LOCUS       NP_958813                674 aa            linear   ROD 28-APR-2025
DEFINITION  leucine-rich repeat transmembrane protein FLRT1 precursor [Mus
            musculus].
ACCESSION   NP_958813
VERSION     NP_958813.1
DBSOURCE    REFSEQ: accession NM_201411.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 674)
  AUTHORS   Liakath-Ali,K., Refaee,R. and Sudhof,T.C.
  TITLE     Cartography of teneurin and latrophilin expression reveals
            spatiotemporal axis heterogeneity in the mouse hippocampus during
            development
  JOURNAL   PLoS Biol 22 (5), e3002599 (2024)
   PUBMED   38713721
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 674)
  AUTHORS   Li,X., Zhao,Q., Yu,X., Cao,W., Zhang,Y., Feng,W., Jiang,L.,
            He,D.Z., Qi,R.Z. and Huang,P.
  TITLE     Apicosome: Newly identified cell-type-specific organelle in mouse
            cochlear and vestibular hair cells
  JOURNAL   iScience 26 (4), 106535 (2023)
   PUBMED   37123250
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 674)
  AUTHORS   Ruff,T., Peters,C., Matsumoto,A., Ihle,S.J., Morales,P.A.,
            Gaitanos,L., Yonehara,K., Del Toro,D. and Klein,R.
  TITLE     FLRT3 Marks Direction-Selective Retinal Ganglion Cells That Project
            to the Medial Terminal Nucleus
  JOURNAL   Front Mol Neurosci 14, 790466 (2021)
   PUBMED   34955746
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 674)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 674)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   6  (residues 1 to 674)
  AUTHORS   Yamagishi,S., Hampel,F., Hata,K., Del Toro,D., Schwark,M.,
            Kvachnina,E., Bastmeyer,M., Yamashita,T., Tarabykin,V., Klein,R.
            and Egea,J.
  TITLE     FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive
            neurons
  JOURNAL   EMBO J 30 (14), 2920-2933 (2011)
   PUBMED   21673655
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 674)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (residues 1 to 674)
  AUTHORS   Wheldon,L.M., Haines,B.P., Rajappa,R., Mason,I., Rigby,P.W. and
            Heath,J.K.
  TITLE     Critical role of FLRT1 phosphorylation in the interdependent
            regulation of FLRT1 function and FGF receptor signalling
  JOURNAL   PLoS One 5 (4), e10264 (2010)
   PUBMED   20421966
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 674)
  AUTHORS   Maretto,S., Muller,P.S., Aricescu,A.R., Cho,K.W., Bikoff,E.K. and
            Robertson,E.J.
  TITLE     Ventral closure, headfold fusion and definitive endoderm migration
            defects in mouse embryos lacking the fibronectin leucine-rich
            transmembrane protein FLRT3
  JOURNAL   Dev Biol 318 (1), 184-193 (2008)
   PUBMED   18448090
REFERENCE   10 (residues 1 to 674)
  AUTHORS   Haines,B.P., Wheldon,L.M., Summerbell,D., Heath,J.K. and Rigby,P.W.
  TITLE     Regulated expression of FLRT genes implies a functional role in the
            regulation of FGF signalling during mouse development
  JOURNAL   Dev Biol 297 (1), 14-25 (2006)
   PUBMED   16872596
  REMARK    GeneRIF: FLRT1 is expressed at brain compartmental boundaries in
            embryo
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031503.1, AC109619.11 and BE947674.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031503.1, BC070403.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..674
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.2 cM"
     Protein         1..674
                     /product="leucine-rich repeat transmembrane protein FLRT1
                     precursor"
                     /note="leucine-rich repeat transmembrane protein FLRT1"
                     /calculated_mol_wt=68776
     sig_peptide     1..51
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6RKD8.3)"
                     /calculated_mol_wt=5393
     mat_peptide     52..674
                     /product="Leucine-rich repeat transmembrane protein FLRT1.
                     /id=PRO_0000434522"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6RKD8.3)"
                     /calculated_mol_wt=68776
     Region          54..84
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          81..105
                     /region_name="LRR 1. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6RKD8.3)"
     Region          <84..331
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          106..126
                     /region_name="LRR 2. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6RKD8.3)"
     Region          108..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          127..149
                     /region_name="LRR 3. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6RKD8.3)"
     Region          129..152
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          151..175
                     /region_name="LRR 4. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6RKD8.3)"
     Region          153..178
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          176..197
                     /region_name="LRR 5. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6RKD8.3)"
     Region          179..199
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          198..220
                     /region_name="LRR 6. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6RKD8.3)"
     Region          200..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          222..246
                     /region_name="LRR 7. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6RKD8.3)"
     Region          224..249
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          247..269
                     /region_name="LRR 8. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6RKD8.3)"
     Region          250..271
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          270..292
                     /region_name="LRR 9. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6RKD8.3)"
     Region          272..295
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          293..316
                     /region_name="LRR 10. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6RKD8.3)"
     Region          296..319
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          300..>406
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Site            305
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6RKD8.3)"
     Region          441..505
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; smart00060"
                     /db_xref="CDD:214495"
     Site            553..573
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6RKD8.3)"
     Site            600
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000305|PubMed:20421966; propagated from
                     UniProtKB/Swiss-Prot (Q6RKD8.3)"
     Site            633
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000305|PubMed:20421966; propagated from
                     UniProtKB/Swiss-Prot (Q6RKD8.3)"
     Site            671
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000305|PubMed:20421966; propagated from
                     UniProtKB/Swiss-Prot (Q6RKD8.3)"
     CDS             1..674
                     /gene="Flrt1"
                     /gene_synonym="D630040I23Rik"
                     /coded_by="NM_201411.2:693..2717"
                     /db_xref="CCDS:CCDS29519.1"
                     /db_xref="GeneID:396184"
                     /db_xref="MGI:MGI:3026647"
ORIGIN      
        1 mvvahsaata tttpaatvta tvvmttatmd lrdwlflcyg liafltevid sttcpsvcrc
       61 dngfiycndr gltsipsdip ddattlylqn nqinnagipq dlktkvkvqv iylyendlde
      121 fpinlprslr elhlqdnnvr tiardslari plleklhldd nsvstvsiee dafadskqlk
      181 llflsrnhls sipsglphtl eelrlddnri stiplhafkg lnslrrlvld gnllanqria
      241 ddtfsrlqnl telslvrnsl aapplnlpsa hlqklylqdn aishipyntl akmrelerld
      301 lsnnnlttlp rglfddlgnl aqlllrnnpw fcgcnlmwlr dwvraraavv nvrglmcqgp
      361 ekvrgmaikd itsemdecfe agsqggaana aakttvsnha sattpqgslf tlkakrpglr
      421 lpdsnidypm atgdgaktlv iqvkpltads iritwkamlp assfrlswlr lghspavgsi
      481 tetlvqgdkt eylltalepk styiicmvtm etgntyvade tpvcakaeta dsygptttln
      541 qeqnagpmag lplagiigga valvflflvl gaicwyvhra gelltrervy nrgsrrkddy
      601 mesgtkkdns ileirgpglq mlpinpyrsk eeyvvhtifp sngsslckga htigygttrg
      661 yreagipdvd ysyt
//
