
    11521 gcatatttaa ttttgtcaac actaagaaat gttcatgtgt tgaatttgta aatataattt
    11581 gcaaccaaat gaagtattta tttttaaaaa gaaaaggtgg aggaaccaat atcaacttgt
    11641 acataatgaa aatatgcgtg tacatatatt ttccttcttg acactacttg atcattatat
    11701 caagtgtatt tttgtacata atatatattg gttagaaaaa aatagattgt ctattgaaag
    11761 aaattctctc tctgcagtag attatattta tcctaatcta ttgatattct gttgatttgt
    11821 tttaagagat agaactctat ttttttgaac ttccagagaa ttgcattcat ggcttccact
    11881 tgtaaatatg ctaagggtat tttaataaat cttggtttca tgtcc
//
