LOCUS       NM_025363                441 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus formation of mitochondrial complex V assembly factor 1
            (Fmc1), mRNA.
ACCESSION   NM_025363
VERSION     NM_025363.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Cater,R.J., Mukherjee,D., Gil-Iturbe,E., Erramilli,S.K., Chen,T.,
            Koo,K., Santander,N., Reckers,A., Kloss,B., Gawda,T., Choy,B.C.,
            Zhang,Z., Katewa,A., Larpthaveesarp,A., Huang,E.J., Mooney,S.W.J.,
            Clarke,O.B., Yee,S.W., Giacomini,K.M., Kossiakoff,A.A., Quick,M.,
            Arnold,T. and Mancia,F.
  TITLE     Structural and molecular basis of choline uptake into the brain by
            FLVCR2
  JOURNAL   Nature 629 (8012), 704-709 (2024)
   PUBMED   38693257
REFERENCE   2  (bases 1 to 441)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 441)
  AUTHORS   Szakats,S., McAtamney,A., Cross,H. and Wilson,M.J.
  TITLE     Sex-biased gene and microRNA expression in the developing mouse
            brain is associated with neurodevelopmental functions and
            neurological phenotypes
  JOURNAL   Biol Sex Differ 14 (1), 57 (2023)
   PUBMED   37679839
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 441)
  AUTHORS   Inoue,N., Ogura,S., Kasai,A., Nakazawa,T., Ikeda,K., Higashi,S.,
            Isotani,A., Baba,K., Mochizuki,H., Fujimura,H., Ago,Y.,
            Hayata-Takano,A., Seiriki,K., Shintani,Y., Shintani,N. and
            Hashimoto,H.
  TITLE     Knockdown of the mitochondria-localized protein p13 protects
            against experimental parkinsonism
  JOURNAL   EMBO Rep 19 (3) (2018)
   PUBMED   29371327
REFERENCE   5  (bases 1 to 441)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 441)
  AUTHORS   Higashi,S., Katagi,K., Shintani,N., Ikeda,K., Sugimoto,Y.,
            Tsuchiya,S., Inoue,N., Tanaka,S., Koumoto,M., Kasai,A.,
            Nakazawa,T., Hayata-Takano,A., Hamagami,K., Tomimoto,S.,
            Yoshida,T., Ohkubo,T., Nagayasu,K., Ago,Y., Onaka,Y., Hashimoto,R.,
            Ichikawa,A., Baba,A. and Hashimoto,H.
  TITLE     p13 overexpression in pancreatic beta-cells ameliorates type 2
            diabetes in high-fat-fed mice
  JOURNAL   Biochem Biophys Res Commun 461 (4), 612-617 (2015)
   PUBMED   25912136
REFERENCE   7  (bases 1 to 441)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 441)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   9  (bases 1 to 441)
  AUTHORS   Osipovich,A.B., Singh,A. and Ruley,H.E.
  TITLE     Post-entrapment genome engineering: first exon size does not affect
            the expression of fusion transcripts generated by gene entrapment
  JOURNAL   Genome Res 15 (3), 428-435 (2005)
   PUBMED   15741512
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK008291.2.
            
            On Apr 5, 2007 this sequence version replaced NM_025363.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008291.2, FO714379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-441               AK008291.2         2-442
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 17.84 cM"
     gene            1..441
                     /gene="Fmc1"
                     /gene_synonym="1110001J03Rik"
                     /note="formation of mitochondrial complex V assembly
                     factor 1"
                     /db_xref="GeneID:66117"
                     /db_xref="MGI:MGI:1913367"
     exon            1..150
                     /gene="Fmc1"
                     /gene_synonym="1110001J03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..354
                     /gene="Fmc1"
                     /gene_synonym="1110001J03Rik"
                     /note="formation of mitochondrial complexes 1 homolog;
                     UPF0562 protein C7orf55 homolog"
                     /codon_start=1
                     /product="protein FMC1 homolog"
                     /protein_id="NP_079639.1"
                     /db_xref="CCDS:CCDS20014.1"
                     /db_xref="GeneID:66117"
                     /db_xref="MGI:MGI:1913367"
                     /translation="MAALGSPARTLRGLLRELRYLNAATGRPYRDTAAYRYLVKAFRA
                     HRVTSEKLCRAQHELHFQAATYLCLLSSIRQHVALHQEFHGKGERSVEESAGLVGLQL
                     PRQPGGKGWEP"
     exon            151..441
                     /gene="Fmc1"
                     /gene_synonym="1110001J03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      420..425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fmc1"
                     /gene_synonym="1110001J03Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      441
                     /gene="Fmc1"
                     /gene_synonym="1110001J03Rik"
                     /note="major polyA site"
ORIGIN      
        1 aaggacagaa aaatggcggc cctggggtcc ccggcgcgca ctctgcgggg ccttctgagg
       61 gagctgcgct acctgaacgc ggccaccggg cggccatatc gcgacacagc ggcctaccgg
      121 tacctcgtta aggctttccg agcacatcgg gttaccagtg agaagttgtg tagagcccaa
      181 cacgaacttc acttccaagc tgccacctat ctctgccttt tgagtagcat ccggcaacat
      241 gtagcccttc atcaggaatt tcatggcaag ggtgagcgtt cagtggagga gtctgctggt
      301 ttagtgggcc tccagttgcc ccgtcagcct ggagggaagg gctgggagcc gtgatgcaga
      361 gagtcctcag atgttccttc attcaagagt ttaaccattt ctaacaatat gtagttatca
      421 ttaaatcttt tttaaagtgt g
//
