LOCUS       NM_010229               3664 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus FMS-like tyrosine kinase 3 (Flt3), mRNA.
ACCESSION   NM_010229
VERSION     NM_010229.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3664)
  AUTHORS   Bowman,R.L., Dunbar,A.J., Mishra,T., Xiao,W., Waarts,M.R.,
            Maestre,I.F., Eisman,S.E., Cai,L., Mowla,S., Shah,N., Youn,A.,
            Bennett,L., Fontenard,S., Gounder,S., Gandhi,A., Bowman,M.,
            O'Connor,K., Zaroogian,Z., Sanchez-Vela,P., Martinez Benitez,A.R.,
            Werewski,M., Park,Y., Csete,I.S., Krishnan,A., Lee,D., Boorady,N.,
            Potts,C.R., Jenkins,M.T., Cai,S.F., Carroll,M.P., Meyer,S.E.,
            Miles,L.A., Ferrell,P.B. Jr., Trowbridge,J.J. and Levine,R.L.
  TITLE     In vivo models of subclonal oncogenesis and dependency in
            hematopoietic malignancy
  JOURNAL   Cancer Cell 42 (11), 1955-1969 (2024)
   PUBMED   39532065
REFERENCE   2  (bases 1 to 3664)
  AUTHORS   Flynn,P.A., Long,M.D., Kosaka,Y., Long,N., Mulkey,J.S., Coy,J.L.,
            Agarwal,A. and Lind,E.F.
  TITLE     Leukemic mutation FLT3-ITD is retained in dendritic cells and
            disrupts their homeostasis leading to expanded Th17 frequency
  JOURNAL   Front Immunol 15, 1297338 (2024)
   PUBMED   38495876
  REMARK    GeneRIF: Leukemic mutation FLT3-ITD is retained in dendritic cells
            and disrupts their homeostasis leading to expanded Th17 frequency.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3664)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3664)
  AUTHORS   Yu,C.I., Maser,R., Marches,F., Banchereau,J. and Palucka,K.
  TITLE     Engraftment of adult hematopoietic stem and progenitor cells in a
            novel model of humanized mice
  JOURNAL   iScience 27 (3), 109238 (2024)
   PUBMED   38433905
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3664)
  AUTHORS   Lara-Astiaso,D., Goni-Salaverri,A., Mendieta-Esteban,J.,
            Narayan,N., Del Valle,C., Gross,T., Giotopoulos,G., Beinortas,T.,
            Navarro-Alonso,M., Aguado-Alvaro,L.P., Zazpe,J., Marchese,F.,
            Torrea,N., Calvo,I.A., Lopez,C.K., Alignani,D., Lopez,A., Saez,B.,
            Taylor-King,J.P., Prosper,F., Fortelny,N. and Huntly,B.J.P.
  TITLE     In vivo screening characterizes chromatin factor functions during
            normal and malignant hematopoiesis
  JOURNAL   Nat Genet 55 (9), 1542-1554 (2023)
   PUBMED   37580596
REFERENCE   6  (bases 1 to 3664)
  AUTHORS   Lyman,S.D., James,L., Vanden Bos,T., de Vries,P., Brasel,K.,
            Gliniak,B., Hollingsworth,L.T., Picha,K.S., McKenna,H.J.,
            Splett,R.R. et al.
  TITLE     Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase
            receptor: a proliferative factor for primitive hematopoietic cells
  JOURNAL   Cell 75 (6), 1157-1167 (1993)
   PUBMED   7505204
REFERENCE   7  (bases 1 to 3664)
  AUTHORS   Galland,F., Karamysheva,A., Mattei,M.G., Rosnet,O., Marchetto,S.
            and Birnbaum,D.
  TITLE     Chromosomal localization of FLT4, a novel receptor-type tyrosine
            kinase gene
  JOURNAL   Genomics 13 (2), 475-478 (1992)
   PUBMED   1319394
REFERENCE   8  (bases 1 to 3664)
  AUTHORS   Rosnet,O., Marchetto,S., deLapeyriere,O. and Birnbaum,D.
  TITLE     Murine Flt3, a gene encoding a novel tyrosine kinase receptor of
            the PDGFR/CSF1R family
  JOURNAL   Oncogene 6 (9), 1641-1650 (1991)
   PUBMED   1656368
REFERENCE   9  (bases 1 to 3664)
  AUTHORS   Matthews,W., Jordan,C.T., Wiegand,G.W., Pardoll,D. and
            Lemischka,I.R.
  TITLE     A receptor tyrosine kinase specific to hematopoietic stem and
            progenitor cell-enriched populations
  JOURNAL   Cell 65 (7), 1143-1152 (1991)
   PUBMED   1648448
REFERENCE   10 (bases 1 to 3664)
  AUTHORS   Rosnet,O., Mattei,M.G., Marchetto,S. and Birnbaum,D.
  TITLE     Isolation and chromosomal localization of a novel FMS-like tyrosine
            kinase gene
  JOURNAL   Genomics 9 (2), 380-385 (1991)
   PUBMED   2004790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163640.1, AK149292.1 and X59398.1.
            
            On Jan 18, 2007 this sequence version replaced NM_010229.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X59398.1, AK149292.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1688              AK163640.1         2-1689
            1689-3582           AK149292.1         1507-3400
            3583-3664           X59398.1           3440-3521
FEATURES             Location/Qualifiers
     source          1..3664
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 86.88 cM"
     gene            1..3664
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /note="FMS-like tyrosine kinase 3"
                     /db_xref="GeneID:14255"
                     /db_xref="MGI:MGI:95559"
     exon            1..270
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..3227
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /EC_number="2.7.10.1"
                     /note="FL cytokine receptor; fetal liver kinase 2;
                     tyrosine-protein kinase FLT3; tyrosine-protein kinase
                     receptor flk-2; receptor-type tyrosine-protein kinase
                     FLT3"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein kinase FLT3
                     precursor"
                     /protein_id="NP_034359.2"
                     /db_xref="CCDS:CCDS39400.1"
                     /db_xref="GeneID:14255"
                     /db_xref="MGI:MGI:95559"
                     /translation="MRALAQRSDRRLLLLVVLSVMILETVTNQDLPVIKCVLISHENN
                     GSSAGKPSSYRMVRGSPEDLQCAPRRQSEGTVYEAATVEVAESGSITLQVQLATPGDL
                     SCLWVFKHSSLGCQPHFDLQNRGIVSMAILNVTETQAGEYLLHIQSEAANYTVLFTVN
                     VRDTQLYVLRRPYFRKMENQDALLCISEGVPEPTVEWVLCSSHRESCKEEGPAVVRKE
                     EKVLHELFGTDIRCCARNALGRECTKLFTIDLNQAPQSTLPQLFLKVGEPLWIRCKAI
                     HVNHGFGLTWELEDKALEEGSYFEMSTYSTNRTMIRILLAFVSSVGRNDTGYYTCSSS
                     KHPSQSALVTILEKGFINATSSQEEYEIDPYEKFCFSVRFKAYPRIRCTWIFSQASFP
                     CEQRGLEDGYSISKFCDHKNKPGEYIFYAENDDAQFTKMFTLNIRKKPQVLANASASQ
                     ASCSSDGYPLPSWTWKKCSDKSPNCTEEIPEGVWNKKANRKVFGQWVSSSTLNMSEAG
                     KGLLVKCCAYNSMGTSCETIFLNSPGPFPFIQDNISFYATIGLCLPFIVVLIVLICHK
                     YKKQFRYESQLQMIQVTGPLDNEYFYVDFRDYEYDLKWEFPRENLEFGKVLGSGAFGR
                     VMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGAC
                     TLSGPVYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQAHSNSSMPG
                     SREVQLHPPLDQLSGFNGNLIHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLCFAYQV
                     AKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVK
                     WMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQP
                     FYATEGIYFVMQSCWAFDSRKRPSFPNLTSFLGCQLAEAEEAMYQNMGGNVPEHPSIY
                     QNRRPLSREAGSEPPSPQAQVKIHGERS"
     exon            271..392
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            393..595
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            596..711
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            712..841
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            842..969
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1109
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1263
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1432
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1536
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1645
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1824
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1931
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2064
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2169
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2280
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2434
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2517
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2651
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2774
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2886
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..2986
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3092
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3657
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3636..3641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /note="hexamer: AATAAA"
     polyA_site      3657
                     /gene="Flt3"
                     /gene_synonym="B230315G04; CD135; Flk-2; Flk2; Flt-3;
                     Ly72; wmfl"
                     /note="major polyA site"
ORIGIN      
        1 gggcacgtgg gatcggctgc agcactgcgc cagttcagcc cgcctagcag cgagcggccg
       61 cggcctctgg agagaggttc ctccccctct gctctgcacc agtccgaggg aatctgtggt
      121 cagtgacgcg catccttcag cgagccacct gcagcccggg gcgcgccgct gggaccgcat
      181 cacaggctgg gccggcggcc tggctaccgc gcgctccgga ggccatgcgg gcgttggcgc
      241 agcgcagcga ccggcggctg ctgctgcttg ttgttttgtc agtaatgatt cttgagaccg
      301 ttacaaacca agacctgcct gtgatcaagt gtgttttaat cagtcatgag aacaatggct
      361 catcagcggg aaagccatca tcgtaccgaa tggtgcgagg atccccagaa gacctccagt
      421 gtgccccgag gcgccagagt gaagggacgg tatatgaagc ggccaccgtg gaggtggccg
      481 agtctgggtc catcaccctg caagtgcagc tcgccacccc aggggacctt tcctgcctct
      541 gggtctttaa gcacagctcc ctgggctgcc agccgcactt tgatttacaa aacagaggaa
      601 tcgtttccat ggccatcttg aacgtgacag agacccaggc aggagaatac ctactccata
      661 ttcagagcga agccgccaac tacacagtac tgttcacagt gaatgtaaga gatacacagc
      721 tgtacgtgct aagaagacct tactttagga agatggaaaa ccaggacgca ctgctctgca
      781 tctccgaggg tgttccagag cccactgtgg agtgggtgct ctgcagctcc cacagggaaa
      841 gctgtaaaga agaaggccct gctgttgtca gaaaggagga aaaggtactt catgagttgt
      901 tcggaacaga catcagatgc tgtgctagaa atgcactggg ccgcgaatgc accaagctgt
      961 tcaccataga tctaaaccag gctcctcaga gcacactgcc ccagttattc ctgaaagtgg
     1021 gggaaccctt gtggatcagg tgtaaggcca tccatgtgaa ccatggattc gggctcacct
     1081 gggagctgga agacaaagcc ctggaggagg gcagctactt tgagatgagt acctactcca
     1141 caaacaggac catgattcgg attctcttgg cctttgtgtc ttccgtggga aggaacgaca
     1201 ccggatatta cacctgctct tcctcaaagc accccagcca gtcagcgttg gtgaccatcc
     1261 tagaaaaagg gtttataaac gctaccagct cgcaagaaga gtatgaaatt gacccgtacg
     1321 aaaagttctg cttctcagtc aggtttaaag cgtacccacg aatccgatgc acgtggatct
     1381 tctctcaagc ctcatttcct tgtgaacaga gaggcctgga ggatgggtac agcatatcta
     1441 aattttgcga tcataagaac aagccaggag agtacatatt ctatgcagaa aatgatgacg
     1501 cccagttcac caaaatgttc acgctgaata taagaaagaa acctcaagtg ctagcaaatg
     1561 cctcagccag ccaggcgtcc tgttcctctg atggctaccc gctaccctct tggacctgga
     1621 agaagtgttc ggacaaatct cccaattgca cggaggaaat cccagaagga gtttggaata
     1681 aaaaggctaa cagaaaagtg tttggccagt gggtgtcgag cagtactcta aatatgagtg
     1741 aggccgggaa agggcttctg gtcaaatgct gtgcgtacaa ttctatgggc acgtcttgcg
     1801 aaaccatctt tttaaactca ccaggcccct tccctttcat ccaagacaac atctccttct
     1861 atgcgaccat tgggctctgt ctccccttca ttgttgttct cattgtgttg atctgccaca
     1921 aatacaaaaa gcaatttagg tacgagagtc agctgcagat gatccaggtg actggccccc
     1981 tggataacga gtacttctac gttgacttca gggactatga atatgacctt aagtgggagt
     2041 tcccgagaga gaacttagag tttgggaagg tcctggggtc tggcgctttc gggagggtga
     2101 tgaacgccac ggcctatggc attagtaaaa cgggagtctc aattcaggtg gcggtgaaga
     2161 tgctaaaaga gaaagctgac agctgtgaaa aagaagctct catgtcggag ctcaaaatga
     2221 tgacccacct gggacaccat gacaacatcg tgaatctgct gggggcatgc acactgtcag
     2281 ggccagtgta cttgattttt gaatattgtt gctatggtga cctcctcaac tacctaagaa
     2341 gtaaaagaga gaagtttcac aggacatgga cagagatttt taaggaacat aatttcagtt
     2401 tttaccctac tttccaggca cattcaaatt ccagcatgcc tggttcacga gaagttcagt
     2461 tacacccgcc cttggatcag ctctcagggt tcaatgggaa tttaattcat tctgaagatg
     2521 agattgaata tgaaaaccag aagaggctgg cagaagaaga ggaggaagat ttgaacgtgc
     2581 tgacgtttga agacctcctt tgctttgcgt accaagtggc caaaggcatg gaattcctgg
     2641 agttcaagtc gtgtgtccac agagacctgg cagccaggaa tgtgttggtc acccacggga
     2701 aggtggtgaa gatctgtgac tttggactgg cccgagacat cctgagcgac tccagctacg
     2761 tcgtcagggg caacgcacgg ctgccggtga agtggatggc acctgagagc ttatttgaag
     2821 ggatctacac aatcaagagt gacgtctggt cctacggcat ccttctctgg gagatatttt
     2881 cactgggtgt gaacccttac cctggcattc ctgtcgacgc taacttctat aaactgattc
     2941 agagtggatt taaaatggag cagccattct atgccacaga agggatatac tttgtaatgc
     3001 aatcctgctg ggcttttgac tcaaggaagc ggccatcctt ccccaacctg acttcatttt
     3061 taggatgtca gctggcagag gcagaagaag cgatgtatca gaacatgggt ggcaacgtcc
     3121 cagaacatcc atccatctac caaaacaggc ggcccctcag cagagaggca ggctcagagc
     3181 cgccatcgcc acaggcccag gtgaagattc acggagaaag aagttagcga ggaggccttg
     3241 gaccccgcca ccctagcagg ctgtagacca cagagccaag attagcctcg cctctgagga
     3301 agcgccctac aggccgttgc ttcgctggac ttttctctag atgctgtctg ccattactcc
     3361 aaagtgactt ctataaaatc aaacctctcc tcgcacaggt gggagagcca ataatgagac
     3421 ttgttggtga gcccgcctac cctggggggc ctttccaggc cccccaggct tgaggggaaa
     3481 gccatgtatc tgaaatatag tatattcttg taaatacgtg aaacaaacca aacccgtttt
     3541 ttgctaaggg aaagctaaat atgattttta aaaatctatg ttttaaaata ctatgtaact
     3601 ttttcatcta tttagtgata tattttatgg atggaaataa actttctact gtagaaaaaa
     3661 aaaa
//
