LOCUS       NM_178382               3984 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus fibronectin leucine rich transmembrane protein 3
            (Flrt3), transcript variant 2, mRNA.
ACCESSION   NM_178382 XM_918334 XM_925664
VERSION     NM_178382.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3984)
  AUTHORS   Despin-Guitard,E., Rosa,V.S., Plunder,S., Mathiah,N., Van
            Schoor,K., Nehme,E., Merino-Aceituno,S., Egea,J., Shahbazi,M.N.,
            Theveneau,E. and Migeotte,I.
  TITLE     Non-apical mitoses contribute to cell delamination during mouse
            gastrulation
  JOURNAL   Nat Commun 15 (1), 7364 (2024)
   PUBMED   39198421
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3984)
  AUTHORS   Liakath-Ali,K., Refaee,R. and Sudhof,T.C.
  TITLE     Cartography of teneurin and latrophilin expression reveals
            spatiotemporal axis heterogeneity in the mouse hippocampus during
            development
  JOURNAL   PLoS Biol 22 (5), e3002599 (2024)
   PUBMED   38713721
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3984)
  AUTHORS   Zhou,Z., Pan,Y., Zhou,S., Wang,S., Zhang,D., Cao,Y., Jiang,X.,
            Li,J., Zhu,L., Zhao,L., Gu,S., Lin,G., Dong,Z. and Sun,H.X.
  TITLE     Single-cell analysis reveals specific neuronal transition during
            mouse corticogenesis
  JOURNAL   Front Cell Dev Biol 11, 1209320 (2023)
   PUBMED   38020907
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3984)
  AUTHORS   Ruff,T., Peters,C., Matsumoto,A., Ihle,S.J., Morales,P.A.,
            Gaitanos,L., Yonehara,K., Del Toro,D. and Klein,R.
  TITLE     FLRT3 Marks Direction-Selective Retinal Ganglion Cells That Project
            to the Medial Terminal Nucleus
  JOURNAL   Front Mol Neurosci 14, 790466 (2021)
   PUBMED   34955746
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3984)
  AUTHORS   Willnow,D., Benary,U., Margineanu,A., Vignola,M.L., Konrath,F.,
            Pongrac,I.M., Karimaddini,Z., Vigilante,A., Wolf,J. and
            Spagnoli,F.M.
  TITLE     Quantitative lineage analysis identifies a hepato-pancreato-biliary
            progenitor niche
  JOURNAL   Nature 597 (7874), 87-91 (2021)
   PUBMED   34433966
REFERENCE   6  (bases 1 to 3984)
  AUTHORS   Egea,J., Erlacher,C., Montanez,E., Burtscher,I., Yamagishi,S.,
            Hess,M., Hampel,F., Sanchez,R., Rodriguez-Manzaneque,M.T.,
            Bosl,M.R., Fassler,R., Lickert,H. and Klein,R.
  TITLE     Genetic ablation of FLRT3 reveals a novel morphogenetic function
            for the anterior visceral endoderm in suppressing mesoderm
            differentiation
  JOURNAL   Genes Dev 22 (23), 3349-3362 (2008)
   PUBMED   19056886
REFERENCE   7  (bases 1 to 3984)
  AUTHORS   Maretto,S., Muller,P.S., Aricescu,A.R., Cho,K.W., Bikoff,E.K. and
            Robertson,E.J.
  TITLE     Ventral closure, headfold fusion and definitive endoderm migration
            defects in mouse embryos lacking the fibronectin leucine-rich
            transmembrane protein FLRT3
  JOURNAL   Dev Biol 318 (1), 184-193 (2008)
   PUBMED   18448090
  REMARK    GeneRIF: Data demonstrate that FLRT3 plays a key role in
            controlling cell adhesion and tissue morphogenesis in the
            developing mouse embryo.
REFERENCE   8  (bases 1 to 3984)
  AUTHORS   Haines,B.P., Wheldon,L.M., Summerbell,D., Heath,J.K. and Rigby,P.W.
  TITLE     Regulated expression of FLRT genes implies a functional role in the
            regulation of FGF signalling during mouse development
  JOURNAL   Dev Biol 297 (1), 14-25 (2006)
   PUBMED   16872596
  REMARK    GeneRIF: FLRT3 has an expression pattern during somite development
REFERENCE   9  (bases 1 to 3984)
  AUTHORS   Jukkola,T., Lahti,L., Naserke,T., Wurst,W. and Partanen,J.
  TITLE     FGF regulated gene-expression and neuronal differentiation in the
            developing midbrain-hindbrain region
  JOURNAL   Dev Biol 297 (1), 141-157 (2006)
   PUBMED   16782087
REFERENCE   10 (bases 1 to 3984)
  AUTHORS   Tanabe,K., Bonilla,I., Winkles,J.A. and Strittmatter,S.M.
  TITLE     Fibroblast growth factor-inducible-14 is induced in axotomized
            neurons and promotes neurite outgrowth
  JOURNAL   J Neurosci 23 (29), 9675-9686 (2003)
   PUBMED   14573547
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928700.7, AK031464.1, AV157204.2 and BG091701.1.
            
            On Feb 5, 2010 this sequence version replaced NM_178382.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161100.1, AK031464.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AL928700.7         65108-65114         c
            8-3436              AK031464.1         2-3430
            3437-3701           AV157204.2         297-561
            3702-3984           BG091701.1         3-285               c
FEATURES             Location/Qualifiers
     source          1..3984
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 69.2 cM"
     gene            1..3984
                     /gene="Flrt3"
                     /gene_synonym="5530600M07Rik; C430047I10Rik; mKIAA1469"
                     /note="fibronectin leucine rich transmembrane protein 3"
                     /db_xref="GeneID:71436"
                     /db_xref="MGI:MGI:1918686"
     exon            1..231
                     /gene="Flrt3"
                     /gene_synonym="5530600M07Rik; C430047I10Rik; mKIAA1469"
                     /inference="alignment:Splign:2.1.0"
     exon            232..430
                     /gene="Flrt3"
                     /gene_synonym="5530600M07Rik; C430047I10Rik; mKIAA1469"
                     /inference="alignment:Splign:2.1.0"
     exon            431..3984
                     /gene="Flrt3"
                     /gene_synonym="5530600M07Rik; C430047I10Rik; mKIAA1469"
                     /inference="alignment:Splign:2.1.0"
     CDS             476..2425
                     /gene="Flrt3"
                     /gene_synonym="5530600M07Rik; C430047I10Rik; mKIAA1469"
                     /note="leucine-rich repeat transmembrane protein FLRT3"
                     /codon_start=1
                     /product="leucine-rich repeat transmembrane protein FLRT3
                     precursor"
                     /protein_id="NP_848469.1"
                     /db_xref="CCDS:CCDS16806.1"
                     /db_xref="GeneID:71436"
                     /db_xref="MGI:MGI:1918686"
                     /translation="MISPAWSLFLIGTKIGLFFQVAPLSVVAKSCPSVCRCDAGFIYC
                     NDRSLTSIPVGIPEDATTLYLQNNQINNVGIPSDLKNLLKVQRIYLYHNSLDEFPTNL
                     PKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLF
                     LSRNHLSTIPGGLPRTIEELRLDDNRISTISSPSLHGLTSLKRLVLDGNLLNNHGLGD
                     KVFFNLVNLTELSLVRNSLTAAPVNLPGTSLRKLYLQDNHINRVPPNAFSYLRQLYRL
                     DMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMC
                     QAPEKVRGMAIKDLSAELFDCKDSGIVSTIQITTAIPNTAYPAQGQWPAPVTKQPDIK
                     NPKLIKDQRTTGSPSRKTILITVKSVTPDTIHISWRLALPMTALRLSWLKLGHSPAFG
                     SITETIVTGERSEYLVTALEPESPYRVCMVPMETSNLYLFDETPVCIETQTAPLRMYN
                     PTTTLNREQEKEPYKNPNLPLAAIIGGAVALVSIALLALVCWYVHRNGSLFSRNCAYS
                     KGRRRKDDYAEAGTKKDNSILEIRETSFQMLPISNEPISKEEFVIHTIFPPNGMNLYK
                     NNLSESSSNRSYRDSGIPDSDHSHS"
     regulatory      3822..3827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Flrt3"
                     /gene_synonym="5530600M07Rik; C430047I10Rik; mKIAA1469"
                     /note="hexamer: AATAAA"
     polyA_site      3844
                     /gene="Flrt3"
                     /gene_synonym="5530600M07Rik; C430047I10Rik; mKIAA1469"
                     /note="major polyA site"
     regulatory      3961..3966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Flrt3"
                     /gene_synonym="5530600M07Rik; C430047I10Rik; mKIAA1469"
                     /note="hexamer: AATAAA"
     polyA_site      3984
                     /gene="Flrt3"
                     /gene_synonym="5530600M07Rik; C430047I10Rik; mKIAA1469"
                     /note="major polyA site"
ORIGIN      
        1 aaacttcaga cttggaggtg ggctgcgcgc agtcaactgg atgctctcgc gcgcagtcct
       61 cagcgcagga gtgatctgaa gcaggaccgc tcaggctgca gctgccgtgg ctttgtgtgc
      121 actggatgcc gcgctccgga gacgggggag ggtttttact tcaactcaca ggcaatggaa
      181 ttacagctgt agcagcaggg tataaaggat tgctttttcc tcgtcttcct ggaggtgctc
      241 agtcctggcc cattttaagg acgagaaata taaagggaat ttagtgtgct tccttctctt
      301 tccatgaaga ctgcatgcac tgtgcccttt gcttcttaaa agagactcca cccactccag
      361 tagaccgggg actaaaacag aaattctgag aaagcagcaa gaagcagaag aaatagctat
      421 ttcacagcag taacagaagc tacctgctat aataaagacc tcaacactgc tgaccatgat
      481 cagcccagcc tggagcctct tcctcatcgg gactaaaatt gggctgttct tccaagtggc
      541 acctctgtca gttgtggcta aatcctgtcc atctgtatgt cgctgtgacg caggcttcat
      601 ttactgtaac gatcgctctc tgacatccat tccagtggga attccggagg atgctacaac
      661 actctacctt cagaacaacc aaataaacaa tgttgggatt ccttccgatt tgaagaactt
      721 gctgaaagta caaagaatat acctatacca caacagttta gatgaattcc ctaccaacct
      781 tccaaagtat gtcaaagagt tacatttgca agagaataac ataaggacta tcacctatga
      841 ttcactttcg aaaattccgt atctggaaga gttacacttg gatgataact cagtctcggc
      901 tgttagcatc gaagagggag catttcgaga cagtaactat ctgcggctgc tttttctgtc
      961 ccgtaaccac cttagcacaa tcccgggggg cttgcccagg actattgagg aattacgcct
     1021 ggatgacaat cgcatatcaa cgatctcttc cccatcactt catggtctca caagcctgaa
     1081 acgcctggtt ttagatggaa acttgttgaa caaccatggt ttgggtgaca aagttttctt
     1141 caacttagta aacttaacag agctgtccct ggtgaggaat tccttgacag cagcgccagt
     1201 gaaccttccc ggcacaagcc tgaggaagct ttaccttcaa gacaaccata tcaaccgggt
     1261 acccccaaat gctttttctt atttaaggca gctgtatcga ctcgatatgt ctaataataa
     1321 cctaagcaat ttacctcagg gtatctttga tgatttggac aatataaccc aactgattct
     1381 tcgcaacaat ccttggtatt gtggatgcaa gatgaaatgg gtacgagact ggttacagtc
     1441 gctaccggtg aaggtcaatg tgcgtgggct catgtgccaa gccccagaaa aggtccgtgg
     1501 aatggctatc aaggacctca gtgcagaact gtttgattgt aaagacagtg ggattgtgag
     1561 caccattcag ataaccactg caatacccaa cacagcatat cctgctcaag gacagtggcc
     1621 agctcctgtg accaaacaac cagatattaa aaaccccaag ctcattaagg atcagcgaac
     1681 tacaggcagc ccctcacgga aaacaatttt aattactgtg aaatctgtca cccctgacac
     1741 aatccacata tcctggagac ttgctctgcc tatgactgct ctgcgactca gctggcttaa
     1801 actgggccat agcccagcct ttggatctat aacagaaaca atcgtaacag gagaacgcag
     1861 tgaatacttg gtcaccgccc tagaacctga atcaccctat agagtatgca tggttcccat
     1921 ggaaaccagt aacctttacc tgtttgatga aacacctgtt tgtattgaga cccaaactgc
     1981 ccctcttcga atgtacaacc ccacaaccac cctcaatcga gagcaagaga aagaacctta
     2041 caaaaatcca aatttacctt tggctgccat cattggtggg gctgtggccc tggtaagcat
     2101 cgccctcctt gctttggtgt gttggtatgt gcataggaac gggtcactgt tttcacggaa
     2161 ctgtgcgtac agcaaagggc ggaggagaaa ggatgactat gcagaagccg gtactaagaa
     2221 agacaactcc atcctggaaa tcagggaaac ttctttccag atgctaccga taagcaatga
     2281 acccatctcc aaggaggagt ttgtaataca caccatattt cctccgaatg ggatgaatct
     2341 gtacaagaac aacctcagtg agagcagtag taaccggagc tacagagaca gtggcatccc
     2401 agactcggac cactcacact catgatgcaa ggaggtccca caccagactg ttccgggttt
     2461 ttttttaaaa aacctaagaa aggtgatggt aggaactctg ttctactgca aaacactgga
     2521 aaagagactg agagaagcaa tgtactgtac atttgccata taatttatat ttaagaactt
     2581 tttattaaaa gtttcagatt tcaggttgct gctgcggttg atgtagtggg gatgcctgaa
     2641 cacaattcta tattttagta ttttttagta atttgtactg tattttcctt gcagatattg
     2701 aagttataaa ccatttactt tgtgttctac tgagtaagat gacttgttga ctgtgaaagt
     2761 gaattttccc gctgtgttga acaatcagga ctgcgttcac atgagaccct tgtagtataa
     2821 gcacaggccg tttttcactt tggtattaat acaatgtaaa aagaaaaaaa aaaaagaaac
     2881 ctggctggat gacaaaataa attttaaaaa ctagttatga aataatgttc caatggttaa
     2941 atttgtatta tcccagtggt attcaataaa tcaaaatctg tggcataacg ggcagtatca
     3001 aacttgccgc acctctcatt ttaccctagg caaattaaat atccttaagg aagttaagca
     3061 tagtttctga actgaataca tcagctggca taaggacaat gtgaaggctt cagctgtcga
     3121 agccaccgtc agcagagctt caagaataaa ggacttcgtg agaagaatca tgtaagtgca
     3181 gggagtatgt gtacttaaaa aaaaaccatg acaacttaga cttctgtagt gtaaccagta
     3241 catatactag aactgcatct tggtttctgc ctggatcatc caggctcttg aaaaagttga
     3301 attctacaca cagaattgtt agtgtttatg atgtttttat tataaaggat gtctgagaac
     3361 aaccatcagc aattcctctc agagatctag agaaagtagt gctttaagta agtgagaatt
     3421 tcagagaaaa ataaatacta gatatcaaat ttagatctgg cttatatgag atgcttgaac
     3481 actgtacata actattcaat ttactttcac catggtggag catactgccc gttactgtca
     3541 cagtttccag atattacata atggacttgt aatgtaacat ttctttacag cttcctactg
     3601 aattgtgagc tattacttgt ttaaaaacca taccactttt tgttgccatg actttttttt
     3661 tttcaacaac ggaaaaaaaa aaaaaaaaaa accaaagtgc actgtacgcc ctttggccag
     3721 tcttgtatgt gccttgatcc aacgctacat gtattcagct tttgaaattc gacaaatttt
     3781 tcatacttcc ttaaatatga aaaattatgg tcttattgct gaataaaact taagaaaaac
     3841 agaataattg tgcttgcttt cgggactatg ttaccatcac taaaagtaga aaattgccag
     3901 cacatgagtc cgaaacaacc ccatgtattt ttctaggcat aaaaataaaa gttgggtaca
     3961 aataaaagaa atgtggcatc ttga
//
