LOCUS       NM_201518               7099 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus fibronectin leucine rich transmembrane protein 2
            (Flrt2), transcript variant 2, mRNA.
ACCESSION   NM_201518
VERSION     NM_201518.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7099)
  AUTHORS   Llao-Cid,C., Peguera,B., Kobialka,P., Decker,L., Vogenstahl,J.,
            Alivodej,N., Srivastava,S., Jin,J., Kirchmaier,B.C., Milla,C.,
            Schlierbach,H., Schanzer,A., Acker,T., Segarra,M. and
            Acker-Palmer,A.
  TITLE     Vascular FLRT2 regulates venous-mediated angiogenic expansion and
            CNS barriergenesis
  JOURNAL   Nat Commun 15 (1), 10372 (2024)
   PUBMED   39609404
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7099)
  AUTHORS   Liakath-Ali,K., Refaee,R. and Sudhof,T.C.
  TITLE     Cartography of teneurin and latrophilin expression reveals
            spatiotemporal axis heterogeneity in the mouse hippocampus during
            development
  JOURNAL   PLoS Biol 22 (5), e3002599 (2024)
   PUBMED   38713721
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7099)
  AUTHORS   Hwang,H.J., Kang,D., Kim,J.R., Choi,J.H., Ryu,J.K., Herman,A.B.,
            Ko,Y.G., Park,H.J., Gorospe,M. and Lee,J.S.
  TITLE     FLRT2 prevents endothelial cell senescence and vascular aging by
            regulating the ITGB4/mTORC2/p53 signaling pathway
  JOURNAL   JCI Insight 9 (7), e172678 (2024)
   PUBMED   38587072
  REMARK    GeneRIF: FLRT2 prevents endothelial cell senescence and vascular
            aging by regulating the ITGB4/mTORC2/p53 signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7099)
  AUTHORS   Queen,R., Crosier,M., Eley,L., Kerwin,J., Turner,J.E., Yu,J.,
            Alqahtani,A., Dhanaseelan,T., Overman,L., Soetjoadi,H., Baldock,R.,
            Coxhead,J., Boczonadi,V., Laude,A., Cockell,S.J., Kane,M.A.,
            Lisgo,S. and Henderson,D.J.
  TITLE     Spatial transcriptomics reveals novel genes during the remodelling
            of the embryonic human arterial valves
  JOURNAL   PLoS Genet 19 (11), e1010777 (2023)
   PUBMED   38011284
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7099)
  AUTHORS   Prigge,C.L., Dembla,M., Sharma,A., El-Quessny,M., Kozlowski,C.,
            Paisley,C.E., Miltner,A.M., Johnson,T.M., Della Santina,L.,
            Feller,M.B. and Kay,J.N.
  TITLE     Rejection of inappropriate synaptic partners in mouse retina
            mediated by transcellular FLRT2-UNC5 signaling
  JOURNAL   Dev Cell 58 (20), 2080-2096 (2023)
   PUBMED   37557174
REFERENCE   6  (bases 1 to 7099)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7099)
  AUTHORS   Maretto,S., Muller,P.S., Aricescu,A.R., Cho,K.W., Bikoff,E.K. and
            Robertson,E.J.
  TITLE     Ventral closure, headfold fusion and definitive endoderm migration
            defects in mouse embryos lacking the fibronectin leucine-rich
            transmembrane protein FLRT3
  JOURNAL   Dev Biol 318 (1), 184-193 (2008)
   PUBMED   18448090
REFERENCE   8  (bases 1 to 7099)
  AUTHORS   Haines,B.P., Wheldon,L.M., Summerbell,D., Heath,J.K. and Rigby,P.W.
  TITLE     Regulated expression of FLRT genes implies a functional role in the
            regulation of FGF signalling during mouse development
  JOURNAL   Dev Biol 297 (1), 14-25 (2006)
   PUBMED   16872596
  REMARK    GeneRIF: FLRT2 is expressed in a subset of the sclerotome, adjacent
            to the region that forms the syndetome in embryo
REFERENCE   9  (bases 1 to 7099)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 7099)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125487.3 and AC122430.4.
            
            On Jul 21, 2009 this sequence version replaced NM_201518.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067058.1, AK135149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               AC125487.3         171990-172379
            391-7099            AC122430.4         75025-81733         c
FEATURES             Location/Qualifiers
     source          1..7099
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 46.44 cM"
     gene            1..7099
                     /gene="Flrt2"
                     /note="fibronectin leucine rich transmembrane protein 2"
                     /db_xref="GeneID:399558"
                     /db_xref="MGI:MGI:3603594"
     exon            1..390
                     /gene="Flrt2"
                     /inference="alignment:Splign:2.1.0"
     exon            391..7099
                     /gene="Flrt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             774..2756
                     /gene="Flrt2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; leucine-rich repeat transmembrane protein
                     FLRT2"
                     /codon_start=1
                     /product="leucine-rich repeat transmembrane protein FLRT2
                     isoform 1 precursor"
                     /protein_id="NP_958926.1"
                     /db_xref="CCDS:CCDS26094.1"
                     /db_xref="GeneID:399558"
                     /db_xref="MGI:MGI:3603594"
                     /translation="MGLQTTKWPGRGAFILKFWLIISLGLYLQVSKLLACPSVCRCDR
                     NFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDE
                     FPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAIS
                     LKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTN
                     KGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFANLR
                     KLERLDISNNQLRMLTQGVFDHLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNV
                     RGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPVFTPAPSTVSPTTQSPTLSVPSPS
                     RGSVPPAPTPSKLPTIPDWDGRERVTPPISERIQLSIHFVNDTSIQVSWLSLFTVMAY
                     KLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRTVEDTI
                     CSEATTHASYLNNGSNTASSHEQTTSHSMGSPFLLAGLIGGAVIFVLVVLLSVFCWHM
                     HKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSILEMTETSFQIVSLNNDQLLKGDFRL
                     QPIYTPNGGINYTDCHIPNNMRYCNSSVPDLEHCHT"
     regulatory      7075..7080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Flrt2"
                     /note="hexamer: AGTAAA"
     polyA_site      7099
                     /gene="Flrt2"
                     /note="major polyA site"
ORIGIN      
        1 agttgtacat ttgaaagcag tcgccatcac ttgtgagttt ggcgtcatcc attgtcacca
       61 ccaaggaatg tgcgctggga gataacacca agggcagtgc ttctcaaaca cgcagagagc
      121 tctttctctc tctgcttcca ggtgcgctct tatctggtcc tctgtcccaa gtttccagaa
      181 cgtggaggca gcagcgcaga accggtcacc gcgtccactg aacctcagga ccagactggc
      241 agttctcaac gatgggcagg agggacctcg gcggcgaccc ctaaaacaat accatgcccg
      301 gggagtccct ctactgccgc tctagcttct tccctttcca cctcccggac ccggttggat
      361 tcggatgagc taaggagaca aggctgccag attacagact ctgcataagc aagaaattcc
      421 taggctgctc tccactggcc tgactttcta tagaagaaag aagatttgcc tgcctggctg
      481 gacttctctt aacagtactt cgcatcacgc tttgcttgtg tcgaaaatcc tgagttgttt
      541 ttgcacatgg aggaccactg catgagggca acctaggcag atcagactga agacatcaga
      601 aagattgtgt taccatcttc cctcagacca tttcctctaa tagaagttct agactttgac
      661 agaacctggt ccggtcattt tgattttgct ttctggtgtt attgtttgtt gtgcttttgt
      721 ttttgattta tttttttccc catcacgttg cattttattt ctgtcctcca gaaatgggcc
      781 tacagactac aaagtggccc ggccgtgggg ctttcatcct caaattttgg ctcatcattt
      841 ccctgggact ctacttacaa gtgtcaaaac tcctggcctg ccctagtgta tgccgctgtg
      901 acaggaactt tgtctactgt aacgagagaa gcttgacctc agtgcctctt gggatcccgg
      961 agggcgtaac cgtactctac ctccacaaca accaaattaa taatgctggc tttcctgcag
     1021 agctgcacaa tgtccagtca gtgcacactg tctaccttta tggcaaccag ttggatgagt
     1081 tccccatgaa ccttcccaag aatgtcagag ttctccatct gcaggaaaac aacattcaga
     1141 ccatctcgcg ggctgctctc gctcagctcc tcaagctgga agaactccac ctggacgaca
     1201 actccatatc tacagtggga gtagaagacg gagcgttccg ggaggcgatt agcctcaaac
     1261 tgttgttttt atcgaagaat cacctgagta gcgtgcctgt tgggcttcct gtagacttgc
     1321 aagagctgag agtggatgaa aaccgaattg ccgtcatatc agacatggcc tttcagaacc
     1381 tcacaagctt ggagcgcctg atcgtggatg ggaatcttct gaccaacaag ggcattgctg
     1441 agggtacctt cagtcatctc accaagctca aggaattttc tatagtccgg aactcgctct
     1501 cccacccacc tcctgatctc ccaggtacgc atctgatcag gctctacttg caggataacc
     1561 agataaacca tatcccattg acagccttcg caaacctccg taagctggaa aggctagata
     1621 tatccaacaa ccagctacga atgttaactc aaggagtctt cgatcatctc tccaacctga
     1681 aacaactcac tgcgcggaat aacccttggt tttgtgactg cagcattaaa tgggtcacag
     1741 aatggctcaa gtatatccct tcttctctca acgtgcgtgg tttcatgtgc caaggtcctg
     1801 agcaagtccg cgggatggct gtcagggagt tgaatatgaa tcttttgtct tgtcccacca
     1861 cgactcctgg cctacctgtc tttaccccag ctccaagtac cgtttctcca acaactcagt
     1921 ctcctactct ctctgttcca agccccagca gaggctctgt gcctccagct cctaccccat
     1981 cgaaacttcc caccatccct gattgggatg gcagagaaag agtgacccca cctatttctg
     2041 aaaggatcca actttccatc cactttgtta atgatacttc gattcaagtc agctggctgt
     2101 ctctctttac tgtgatggcc tacaaactga catgggtgaa aatgggccac agtctcgtag
     2161 ggggcatcgt tcaggaacga attgtcagtg gtgagaagca acacctgagc ttggttaatt
     2221 tagagcccag atccacgtat aggatttgtt tagtgccgct ggatgcgttc aactaccgca
     2281 ctgtggaaga taccatctgt tcggaggcta ccacccatgc ctcttatttg aacaacggca
     2341 gcaacactgc ttctagccat gagcagacga cttcccacag tatgggctcc ccttttctgc
     2401 tcgcaggctt gattgggggc gcagtgattt ttgtgctcgt tgtcttgctc agcgtctttt
     2461 gctggcacat gcacaaaaag ggacgctaca cctcccagaa gtggaaatac aaccggggcc
     2521 gacggaaaga cgactattgt gaagcgggta ccaaaaaaga caactccatc ttggagatga
     2581 cagaaacaag ttttcagatt gtctccttaa ataacgatca gctccttaaa ggagatttca
     2641 gactgcagcc catttatacc ccaaatgggg gcattaatta cacagactgc cacatcccca
     2701 acaacatgag atactgcaac agcagtgtgc cagatctaga gcattgccat acgtaacagc
     2761 ctagaggtcc agcgttagaa aggtggacaa acaaactctc aagaacacac atacgtgtgc
     2821 acataaagac acgcaaatta catttgataa atgttaccca gatgcatttg tgcatttgaa
     2881 tactctgtaa tttatacggt gtactatata acgggattta aaaaaaaagt gctatctttt
     2941 ctatttcaag ttaattacaa acagttttgt aactctttgc tttttaaaat taaaaaaaaa
     3001 atgttgctga agtactgtac ggggttgtac aatgagaacc cgatgccaag gcagaagaat
     3061 gagcaaatca tccttaagat gcagattaac cacttcgctg ttgaggctgt cagaacaaat
     3121 tcctttccta gagctgatag tcagatgaaa ggataatgtc aggtgggctc atcagagtaa
     3181 gagggagagt ttgagtaaag aaagaacggc ctagttattt ctatgttttc tatacctcct
     3241 ggaagacaca gtttgtggga aataaatcta taatataata attgaggaag ttactccagt
     3301 ttgactgaat gcaggaacta gaatatcatg aggaagccag ttcccatgag ataagttagg
     3361 cctacttgac caaatcaagg aaactgagag atttggaatg tccttaaagc cccaaggttg
     3421 gctttctgac tgtgaacttg gaaatcactc ttcaggcttc cctggcctta cgtgataaca
     3481 gattggaaac ctgagtctca ttcttggtgt cttcaggaac cagtaggatc agttctagca
     3541 agaaaattcc ccttaaaact gtcactgttc aaatcacatg tcaggttgaa tcctatccaa
     3601 cagagttata ttctagaata attttttaga agaggctaat aaaaataatg ggaagaatta
     3661 tattgaatgc aattattttt gataacaaaa attatttggg tatattcact gaggctatat
     3721 caacatgata tttagaccaa caaaggagca gtgttcagaa tctactacca tgtgttgatt
     3781 taaaaagtac taatgacatt tagacaaaaa tattggtggt tctctttcac tgtgtcaatg
     3841 gactctgtat cacgttgaaa tagcttgaat taatacctat attctccctc aaattcttgt
     3901 cttccgatca tcttgcatat atttttttgt aattaagttg tatatgccat ctttgcccca
     3961 tgcccccact gaatatttca aagaaaaata tggatgcaaa ttttggttgc acaaaatatt
     4021 cttggtgtat ttttgcatat taaagcccat attaccattc cttgccaatg attctgtgaa
     4081 ggcgcccaag ctggccaaat cagtgcgtat tgttaaaagc aatactatat tttcattttg
     4141 aattaacttt gctcctgttc cacatggaaa ttccatttgt ttcttttaga ttgtggatat
     4201 ccctgtaatt tggtaattat ggaatgataa ttaaccattt ggtaaaagac tacccgtgaa
     4261 aaggagtaag tcagagagtg aaagtttccc caaatcatgg cagactaggc taaaagcaga
     4321 gggcatggta ggatagaggt acattaatgg ttgatgctag atatttttga agcaagtcca
     4381 ttttcaggaa acatgcataa tttatcctaa ttcttgccat cacataggtg tagaagggct
     4441 atagaccata tgtactgtct aaagaaattc acccgtgggg actttttttt tcaaagccac
     4501 ttttagacat ttcattctct gctcctttaa catcatcctc cactttagag acccgtgaaa
     4561 tcaatgtaat cctcttcttg ctttctctct ctctctctaa gcaaaataaa actgtgatgt
     4621 gtcttcttgt aaaatttagg tatacaatgc tatgcaagct tttctttata gtgagagctt
     4681 tattttcgtt aataatatac cccaacttat atgttttaat ctccctcatc cctcagaata
     4741 ggcagaaaaa tataactgca gtgataatgt tatagacaaa agcattaaaa ctgtgcagtc
     4801 aatagacctg aacatagtta tgaattaatt taattaattc taaaatgact cgggtttccc
     4861 ctttagtcta ttagctcaag ggtttgggct gttggtttct gtaaaagtag gttcacacag
     4921 taaagggata ataccatctg gaacaatgat cagtgtagag ttacatcatc taaaaccagg
     4981 acagtaatgt ggggctctat gtggtagctg gatgtttccc tttcaatgtc ctcatgcctc
     5041 tcactttgta ggtaaaactg tgtgctgaaa atataatggt actttgatta ttttgaggat
     5101 ttttattttc ttatataaga agaaaatcat tattgtctct tggtattgca tatttaactc
     5161 tcagtggtat ttgggactgt ggaaatgtct tctttgtccc aagaggaacg agagtggagt
     5221 gattcccaca atattgtatg gtgtccacaa cactactggg agtccaagtg gtactgggga
     5281 gggccagtca tgtgaaacaa ttagggtgct ctcaaaattg ctctggtaga aggtatttct
     5341 gaaaccgagt ctttattttg atctcataaa caacatggga cgggcatcta ccatgaaaat
     5401 cagtacctat ccatagtact gtgcttgagg gactcgccta catcagatta gaaatcacct
     5461 catggaatct atactagcat atgaaaattt gaaaaaaaaa aaaccaaaca aacaaacaaa
     5521 ttgccagcag tccttactgg atgacatttt ggctgtcatc tttaatcagg agactacatt
     5581 ccatagttac atctcctctg attttggtcc tctctcagcc tcatcattac ttattttgag
     5641 gtaattagtc aaaagtcaaa gttgagttga tcccatatat tgtctactcc ttgtctgccc
     5701 agtaactatt tgcacagagg acattgcaaa aggcaaagca aagcatgatc atacagatgt
     5761 tattggtagt taaatggaag gtgatcacca atacattttt gctcatcaag atgcatttga
     5821 ccctggggag gttctgggtt tcacttaaac actgccatat gcactggaga ggtagtacaa
     5881 cacatgcgtc aatcacagac aggcatgaca agagtaaaaa tcctcccttg tgacaaataa
     5941 tgctatttgt aattttccag atgtttgttg atacaatatt agacattttc tcttgagagt
     6001 aaaaacaaaa tctgtaatat caactttttg ataaaaatgt attaatggca tagctaatat
     6061 tacacctttg gtttttcttt ttttgaacaa tggaggtcat aatggtctaa ggcatggcac
     6121 acagccagaa cttccttctc cccttgagaa aacgtagctc ttcatgtgag gggagcatct
     6181 attccaaaca caaggcagca ctgtttaatt cagaggcagg tgccgcactg gatcagcata
     6241 cttcaagctg cagtgtcccc tgcagctttg aacagtgaag tggttaattt ccatagatgt
     6301 ctttatagca tttatctctg acctatcaaa agaggatatt agatgttgct ttagaacttg
     6361 aggataacat atcagctcat aacttgtttt tttttttccc caaatgaatg ggaaagcaaa
     6421 acagaagagt tcccaacaca aaaaatagta tttacataaa acaactctca attcttagcc
     6481 ttgttaaact ttgctgtttt aaaagttaaa gtaagcgaag aaaggaagct gtatctacac
     6541 tgctttccag tttaatcagc gggatcgaaa gaatagttgg caacagcgat gcttttcact
     6601 gattgtgggg ggaagccttt tgtacacagt ataatactgt tttagcaaac caggctgttt
     6661 tgttatagta tttggttttc tagctgcaca tccacgagaa gagcacaaac caagaccata
     6721 gcaacaggca ttttaaaatt aatataaaac atgcaaatcc atgcatacac atacattgga
     6781 gtgtttgtaa aggtgtctat gggatgtaag atttgtaact acttatggca aaatgaggca
     6841 tcaccactgt ataccctcct aggatgacat ttctgaaagg gtaactctta tgatctgtta
     6901 ctgtttgaat cctatgttga tttaattcta gtttgtgttt agtgtgtttc tctgacaagg
     6961 gactgcaagg ggctggaaga ttctgtgtca tgcatcctcg gagacctacc atgttgcaca
     7021 ctttgttaac tacaaacttc actctacact atacagtacc ttgttgatat attcagtaaa
     7081 ggcttatttt aaaagaaaa
//
