LOCUS       NM_201411               5876 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus fibronectin leucine rich transmembrane protein 1
            (Flrt1), mRNA.
ACCESSION   NM_201411
VERSION     NM_201411.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5876)
  AUTHORS   Liakath-Ali,K., Refaee,R. and Sudhof,T.C.
  TITLE     Cartography of teneurin and latrophilin expression reveals
            spatiotemporal axis heterogeneity in the mouse hippocampus during
            development
  JOURNAL   PLoS Biol 22 (5), e3002599 (2024)
   PUBMED   38713721
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5876)
  AUTHORS   Li,X., Zhao,Q., Yu,X., Cao,W., Zhang,Y., Feng,W., Jiang,L.,
            He,D.Z., Qi,R.Z. and Huang,P.
  TITLE     Apicosome: Newly identified cell-type-specific organelle in mouse
            cochlear and vestibular hair cells
  JOURNAL   iScience 26 (4), 106535 (2023)
   PUBMED   37123250
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5876)
  AUTHORS   Ruff,T., Peters,C., Matsumoto,A., Ihle,S.J., Morales,P.A.,
            Gaitanos,L., Yonehara,K., Del Toro,D. and Klein,R.
  TITLE     FLRT3 Marks Direction-Selective Retinal Ganglion Cells That Project
            to the Medial Terminal Nucleus
  JOURNAL   Front Mol Neurosci 14, 790466 (2021)
   PUBMED   34955746
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5876)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5876)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   6  (bases 1 to 5876)
  AUTHORS   Yamagishi,S., Hampel,F., Hata,K., Del Toro,D., Schwark,M.,
            Kvachnina,E., Bastmeyer,M., Yamashita,T., Tarabykin,V., Klein,R.
            and Egea,J.
  TITLE     FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive
            neurons
  JOURNAL   EMBO J 30 (14), 2920-2933 (2011)
   PUBMED   21673655
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5876)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 5876)
  AUTHORS   Wheldon,L.M., Haines,B.P., Rajappa,R., Mason,I., Rigby,P.W. and
            Heath,J.K.
  TITLE     Critical role of FLRT1 phosphorylation in the interdependent
            regulation of FLRT1 function and FGF receptor signalling
  JOURNAL   PLoS One 5 (4), e10264 (2010)
   PUBMED   20421966
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5876)
  AUTHORS   Maretto,S., Muller,P.S., Aricescu,A.R., Cho,K.W., Bikoff,E.K. and
            Robertson,E.J.
  TITLE     Ventral closure, headfold fusion and definitive endoderm migration
            defects in mouse embryos lacking the fibronectin leucine-rich
            transmembrane protein FLRT3
  JOURNAL   Dev Biol 318 (1), 184-193 (2008)
   PUBMED   18448090
REFERENCE   10 (bases 1 to 5876)
  AUTHORS   Haines,B.P., Wheldon,L.M., Summerbell,D., Heath,J.K. and Rigby,P.W.
  TITLE     Regulated expression of FLRT genes implies a functional role in the
            regulation of FGF signalling during mouse development
  JOURNAL   Dev Biol 297 (1), 14-25 (2006)
   PUBMED   16872596
  REMARK    GeneRIF: FLRT1 is expressed at brain compartmental boundaries in
            embryo
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031503.1, AC109619.11 and BE947674.1.
            
            On Mar 21, 2008 this sequence version replaced NM_201411.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031503.1, BC070403.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3334              AK031503.1         1-3334
            3335-5859           AC109619.11        87028-89552         c
            5860-5876           BE947674.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..5876
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.2 cM"
     gene            1..5876
                     /gene="Flrt1"
                     /gene_synonym="D630040I23Rik"
                     /note="fibronectin leucine rich transmembrane protein 1"
                     /db_xref="GeneID:396184"
                     /db_xref="MGI:MGI:3026647"
     exon            1..643
                     /gene="Flrt1"
                     /gene_synonym="D630040I23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            644..5872
                     /gene="Flrt1"
                     /gene_synonym="D630040I23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             693..2717
                     /gene="Flrt1"
                     /gene_synonym="D630040I23Rik"
                     /note="leucine-rich repeat transmembrane protein FLRT1"
                     /codon_start=1
                     /product="leucine-rich repeat transmembrane protein FLRT1
                     precursor"
                     /protein_id="NP_958813.1"
                     /db_xref="CCDS:CCDS29519.1"
                     /db_xref="GeneID:396184"
                     /db_xref="MGI:MGI:3026647"
                     /translation="MVVAHSAATATTTPAATVTATVVMTTATMDLRDWLFLCYGLIAF
                     LTEVIDSTTCPSVCRCDNGFIYCNDRGLTSIPSDIPDDATTLYLQNNQINNAGIPQDL
                     KTKVKVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDD
                     NSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAF
                     KGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLY
                     LQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGC
                     NLMWLRDWVRARAAVVNVRGLMCQGPEKVRGMAIKDITSEMDECFEAGSQGGAANAAA
                     KTTVSNHASATTPQGSLFTLKAKRPGLRLPDSNIDYPMATGDGAKTLVIQVKPLTADS
                     IRITWKAMLPASSFRLSWLRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYIICMV
                     TMETGNTYVADETPVCAKAETADSYGPTTTLNQEQNAGPMAGLPLAGIIGGAVALVFL
                     FLVLGAICWYVHRAGELLTRERVYNRGSRRKDDYMESGTKKDNSILEIRGPGLQMLPI
                     NPYRSKEEYVVHTIFPSNGSSLCKGAHTIGYGTTRGYREAGIPDVDYSYT"
     regulatory      3341..3346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Flrt1"
                     /gene_synonym="D630040I23Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      3357
                     /gene="Flrt1"
                     /gene_synonym="D630040I23Rik"
                     /note="major polyA site"
     regulatory      3569..3574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Flrt1"
                     /gene_synonym="D630040I23Rik"
                     /note="hexamer: AATAGA"
     polyA_site      3603
                     /gene="Flrt1"
                     /gene_synonym="D630040I23Rik"
                     /note="major polyA site"
     regulatory      4185..4190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Flrt1"
                     /gene_synonym="D630040I23Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4205
                     /gene="Flrt1"
                     /gene_synonym="D630040I23Rik"
ORIGIN      
        1 cccacacaca gatgcagcct gagtggcagg aatactgagt ctttggagag tggctccctc
       61 tcagctctgt cacgcaagag cgctctctgc actgagccat tctgccaagt gacttaaagg
      121 gatttaaaaa aaacaaaaac aaaaaaaaaa ccccaaaaac aaaaaaaacc ttggtaaaga
      181 aaagaaggca acagtcctag cagggacatt ttgggagagg tgcagcctgt ggacaaaaga
      241 ctaaagttac aaagagctgt ggtggacgtg gtggccaagg agaggccaca tcccccgggg
      301 actggctctg ggctgtaggg catgcccggc tcaggagtcc ccgggggtgc cccgtgcacc
      361 ccgagcacac aaccttcact tcggagagcc aagccatcgg tgcctgtggc ctagggtgcc
      421 gaagatgcag cgggggacct gcaggcatat ctgaggcctg gccacaagga agactataag
      481 acttctgtag tctctgtgtg cctctgtgct ccctctgccc cagggttgta gtctgtggtt
      541 ttgagcctgc tggtgacatg gggccaagga tgtgagtgtg gcctggaaca ttgaagcagt
      601 gaccagtggg acccagtggc tccagggagc agcagcagag gaggtattga gactccaggt
      661 tgggtgggtc aggcctccag cagccatcca ccatggtggt ggcacactct gctgccaccg
      721 ctaccaccac acctgctgcc acggtcacag ccactgtcgt gatgaccaca gccaccatgg
      781 acctgcggga ctggctgttt ctctgttatg ggctcattgc cttcctcacg gaggtcatcg
      841 atagcaccac ctgcccatca gtgtgccgct gtgacaatgg cttcatctac tgcaatgacc
      901 ggggactcac atccatcccc tcagacatcc ccgacgatgc caccaccctc tacctacaga
      961 acaaccagat caacaatgcg ggcatccctc aggacctcaa gaccaaggtc aaggtgcagg
     1021 tcatctacct gtatgagaat gacctggacg agttccctat caatctcccc cgctccctga
     1081 gagagctgca tctgcaggac aacaatgtgc gcaccatcgc cagggactct ttggctcgca
     1141 tcccgctgct ggagaagctg cacctggacg acaactccgt ttccaccgtg agcatcgagg
     1201 aggatgcttt tgctgacagc aagcagctca agctgctttt cctgagccgg aaccacctga
     1261 gcagcatccc gtcagggctg ccccacacgc tggaggaact gaggctagat gacaaccgca
     1321 tctctaccat ccccctgcac gcattcaagg gtctcaacag cctgcggcgc ctggttctgg
     1381 atggcaacct gctggccaac cagcgcattg ccgacgacac cttcagccgg ctgcagaacc
     1441 tcacggagct gtcgctagta cggaactcgc tggctgcccc gccccttaat ctgcccagcg
     1501 cccacctgca gaagctctac ctgcaggaca atgccatcag tcacattccc tacaacaccc
     1561 tggccaagat gcgggagctg gagaggttgg acctgtccaa caacaacctc accacgctgc
     1621 ctcggggcct gtttgatgac ctggggaacc tggcacagct gcttctcagg aacaacccct
     1681 ggttctgtgg ctgtaacctc atgtggctga gggactgggt gagggcacgg gctgcagtgg
     1741 tcaatgtgcg gggcctcatg tgccagggcc ctgagaaggt ccggggcatg gccatcaaag
     1801 acatcaccag cgagatggat gagtgctttg aggcggggtc acagggcggt gctgctaatg
     1861 cagccgccaa gaccacagtc agcaaccatg cctctgccac cacaccccag ggctctctgt
     1921 ttaccctcaa ggccaagagg ccaggactgc gcctcccaga ctccaacatt gactacccca
     1981 tggccactgg cgatggcgcc aagacattgg tcatccaggt gaagccactg acggcagact
     2041 ctatccgaat cacatggaag gccatgctac ccgcctcttc tttccggctc agttggctac
     2101 gtctgggcca tagcccggct gtgggctcta taacagagac cctggtgcag ggggacaaga
     2161 cagagtactt gctgacagca ctggagccca agtccaccta catcatctgt atggtcacca
     2221 tggagactgg caacacctac gtggccgatg agacacctgt gtgtgccaag gcagagacag
     2281 cagatagcta tggccctacc accacgctca accaggaaca gaatgctggc cctatggcgg
     2341 ggctgcccct ggctgggatt attggtggtg ccgtggctct tgtatttctc ttcctggtcc
     2401 tgggagccat ttgctggtac gtgcaccggg ctggcgagct gctgacccga gagagggtct
     2461 acaacagggg cagcaggagg aaggacgact acatggagtc agggaccaag aaggataact
     2521 ccattctaga aatccgtggc ccaggactgc agatgctacc catcaacccg taccgctcca
     2581 aagaggagta cgtggtgcac accatatttc cctccaatgg cagcagcctc tgcaagggtg
     2641 cccacactat tggctatggc accacacgag gctaccggga agcgggcatc cctgatgtgg
     2701 actactccta cacatgaagc tggccgcccg cgccgcaccg caccggtgtg tcacgtggct
     2761 ctgtctagcc cactgcaaca ccaggagcca ggaagagaaa ctccacagtg accttccaaa
     2821 cagaaagcaa agtttgggga gggttggtga ttttgcagaa caccacagtg gggttaaaaa
     2881 aaaaaaaaac atagaagcca ggaaggggat tcagcattgt tggagatgta atttatacca
     2941 gaacatgagc gttaaagact aaatatctcg caggaagggt tgggttgggt tgggactttt
     3001 ttttttcttg aaccagattg atgctacctg tacaacattt gtattcacct cgagctccat
     3061 tcagggccag cagagagaag ccgataacaa acacgtgacg gcacggagcc ccacccccat
     3121 ccccaccccc aagcaactgt ccttgtggat gctcacgggt gacaactcag tgaaaggttt
     3181 tcaggttcct cacaaaagag ccaggggagg aaaaagactt tgctctggag acagtggcct
     3241 ggaatctctt ccctggtctt tcctgtgccg tttccttccc agatctacag aaatatgacg
     3301 ttctccgaga tactctccca acaataccat agtcaattaa aagaaaaata agtcaaactt
     3361 ttccttccag tgctgagcac ttcggttcca tccaccggac tctgcagaaa gctctgagga
     3421 aagcaaactg gagctctctc tgccgcgtgg aggtgcgtct gtctgcccac ccatggccgt
     3481 gtcctgtgtc tcagtacgga tgggtagaca gagctgcgtg tctgtcctct cagcacttcc
     3541 tgggtcagtc cttgacattt cctcagacaa tagaattgca aaaatcttgc tttctcctag
     3601 aaatcattga gtaagtagag tgtgtggagg tggaggggag gtgcctcagt ccaggtggta
     3661 ggaaagagat cctgtgtcag ccagcccaga gccgggccac tcccctttct ggtaccaaga
     3721 aaagctttcc ttgatgacca gtgccctcat ctgtccctcc cccaatagat gctgtcccca
     3781 caatagtgtt tactctttct cctgggacag gtaatttata aacaggaact gtttatacac
     3841 acacatcagc tggctagacc tattggagtt tccatggctg tccaaataaa gcccagaaaa
     3901 aaagaaaaaa attttcagaa aagcgctggg agacatcagc atacacacac acacacacac
     3961 acacacacac acacacacac acacacacat gcacaatctc agctataacc acactagggg
     4021 ctctgttctc aagaggggaa aatcagattt ctttgtataa aaaaaaatca acctccaaaa
     4081 gggtactgac cgggccctca gaagagctaa gattttattc cctctctgtg gaatcaatgt
     4141 cgttatcatt tatcaactga caccacagtg tggtgagcca tgagattaaa accatgataa
     4201 aataatgaca gcaaatccgg aaaggaggga agagcggtgc ctggggttct gatgtctgct
     4261 tcgtcctgta cttggggagc ccgggtcacc atctgtcaat gcatcgcttt gccctgcacc
     4321 gggggaaaat agtcatcaaa gggaaggcac tgctctgagg gcagccggat gagaaggggt
     4381 ccagctcctg atactgatgt tttcaaaaga cctctgccac tccatccaaa gcaaaggcag
     4441 gaagaaaagc caggcagctg cccaaagtgt acctggtggg gcatctgctt gctggacatt
     4501 aaagagccaa ctagcccgtc agtgaagaga tgagatagaa agaaatggac ccggcaggtg
     4561 cctcagagta gtggaaagag gcacaggctc ctgatcttag cccaaggggt catcacacca
     4621 aatggagacc cccaacccac cagccccagg gaacggccaa ggggtatgga cacggatcac
     4681 tccagaggag acctttcttc ctcttcatcc caagtcattt ttcccacata atgaggtcaa
     4741 gagagaaatg ttcctgagcc ccagattcag gtctgtataa acatgcaccc tggagccctg
     4801 tggtccccag tgaccctaat gatgccctag tcctggcagg ctcagaggag acccatctgt
     4861 aaggaacagg tatgtgaggg agagtcccag atgctgaaca aggcatcgag ggcaccgtgc
     4921 cagcttcccc agggccgcag ggaaatcaaa ctccacgtcc tcacccctac cttgcacctg
     4981 taacttgccc tgtctgatac gctttcatgc cccccttcct tgtttcctgc tccaggaagg
     5041 gtctggtggc caaatgcttg aaacacctgg gctgtggtaa atctcttccc ccaccacaca
     5101 gaataagcct tggcagtcac aggcagaatg tcaaagattg aggaccagtc taaggggctt
     5161 actccagatt acacctagtt ggacagccca aggctggcat tgccccctaa cgagccctgg
     5221 atgctgatca gagtgaacac tgcccagcca tggccctgca gcccctccaa tagcccttcc
     5281 tgtgccattc cacccctgct ggtcctatca ttttcccagt accctttatt ctgtgtgtat
     5341 tggggatgga ataacactgg agactaaatc cagggcctag ccatgcaagg caaacacccc
     5401 accactgtgc tgcatcccca gaactgcact tggaggcatc ctttcagaaa gcccccaagt
     5461 gtgacctttg tcccagttct ccaaaggaga aaaggaacct ggcttctggc ctcacaatac
     5521 aatagaagag gctcagggca cccagccttt ctaccctcag aagtgaggga ggccagggtt
     5581 ggcactggac ggccaatggg atgctgtccg tgtgcagctg acatttccat agggaagtct
     5641 gtggctggcc agcctgaccc tcacagtttc taaccagcca gaacaacctc catggcctca
     5701 gctctgggga gtgtattttg tggcatttaa ggcaagttta aactaaaaaa acccagtgac
     5761 acttctttgg ctaagtggtt tacccttcgt ggtaattaga tgcagcgatt ggaatctctt
     5821 tttctattac atggcaattt tactttaaat ttcctcttta aaaaaaaaaa aaaaaa
//
