LOCUS       NM_010228               6895 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus FMS-like tyrosine kinase 1 (Flt1), transcript variant
            1, mRNA.
ACCESSION   NM_010228
VERSION     NM_010228.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6895)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   2  (bases 1 to 6895)
  AUTHORS   Verma,M., Asakura,Y., Wang,X., Zhou,K., Unverdi,M., Kann,A.P.,
            Krauss,R.S. and Asakura,A.
  TITLE     Endothelial cell signature in muscle stem cells validated by
            VEGFA-FLT1-AKT1 axis promoting survival of muscle stem cell
  JOURNAL   Elife 13, e73592 (2024)
   PUBMED   38842166
  REMARK    GeneRIF: Endothelial cell signature in muscle stem cells validated
            by VEGFA-FLT1-AKT1 axis promoting survival of muscle stem cell.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6895)
  AUTHORS   Xu,K., Fei,W., Gao,W., Fan,C., Li,Y., Hong,Y. and Cui,R.
  TITLE     SOD3 regulates FLT1 to affect bone metabolism by promoting
            osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK
            pathways
  JOURNAL   Free Radic Biol Med 212, 65-79 (2024)
   PUBMED   38141889
  REMARK    GeneRIF: SOD3 regulates FLT1 to affect bone metabolism by promoting
            osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK
            pathways.
REFERENCE   4  (bases 1 to 6895)
  AUTHORS   Zhao,H., Wong,R.J. and Stevenson,D.K.
  TITLE     The placental vasculature is affected by changes in gene expression
            and glycogen-rich cells in a diet-induced obesity mouse model
  JOURNAL   PLoS One 18 (11), e0294185 (2023)
   PUBMED   37948457
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6895)
  AUTHORS   Lee,C., Chen,R., Sun,G., Liu,X., Lin,X., He,C., Xing,L., Liu,L.,
            Jensen,L.D., Kumar,A., Langer,H.F., Ren,X., Zhang,J., Huang,L.,
            Yin,X., Kim,J., Zhu,J., Huang,G., Li,J., Lu,W., Chen,W., Liu,J.,
            Hu,J., Sun,Q., Lu,W., Fang,L., Wang,S., Kuang,H., Zhang,Y.,
            Tian,G., Mi,J., Kang,B.A., Narazaki,M., Prodeus,A., Schoonjans,L.,
            Ornitz,D.M., Gariepy,J., Eelen,G., Dewerchin,M., Yang,Y., Ou,J.S.,
            Mora,A., Yao,J., Zhao,C., Liu,Y., Carmeliet,P., Cao,Y. and Li,X.
  TITLE     VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1
            pathway
  JOURNAL   Signal Transduct Target Ther 8 (1), 305 (2023)
   PUBMED   37591843
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6895)
  AUTHORS   Chakraborty,I., Das,S.K. and Dey,S.K.
  TITLE     Differential expression of vascular endothelial growth factor and
            its receptor mRNAs in the mouse uterus around the time of
            implantation
  JOURNAL   J Endocrinol 147 (2), 339-352 (1995)
   PUBMED   7490564
REFERENCE   7  (bases 1 to 6895)
  AUTHORS   Shalaby,F., Rossant,J., Yamaguchi,T.P., Gertsenstein,M., Wu,X.F.,
            Breitman,M.L. and Schuh,A.C.
  TITLE     Failure of blood-island formation and vasculogenesis in
            Flk-1-deficient mice
  JOURNAL   Nature 376 (6535), 62-66 (1995)
   PUBMED   7596435
REFERENCE   8  (bases 1 to 6895)
  AUTHORS   de Vries,C., Escobedo,J.A., Ueno,H., Houck,K., Ferrara,N. and
            Williams,L.T.
  TITLE     The fms-like tyrosine kinase, a receptor for vascular endothelial
            growth factor
  JOURNAL   Science 255 (5047), 989-991 (1992)
   PUBMED   1312256
REFERENCE   9  (bases 1 to 6895)
  AUTHORS   Breier,G., Albrecht,U., Sterrer,S. and Risau,W.
  TITLE     Expression of vascular endothelial growth factor during embryonic
            angiogenesis and endothelial cell differentiation
  JOURNAL   Development 114 (2), 521-532 (1992)
   PUBMED   1592003
REFERENCE   10 (bases 1 to 6895)
  AUTHORS   Raz,V., Kelman,Z., Avivi,A., Neufeld,G., Givol,D. and Yarden,Y.
  TITLE     PCR-based identification of new receptors: molecular cloning of a
            receptor for fibroblast growth factors
  JOURNAL   Oncogene 6 (5), 753-760 (1991)
   PUBMED   1711190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122299.5 and AC131730.2.
            
            On May 9, 2018 this sequence version replaced NM_010228.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D88689.1, X78568.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               AC122299.5         51105-51445         c
            342-438             AC122299.5         25755-25851         c
            439-668             AC122299.5         25216-25445         c
            669-793             AC131730.2         12889-13013
            794-956             AC131730.2         14823-14985
            957-1093            AC131730.2         15080-15216
            1094-1268           AC131730.2         18512-18686
            1269-1386           AC131730.2         20392-20509
            1387-1556           AC131730.2         23128-23297
            1557-1716           AC131730.2         24107-24266
            1717-1831           AC131730.2         41619-41733
            1832-1940           AC131730.2         50597-50705
            1941-2249           AC131730.2         57297-57605
            2250-2396           AC131730.2         62307-62453
            2397-2528           AC131730.2         81570-81701
            2529-2635           AC131730.2         93204-93310
            2636-2768           AC131730.2         97159-97291
            2769-2873           AC131730.2         102170-102274
            2874-2987           AC131730.2         106955-107068
            2988-3076           AC131730.2         108214-108302
            3077-3230           AC131730.2         114126-114279
            3231-3328           AC131730.2         114630-114727
            3329-3451           AC131730.2         116406-116528
            3452-3563           AC131730.2         118394-118505
            3564-3663           AC131730.2         120591-120690
            3664-3769           AC131730.2         125274-125379
            3770-3912           AC131730.2         125824-125966
            3913-3997           AC131730.2         128004-128088
            3998-4092           AC131730.2         130336-130430
            4093-6895           AC131730.2         132424-135226
FEATURES             Location/Qualifiers
     source          1..6895
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 87.01 cM"
     gene            1..6895
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /note="FMS-like tyrosine kinase 1"
                     /db_xref="GeneID:14254"
                     /db_xref="MGI:MGI:95558"
     exon            1..341
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..4279
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; vascular endothelial growth factor receptor 1;
                     embryonic receptor kinase 2; tyrosine-protein kinase
                     receptor FLT; vascular permeability factor receptor"
                     /codon_start=1
                     /product="vascular endothelial growth factor receptor 1
                     isoform 1 precursor"
                     /protein_id="NP_034358.2"
                     /db_xref="CCDS:CCDS19879.1"
                     /db_xref="GeneID:14254"
                     /db_xref="MGI:MGI:95558"
                     /translation="MVSCWDTAVLPYALLGCLLLTGYGSGSKLKVPELSLKGTQHVMQ
                     AGQTLFLKCRGEAAHSWSLPTTVSQEDKRLSITPPSACGRDNRQFCSTLTLDTAQANH
                     TGLYTCRYLPTSTSKKKKAESSIYIFVSDAGSPFIEMHTDIPKLVHMTEGRQLIIPCR
                     VTSPNVTVTLKKFPFDTLTPDGQRITWDSRRGFIIANATYKEIGLLNCEATVNGHLYQ
                     TNYLTHRQTNTILDVQIRPPSPVRLLHGQTLVLNCTATTELNTRVQMSWNYPGKATKR
                     ASIRQRIDRSHSHNNVFHSVLKINNVESRDKGLYTCRVKSGSSFQSFNTSVHVYEKGF
                     ISVKHRKQPVQETTAGRRSYRLSMKVKAFPSPEIVWLKDGSPATLKSARYLVHGYSLI
                     IKDVTTEDAGDYTILLGIKQSRLFKNLTATLIVNVKPQIYEKSVSSLPSPPLYPLGSR
                     QVLTCTVYGIPRPTITWLWHPCHHNHSKERYDFCTENEESFILDPSSNLGNRIESISQ
                     RMTVIEGTNKTVSTLVVADSQTPGIYSCRAFNKIGTVERNIKFYVTDVPNGFHVSLEK
                     MPAEGEDLKLSCVVNKFLYRDITWILLRTVNNRTMHHSISKQKMATTQDYSITLNLVI
                     KNVSLEDSGTYACRARNIYTGEDILRKTEVLVRDSEAPHLLQNLSDYEVSISGSTTLD
                     CQARGVPAPQITWFKNNHKIQQEPGIILGPGNSTLFIERVTEEDEGVYRCRATNQKGA
                     VESAAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKLKRSSSEVKTDYLSI
                     IMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTC
                     RTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCK
                     YGNLSNYLKSKRDLFCLNKDAALHMELKKESLEPGLEQGQKPRLDSVSSSSVTSSSFP
                     EDRSVSDVEGDEDYSEISKQPLTMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILL
                     SENNVVKICDFGLARDIYKNPDYVRRGDTRLPLKWMAPESIFDKVYSTKSDVWSYGVL
                     LWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKERPR
                     FAELVEKLGDLLQANVQQDGKDYIPLNAILTRNSGFTYSTPTFSEDLFKDGFADPHFH
                     SGSSDDVRYVNAFKFMSLERIKTFEELSPNSTSMFEDYQLDTSTLLGSPLLKRFTWTE
                     TKPKASMKIDLRIASKSKEAGLSDLPRPSFCFSSCGHIRPVQDDESELGKESCCSPPP
                     DYNSVVLYSSPPA"
     exon            342..438
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..668
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..793
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..956
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1093
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1268
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1386
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1556
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1716
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1831
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1940
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2249
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2396
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2528
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2635
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2768
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2873
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..2987
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3076
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3230
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3328
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3329..3451
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3452..3563
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..3663
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3769
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3770..3912
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3913..3997
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3998..4092
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4093..6895
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6872..6877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /note="hexamer: AATAAA"
     polyA_site      6895
                     /gene="Flt1"
                     /gene_synonym="Flt-1; sFlt1; VEGFR-1; VEGFR1"
                     /note="major polyA site"
ORIGIN      
        1 agcgaggtcc ttgagaggct cggagcgcgg tggcggacac tcccgggagg tagtgctagt
       61 ggtggtggct gctgctcgga gcgggctccg ggactcaagc gcagcggcta gcggacgcgg
      121 gacggcgagg atccccccac accacccccc tcggctgcag gcgcggagaa gggctctcgc
      181 ggcgccaagc agaagcagga ggggaccggc tcgagcggct gcgccgtcgg cctcggagag
      241 cgcgggcacc gggccaacag gccgcgtctt gctcaccatg gtcagctgct gggacaccgc
      301 ggtcttgcct tacgcgctgc tcgggtgtct gcttctcaca ggatatggct cagggtcgaa
      361 gttaaaagtg cctgaactga gtttaaaagg cacccagcat gtcatgcaag caggccagac
      421 tctctttctc aagtgcagag gggaggcagc ccactcatgg tctctgccca cgaccgtgag
      481 ccaggaggac aaaaggctga gcatcactcc cccatcggcc tgtgggaggg ataacaggca
      541 attctgcagc accttgacct tggacacggc gcaggccaac cacacgggcc tctacacctg
      601 tagatacctc cctacatcta cttcgaagaa aaagaaagcg gaatcttcaa tctacatatt
      661 tgttagtgat gcagggagtc ctttcataga gatgcacact gacataccca aacttgtgca
      721 catgacggaa ggaagacagc tcatcatccc ctgccgggtg acgtcaccca acgtcacagt
      781 caccctaaaa aagtttccat ttgatactct tacccctgat gggcaaagaa taacatggga
      841 cagtaggaga ggctttataa tagcaaatgc aacgtacaaa gagataggac tgctgaactg
      901 cgaagccacc gtcaacgggc acctgtacca gacaaactat ctgacccatc ggcagaccaa
      961 tacaatccta gatgtccaaa tacgcccgcc gagcccagtg agactgctcc acgggcagac
     1021 tcttgtcctc aactgcaccg ccaccacgga gctcaatacg agggtgcaaa tgagctggaa
     1081 ttaccctggt aaagcaacta agagagcatc tataaggcag cggattgacc ggagccattc
     1141 ccacaacaat gtgttccaca gtgttcttaa gatcaacaat gtggagagcc gagacaaggg
     1201 gctctacacc tgtcgcgtga agagtgggtc ctcgttccag tctttcaaca cctccgtgca
     1261 tgtgtatgaa aaaggattca tcagtgtgaa acatcggaag cagccggtgc aggaaaccac
     1321 agcaggaaga cggtcctatc ggctgtccat gaaagtgaag gccttcccct ccccagaaat
     1381 cgtatggtta aaagatggct cgcctgcaac attgaagtct gctcgctatt tggtacatgg
     1441 ctactcatta attatcaaag atgtgacaac cgaggatgca ggggactata cgatcttgct
     1501 gggcataaag cagtcaaggc tatttaaaaa cctcactgcc actctcattg taaacgtgaa
     1561 acctcagatc tacgaaaagt ccgtgtcctc gcttccaagc ccacctctct atccgctggg
     1621 cagcagacaa gtcctcactt gcaccgtgta tggcatccct cggccaacaa tcacgtggct
     1681 ctggcacccc tgtcaccaca atcactccaa agaaaggtat gacttctgca ctgagaatga
     1741 agaatccttt atcctggatc ccagcagcaa cttaggaaac agaattgaga gcatctctca
     1801 gcgcatgacg gtcatagaag gaacaaataa gacggttagc acattggtgg tggctgactc
     1861 tcagacccct ggaatctaca gctgccgggc cttcaataaa atagggactg tggaaagaaa
     1921 cataaaattt tatgtcacag atgtgccgaa tggctttcac gtttccttgg aaaagatgcc
     1981 agccgaagga gaggacctga aactgtcctg tgtggtcaat aaattcctgt acagagacat
     2041 tacctggatt ctgctacgga cagttaacaa cagaaccatg caccatagta tcagcaagca
     2101 aaaaatggcc accactcaag attactccat cactctgaac cttgtcatca agaacgtgtc
     2161 tctagaagac tcgggcacct atgcgtgcag agccaggaac atatacacag gggaagacat
     2221 ccttcggaag acagaagttc tcgttagaga ttcggaagcg ccacacctgc ttcaaaacct
     2281 cagtgactac gaggtctcca tcagtggctc tacgacctta gactgtcaag ctagaggtgt
     2341 ccccgcgcct cagatcactt ggttcaaaaa caaccacaaa atacaacaag aaccgggaat
     2401 tattttagga ccaggaaaca gcacgctgtt tattgaaaga gtcacagagg aggatgaggg
     2461 tgtctatagg tgccgagcca ccaaccagaa gggggccgtg gaaagcgcag cctacctcac
     2521 cgtgcaagga acctcagaca agtcaaacct ggagctgatc acgctcacgt gcacatgcgt
     2581 ggctgcgacc ctcttttggc tccttctaac tctcttcatc agaaaactga agcggtcttc
     2641 ttccgaagta aagacagact acctgtcaat cattatggac ccagatgaag ttcccctgga
     2701 tgagcagtgt gaacggctgc cctatgatgc cagcaagtgg gagtttgcac gggagagact
     2761 gaaactaggc aaatcgctcg gaagaggggc ttttgggaaa gtcgttcaag cctctgcatt
     2821 tggcattaag aaatcaccca cctgccggac tgtggctgtg aagatgttga aagagggggc
     2881 cacagccagt gagtacaaag ctctgatgac cgaactcaag atcttgaccc acatcggcca
     2941 tcatctgaat gtggttaacc tcctgggagc ctgcacgaag caaggagggc ctctgatggt
     3001 gatcgtggaa tactgcaaat acggaaacct gtccaactac ctcaagagca aacgtgactt
     3061 attctgtctc aacaaggacg cagccttgca tatggagctc aagaaagaga gcctggaacc
     3121 aggcctggag cagggccaga agccccgcct agacagtgtc agcagctcaa gtgtcaccag
     3181 ctccagcttc cctgaagacc gaagcgtgag cgatgtggaa ggagacgagg attacagtga
     3241 gatctccaag cagcccctca ccatggaaga cctgatttcc tacagtttcc aagtggccag
     3301 aggcatggag tttctgtcct ccagaaagtg cattcatcgg gacctggcag cgagaaacat
     3361 ccttttatct gagaacaatg tggtgaagat ttgcgacttt ggcctggccc gggatattta
     3421 taagaaccct gattatgtga ggagaggaga tactcgactt cccctaaaat ggatggctcc
     3481 tgaatccatc tttgacaagg tctacagcac caagagcgat gtgtggtcct atggcgtgtt
     3541 gctgtgggag atcttctcct tagggggttc tccataccca ggagtgcaaa tggatgaaga
     3601 cttctgcagc cgcctgaagg aaggcatgcg gatgagaacc ccggagtatg ccacacctga
     3661 aatctaccaa atcatgttgg attgctggca caaagacccc aaagagaggc cccggtttgc
     3721 tgaacttgtg gagaaacttg gtgacctgct tcaagccaac gtccaacagg atgggaaaga
     3781 ttacatcccc ctcaatgcca tactgactag aaacagtggc ttcacatact cgacccccac
     3841 cttctctgag gaccttttca aggacggctt tgcagatcca cattttcatt ccggaagctc
     3901 tgatgatgtg agatatgtaa acgctttcaa attcatgagc ctggaaagaa tcaaaacctt
     3961 tgaggagctt tcaccgaact ccacctccat gtttgaggac tatcagctgg acactagcac
     4021 tctgctgggc tcccccttgc tgaagcggtt cacctggact gagaccaagc ccaaggcctc
     4081 catgaagata gacttgagaa tagcgagtaa aagcaaggag gcgggacttt ccgatctgcc
     4141 gaggcccagc ttctgcttct ccagctgtgg ccacatcagg cccgtgcagg acgatgaatc
     4201 tgagctggga aaggagtcct gctgttctcc acccccagac tacaactccg tggtgttgta
     4261 ctcctccccg cccgcctaaa gcttctcacc agccccgaca accagcccct gacagtatta
     4321 tacatctatg agtttacacc tattccgctc cacaggagcc agctgctttt cgtgaccttt
     4381 aatcgtgctt ttttgttttt tgttttgttt gttgttgctg ttttgactaa caagaatgta
     4441 accccagtta gtgacgtgtg aagaatacta ttgttagaga aatccccccc gcaaagcctc
     4501 agggtaacct ggacaggaag gagcaggtgc ctctggcgac cgccccgccc accggccatg
     4561 gccccaccca ccctccctgc agctgtggga ctagaggcag taagcccatt agctcatggc
     4621 tgcatgcact gacctgctct gtctctctta tggaggaaag ggagaacaga gcaaacagga
     4681 ggcacaggaa aaggctttgg gatgcgtccg tcctgtggag cccgtgcagg agggggctcc
     4741 gctatgccac ttcagtgact tctcactcct ggcctccgct gtttcgggcc cccttccaag
     4801 aggtatcaga gcagaacatg agggacgttt cctagaccag ggcacatgtt ctcgggaacc
     4861 acagttaatc ttaaatcttt tcccgggagt cttctgttgt ctgtttacca tccaaagcat
     4921 atttaacatg tgtcagtggg ggtggcgctt ggcttctgag gccagagcca tcatcagttc
     4981 ctctagtgag atgcattgag gtcataccca agcttgcagg cctgaccttc gcatactgct
     5041 cacggggagt taagtggtcc agtttggcct agtaaggttg cctactgatg ggctcaaaag
     5101 ccacatttta aacaggtttt atctcaagta ttaatatata gacaagacac ttatgcatta
     5161 tcctgtttta tatatccaat gaatataact ggggcgagtt aagagtcatg gtctagaaaa
     5221 ggggtttctc tgtacccaaa tcgggctggt tggaccaaga cccagagagg cagagtggtt
     5281 gtcccagcta tagttactaa actactcacc caaagttggg acctcactgg cttctcttta
     5341 cttcatcatg gatttcacca tcccaaggca gtctgagagg agctaaagag tatcagccca
     5401 tatttattaa gcactttatg ctccttggca cagcaggtga tgtgtaattt atgcaagctc
     5461 cctctccagc taggactcag gatattagtc aatgagccat caaaaggaaa aaaaaaaaac
     5521 catcttattt tcatctgttt cataccttgt ctggggtcta atgacgatgg caacagggta
     5581 gacatgggaa gacagggtag aaaagggtgc ccgctctttg gggtctagag atgagccctg
     5641 ggtctctaaa atggctctct tagaagttgt atgtgcaaat tatggtctgt gtgcttaggt
     5701 cgtgcacacc tgccggagcc ggtcacagct gggcagacga tgaatagctg ctttgggaga
     5761 gcagagcatg ctagccactt aattctctga ccgggccagc atcatgggta cctgctcccc
     5821 tgtgtacccc atccttaagg ttttctgtct gatgagactg gaggcccagt gcaatcccca
     5881 ctgagacagc ctgcagccca ctgtggctct tggtgcactc accagccagg actagacaag
     5941 taggaaaggg cttctagcca cactggagaa aaagaaaatc aggtagggct ggccaaagac
     6001 atctttgtcc attcgcaaaa gctcttgtcg gctgcagtgt gtaagtcagg cgatgagaca
     6061 gaggctacca gagaaacgga tgagaacagc agcctgaggt ttctcatcca gatatccagc
     6121 aattgggggg tgggggaaga ccatagatgg tcctgtatta ttccgatttt aataatctaa
     6181 ttcgtgatca ttaagagact ttagtaaatg tccctttccc acaaaagtaa agaaaagcta
     6241 tcgggattct ctggttctgc ttaaagactt agctttggag cctatgaaag ttgatcagcc
     6301 aggaaaaaaa aaaaaaaagg aaagaaagga aagaaagaaa aaaagaagga agacggttcc
     6361 ttctgagttt ttagggtagg aagaaaaatg gaaacttcta acgacagaca tacctaggtg
     6421 cactgggcct gatcaccaag aacatgattg gatgctaaga gcctggacag tggcattcaa
     6481 accgtttgcc attcaaggcc caagtagatg gcactgagga agaacagaca tttctcccag
     6541 tgtgtgagat cgccagtgtg tgactaggga gctgaaggtc aggcaagtct gcattagcct
     6601 gagatggact gtcagggggc agtgctgttc aaagcctgtt gcacgggact cagtgcaggg
     6661 agagggcagg gcacccttga cccacggtgg caggaactgt acgtgtttgt gtgtgtgtat
     6721 ctgtatgttt tgtgcataac tatttaaaga aactggaatt ttgaagttac ttttatatga
     6781 gtcaagatta tatgctacag acagaactaa gacatggtct ggcctcacct ttctagtcat
     6841 gatgaatgta tttcacatat tatcttcatt taataaaatt aactttcaaa accaa
//
