LOCUS       NM_008029               5853 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus FMS-like tyrosine kinase 4 (Flt4), mRNA.
ACCESSION   NM_008029
VERSION     NM_008029.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5853)
  AUTHORS   Do,L.N.H., Delgado,E., Lim,C.G., Bkhache,M., Peluzzo,A.M., Hua,Y.,
            Oza,M., Mohsin,S., Chen,H., Autieri,M.V., Kim,S. and Liu,X.
  TITLE     A neuro-lymphatic communication guides lymphatic development by
            CXCL12 and CXCR4 signaling
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39470100
REFERENCE   2  (bases 1 to 5853)
  AUTHORS   Vallecillo-Garcia,P., Kuhnlein,M.N., Orgeur,M., Hansmeier,N.R.,
            Kotsaris,G., Meisen,Z.G., Timmermann,B., Giesecke-Thiel,C.,
            Hagerling,R. and Stricker,S.
  TITLE     Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel
            formation
  JOURNAL   Development 151 (17) (2024)
   PUBMED   39221968
REFERENCE   3  (bases 1 to 5853)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   4  (bases 1 to 5853)
  AUTHORS   Brouillard,P., Murtomaki,A., Leppanen,V.M., Hyytiainen,M.,
            Mestre,S., Potier,L., Boon,L.M., Revencu,N., Greene,A.,
            Anisimov,A., Salo,M.H., Hinttala,R., Eklund,L., Quere,I.,
            Alitalo,K. and Vikkula,M.
  TITLE     Loss-of-function mutations of the TIE1 receptor tyrosine kinase
            cause late-onset primary lymphedema
  JOURNAL   J Clin Invest 134 (14), e173586 (2024)
   PUBMED   38820174
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5853)
  AUTHORS   Nelson-Maney,N.P., Balint,L., Beeson,A.L., Serafin,D.S.,
            Kistner,B.M., Douglas,E.S., Siddiqui,A.H., Tauro,A.M. and
            Caron,K.M.
  TITLE     Meningeal lymphatic CGRP signaling governs pain via cerebrospinal
            fluid efflux and neuroinflammation in migraine models
  JOURNAL   J Clin Invest 134 (15), e175616 (2024)
   PUBMED   38743922
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5853)
  AUTHORS   Fournier,E., Dubreuil,P., Birnbaum,D. and Borg,J.P.
  TITLE     Mutation at tyrosine residue 1337 abrogates ligand-dependent
            transforming capacity of the FLT4 receptor
  JOURNAL   Oncogene 11 (5), 921-931 (1995)
   PUBMED   7675451
REFERENCE   7  (bases 1 to 5853)
  AUTHORS   Fong,G.H., Rossant,J., Gertsenstein,M. and Breitman,M.L.
  TITLE     Role of the Flt-1 receptor tyrosine kinase in regulating the
            assembly of vascular endothelium
  JOURNAL   Nature 376 (6535), 66-70 (1995)
   PUBMED   7596436
REFERENCE   8  (bases 1 to 5853)
  AUTHORS   Shalaby,F., Rossant,J., Yamaguchi,T.P., Gertsenstein,M., Wu,X.F.,
            Breitman,M.L. and Schuh,A.C.
  TITLE     Failure of blood-island formation and vasculogenesis in
            Flk-1-deficient mice
  JOURNAL   Nature 376 (6535), 62-66 (1995)
   PUBMED   7596435
REFERENCE   9  (bases 1 to 5853)
  AUTHORS   Martin,H.M., Nash,A.D. and Andrews,A.E.
  TITLE     Cloning and characterisation of an ovine interleukin-10-encoding
            cDNA
  JOURNAL   Gene 159 (2), 187-191 (1995)
   PUBMED   7622047
REFERENCE   10 (bases 1 to 5853)
  AUTHORS   Galland,F., Karamysheva,A., Mattei,M.G., Rosnet,O., Marchetto,S.
            and Birnbaum,D.
  TITLE     Chromosomal localization of FLT4, a novel receptor-type tyrosine
            kinase gene
  JOURNAL   Genomics 13 (2), 475-478 (1992)
   PUBMED   1319394
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY311090.1, BC138346.1, AL646088.23 and BU757635.1.
            
            On Apr 16, 2009 this sequence version replaced NM_008029.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138346.1, SRR10223969.10581.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BY311090.1         2-29
            29-4873             BC138346.1         1-4845
            4874-5513           AL646088.23        201279-201918
            5514-5853           BU757635.1         1-340               c
FEATURES             Location/Qualifiers
     source          1..5853
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 29.69 cM"
     gene            1..5853
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /note="FMS-like tyrosine kinase 4"
                     /db_xref="GeneID:14257"
                     /db_xref="MGI:MGI:95561"
     exon            1..149
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..4183
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /EC_number="2.7.10.1"
                     /note="vascular endothelial growth factor receptor 3;
                     receptor protein tyrosine kinase; tyrosine-protein kinase
                     receptor FLT4; chylous ascites"
                     /codon_start=1
                     /product="vascular endothelial growth factor receptor 3
                     precursor"
                     /protein_id="NP_032055.1"
                     /db_xref="CCDS:CCDS24618.1"
                     /db_xref="GeneID:14257"
                     /db_xref="MGI:MGI:95561"
                     /translation="MQPGAALNLRLWLCLGLLQGLANGYSMTPPTLNITEDSYVIDTG
                     DSLSISCRGQHPLEWTWPGAQEVLTTGGKDSEDTRVVHDCEGTEARPYCKVLLLAQTH
                     ANNTGSYHCYYKYIKARIEGTTAASTYVFVRDFKHPFINKPDTLLVNRKDSMWVPCLV
                     SIPGLNITLRSQSSALHPDGQEVLWDDRRGMRVPTQLLRDALYLQCETTWGDQNFLSN
                     LFVVHITGNELYDIQLYPKKSMELLVGEKLVLNCTVWAEFDSGVTFDWDYPGKQAERA
                     KWVPERRSQQTHTELSSILTIHNVSQNDLGPYVCEANNGIQRFRESTEVIVHEKPFIS
                     VEWLKGPVLEATAGDELVKLPVKLAAYPPPEFQWYKDRKAVTGRHNPHALVLKEVTEA
                     SAGVYTLALWNSAAGLRQNISLELVVNVPPHIHEKEASSPSIYSRHSRQTLTCTAYGV
                     PQPLSVQWHWRPWTPCKTFAQRSLRRRQQRDGMPQCRDWKEVTTQDAVNPIESLDSWT
                     EFVEGKNKTVSKLVIQDANVSAMYKCVVVNKVGQDERLIYFYVTTIPDGFSIESEPSE
                     DPLEGQSVRLSCRADNYTYEHLRWYRLNLSTLHDAQGNPLLLDCKNVHLFATPLEANL
                     EEAEPGARHATLSLNIPRVAPEDEGDYVCEVQDRRSQDKHCHKKYLSVQALEAPRLTQ
                     NLTDLLVNVSDSLEMRCPVAGAHVPSIVWYKDERLLEKESGIDLADSNQRLSIQRVRE
                     EDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILIGTGVIAVFFWVLLLLIFC
                     NMKRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGHGAF
                     GKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLG
                     ACTKPNGPLMVIVEFCKYGNLSNFLRVKRDTFNPYAEKSPEQRRRFRAMVEGAKADRR
                     RPGSSDRALFTRFLMGKGSARRAPLVQEAEDLWLSPLTMEDLVCYSFQVARGMEFLAS
                     RKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFD
                     KVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRAPELATPAIRH
                     IMQSCWSGDPKARPAFSDLVEILGDLLQGGGWQEEEEERMALHSSQSSEEDGFMQAST
                     TALHITEADADDSPPSMHCHSLAARYYNCVSFPGRLARGTKTPGSSRMKTFEELPMTP
                     TTYKASMDNQTDSGMVLASEEFEELESRHRPEGSFSCKGPGQHMDIPRGHPDPQGRRR
                     RPTQGAQGGKVFYNNEYGEVSQPCTEGDCCPSAGSTFFADSSY"
     exon            150..246
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            247..491
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            492..604
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            605..767
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            768..907
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1076
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1194
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1349
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1512
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1639
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1748
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..2111
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2258
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2390
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2497
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2633
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2738
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2852
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..2941
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3092
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3187
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3188..3310
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3311..3422
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3522
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3523..3628
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..3777
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3778..3898
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3899..3984
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3985..5839
                     /gene="Flt4"
                     /gene_synonym="Chy; Flt-4; VEGFR-3; VEGFR3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtccgcgcc ccgccggcgc ctcggcgcgc gctctcactc ccagcctaga gctgcggccg
       61 cgcaggtccc acccgcgccc aggggccgga gatgcagccg ggcgctgcgc tgaacctgcg
      121 cctgtggctc tgcctcggac tcctccaagg cctggcaaat ggttactcca tgacccctcc
      181 aaccctgaac atcacagagg attcatatgt gattgacacc ggggacagcc tatccatatc
      241 ctgcagggga cagcaccccc tcgagtggac ctggccaggg gcccaggagg tactgaccac
      301 aggtgggaag gacagtgaag acacacgggt tgtgcatgac tgtgaaggca cagaagctag
      361 gccctactgc aaggtgctac tgctggccca gactcacgcc aacaacacgg gcagctacca
      421 ctgctactac aagtacatca aggcccggat tgagggcacc acagctgcca gcacctatgt
      481 gtttgtaaga gactttaaac accctttcat caacaaacct gacacgctcc tggtcaacag
      541 gaaggactcg atgtgggtgc cctgcttggt gtccattccc ggcctcaaca tcacactgcg
      601 ctcgcaaagc tcagcgctgc accccgacgg gcaggaggtg ctgtgggatg accgccgggg
      661 catgcgggtg cccactcaac tgttgcgcga tgccctgtac ctgcagtgcg agaccacctg
      721 gggtgaccag aacttccttt ccaatctctt cgtcgtgcac atcacaggca atgagctcta
      781 tgacatccag ctgtacccca agaagtcaat ggagctgttg gttggagaga agctggtttt
      841 gaactgtaca gtgtgggctg agttcgactc aggtgtcacc ttcgactggg attatccagg
      901 gaagcaggca gagcgggcta agtgggtacc tgagcggcgt tcccagcaga cccacacaga
      961 actctccagc atcctgacca tccacaatgt cagccagaat gacctgggcc cctatgtgtg
     1021 tgaggccaac aatgggattc agcggttccg ggaaagcaca gaggtcattg tgcacgaaaa
     1081 gcccttcatc agtgtcgagt ggctcaaagg acctgtcctg gaggccacag ccggtgacga
     1141 gctggtgaag ctacccgtga agctggcagc ttatccccca ccggagttcc aatggtacaa
     1201 ggacagaaag gcagtgactg ggcgccacaa tccccatgct ctggtgctca aagaggtgac
     1261 cgaggccagc gcaggggtct acactctcgc cctgtggaac tctgcagctg gtctgaggca
     1321 aaacatcagt ctggagctgg tggtgaatgt gcctcctcac atccacgaaa aggaagcctc
     1381 ttcacccagc atctactccc gccacagtcg ccagaccctc acctgcaccg cctatggagt
     1441 accccaaccc ctcagtgtcc agtggcactg gaggccctgg acaccctgca agacgtttgc
     1501 ccagcgcagc ctccggaggc ggcagcagcg ggatggcatg ccacagtgcc gagactggaa
     1561 ggaggtgacc actcaggatg ctgtgaaccc catcgagagt ctggacagct ggacggagtt
     1621 tgtggagggg aagaataaga cggtgagcaa gctggtgatc caggatgcca atgtgtcagc
     1681 catgtacaag tgtgtggtcg tcaacaaagt gggccaggat gagagactca tctacttcta
     1741 tgtgaccacc atcccggacg gtttcagtat cgagtcggag ccttctgagg atcccttaga
     1801 aggccagtcc gtgcgcctca gctgccgggc ggacaactac acgtacgaac atctgcgctg
     1861 gtaccggctc aacctctcca cactgcacga tgctcaaggg aaccccctat tgctggactg
     1921 caaaaacgtg cacctgtttg ccacgcccct agaggccaac ctagaggagg cagagcccgg
     1981 ggcccgccac gccaccctca gtttgaatat cccccgagtg gcgcccgagg acgagggtga
     2041 ctacgtgtgt gaagtgcagg ataggcgcag ccaggacaag cactgccaca agaagtacct
     2101 gtccgtgcag gccctggaag ctcctcggct cacgcagaac ttgaccgacc tcctggtgaa
     2161 cgtgagtgac tccctggaga tgcgatgccc ggtggctgga gcgcatgtgc ccagtattgt
     2221 gtggtacaaa gatgaaaggc tcctggagaa agagtcggga atcgacctgg cagactccaa
     2281 tcagaggctg agcatccagc gcgtgcgcga ggaggacgca ggtcgttatc tgtgcagcgt
     2341 gtgcaatgcc aagggctgcg taaactcctc tgccagcgtg gcagtggaag gctctgaaga
     2401 taaaggcagc atggagattg tgatactcat tggcactggc gtcatcgcag ttttcttctg
     2461 ggtcctcctc ctgctcatct tctgtaacat gaaaaggcct gcccatgcag acatcaagac
     2521 gggctacctg tccatcatca tggaccccgg ggaggtgcct ttggaggagc agtgtgaata
     2581 cctgtcctat gacgccagcc agtgggagtt ccccagggaa aggttgcacc tcgggagagt
     2641 cctaggccac ggggcttttg ggaaggtggt ggaagcctca gcttttggca tcaataaagg
     2701 cagcagctgt gacaccgtgg ctgtgaagat gctgaaagag ggcgctactg ccagcgagca
     2761 ccgtgccctg atgtcggagc tcaagatcct aattcacatc ggcaaccatc tcaacgtggt
     2821 caacctccta ggggcgtgca ccaagcccaa cggccctctc atggtgatcg tggagttttg
     2881 caaatacggc aacctctcca acttcttgcg tgtcaagcgg gacacgttca acccctacgc
     2941 ggagaagtct ccggagcaac gcaggcgctt ccgcgccatg gtagaaggcg ccaaagctga
     3001 taggaggaga cctggaagca gcgacagggc cctgttcacg cggttcctga tgggcaaagg
     3061 aagtgcacgg cgagccccac ttgtccaaga agctgaggac ctatggctga gcccactgac
     3121 catggaagac cttgtatgct acagcttcca agttgcccgg ggaatggagt tcctggcttc
     3181 ccgcaagtgc attcacagag acctggctgc tcggaacatc ctactgtcag aaagtgacat
     3241 agtgaagatc tgcgactttg gcctcgctcg ggacatctac aaagaccccg actatgtccg
     3301 aaagggcagt gcccgacttc ctctgaaatg gatggccccc gagagcatct ttgataaggt
     3361 gtacaccacg cagagtgatg tgtggtcctt cggcgtgctg ctgtgggaga tcttctcatt
     3421 gggggcctct ccataccctg gggtacagat caatgaggag ttctgccagc ggctgaagga
     3481 tggcactcga atgagagccc cggaactggc cactcctgcc atacgccaca tcatgcagag
     3541 ttgctggtct ggagacccta aagcaagacc tgctttctct gacctagtgg agatcctggg
     3601 ggacctgctt cagggcggag gctggcagga ggaggaagag gagcgcatgg ccctgcacag
     3661 ctctcagagc tccgaggagg atggcttcat gcaggcatcc accacagctc tacatatcac
     3721 cgaagcagac gctgatgata gtccacccag catgcattgc cacagcctgg cagccagata
     3781 ttacaactgt gtgtcctttc ctgggcgcct ggccagaggc actaagactc caggctcttc
     3841 caggatgaag acatttgaag aattgcccat gacccctaca acctacaaag cctccatgga
     3901 taaccagaca gacagcggga tggtgctggc ctcagaagag tttgaggagc tagaaagcag
     3961 gcatagacca gaaggcagct tcagctgtaa aggtcctggc cagcacatgg atattcccag
     4021 aggacaccct gacccccagg ggaggcggcg acggcccact caaggggcac aaggaggcaa
     4081 ggtgttttat aacaacgagt atggggaggt ctcccagcca tgtacagaag gtgactgctg
     4141 cccgtctgct ggctccacct tcttcgcaga cagcagctac taaggaacat gtggcaaggc
     4201 ctcctgcccg ttgctgcaac cggctctgac agctgggctg gaggcccagg ttgggaattc
     4261 aactcctctg actccagccc tggaggtgtt ttatgtccca cccccactac agcctccata
     4321 tccaggaaga gtcaaactca gacaacgagg gctcccttga actctgtacc gctcctgtac
     4381 ccttccctgg gcagccaccc tcacccgcac attcgattgc cttgtagctc agcctccaca
     4441 gatgctggcc ctggaataag cactctggca gagaattctt ctccagcacc tattttcatc
     4501 gctctggtgg gcgacagggt tctcataagg aatacatatg tctgagagtc acacgatgaa
     4561 tcaagaaaga gttagaccag agccaccatg tcctggcccc aaaccatcct ctccacacac
     4621 acagtccctc tacttccaac tgcttcctgc ttccttctcc tggccccgga gggctgaaga
     4681 aagatatttt ctatctcaaa gtcacagagg aggagtggag gagggggagg actcctctga
     4741 gcatctatct agctcgtggg tagctgtctg tacacaatga ctaatcacaa tgaggcaacg
     4801 cctctgcccc tgagtgttga gaagaaccgt ttttttgttt gtgtgtgtgt gtgtgtgttg
     4861 gttttttttt ttttaatcag aagatcgggc gctgttgtaa agaatttact catcaaaaga
     4921 tcatctggaa aagaagccca atcaataact gttctagatc ctagtcccca ataactgaag
     4981 ggcggacatg acacaacatg ccagtcacca cagctcttcc cccgccccct ctctcgaagg
     5041 ctcccaggct ccaccggcct ggtctagaac ctaagacacc agctgctgtt ctgatccccc
     5101 ctcactgtgg gtctttcctc tagagcctgg atctgattgt ctgtggattc tgtcaaggaa
     5161 agcttcaggg gctggtacag aggaccacat ggctgggggc cactcagcca tcaccccgtg
     5221 tccccttggg ggcccctgcc ttcagcttac cctatacttt tacctgactt taacacctaa
     5281 acaaatcaaa cctctgtcct gaacgatccc tccagcccag ctcctgctgc cccccccccc
     5341 cacctccgtc atggccagaa gaaaccttca tgaagattag ccctgatgat ccctagcccc
     5401 atcccaaaaa gaacgcttgc aggacaggcg accatacagc aagcaggggc ttgctcagca
     5461 gaccctcccc actaagtgca ttgttctcct atgatatgtt gaaccgcatg tatgactgta
     5521 gtcctctttg tccctgtgga gcccccaccc ctattcctcc acatctaacc tgtctgtggg
     5581 attgagtgtc aagctcacca ctaggaagta gagactgttc tctcagagga ccgaaggctg
     5641 caaatggggc tgcagagccc ttctcaaacc ctcccttacg tatcacctgt ctgtgtcacc
     5701 tctcctgact tgtaactaca cacatacgaa atgtactggg gaagaaaacg tgctctgccc
     5761 tttttggcag tgttctgaaa tgagctaaga tatttaacga aagataataa taaatttgat
     5821 gccagtcttt gagttataaa aaaaaaaaaa aaa
//
