LOCUS       NM_001402831            1018 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus FMS-like tyrosine kinase 3 ligand (Flt3l), transcript
            variant 3, mRNA.
ACCESSION   NM_001402831
VERSION     NM_001402831.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1018)
  AUTHORS   Gong,W., Zhou,J., Hou,Y., Zhang,J., He,P. and Yu,Q.
  TITLE     The causal relationship between immune cells mediating FIT3L, CCL4,
            OSM, and skin-derived deteriorated tumors
  JOURNAL   Skin Res Technol 30 (7), e13774 (2024)
   PUBMED   38953214
  REMARK    GeneRIF: The causal relationship between immune cells mediating
            FIT3L, CCL4, OSM, and skin-derived deteriorated tumors.
REFERENCE   2  (bases 1 to 1018)
  AUTHORS   Momenilandi,M., Levy,R., Sobrino,S., Li,J., Lagresle-Peyrou,C.,
            Esmaeilzadeh,H., Fayand,A., Le Floc'h,C., Guerin,A., Della Mina,E.,
            Shearer,D., Delmonte,O.M., Yatim,A., Mulder,K., Mancini,M.,
            Rinchai,D., Denis,A., Neehus,A.L., Balogh,K., Brendle,S.,
            Rokni-Zadeh,H., Changi-Ashtiani,M., Seeleuthner,Y., Deswarte,C.,
            Bessot,B., Cremades,C., Materna,M., Cederholm,A., Ogishi,M.,
            Philippot,Q., Beganovic,O., Ackermann,M., Wuyts,M., Khan,T.,
            Fouere,S., Herms,F., Chanal,J., Palterer,B., Bruneau,J.,
            Molina,T.J., Leclerc-Mercier,S., Pretet,J.L., Youssefian,L.,
            Vahidnezhad,H., Parvaneh,N., Claeys,K.G., Schrijvers,R., Luka,M.,
            Perot,P., Fourgeaud,J., Nourrisson,C., Poirier,P., Jouanguy,E.,
            Boisson-Dupuis,S., Bustamante,J., Notarangelo,L.D., Christensen,N.,
            Landegren,N., Abel,L., Marr,N., Six,E., Langlais,D., Waterboer,T.,
            Ginhoux,F., Ma,C.S., Tangye,S.G., Meyts,I., Lachmann,N., Hu,J.,
            Shahrooei,M., Bossuyt,X., Casanova,J.L. and Beziat,V.
  TITLE     FLT3L governs the development of partially overlapping
            hematopoietic lineages in humans and mice
  JOURNAL   Cell 187 (11), 2817-2837 (2024)
   PUBMED   38701783
  REMARK    GeneRIF: FLT3L governs the development of partially overlapping
            hematopoietic lineages in humans and mice.
REFERENCE   3  (bases 1 to 1018)
  AUTHORS   Minutti,C.M., Piot,C., Pereira da Costa,M., Chakravarty,P.,
            Rogers,N., Huerga Encabo,H., Cardoso,A., Loong,J., Bessou,G.,
            Mionnet,C., Langhorne,J., Bonnet,D., Dalod,M., Tomasello,E. and
            Reis E Sousa,C.
  TITLE     Distinct ontogenetic lineages dictate cDC2 heterogeneity
  JOURNAL   Nat Immunol 25 (3), 448-461 (2024)
   PUBMED   38351322
REFERENCE   4  (bases 1 to 1018)
  AUTHORS   Tu,H.F., Kung,Y.J., Lim,L., Tao,J., Hu,M.H., Cheng,M., Xing,D.,
            Wu,T.C. and Hung,C.F.
  TITLE     FLT3L-induced virtual memory CD8 T cells engage the immune system
            against tumors
  JOURNAL   J Biomed Sci 31 (1), 19 (2024)
   PUBMED   38287325
  REMARK    GeneRIF: FLT3L-induced virtual memory CD8 T cells engage the immune
            system against tumors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1018)
  AUTHORS   Regnier,P., Vetillard,M., Bansard,A., Pierre,E., Li,X., Cagnard,N.,
            Gautier,E.L., Guermonprez,P., Manoury,B., Podsypanina,K. and
            Darrasse-Jeze,G.
  TITLE     FLT3L-dependent dendritic cells control tumor immunity by
            modulating Treg and NK cell homeostasis
  JOURNAL   Cell Rep Med 4 (12), 101256 (2023)
   PUBMED   38118422
REFERENCE   6  (bases 1 to 1018)
  AUTHORS   Lyman,S.D., Stocking,K., Davison,B., Fletcher,F., Johnson,L. and
            Escobar,S.
  TITLE     Structural analysis of human and murine flt3 ligand genomic loci
  JOURNAL   Oncogene 11 (6), 1165-1172 (1995)
   PUBMED   7566977
REFERENCE   7  (bases 1 to 1018)
  AUTHORS   Brasel,K., Escobar,S., Anderberg,R., de Vries,P., Gruss,H.J. and
            Lyman,S.D.
  TITLE     Expression of the flt3 receptor and its ligand on hematopoietic
            cells
  JOURNAL   Leukemia 9 (7), 1212-1218 (1995)
   PUBMED   7630197
REFERENCE   8  (bases 1 to 1018)
  AUTHORS   Lavagna,C., Marchetto,S., Birnbaum,D. and Rosnet,O.
  TITLE     Identification and characterization of a functional murine FLT3
            isoform produced by exon skipping
  JOURNAL   J Biol Chem 270 (7), 3165-3171 (1995)
   PUBMED   7531700
REFERENCE   9  (bases 1 to 1018)
  AUTHORS   Lyman,S.D., James,L., Escobar,S., Downey,H., de Vries,P.,
            Brasel,K., Stocking,K., Beckmann,M.P., Copeland,N.G.,
            Cleveland,L.S. et al.
  TITLE     Identification of soluble and membrane-bound isoforms of the murine
            flt3 ligand generated by alternative splicing of mRNAs
  JOURNAL   Oncogene 10 (1), 149-157 (1995)
   PUBMED   7824267
REFERENCE   10 (bases 1 to 1018)
  AUTHORS   Lyman,S.D., James,L., Vanden Bos,T., de Vries,P., Brasel,K.,
            Gliniak,B., Hollingsworth,L.T., Picha,K.S., McKenna,H.J.,
            Splett,R.R. et al.
  TITLE     Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase
            receptor: a proliferative factor for primitive hematopoietic cells
  JOURNAL   Cell 75 (6), 1157-1167 (1993)
   PUBMED   7505204
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126256.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777534.321857.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC126256.4         180552-180616       c
            66-132              AC126256.4         180191-180257       c
            133-246             AC126256.4         179837-179950       c
            247-300             AC126256.4         179295-179348       c
            301-444             AC126256.4         178546-178689       c
            445-589             AC126256.4         178055-178199       c
            590-774             AC126256.4         176401-176585       c
            775-1018            AC126256.4         175361-175604       c
FEATURES             Location/Qualifiers
     source          1..1018
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.14 cM"
     gene            1..1018
                     /gene="Flt3l"
                     /gene_synonym="Flt3lg; Ly72L"
                     /note="FMS-like tyrosine kinase 3 ligand"
                     /db_xref="GeneID:14256"
                     /db_xref="MGI:MGI:95560"
     exon            1..65
                     /gene="Flt3l"
                     /gene_synonym="Flt3lg; Ly72L"
                     /inference="alignment:Splign:2.1.0"
     exon            66..132
                     /gene="Flt3l"
                     /gene_synonym="Flt3lg; Ly72L"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..804
                     /gene="Flt3l"
                     /gene_synonym="Flt3lg; Ly72L"
                     /note="isoform a precursor is encoded by transcript
                     variant 3; flt3 ligand; fms-related tyrosine kinase 3
                     ligand"
                     /codon_start=1
                     /product="fms-related tyrosine kinase 3 ligand isoform a
                     precursor"
                     /protein_id="NP_001389760.1"
                     /db_xref="GeneID:14256"
                     /db_xref="MGI:MGI:95560"
                     /translation="MTVLAPAWSPNSSLLLLLLLLSPCLRGTPDCYFSHSPISSNFKV
                     KFRELTDHLLKDYPVTVAVNLQDEKHCKALWSLFLAQRWIEQLKTVAGSKMQTLLEDV
                     NTEIHFVTSCTFQPLPECLRFVQTNISHLLKDTCTQLLALKPCIGKACQNFSRCLEVQ
                     CQPDSSTLLPPRSPIALEATELPEPRPRQLLLLLLLLLPLTLVLLAAAWGLRWQRARR
                     RGELHPGSWEPKQGTS"
     exon            133..246
                     /gene="Flt3l"
                     /gene_synonym="Flt3lg; Ly72L"
                     /inference="alignment:Splign:2.1.0"
     exon            247..300
                     /gene="Flt3l"
                     /gene_synonym="Flt3lg; Ly72L"
                     /inference="alignment:Splign:2.1.0"
     exon            301..444
                     /gene="Flt3l"
                     /gene_synonym="Flt3lg; Ly72L"
                     /inference="alignment:Splign:2.1.0"
     exon            445..589
                     /gene="Flt3l"
                     /gene_synonym="Flt3lg; Ly72L"
                     /inference="alignment:Splign:2.1.0"
     exon            590..774
                     /gene="Flt3l"
                     /gene_synonym="Flt3lg; Ly72L"
                     /inference="alignment:Splign:2.1.0"
     exon            775..1018
                     /gene="Flt3l"
                     /gene_synonym="Flt3lg; Ly72L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      998..1003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Flt3l"
                     /gene_synonym="Flt3lg; Ly72L"
                     /note="hexamer: AATAAA"
     polyA_site      1018
                     /gene="Flt3l"
                     /gene_synonym="Flt3lg; Ly72L"
                     /note="major polyA site"
ORIGIN      
        1 ctttcacttt cggtctttgg ctgtcatcca gctttggctt tccacaccca gctggggcaa
       61 gcctgaacct gtcacaggca tgaggggtcc ccggcagaga tgacagtgct ggcgccagcc
      121 tggagcccaa attcctccct gttgctgctg ttgctgctgc tgagtccttg cctgcggggg
      181 acacctgact gttacttcag ccacagtccc atctcctcca acttcaaagt gaagtttaga
      241 gagttgactg accacctgct taaagattac ccagtcactg tggccgtcaa tcttcaggac
      301 gagaagcact gcaaggcctt gtggagcctc ttcctagccc agcgctggat agagcaactg
      361 aagactgtgg cagggtctaa gatgcaaacg cttctggagg acgtcaacac cgagatacat
      421 tttgtcacct catgtacctt ccagccccta ccagaatgtc tgcgattcgt ccagaccaac
      481 atctcccacc tcctgaagga cacctgcaca cagctgcttg ctctgaagcc ctgtatcggg
      541 aaggcctgcc agaatttctc tcggtgcctg gaggtgcagt gccagccgga ctcctccacc
      601 ctgctgcccc caaggagtcc catagcccta gaagccacgg agctcccaga gcctcggccc
      661 aggcagctgt tgctcctgct gctgctgctg ctgcctctca cactggtgct gctggcagcc
      721 gcctggggcc ttcgctggca aagggcaaga aggagggggg agctccaccc tgggagttgg
      781 gaaccaaaac aaggaacaag ctaggcaagt gctgtgctga gttacatccc cagcccagag
      841 gacacactgt ctgggtatgg cgatggacac tgtaattcca gtgcttctgg attggacatg
      901 ctgaaactgg aggatactga ctttaagaaa aacagaaagg aagaaggggg gtgcgttgta
      961 gccctgtgtg gttgcttttg tcacctccac cccttaaaat aaaagcaact gctgggta
//
