LOCUS       NM_001081259            4087 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus feline leukemia virus subgroup C cellular receptor 1
            (Flvcr1), transcript variant 1, mRNA.
ACCESSION   NM_001081259 XM_619720
VERSION     NM_001081259.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4087)
  AUTHORS   Qu,Y., Meng,B., Cai,S., Yang,B., He,Y., Fu,C., Li,X., Li,P.,
            Cao,Z., Mao,X., Teng,W. and Shi,S.
  TITLE     Apoptotic metabolites ameliorate bone aging phenotypes via
            TCOF1/FLVCR1-mediated mitochondrial homeostasis
  JOURNAL   J Nanobiotechnology 22 (1), 549 (2024)
   PUBMED   39237990
  REMARK    GeneRIF: Apoptotic metabolites ameliorate bone aging phenotypes via
            TCOF1/FLVCR1-mediated mitochondrial homeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4087)
  AUTHORS   Bertino,F., Mukherjee,D., Bonora,M., Bagowski,C., Nardelli,J.,
            Metani,L., Zanin Venturini,D.I., Chianese,D., Santander,N.,
            Salaroglio,I.C., Hentschel,A., Quarta,E., Genova,T., McKinney,A.A.,
            Allocco,A.L., Fiorito,V., Petrillo,S., Ammirata,G., De Giorgio,F.,
            Dennis,E., Allington,G., Maier,F., Shoukier,M., Gloning,K.P.,
            Munaron,L., Mussano,F., Salsano,E., Pareyson,D., di Rocco,M.,
            Altruda,F., Panagiotakos,G., Kahle,K.T., Gressens,P., Riganti,C.,
            Pinton,P.P., Roos,A., Arnold,T., Tolosano,E. and Chiabrando,D.
  TITLE     Dysregulation of FLVCR1a-dependent mitochondrial calcium handling
            in neural progenitors causes congenital hydrocephalus
  JOURNAL   Cell Rep Med 5 (7), 101647 (2024)
   PUBMED   39019006
  REMARK    GeneRIF: Dysregulation of FLVCR1a-dependent mitochondrial calcium
            handling in neural progenitors causes congenital hydrocephalus.
REFERENCE   3  (bases 1 to 4087)
  AUTHORS   Mistretta,M., Fiorito,V., Allocco,A.L., Ammirata,G., Hsu,M.Y.,
            Digiovanni,S., Belicchi,M., Napoli,L., Ripolone,M., Trombetta,E.,
            Mauri,P., Farini,A., Meregalli,M., Villa,C., Porporato,P.E.,
            Miniscalco,B., Crich,S.G., Riganti,C., Torrente,Y. and Tolosano,E.
  TITLE     Flvcr1a deficiency promotes heme-based energy metabolism
            dysfunction in skeletal muscle
  JOURNAL   Cell Rep 43 (3), 113854 (2024)
   PUBMED   38412099
REFERENCE   4  (bases 1 to 4087)
  AUTHORS   Manco,M., Ammirata,G., Petrillo,S., De Giorgio,F., Fontana,S.,
            Riganti,C., Provero,P., Fagoonee,S., Altruda,F. and Tolosano,E.
  TITLE     FLVCR1a Controls Cellular Cholesterol Levels through the Regulation
            of Heme Biosynthesis and Tricarboxylic Acid Cycle Flux in
            Endothelial Cells
  JOURNAL   Biomolecules 14 (2), 149 (2024)
   PUBMED   38397386
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4087)
  AUTHORS   Kenny,T.C., Khan,A., Son,Y., Yue,L., Heissel,S., Sharma,A.,
            Pasolli,H.A., Liu,Y., Gamazon,E.R., Alwaseem,H., Hite,R.K. and
            Birsoy,K.
  TITLE     Integrative genetic analysis identifies FLVCR1 as a plasma-membrane
            choline transporter in mammals
  JOURNAL   Cell Metab 35 (6), 1057-1071 (2023)
   PUBMED   37100056
REFERENCE   6  (bases 1 to 4087)
  AUTHORS   Vinchi,F., Ingoglia,G., Chiabrando,D., Mercurio,S., Turco,E.,
            Silengo,L., Altruda,F. and Tolosano,E.
  TITLE     Heme exporter FLVCR1a regulates heme synthesis and degradation and
            controls activity of cytochromes P450
  JOURNAL   Gastroenterology 146 (5), 1325-1338 (2014)
   PUBMED   24486949
  REMARK    GeneRIF: Flvcr1a maintains a free heme pool that regulates heme
            synthesis and degradation as well as cytochromes P450 expression
            and activity.
REFERENCE   7  (bases 1 to 4087)
  AUTHORS   Byon,J.C., Chen,J., Doty,R.T. and Abkowitz,J.L.
  TITLE     FLVCR is necessary for erythroid maturation, may contribute to
            platelet maturation, but is dispensable for normal hematopoietic
            stem cell function
  JOURNAL   Blood 122 (16), 2903-2910 (2013)
   PUBMED   24021674
  REMARK    GeneRIF: FLVCR is redundant in stem cells but has critical and
            contrasting stage-specific roles in discrete hematopoietic lineages
REFERENCE   8  (bases 1 to 4087)
  AUTHORS   Chiabrando,D., Marro,S., Mercurio,S., Giorgi,C., Petrillo,S.,
            Vinchi,F., Fiorito,V., Fagoonee,S., Camporeale,A., Turco,E.,
            Merlo,G.R., Silengo,L., Altruda,F., Pinton,P. and Tolosano,E.
  TITLE     The mitochondrial heme exporter FLVCR1b mediates erythroid
            differentiation
  JOURNAL   J Clin Invest 122 (12), 4569-4579 (2012)
   PUBMED   23187127
REFERENCE   9  (bases 1 to 4087)
  AUTHORS   Gnana-Prakasam,J.P., Reddy,S.K., Veeranan-Karmegam,R., Smith,S.B.,
            Martin,P.M. and Ganapathy,V.
  TITLE     Polarized distribution of heme transporters in retinal pigment
            epithelium and their regulation in the iron-overload disease
            hemochromatosis
  JOURNAL   Invest Ophthalmol Vis Sci 52 (12), 9279-9286 (2011)
   PUBMED   22058337
  REMARK    GeneRIF: Hemochromatosis is associated not only with excessive
            accumulation of free iron in the retina and retinal pigment
            epithelium but also with excessive accumulation of heme.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4087)
  AUTHORS   Keel,S.B., Doty,R.T., Yang,Z., Quigley,J.G., Chen,J., Knoblaugh,S.,
            Kingsley,P.D., De Domenico,I., Vaughn,M.B., Kaplan,J., Palis,J. and
            Abkowitz,J.L.
  TITLE     A heme export protein is required for red blood cell
            differentiation and iron homeostasis
  JOURNAL   Science 319 (5864), 825-828 (2008)
   PUBMED   18258918
  REMARK    GeneRIF: data show that FLVCR exports heme & is required by
            erythroid progenitors to complete terminal differentiation; data
            show that FLVCR functions in macrophage heme-iron recycling and
            that systemic iron balance involves heme-iron trafficking via FLVCR
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY314941.1, BC157992.1, AK044206.1, AK036315.1 and AV018812.1.
            
            On Feb 6, 2007 this sequence version replaced XM_619720.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165872.1, BC157992.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BY314941.1         1-32
            33-1829             BC157992.1         1-1797
            1830-3364           AK044206.1         210-1744
            3365-4070           AK036315.1         2962-3667
            4071-4087           AV018812.1         352-368
FEATURES             Location/Qualifiers
     source          1..4087
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 96.28 cM"
     gene            1..4087
                     /gene="Flvcr1"
                     /gene_synonym="9630055N22Rik; FLVCR; Mfsd7b"
                     /note="feline leukemia virus subgroup C cellular receptor
                     1"
                     /db_xref="GeneID:226844"
                     /db_xref="MGI:MGI:2444881"
     exon            1..814
                     /gene="Flvcr1"
                     /gene_synonym="9630055N22Rik; FLVCR; Mfsd7b"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1780
                     /gene="Flvcr1"
                     /gene_synonym="9630055N22Rik; FLVCR; Mfsd7b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     feline leukemia virus subgroup C receptor-related protein
                     1; heme transporter FLVCR1; major facilitator superfamily
                     domain containing 7B; choline/ethanolamine transporter
                     FLVCR1"
                     /codon_start=1
                     /product="choline/ethanolamine transporter FLVCR1 isoform
                     1"
                     /protein_id="NP_001074728.1"
                     /db_xref="CCDS:CCDS35823.1"
                     /db_xref="GeneID:226844"
                     /db_xref="MGI:MGI:2444881"
                     /translation="MARPDDEVGPAVAPGHPLGKGYLPVPKGAPDGEARLVPQNGPEA
                     LNGGPGLGPLIAGAQGGPQALIAAEEETQARLLPAGDGEDVPCPACPPRTALSPRRFV
                     VLLIFSLYSLVNAFQWIQYSSISNVFEDFYEVSPLHINWLSMVYMVAYVPLIFPATWL
                     LDTRGLRLTALLGSGLNCLGAWVKCGSVQRHLFWVTMLGQILCSVAQVFILGLPSPVA
                     SVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLVPALGTQNSTGLLAHTQNNTDLLA
                     HNINTMFYGTAFISTFLFFLTIIAFKEKPPLPPSQAQAVLRDSPPEEYSYKSSIWNLC
                     RNIPFVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIGLTLVVAGMVGSIL
                     CGLWLDYTKTYKQTTLIVYVLSFIGMLIFTFTLNLGYIIVVFFTGGILGFFMTGYLPL
                     GFEFAVEITYPESEGMSSGLLNTAAQILGIFFTLAQGKITTDYNSPEAGNIFLCAWMF
                     VGIILTALIKSDLRRHNINTGLTNIDVKAVPVDSRVDPKPKVMVSIQSESSL"
     exon            815..995
                     /gene="Flvcr1"
                     /gene_synonym="9630055N22Rik; FLVCR; Mfsd7b"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1136
                     /gene="Flvcr1"
                     /gene_synonym="9630055N22Rik; FLVCR; Mfsd7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1204
                     /gene="Flvcr1"
                     /gene_synonym="9630055N22Rik; FLVCR; Mfsd7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1308
                     /gene="Flvcr1"
                     /gene_synonym="9630055N22Rik; FLVCR; Mfsd7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1419
                     /gene="Flvcr1"
                     /gene_synonym="9630055N22Rik; FLVCR; Mfsd7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1525
                     /gene="Flvcr1"
                     /gene_synonym="9630055N22Rik; FLVCR; Mfsd7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1640
                     /gene="Flvcr1"
                     /gene_synonym="9630055N22Rik; FLVCR; Mfsd7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1708
                     /gene="Flvcr1"
                     /gene_synonym="9630055N22Rik; FLVCR; Mfsd7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..4087
                     /gene="Flvcr1"
                     /gene_synonym="9630055N22Rik; FLVCR; Mfsd7b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4048..4053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Flvcr1"
                     /gene_synonym="9630055N22Rik; FLVCR; Mfsd7b"
                     /note="hexamer: AATAAA"
     polyA_site      4072
                     /gene="Flvcr1"
                     /gene_synonym="9630055N22Rik; FLVCR; Mfsd7b"
                     /note="major polyA site"
ORIGIN      
        1 ttagtcagca agcggcgcag gcgagcgcgc tgaaccgggt gggacctagg agccggcgag
       61 gagcactaag gggcggcggg gcggggagcc gggaggcatg gcgcggcccg atgacgaggt
      121 ggggccggcc gtggcgcccg ggcacccgct ggggaaggga taccttccag tgcccaaggg
      181 cgccccggac ggggaggcgc gcttggtacc gcaaaacggg cctgaggcgc tgaacggagg
      241 ccccgggctc ggcccgctga tcgcgggagc ccagggcggg ccgcaagccc tgatagcggc
      301 ggaggaggag acccaggccc ggctgttgcc cgcgggcgac ggggaggacg tcccatgccc
      361 cgcgtgtccc ccgcgcacag cgctgtcgcc gaggcgcttc gtggtgctgc tcatcttcag
      421 cctttactcg ctggtgaacg ccttccagtg gatccagtac agcagcatca gcaacgtgtt
      481 cgaggacttc tacgaggtgt cgccgctgca catcaactgg ctgtccatgg tgtacatggt
      541 ggcctacgtg cccctcatct tcccggccac ctggctgctg gacacgcgag gcctgcggct
      601 cacggcgctg ctgggctccg gcctcaactg cctgggagcc tgggtcaagt gcggcagcgt
      661 gcagcggcac ctcttctggg tcaccatgct ggggcagatc ctgtgctccg tggcccaggt
      721 cttcatcctg ggcttgccct cccccgtcgc ctcggtatgg tttggaccca aggaggtgtc
      781 gacggcttgt gccacagcag tgctgggcaa tcagcttgga actgcagttg gttttttgtt
      841 gccacctgtt ttagtgcctg ccttgggcac acagaatagc acaggcctcc tggctcacac
      901 acagaataac acagacctcc tggctcataa catcaacacc atgttttacg gaacagcatt
      961 tatctccaca tttttatttt ttttaacaat aattgcattc aaggagaaac ctccgttgcc
     1021 tccaagtcag gctcaggcag ttcttcgaga cagcccccct gaagagtact cctacaagag
     1081 ttctatctgg aacctgtgca gaaacatccc ctttgttctc ctgctggtca gttatggtat
     1141 catgactgga gcattttatt caatctcaac attattgaat caaataatat tgacatatta
     1201 tgtgggagaa gaggtgaatg ctgggaggat cgggctgaca ctggtggtag ctggaatggt
     1261 gggctctatt ctctgtggct tatggctgga ctataccaaa acctacaagc agacaactct
     1321 gatagtgtac gttctgtctt tcattggaat gctcatattc acattcacac tgaacctcgg
     1381 gtacatcatc gtggtgtttt ttactggtgg gattcttggc ttcttcatga ctggttacct
     1441 cccgctgggc tttgagtttg ctgtggagat cacctaccct gagtctgagg gcatgtcctc
     1501 agggctcctc aacactgctg cacagatact tggaattttc ttcacattgg ctcaaggaaa
     1561 gatcacaaca gactataata gtccagaggc aggaaacatt ttcctttgtg cctggatgtt
     1621 tgtaggcata attttaacag cgttgatcaa gtctgatctg agaaggcaca atataaacac
     1681 cgggcttaca aacattgacg ttaaagctgt accagttgat agtcgggtag atccaaaacc
     1741 caaagtgatg gtgtctatac agtcggaatc ttcactctga agaagccggt gtggctgccc
     1801 ctcaacatgg gcatgtggct tcgtctttgg gcagctgtgt gaggtgtgag gcacttgaaa
     1861 attattggat gagttctgaa tattttgttt tgtgttaatc agcgattgtg cttacaatgt
     1921 cctcgtgtta gcactcccat tcatgtaaac ctgtctagtc tcagttgtgt agtgtgtacc
     1981 tgaaagtaac attattgaca ttttttttca ggatgctttg tttttttatg ggtgtctagt
     2041 tcctgtaaga catataagag tgtgcaattc acacataaac acatctggta cattcccagt
     2101 cagttgtcac ctgactgtac tgaccatgtc agggtcacgg ttagagtcac agtgtgaatg
     2161 cagagtccca tgagaagcac tgacccactc ggacagggct ggggttagat tcccatctct
     2221 tacacacctg tgtattgtga catgttctgt cccacaaaaa caaacaaaca aacaaacaaa
     2281 ccaacaaaat ggttttatgc acagattaag tccattatac tctggttagc taggtagctg
     2341 agacacacac agatcatctg agatcttctt tgtgctgcct tcatacaggt aaacattaat
     2401 gtactacaac ttgtagtagt tttatgccct ttgtccattt tcactctctt aaaagaaact
     2461 ttcatcatct gtgttacggg ctagctcgtg atttcttaca tcacatctaa ttttgcctcg
     2521 aagatgccca agataaggaa gtctgtgata acttcagaga gcccatgtgt ctccattctg
     2581 tggagagtcc ttgaaatact agctgctgtc tttccaggat cattcctctg tctgaccact
     2641 gtttttaagg actaccagcc cttgcacatg tcctgtgaac gctgggagca ggttctgctg
     2701 caccacaccg tgtgtgtagt cagtactctg tggacactat ctcgtacaca ctcaggacaa
     2761 ggcgagtggg accaagtgta ttttcacagt gcctaccact gtgtcttgtt tacagtgaga
     2821 attaaatgtc tttgatgttt tgactcttaa gcttacattc atgacatttg atcaatcata
     2881 atatttacat agtgtgattt tgaaaatttt acaaaaaatt tacataatat aaaatgcaca
     2941 cagaaaaagt aatcatgtaa tgaatatggt tgaagcaaat gcaactttga tttaggcaaa
     3001 atatgcattg acttatcttg atattatatt ctgtttcatc agattactat aaattatgtg
     3061 gaacttgaca ttggaaaaat gtactgaaag aacttagtat cactcaggat caggaattct
     3121 ggttttgtgt cctgggcatg ttctgccttg gtaactctgg acacatcatt taccctctcc
     3181 ggcaacattt tcctgatcca tgaaataatg cattcacact gatctaaatg atctttttaa
     3241 aatattgtca ttcatcacga agtaggccaa atcatggtac cacaggaatt tagaaatcta
     3301 actgcaatct gggcagtggt ggaacacacc tacaccctgt cttgaaaaac caaaaaggag
     3361 gaaggaagga ggaaggaagt aatctagttc gagtaaacaa ttgtgattgg ttatgtagag
     3421 gcagagaact tcagctctgt ttttaactcc ttagtcagtc tgtaatagtt caggtagaat
     3481 ctgtatcatc agcaacttct tttagttttt ctgtcacagg ttacaaatga ccaaaaatgc
     3541 actgtctccc ccagctgttt ctgtttctaa attgacagtg ttgtttacaa gaccatatac
     3601 atgttacttc ctgaagcttt gaacaaatta cagataaaag ttggaatact taatgtctga
     3661 aaagtatatt cttgttttgt tttttattgt ttagaaaagg gataaagtct gacgtaataa
     3721 tgcaaaatga atcgatgatg ttctcagtat tttaagtgga tgtatgggta atacatcaga
     3781 taagaatttg ataaaattct atgtcatggg tatagaagta gtaattatca tcacctgtgt
     3841 ctgccttcat cagatggttt cagaagctgt tgcatctgta aatgttgtga catagctttt
     3901 gtctattgag attgttggag taatatcttt gaaaatgttt atgttagcaa ctggaatggc
     3961 acctatgtct aatgtcttca ttcctgttct tattttgcta cttttataat ttctctatgt
     4021 gcctgttctt cattatttca tacttaaaat aaatttattt ttttagtgct aattttatat
     4081 gtccttt
//
