LOCUS       NM_001040403            2636 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus flotillin 2 (Flot2), transcript variant 1, mRNA.
ACCESSION   NM_001040403
VERSION     NM_001040403.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2636)
  AUTHORS   Moon,S., Zhao,F., Uddin,M.N., Tucker,C.J., Karmaus,P.W. and
            Fessler,M.B.
  TITLE     Flotillin-2 dampens T cell antigen sensitivity and functionality
  JOURNAL   JCI Insight 9 (24), e182328 (2024)
   PUBMED   39499901
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2636)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2636)
  AUTHORS   Yang,Q., Zhang,Z., Chen,Z., Wang,Y., Chen,Y., Zheng,J., Li,R.,
            Li,L., Mo,L., Liang,Q., Chen,F., Wang,J. and Li,X.
  TITLE     Flot2 deficiency facilitates B cell-mediated inflammatory responses
            and endotoxic shock
  JOURNAL   Immunology 170 (4), 567-578 (2023)
   PUBMED   37688314
  REMARK    GeneRIF: Flot2 deficiency facilitates B cell-mediated inflammatory
            responses and endotoxic shock.
REFERENCE   4  (bases 1 to 2636)
  AUTHORS   Wisniewski,D.J., Liyasova,M.S., Korrapati,S., Zhang,X.,
            Ratnayake,S., Chen,Q., Gilbert,S.F., Catalano,A., Voeller,D.,
            Meerzaman,D., Guha,U., Porat-Shliom,N., Annunziata,C.M. and
            Lipkowitz,S.
  TITLE     Flotillin-2 regulates epidermal growth factor receptor activation,
            degradation by Cbl-mediated ubiquitination, and cancer growth
  JOURNAL   J Biol Chem 299 (1), 102766 (2023)
   PUBMED   36470425
  REMARK    GeneRIF: Flotillin-2 regulates epidermal growth factor receptor
            activation, degradation by Cbl-mediated ubiquitination, and cancer
            growth.
REFERENCE   5  (bases 1 to 2636)
  AUTHORS   Pernot,M., Jaspard-Vinassa,B., Abelanet,A., Rubin,S., Forfar,I.,
            Jeanningros,S., Cetran,L., Yu,M.H., Balse,E., Hatem,S.,
            Dufourcq,P., Couffinhal,T. and Duplaa,C.
  TITLE     Decrease of Pdzrn3 is required for heart maturation and protects
            against heart failure
  JOURNAL   Sci Rep 12 (1), 8 (2022)
   PUBMED   34996942
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2636)
  AUTHORS   Edgar,A.J. and Polak,J.M.
  TITLE     Flotillin-1: gene structure: cDNA cloning from human lung and the
            identification of alternative polyadenylation signals
  JOURNAL   Int J Biochem Cell Biol 33 (1), 53-64 (2001)
   PUBMED   11167132
REFERENCE   7  (bases 1 to 2636)
  AUTHORS   Volonte,D., Galbiati,F., Li,S., Nishiyama,K., Okamoto,T. and
            Lisanti,M.P.
  TITLE     Flotillins/cavatellins are differentially expressed in cells and
            tissues and form a hetero-oligomeric complex with caveolins in
            vivo. Characterization and epitope-mapping of a novel flotillin-1
            monoclonal antibody probe
  JOURNAL   J Biol Chem 274 (18), 12702-12709 (1999)
   PUBMED   10212252
REFERENCE   8  (bases 1 to 2636)
  AUTHORS   Bickel,P.E., Scherer,P.E., Schnitzer,J.E., Oh,P., Lisanti,M.P. and
            Lodish,H.F.
  TITLE     Flotillin and epidermal surface antigen define a new family of
            caveolae-associated integral membrane proteins
  JOURNAL   J Biol Chem 272 (21), 13793-13802 (1997)
   PUBMED   9153235
REFERENCE   9  (bases 1 to 2636)
  AUTHORS   Cho,Y.J., Chema,D., Moskow,J.J., Cho,M., Schroeder,W.T.,
            Overbeek,P., Buchberg,A.M. and Duvic,M.
  TITLE     Epidermal surface antigen (MS17S1) is highly conserved between
            mouse and human
  JOURNAL   Genomics 27 (2), 251-258 (1995)
   PUBMED   7557989
REFERENCE   10 (bases 1 to 2636)
  AUTHORS   Bonhomme,F., Catalan,J., Britton-Davidian,J., Chapman,V.M.,
            Moriwaki,K., Nevo,E. and Thaler,L.
  TITLE     Biochemical diversity and evolution in the genus Mus
  JOURNAL   Biochem Genet 22 (3-4), 275-303 (1984)
   PUBMED   6375655
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669840.5, BY204171.1, BC070423.1 and CD774654.1.
            
            On Apr 21, 2018 this sequence version replaced NM_001040403.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170557.1, AK030199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AL669840.5         22739-22748
            11-394              BY204171.1         2-385
            395-2619            BC070423.1         434-2658
            2620-2636           CD774654.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2636
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..2636
                     /gene="Flot2"
                     /gene_synonym="Esa; reggie-2"
                     /note="flotillin 2"
                     /db_xref="GeneID:14252"
                     /db_xref="MGI:MGI:103309"
     exon            1..182
                     /gene="Flot2"
                     /gene_synonym="Esa; reggie-2"
                     /inference="alignment:Splign:2.1.0"
     exon            183..264
                     /gene="Flot2"
                     /gene_synonym="Esa; reggie-2"
                     /inference="alignment:Splign:2.1.0"
     exon            265..355
                     /gene="Flot2"
                     /gene_synonym="Esa; reggie-2"
                     /inference="alignment:Splign:2.1.0"
     exon            356..479
                     /gene="Flot2"
                     /gene_synonym="Esa; reggie-2"
                     /inference="alignment:Splign:2.1.0"
     exon            480..598
                     /gene="Flot2"
                     /gene_synonym="Esa; reggie-2"
                     /inference="alignment:Splign:2.1.0"
     exon            599..712
                     /gene="Flot2"
                     /gene_synonym="Esa; reggie-2"
                     /inference="alignment:Splign:2.1.0"
     exon            713..832
                     /gene="Flot2"
                     /gene_synonym="Esa; reggie-2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1047
                     /gene="Flot2"
                     /gene_synonym="Esa; reggie-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1231
                     /gene="Flot2"
                     /gene_synonym="Esa; reggie-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1381
                     /gene="Flot2"
                     /gene_synonym="Esa; reggie-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..2621
                     /gene="Flot2"
                     /gene_synonym="Esa; reggie-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2599..2604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Flot2"
                     /gene_synonym="Esa; reggie-2"
                     /note="hexamer: AATAAA"
     polyA_site      2621
                     /gene="Flot2"
                     /gene_synonym="Esa; reggie-2"
                     /note="major polyA site"
ORIGIN      
        1 ccgcggccgc agaggggcgc aggcgggcgg ggctggggga ggcgggatag gctgggcgcg
       61 gccggcgctg cggacccgcc acagccctcc cggtcgctgc ggacccaagg cctgctggcc
      121 tgccaacggc gccatgggca actgccacac ggtgggcccc aacgaggcgc tggtggtctc
      181 aggaggctgt tgtggttctg actacaaaca gtatgtgttt ggaggctggg cttgggcctg
      241 gtggtgtatc tcggacactc agaggatttc cctagagatt atgacgttgc agccccgctg
      301 tgaggacgta gagacggccg agggggtagc tttaactgtg acgggtgtcg cccaggtgaa
      361 gatcatgacg gagaaggagc tcctggctgt agcctgtgaa cagttcctgg gcaagaacgt
      421 acaggacatt aagaacgtcg tgctgcagac cctggagggg catctacgct ctatcctagg
      481 gactctgact gtagaacaga tttatcagga ccgagaccag tttgccaagc tggtgcggga
      541 agtggcggcc cccgatgttg gccgcatggg catcgagatc ctcagcttca ccatcaagga
      601 tgtttatgac aaagtagact atctgagctc cctgggcaag acacagactg ctgtggtgca
      661 gagagatgca gacattggtg tggcagaggc agaacgggac gcaggcatcc gggaagctga
      721 atgcaagaag gagatgctag atgtgaagtt catggcagac accaagatcg ctgactctaa
      781 gagagccttt gagcttcaaa agtcagcctt cagcgaggaa gtcaacatca agacagctga
      841 ggcccagttg gcctatgagc tgcaaggggc ccgcgagcaa cagaagatcc ggcaggaaga
      901 gattgagatt gaggtcgtac agcgcaagaa gcagatcgcc gtggaggcgc aggagatcct
      961 ccgcaccgac aaggagctca tcgccaccgt gcgccgccct gcagaggctg aggcccaccg
     1021 catccagcag atcgctgagg gcgaaaaggt gaaacaagtc ctcttggcac aagcagaagc
     1081 tgagaagatt cgcaaaattg gagaggcaga ggcagcagtc attgaggcaa tgggcaaggc
     1141 cgaggctgag cggatgaagc ttaaggctga ggcctaccag aagtatgggg atgcagccaa
     1201 gatggccttg gtgctggagg ccctgcccca gattgctgcc aagatctccg cgcccctgac
     1261 taaagtcgat gagattgtgg ttctcagtgg ggacaacagc aaggtgacat cagaagtaaa
     1321 ccggctgcta gcagaactgc cagcctctgt gcacgccctc accggtgtgg acctttcaaa
     1381 gatacccctg atcaagaacg ccactggtgc acaggtgtga ggctcctgca cactcagcct
     1441 ccagcagctg cctgcccttc cagcgcctgt tttaacgtca cagggacagc gagaacattt
     1501 ctgactctgg tgccttattt tgtagggacc agaagtgctg cgtgttcagg ccatctctgg
     1561 ctatcttcct ttctctcctg tctgccttcc tctctcccat gccctcacat taatggccac
     1621 cttcatccag cctgtctcct catctgccat atgtgcctct tcctctggct atctgtttct
     1681 ctcccctttc tccccaactt cacacacatc atctacttta actgaagttg aagttgtgta
     1741 tgataatcac tgtctgtctg tgaggagtgg cctcgctgct cctcagaatc ctggtgcctt
     1801 caagttctac atgtatctgt ctgtcctccc tggccctggc agagcccagc atgggtacaa
     1861 gggtcctagg taggacaccc actctcctct ctcctggtct gaatctccga gtgctgaacg
     1921 ctgttgcggg aagcccacaa cccacacgct cttgcccttt gaggcctgag tggccatggc
     1981 ctattggccc tagagtaatg cccttgacat gccgaggccc aggcctgctg tcatacctgc
     2041 ccctgtcccc tgcaccatca cggaggcaca gaagcaaggc ctcctgtcta tagcagcttc
     2101 ctcagcttac tactgcctta ggaggccctg cttgtgctca gggacatccc ttcccttggc
     2161 ttgtccttga ttggtgggtg ggtcttagtc tgatcccatt aagtgtttct ggggtcaatg
     2221 tctagctctg ttggggacaa gtaaggttta taggccttct tcctgctagt gcatggagct
     2281 ctcccaggag gccagggctg tgccaaccct aagagaatca agtgctgtag actggccaaa
     2341 cctcattccc tcaatgccat tttcttggcc agaataatgg ggacatggga agcagctaaa
     2401 tattctatac ctttgcacca ctggtggctg aagaggccaa tgccctggtg tcctagtagg
     2461 ggtacaaggg tgtcccgtgg gccccgtccc cacccctggc cctgcccagc ctgtgtagct
     2521 gttctgcatg tgaatgctgc atgtctggtc cgggatttgg atgttgcact accccactgc
     2581 ctgtccccct ctggtgaaaa taaagatctc ttatacccac aaaaaaaaaa aaaaaa
//
