LOCUS       NM_145447               3435 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus feline leukemia virus subgroup C cellular receptor 2
            (Flvcr2), mRNA.
ACCESSION   NM_145447
VERSION     NM_145447.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3435)
  AUTHORS   Wang,H., You,X., Wang,J., Chen,X., Gao,Y., Wang,M., Zhang,W.,
            Zhang,J., Yu,Y., Han,B., Qi,M., Liu,X., Lou,H. and Dong,T.
  TITLE     MFSD7C protects hemolysis-induced lung impairments by inhibiting
            ferroptosis
  JOURNAL   Nat Commun 15 (1), 8226 (2024)
   PUBMED   39300060
  REMARK    GeneRIF: MFSD7C protects hemolysis-induced lung impairments by
            inhibiting ferroptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3435)
  AUTHORS   Cater,R.J., Mukherjee,D., Gil-Iturbe,E., Erramilli,S.K., Chen,T.,
            Koo,K., Santander,N., Reckers,A., Kloss,B., Gawda,T., Choy,B.C.,
            Zhang,Z., Katewa,A., Larpthaveesarp,A., Huang,E.J., Mooney,S.W.J.,
            Clarke,O.B., Yee,S.W., Giacomini,K.M., Kossiakoff,A.A., Quick,M.,
            Arnold,T. and Mancia,F.
  TITLE     Structural and molecular basis of choline uptake into the brain by
            FLVCR2
  JOURNAL   Nature 629 (8012), 704-709 (2024)
   PUBMED   38693257
  REMARK    GeneRIF: Structural and molecular basis of choline uptake into the
            brain by FLVCR2.
REFERENCE   3  (bases 1 to 3435)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3435)
  AUTHORS   Nguyen,X.T.A., Le,T.N.U., Nguyen,T.Q., Thi Thuy Ha,H., Artati,A.,
            Leong,N.C.P., Nguyen,D.T., Lim,P.Y., Susanto,A.V., Huang,Q.,
            Fam,L., Leong,L.N., Bonne,I., Lee,A., Granadillo,J.L., Gooch,C.,
            Yu,D., Huang,H., Soong,T.W., Chang,M.W., Wenk,M.R., Adamski,J.,
            Cazenave-Gassiot,A. and Nguyen,L.N.
  TITLE     MFSD7c functions as a transporter of choline at the blood-brain
            barrier
  JOURNAL   Cell Res 34 (3), 245-257 (2024)
   PUBMED   38302740
  REMARK    GeneRIF: MFSD7c functions as a transporter of choline at the
            blood-brain barrier.
REFERENCE   5  (bases 1 to 3435)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3435)
  AUTHORS   Santander,N., Lizama,C.O., Meky,E., McKinsey,G.L., Jung,B.,
            Sheppard,D., Betsholtz,C. and Arnold,T.D.
  TITLE     Lack of Flvcr2 impairs brain angiogenesis without affecting the
            blood-brain barrier
  JOURNAL   J Clin Invest 130 (8), 4055-4068 (2020)
   PUBMED   32369453
  REMARK    GeneRIF: Lack of Flvcr2 impairs brain angiogenesis without
            affecting the blood-brain barrier.
REFERENCE   7  (bases 1 to 3435)
  AUTHORS   Kalailingam,P., Wang,K.Q., Toh,X.R., Nguyen,T.Q.,
            Chandrakanthan,M., Hasan,Z., Habib,C., Schif,A., Radio,F.C.,
            Dallapiccola,B., Weiss,K. and Nguyen,L.N.
  TITLE     Deficiency of MFSD7c results in microcephaly-associated
            vasculopathy in Fowler syndrome
  JOURNAL   J Clin Invest 130 (8), 4081-4093 (2020)
   PUBMED   32369449
  REMARK    GeneRIF: Deficiency of MFSD7c results in microcephaly-associated
            vasculopathy in Fowler syndrome.
REFERENCE   8  (bases 1 to 3435)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   9  (bases 1 to 3435)
  AUTHORS   Meyer,E., Ricketts,C., Morgan,N.V., Morris,M.R., Pasha,S.,
            Tee,L.J., Rahman,F., Bazin,A., Bessieres,B., Dechelotte,P.,
            Yacoubi,M.T., Al-Adnani,M., Marton,T., Tannahill,D., Trembath,R.C.,
            Fallet-Bianco,C., Cox,P., Williams,D. and Maher,E.R.
  TITLE     Mutations in FLVCR2 are associated with proliferative vasculopathy
            and hydranencephaly-hydrocephaly syndrome (Fowler syndrome)
  JOURNAL   Am J Hum Genet 86 (3), 471-478 (2010)
   PUBMED   20206334
REFERENCE   10 (bases 1 to 3435)
  AUTHORS   Brasier,G., Tikellis,C., Xuereb,L., Craigie,J., Casley,D.,
            Kovacs,C.S., Fudge,N.J., Kalnins,R., Cooper,M.E. and Wookey,P.J.
  TITLE     Novel hexad repeats conserved in a putative transporter with
            restricted expression in cell types associated with growth, calcium
            exchange and homeostasis
  JOURNAL   Exp Cell Res 293 (1), 31-42 (2004)
   PUBMED   14729055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117240.4 and AC138303.4.
            
            On Nov 17, 2006 this sequence version replaced NM_145447.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011209.1, AY260576.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1051              AC117240.4         47093-48143         c
            1052-1193           AC117240.4         11584-11725         c
            1194-1334           AC117240.4         8454-8594           c
            1335-1402           AC138303.4         185533-185600       c
            1403-1506           AC138303.4         183174-183277       c
            1507-1617           AC138303.4         178530-178640       c
            1618-1723           AC138303.4         177302-177407       c
            1724-1835           AC138303.4         177068-177179       c
            1836-1891           AC138303.4         176524-176579       c
            1892-3435           AC138303.4         168190-169733       c
FEATURES             Location/Qualifiers
     source          1..3435
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.8 cM"
     gene            1..3435
                     /gene="Flvcr2"
                     /gene_synonym="CCT; Mfsd7c"
                     /note="feline leukemia virus subgroup C cellular receptor
                     2"
                     /db_xref="GeneID:217721"
                     /db_xref="MGI:MGI:2384974"
     exon            1..1051
                     /gene="Flvcr2"
                     /gene_synonym="CCT; Mfsd7c"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1969
                     /gene="Flvcr2"
                     /gene_synonym="CCT; Mfsd7c"
                     /note="feline leukemia virus subgroup C receptor-related
                     protein 2; calcium-chelate transporter; heme transporter
                     FLVCR2; major facilitator superfamily domain containing
                     7C; feline leukemia virus subgroup C cellular receptor
                     family, member 2"
                     /codon_start=1
                     /product="choline/ethanolamine transporter FLVCR2"
                     /protein_id="NP_663422.1"
                     /db_xref="CCDS:CCDS26062.1"
                     /db_xref="GeneID:217721"
                     /db_xref="MGI:MGI:2384974"
                     /translation="MVNESLNQEESNDRPAPESEFQMDTSYSTQPSGSIHPSVSGHPS
                     VSGHPSVSGHPSVSIHPSVSIDPSVSVRPSSSALPSTLAQPSGLTHHSSLVREDSVIK
                     VSKRRWVVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPL
                     LLPVAWMLEKFGLRTIAITGSALNCLGAWVKLGSLEPHLFPVTMVGQVICSVAQVFIL
                     GMPSRIASVWFGADEVSTACSVAVFGNQLGIAIGFLVPPVLVPNIKDPEKLAYHISIM
                     FYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYALATTDASYLSSIVRLFKNLNFV
                     LLVITYGLNAGAFYALSTLLNRMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLD
                     KSKTYKETTLVVYIMTLVGMVVYTFTLNLNHLWVVFITAGTLGFFMTGYLPLGFEFAV
                     ELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGSALTA
                     FIKSDLRRQRANKDAPETKVQEEEEEEEGSNTSKVPVVSEAHL"
     exon            1052..1193
                     /gene="Flvcr2"
                     /gene_synonym="CCT; Mfsd7c"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1334
                     /gene="Flvcr2"
                     /gene_synonym="CCT; Mfsd7c"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1402
                     /gene="Flvcr2"
                     /gene_synonym="CCT; Mfsd7c"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1506
                     /gene="Flvcr2"
                     /gene_synonym="CCT; Mfsd7c"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1617
                     /gene="Flvcr2"
                     /gene_synonym="CCT; Mfsd7c"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1723
                     /gene="Flvcr2"
                     /gene_synonym="CCT; Mfsd7c"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1835
                     /gene="Flvcr2"
                     /gene_synonym="CCT; Mfsd7c"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1891
                     /gene="Flvcr2"
                     /gene_synonym="CCT; Mfsd7c"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..3435
                     /gene="Flvcr2"
                     /gene_synonym="CCT; Mfsd7c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3417..3422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Flvcr2"
                     /gene_synonym="CCT; Mfsd7c"
                     /note="hexamer: AATAAA"
     polyA_site      3435
                     /gene="Flvcr2"
                     /gene_synonym="CCT; Mfsd7c"
                     /note="major polyA site"
ORIGIN      
        1 aggccccagc ctgcccggga gcaaaccgag ctcgccctgc cacagttcgc tgttcaggag
       61 tcaaactttt tccaggacgg tcaacgcttc atctggacag cctggaacgc gtggcaaggc
      121 gtctgcggcc aacttggggg acaacagttt gctagggagt gatcgtagga acctgagatc
      181 tcgatttctc cgctaacaga ggtgcgctcc cggagaagtg ttgcctcagc tctaggggga
      241 caggcaaaag gctgctgacc cataagactg taggagtcag tacgtgcctg ggattcagga
      301 gctcgttgtg gtcatggtga atgaaagtct caaccaggag gagagcaatg acagacctgc
      361 gccagagtcg gaattccaga tggacaccag ctactccacc cagcccagcg gctccatcca
      421 tcccagcgtc tcaggccacc ccagcgtctc aggccacccc agcgtctcag gccaccccag
      481 tgtctccatc catcctagtg tctccatcga ccccagcgtc tctgtccgtc ccagcagttc
      541 agcactcccc agtaccttgg ctcaacccag cggtttgacc catcatagta gcttggttag
      601 agaagacagc gtgatcaagg tgagcaagcg tcgttgggtc gtggtcctgg tgttcagttg
      661 ctactccttg tgcaatgcct tccagtggat tcagtacggc tccatcaata acatcttcat
      721 gaacttctac ggtgtcagtg cctttgccat tgattggctg tccatgtgct acatgctgac
      781 ctacatccct ctgctcctgc ccgtggcctg gatgctggag aaatttggtc ttcgaaccat
      841 cgctatcacc ggctcagctc tcaattgcct gggagcctgg gtaaagctgg gcagcctaga
      901 gcctcacctc ttcccggtca caatggtggg tcaggtcatc tgctctgtgg cacaggtctt
      961 cattctgggc atgccctcac gcattgcttc ggtctggttt ggagctgatg aggtttcaac
     1021 agcctgctcc gtggctgtgt ttggcaatca gcttggaatt gcaattgggt ttttggtccc
     1081 tcctgttctg gtacccaaca tcaaagaccc ggaaaagctt gcctaccaca tcagcatcat
     1141 gttctacata ataggaggcg tggccacttt cctcttcatc cttgtcatca tcgtattcaa
     1201 ggagaagccc aagcaccctc ccagcagggc ccagtccttg agctatgcct tagcgaccac
     1261 tgatgcttcc tacttaagtt ccattgtccg actcttcaaa aacctcaact tcgtgctgct
     1321 ggtcatcacc tatggtctga atgctggtgc tttctacgcc ttatccactc tgctgaatcg
     1381 catggtgatc ttgcacttcc cgggggaaga agtgaatgct ggaagaatcg gtctgaccat
     1441 cgtcattgca ggaatgtttg gtgctatgat ctcaggcatc tggctggata aatccaaaac
     1501 ctacaaggag acaaccctgg tagtgtatat catgactctg gtgggcatgg tggtatacac
     1561 attcaccttg aacctgaacc atttgtgggt agtattcatc actgctggca cactgggctt
     1621 cttcatgact ggctatctgc ccctggggtt tgagtttgct gtggagctca catacccaga
     1681 atctgaaggc gtgtcatctg gcctcctcaa cgtgtcggca caggtatttg ggatcgtttt
     1741 caccatctct caaggccaga ttattgacaa ccatggaacc atgtttggga acatcttcct
     1801 gtgtgtgttc cttgcccttg gatcagctct aacagctttc attaagtcag atcttcggag
     1861 acagagggca aacaaggatg ctcctgagac caaagtccag gaggaggaag aggaggagga
     1921 ggggagcaat accagcaagg tacccgtcgt gtcggaggct catctctgag agaggtggca
     1981 gatactcagg aacacaaaca ctcacctctt ggttccagtt agctgttact gccagtactg
     2041 agattctcat ggggaaactt ttcgaagcag ctggaagatg tgtgcctcgc acggcagtgc
     2101 ctgagcctac tggaccctac ccgagaacct gcatggttta ctcggggaaa acctcacctc
     2161 tcttcagatg cagactggat tctggtcccc actccctttt aggtcttggg ctagtgctgg
     2221 gagaggccgt ggaggtgttg aagtccgtcc ttgcttggtc tcttgccttc tctcatccct
     2281 ttcttctctc gtggagaatg cttgcaaaat tatcctaaga aagcttattc aggatattaa
     2341 ctttttctaa tgtcttaaga gcacttctta ctgcaaatgg gcgaactgct ctgcctgagg
     2401 gtcacgagag gaagcacccc aacaggcctc catcatccca aggcagctca atccggactc
     2461 ttggctttgc cccccccccc cccaaactgc agtgtttctt cagatcgtct ttcctagagt
     2521 caaggagact aaacaccaat aaaccagata aaacctttgt ggccacaaag gagaaagcga
     2581 ttagagaagg ctctctgcct aggtgcgaca gtgcagggag ggggctgccg ggagtgtgtg
     2641 tggggctgag ttgggatggg aaggtgtttt cctacaaagg tggtgctcgc ccatggcctt
     2701 ctgtgtccca aagcactcag aatatcttca ttggatattg cactgtgaaa tgcagccatc
     2761 aggggctcgt ggctctaacc tttattaaaa gttagtctca ctcactctac tctgacacat
     2821 aaggctatct cctcaggagg agagaggtag aaggtggctc ttaaaataga catgtctgct
     2881 ccagttaaac atgaggccat gcatgttgag gactatttga acaaccaaac cccctccctg
     2941 tccctgctgg cgagaatctt tgtcagttat tttacattta aaaggattat ttttaaacca
     3001 atctcagttg acctttttac ccacccagtc tgctggttat actcatgggc tttcatagtg
     3061 tcttccccaa agagaaactg gcagctaatt gttcctatgc cttgagcaac tctggtcatg
     3121 gactgttggg ttgtctggcc ttagcatacc agattacccc gtttgcctgc agtactgggg
     3181 tatcgggcca gatatgtgtg tgtttgtgca gtggatggga gggaagcagc cgcctggtgg
     3241 agggagtgtt agggatggaa gagatgcctt actttctgtc aagagaaagg tgttttttct
     3301 ttaattgttc aaagtggacg tgtttactca attcatttct ttattaattc atttctttat
     3361 ttaaaaaaaa caacataatt tgtatttcct gtgtgcaata ccagatattt taaggcaata
     3421 aagattttca aagtg
//
